Work Address:Saha Cardiovascular Research Center

Hong Lu

Curriculum vitae

Page 1

Hong Lu, MD, PhD

CURRICULUM VITAE

June, 2015

Work address:Saha Cardiovascular Research Center

741 South Limestone
BBSRB Room B249
University of Kentucky
Lexington, KY 40536

E-mail address:

Telephone No:859-323-4639 (office);859-489-1124 (cell)

Fax No:859-257-3235

Immigration Status:Permanent Resident of the U.S.A.

Nationality:Chinese

Education:

09/1988-07/1993:MD. School of Medicine, Zhejiang University, Hangzhou, China

04/2000-03/2003:PhD. Molecular Genetics of Internal Medicine,Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan

Training:

07/1992-06/1993:Intern, PekingUnionMedicalCollegeHospital, Beijing, China

07/1993-06/1996:Resident, Internal Medicine Department, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

07/1996-06/1997:Chief Resident, Internal Medicine Department, and Fellow, Cardiology Division, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

07/1996-02/1998:Fellow, Cardiology Division of Internal Medicine Department, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

02/1998-02/1999:Exchange Scholar, the First Department of Internal Medicine, FukuiMedicalUniversity, Fukui, Japan

02/1999-05/1999:Fellow, Cardiology Division of Internal Medicine Department, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

07/1999-03/2000:Researcher, Number 2 Department of Internal Medicine, Kanazawa University, Kanazawa, Japan

04/2003-09/2007:Postdoctoral Fellow, Internal Medicine Department, University of Kentucky, Lexington, KY

Appointments:

10/2007-6/2008:Scientist III, Department of Internal Medicine, University of Kentucky, Lexington, KY

7/2008-12/2009:Research Assistant Professor, Internal Medicine Department, University of Kentucky Medical Center, Lexington, KY

10/2008-12/2009:Pathology Core Director, NIH research funding PO1 HL80100

(Program Director: Alan Daugherty).

Title-Mechanisms of abdominal aortic aneurysm formation.

1/2010-12/2011:Research Assistant Professor, Department of Cell Biology and

Anatomy, University of South Carolina School of Medicine,

Columbia, SC

1/2010-12/2011:Adjunct Professor, Saha Cardiovascular Research Center,

University of Kentucky Medical Center, Lexington, KY

1/2012-6/2015:Research Assistant Professor, Saha Cardiovascular Research

Center, Department of Internal Medicine, University of Kentucky

Medical Center, Lexington, KY

7/2015-present:Research Associate Professor, Saha Cardiovascular Research

Center, Department of Internal Medicine, University of Kentucky

Medical Center, Lexington, KY

Awards:

2004:New Investigator Travel Award, Arteriosclerosis, Thrombosis, and Vascular Biology Council of the American Heart Association.

2005:Finalist, Junior Women’s Award, Arteriosclerosis, Thrombosis, and Vascular Biology Council of the American Heart Association.

2006:New Investigator Travel Award, Arteriosclerosis, Thrombosis, and Vascular Biology Council of the American Heart Association.

2009:Early Career Investigator Travel Award, Arteriosclerosis, Thrombosis, and Vascular Biology Council of the American Heart Association.

USMLE Status:ECFMG certificate (February, 2007)

Grants:

09/1988-07/1992:Outstanding Student Yearly Award, Zhejiang Medical University, China.

04/2002-03/2003:International Rotary Club Scholarship for Outstanding Graduate Students in Medical Sciences, Japan, ¥ 1,800,000 (Japanese).

07/2004-06/2006:AHA Postdoctoral Fellowship Award. AHA identification No: 0425372B. $ 84,000.

5/1/2015-4/30/2016: Pilot project of 8P20GM103527-05 (PI: Cassis). $50,000

6/2015 – 5/2016:Merck project to determine anti fibrosis on AngII-induced aortic aneurysms (PI: Hong Lu). $150,000

Membership of Learned Societies:

American Heart Association, ID No: 119606022, April, 2003-present

American Society for Investigative Pathology, ID No: 96123, Jan, 2008-present

Editorial Board:

Arteriosclerosis Thrombosis and Vascular Biology, October 2013-present

Manuscript Reviewer:

Atherosclerosis

American Journal of Cardiology

Arteriosclerosis Thrombosis and VascularBiology (27 manuscripts reviewed in 2013. Rated as a Top 10 Reviewers for 2014).

