Fanny’s publications
2009
1. Localization of DNA and RNA inEosinophil Secretory Granules
Ali R. Behzad David C. Walker Thomas Abraham John McDonough
Salahadin Mahmudi-Azer Fanny Chu Furquan Shaheen James C. Hogg
Peter D. PareThe James Hogg iCAPTURE, Int Arch Allergy Immunol 117; 2009
2008
2. Research Letters
AIDS 2008, 22:1221–1229
Liver ultrastructural morphology and mitochondrial DNA levels in HIV/hepatitis C virus
coinfection: no evidence of mitochondrial damage with highly active antiretroviral therapy
Motoi Matsukuraa, Fanny F.S. Chub, May Aua, Helen Lua, Jennifer Chena, Sonja Rietkerkc, Rolando Barriosd, John D. Farleye, Julio S. Montanerd, Valentina C. Montessorid, David C. Walkera,b and He´le`ne C.F. Coˆ te
Dr. Hogg’s 2007
3. Survival after Lung Volume Reduction in Chronic Obstructive Pulmonary Disease - Insights from Small Airway Pathology
James C. Hogg1, Fanny S. F. Chu1, Wan C. Tan1, Don D. Sin1, Sanjay A. Patel2, Peter D. Pare1,
Fernando J. Martinez3, Robert M. Rogers2, Barry J. Make4, Gerard J. Criner5, Reuben M. Cherniack4,
Amir Sharafkhaneh6, James D. Luketich2, Harvey O. Coxson1, W. Mark Elliott1, and Frank C. Sciurba2
20064. Alteration of Fibroblast Architecture and Loss of Basal Lamina Apertures in Human Emphysematous Lung
Faye E. Sirianni, Alireza Milaninezhad, Fanny S. F. Chu, and David C. Walker
Am J Respir Crit Care Med Vol 173. pp 632–638, 2006
5. 2004 NEJMN Engl J Med 2004;351(13):1367.
The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
James C. Hogg, M.D., Fanny Chu, B.Sc., Soraya Utokaparch, B.Sc., Ryan Woods, M.Sc., W. Mark Elliott, Ph.D., Liliana Buzatu, M.D., Ruben M. Cherniack, M.D., Robert M. Rogers, M.D., Frank C. Sciurba, M.D., Harvey O. Coxson, Ph.D., and Peter D. Paré, M.D.
6. Human alveolar wall fibroblasts directly link epithelial type 2 cells to capillary endothelium
Faye E. Sirianni, Fanny S. F. Chu and David C. WalkerAm J Respir Crit Care Med Vol 168. pp 1532–1537, 2003
7. Zheng X, Karsan A, Duronio V, Chu F, Bai TR, Schellenberg RR. IL-3, but not GM-CSF and IL-5, inhibits apoptosis of human basophils through phosphatidylinositol 3-kinase (PI3-K): requirement of NF-?B-dependent and independent pathways. Immunology 107:1-10, 2002.
8. Neutrophil Migration through Preexisting Holes in the Basal Laminae of Alveolar Capillaries and Epithelium during Streptococcal Pneumonia
David C. Walkera, Ali R. Behzada and Fanny ChuaMicrovascular ResearchVolume 50, Issue 3, November 1995, Pages 397-416
9. Fibroblasts Are in a Position to Provide Directional Information to Migrating Neutrophils during Pneumonia in Rabbit Lungs Ali R. Behzad, Fanny Chu and David C. WalkerMicrovascular ResearchVolume 51, Issue 3, May 1996, Pages 303-316
10. Pathway of leukocyte emigration from the pulmonary vasculature during pneumonia in rabbits DC Walker, F Chu, A MacKenzie - Am Rev Respir Dis, 1991
Posters?
1a. FASEB poster? Serial section reconstruction of neutrophils, endothelium and tight junction during diapedesis in capillaries of rabbit lung UBC eLinkDC Walker, LJ Brown, SD MacDonell, F Chu, AR Burns - FASEB J, 1998
2a FASEB poster? The role of fibroblasts in eosinophil and neutrophil migration through the conducting airway interstitium
UBC eLinkSD MacDonell, F Chu, DC Walker - FASEB J, 1998
Leading to papers:
(1) RETINAL CELL BIOLOGY:
Khaliq H. Kurji, Jing Z. Cui, Tony Lin, David Harriman, Shiv S. Prasad, Ljuba Kojic, and Joanne A. Matsubara
Microarray Analysis Identifies Changes in Inflammatory Gene Expression in Response to Amyloid-β Stimulation of Cultured Human Retinal Pigment Epithelial Cells
Invest. Ophthalmol. Vis. Sci. 2010 51: 1151-1163.
(2) Erin’sMacrophage-Derived Foam Cell Emigration from Atherosclerotic Plaques Following the Deposition of Airborne Particulate Matter in the Lungs 2010
Erin M Tranfield, Stephan F van Eeden, Kazuhiro Yatera, James C Hogg, and David C Walker
2009
The Disruption of the Epithelial Mesenchymal Trophic Unit in COPD Ali R. Behzad, John E. McDonough, Nazgol Seyednejad, James C. Hogg and David C. Walker:
(In press, Journal of COPD)
(3) State of preservation of tissues from ancient human remains found in a glacier in Canada
American Journal of Physical Anthropology 137(3):348-355 Published online July 7, 08
Maria Victoria Monsalve1, Elaine Humphrey2, David Walker1, Claudia Cheung3, Wayne Vogl4, Mike Nimmo1
1 Department of Pathology and Laboratory Medicine, UBC
2 Bio-imaging Facilities, UBC
3 Faculty of Medicine, UBC
(4) Mycobacterium tuberculosis VirulenceIs Mediated by PtpA dephosphorylationof Human Vacuolar Protein Sorting 33B
Horacio Bach,1 Kadamba G. Papavinasasundaram,1 Dennis Wong,1 Zakaria Hmama,1 and Yossef Av-Gay1,*
Cell Host & Microbe 3, 316–322, May 2008
(5) Lipoamide dehydrogenase mediates retention of coronin-1 on BCGvacuoles, leading to arrest in phagosome maturation
Ala-Eddine Deghmane, Hafid Soualhine, Horacio Bach, Khalid Sendide, Saotomo Itoh, Andrea Tam,
Sanaa Noubir, Amina Talal, Raymond Lo, Satoshi Toyoshima, Yossef Av-Gay and Zakaria Hmama
Journal of Cell Science 120, 3489 (2007) doi:10.1242/jcs.022335
There was an error published in J. Cell Sci. 120, 2796-2806.
(6) Tenocyte Responses to Mechanical Loading In Vivo
A Role for Local Insulin-Like Growth Factor 1 Signaling in Early Tendinosis in Rats
Alexander Scott,1 Jill L. Cook,2 David A. Hart,3 David C. Walker,4 Vincent Duronio,1 and Karim M. Khan1
ARTHRITIS & RHEUMATISM Vol. 56, No. 3, March 2007, pp 871–881
Details from papers
Ancient remains preserved in glaciers present a unique opportunity for us to advance ourknowledge of human origins, diversity, and health, acentral focus of anthropological studies. Cellular componentsof hard and soft tissue from frozen human remains
dated between 1670 to 1850 cal AD recovered from a glacier
in Canadawere studied. Despite the expected icecrystal damage in some samples, regions of recognizablestructure and ultrastructure were observed. We found
that the state of preservation was tissue specific andthat in some tissues the organelles were better preservedthan in others. Skeletal, connective, nervous, and epithelial
tissues were recognizable in some of the samples.
DNA had been previously extracted from these remainsand this study illustrates that the ability to successfullyextract DNA may correlate with good preservation of histology.
Liver ultrastructural morphology and mitochondrial DNA levels in HIV/hepatitis C virus coinfection: no evidence of mitochondrial damage with highly active antiretroviral therapy
Motoi Matsukuraa, Fanny F.S. Chub, May Aua, Helen Lua, Jennifer Chena, Sonja Rietkerkc, Rolando Barriosd, John D. Farleye, Julio S. Montanerd, Valentina C. Montessorid, David C. Walkera,b and He´le`ne C.F. Coˆ te´a
AIDS. 22(10):1226-1229, June 19, 2008.
Liver mitochondrial toxicity is a concern, particularly in HIV/hepatitis C virus (HCV) coinfection. Liver biopsies from HIV/HCV co-infected patients, Age (years) 43 (39–47) 48 (46–53) 14 ON-highly active antiretroviral therapy (HAART) and nine OFF-HAART, were assessed by
electron microscopy quantitative morphometric analyses.
Two ultrasound-guided liver tissue biopsies collected between 2003 and 2006 from each subject.
The first one was used for pathology using modified Ishak–Knodell scale scoring whereas the second was used for mtDNA and mtRNA quantifications and electronmicroscopic stereological morphometry.
Hepatocytes tended to be larger
ON-HAART than OFF-HAART (PU0.05), but mitochondrial volume, cristae density, lipid
volume, mitochondrial DNA and RNA levels were similar. We found no evidence of increased mitochondrial toxicity in individuals currently on HAART, suggesting that concomitant HAART should not delay HCV therapy.
The Disruption of the Epithelial Mesenchymal Trophic Unit in COPD
Ali R. Behzad a; John E. McDonough a; Nazgol Seyednejad a; James C. Hogg a; David C. Walker a
a The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital,
Depts. of Medicine and Pathology, University of British Columbia, Canada
COPD: Journal of Chronic Obstructive Pulmonary Disease
\25 November 2009
capillary endothelium(Endothelium of capillary) - NextBio
Faye E Sirianni; Ranganath Muniyappa; Tiina Henttinen; David C Walker; Fanny S F Chu... University of British Columbia; National Institutes of Health ...
- United States
Survival after lung volume reduction in chronic obstructive ...
by JC HOGG - 2007 - Cited by 28 - Related articles
HOGG James C. (1) ; CHU Fanny S. F. (1) ; TAN Wan C. (1) ; SIN Don D. (1) ... (1) University of British Columbia iCAPTURE Center for Cardiovascular and ...
cat.inist.fr/?aModele=afficheN&cpsidt=19034991
Published:
1. Alteration of Fibroblast Architecture and Loss of Basal Lamina Apertures in Human Emphysematous Lung
Faye E. Sirianni, Alireza Milaninezhad, Fanny S. F. Chu and David C. Walker
Am J Respir Crit Care Med. 2006 Mar 15;173(6):632-8.
2. Tenocyte responses to mechanical loading in vivo: a role for local insulin-like growth factor 1 signaling in early tendinosis in rats.
Scott A, Cook JL, Hart DA, Walker DC, Duronio V, Khan KM.
Arthritis Rheum. 2007 Mar; 56(3):871-81.
3. Cover page images for The Journal of Allergy and Clinical Immunology Vol. 120, No 1 July 2007 byDavid C Walker
In press:
1. Liver ultrastructural morphology and mitochondrial DNA levels in HIV/HCV co-infection: no evidence of mitochondrial damage with HAART Motoi Matsukura, Fanny F.S. Chu, May Au, Helen Lu, Jennifer Chen, Sonja Rietkerk, Rolando Barrios, John D. Farley, Julio S. Montaner, Valentina C. Montessori, David C. Walker, Hélène C.F. Côté – submitted to and accepted by AIDS Journal(In press)
Submitted:
1. State of preservation of tissues from ancient human remains found in a glacier in Canada
Maria Victoria Monsalve1, Elaine Humphrey, David G. Walker, Claudia Cheung, Wayne Vogl, Mike Nimmo - submitted to American Journal of Physical Anthropology
2. In process of submitting to a journal
Macrophage-Derived Foam Cell Emigration from Atherosclerotic Plaques Following the Deposition of Airborne Particulate Matter in the Lungs
Erin M Tranfield, Stephan F van Eeden, Kazuhiro Yatera, James C Hogg, and David C Walker
David’s
PUBLISHED (2006-2007)
1. Alteration of Fibroblast Architecture and Loss of Basal Lamina Apertures in Human Emphysematous Lung
Faye E. Sirianni, Alireza Milaninezhad, Fanny S. F. Chu and David C. Walker
Am J Respir Crit Care Med. 2006 Mar 15;173(6):632-8.
2. Tenocyte responses to mechanical loading in vivo: a role for local insulin-like growth factor 1 signaling in early tendinosis in rats.
Scott A, Cook JL, Hart DA, Walker DC, Duronio V, Khan KM.
Arthritis Rheum. 2007 Mar; 56(3):871-81.
3.Cover page images for The Journal of Allergy and Clinical Immunology Vol. 120, No 1 July 2007 byDavid C Walker
PUBLISHED (2008-2009)
State of preservation of tissues from ancient human remains found in a glacier in Canada
Maria Victoria Monsalve1, Elaine Humphrey2, David Walker1, Claudia Cheung3, Wayne Vogl4, Mike Nimmo1
1 Department of Pathology and Laboratory Medicine, UBC
2 Bio-imaging Facilities, UBC
3 Faculty of Medicine, UBC
4 Cellular and Physiological Sciences, UBC
American Journal of Physical Anthropology 137(3):348-355 Published online July 7, 08
(2) Liver ultrastructural morphology and mitochondrial DNA levels in HIV/hepatitis C virus coinfection: no evidence of mitochondrial damage with highly active antiretroviral therapy
Matsukura, Motoi; Chu, Fanny FS; Au, May; Lu, Helen; Chen, Jennifer; Rietkerk, Sonja; Barrios, Rolando; Farley, John D; Montaner, Julio S; Montessori, Valentina C; Walker, David C; Côté, Hélène CF
1: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC,Canada
2: The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Vancouver, BC, Canada
3: Centre for Excellence in HIV/AIDS, Providence Research Institute
AIDS 2008, 22(10):1221–1229
IN PRESS
The Disruption of the Epithelial Mesenchymal Trophic Unit in COPD Ali R. Behzad, John E. McDonough, Nazgol Seyednejad, James C. Hogg and David C. Walker:
(In press, Journal of COPD)
Localization of DNA and RNA in Eosinophil Secretory Granules
Ali R Behzad, David C Walker, John McDonough, Thomas Abraham, Salahadin Mahmudi-Azer, Fanny Chu, Furquan Shaheen, James C Hogg, and Peter D Paré .
(In press, International Archives of Allergy and Immunology)
Accepted July 2009
In process of submitting to a journal
Macrophage-Derived Foam Cell Emigration from Atherosclerotic Plaques Following the Deposition of Airborne Particulate Matter in the Lungs
Erin M Tranfield, Stephan F van Eeden, Kazuhiro Yatera, James C Hogg, and David C Walker
The Association Between Small Airway Obstruction and Emphysema Phenotypes in COPD*
Chest 2007;131;1372-1378; Prepublished online February 22, 2007;
Yee, Robert D. Levy, Peter D. Paré and James C. Hogg
Won-Dong Kim, Sean H. Ling, Harvey O. Coxson, John C. English, John
Busy in Core 2 2009
In a collaborative effort with Dr Cote and graduate student Motoi Matsukura we demonstrated by ultrastructural morphometric analysis that whether or not HIV/HC co-infected patients were on highly active antiretroviral therapy (HAART) had no effect on mitochondrial ultrastructure in tissues from liver biopsies. Only hepatocytes sizes were different. Thus treatment for HCV should not be postponed for pathients on HAART.
This collaboration will continue for the next two years with Hayley Spencer who is beginning her MSc with Drs Cote and Walker looking at hepatocytes well being with HCV therapy by TEM morphometric analysis. Further, to this in collaboration with Blair Levitt and Helen Cote we will be looking at mitochondrial ultrastructural changes in a mouse model of Huntington’s disease. In both of these studies we will use electron tomography to quantitatively assess the mitochondrial cristae.
Recently, with Dr Vicky Monsalve we have had the privilege of examining electron microscopic samples from heart, lung and skeletal muscle tissues from the corps of BC’s 350 year old “Ice Man” found in a glacier a few years ago. Having just procured some more embedded tissues we will look a little further. This study published in the American Journal of Physical Anthropology correlates successful DNA recovery with ultrastructural integrity of the tissues. This was down right fun!
With Dr Ali Behzad and Nazgol Seyednezad we have again shown that the relationships between the conducting airway epithelium and subtending mesenchymal cells are reduced in number with progressively worse GOLD standard ranking. This is in press. Work with Nazgol is currently slowed but ongoing looking at extracellular matrix around these and control airways. The first is in press with the Journal of COPD.
In our facility Dr Behzad also just had a paper accepted which localizes DNA and RNA in Eosinohil secretory granules. This will appear in Int. Archives of Allergy and Immunology.
Dr Walker is in discussions for a possible collaboration with Drs Alan Burns and Wayne Smith to look at collagen re-arrangement during leukocyte migration in edema in the corneas of mice using High Pressure Freezing and electron tomography to overcome chemical fixation artifacts. This is vital as collagen arrangement plays a role in corneal function in optics.
Your stuff Fanny with TB etc.