Circulation Research

Journal of Cardiovascular Pharmacology

Assisted manuscript reviews for Nature Medicine, Nature Communication, Journal of Clinical Investigation, Science Translational Medicine, Clinical Science, British Journal of Pharmacology, PLoS ONE, and Circulation.

Abstract Grading:

ATVB conference, 2013 - 2015

Grant Review:

1.AHA SURF1 grants, March and October 2013, March 2014

2.AHA Thrombosis basic science grants, October 2014 and April 2015

Publications:

1.Lu D, Lu H, Xu Z. The relation between periodic rhythm and heart rate in patients with severe ventricular premature beats. Cardioelectric Journal 1996; 15(3): 71-75. (Chinese)

2.Wang JA, Lu H, Xian T. The appliances of transeophageal echocardiography in heart diseases. Zhejiang Medicine 1996; 18(6): 329-330. (Chinese)

3.Wang JA, Lu H, Xian T. The appliances of transeophageal echocardiography in percutaneous balloon mitral valvuloplasty. Clinical Journal of Cardiology 1997; 13(2): 117. (Chinese)

4.Lu H, Lu D. The basic and clinic factors in heart failure patients with ventricular arrhythmia. Foreign Medical Sciences, heart disease 1998; 25(2):91-93. (Chinese)

5.Lu H, Higashikata T, Inazu A et al. Association of estrogen receptor- gene polymorphisms with coronary artery disease in patients with familial hypercholesterolemia. Arteriosclerosis, Thrombosis and Vascular Biology. 2002; 22 (5): 817-823.

6.Yu W, Nohara A, Higashikata T, Lu H et al. Molecular genetic analysis of familial hypercholesterolemia: spectrum and regional difference of LDL receptor gene mutations in Japanese population. Atherosclerosis 2002; 165(2): 335-342.

7.Lu H, Inazu A, Moriyama Y et al. Haplotype analyses of cholesteryl ester transfer protein gene promoter: a clue to an unsolved mystery of TaqIB polymorphism. Journal of Molecular Medicine 2003; 81 (4): 246-255.

8.Daugherty A, Rateri DL,Lu H et al. Cassis. Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1a receptor. Circulation 2004; 110 (25): 3849-3857.

9.Mabuchi H, Higashikata T, Nohara A, Lu H et al. Cutoff point separating affected and unaffected familial hypercholesterolemic patients validated by LDL-receptor gene mutants. Journal of Atherosclerosis and Thrombosis 2005; 12(1): 35-40.

10.Cassis LA, Rateri DL, Lu H,Alan Daugherty. Bone marrow transplantation reveals that recipient AT1a receptors are required to intitiate AngII-induced atherosclroisis and aneurysms. Arteriosclerosis, Thrombosis, and Vascular Biology; 2007; 27(2): 380-386.(PMID 17158350)

11.Lu H, Boustany-Kari CM, Daugherty A, Cassis LA. AngII increases adipose angiotensinogen expression. American Journal of Physiology-Endocrinology and Metabolism 2007; 292(5): E1280-1287.

12.Lu H, Rateri DL, Feldman DL et al. Renin inhibition reduces hypercholesterolemia-induced atherosclerosis. Journal of Clinical Investigation; 2008; 118(3): 984-993.(PMID 18274671; PMC2242618)

13.Uchida HA, Kristo F, Rateri DL, Lu H et al. Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice. Atherosclerosis; 2010; 211(2): 399-403.(PMID 20362292; PMC2900415)

14.Thatcher SE, Zhang X, Howatt DA, Lu H et al.Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in LDL receptor -/- mice. Arteriosclerosis, Thrombosis and Vascular Biology 2011;31: 758-765.

15.Liang Q, Wu Q, Jiang J, Duan J, Wang C, Smith MD, Lu H et al. Characterization of Sparstolonin B, a Chinese herb-derived compound as a selective Toll-like receptor antagonist with potent anti-inflammatory properties. Journal of Biological Chemistry 2011; 286: 26470-26479.

16.Owens III AP, Rateri DL, Howatt DA, Moore KJ, Tobias PS, Curtiss LK, Lu H et al. MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through toll-like receptors 2 and 4. Arteriosclerosis, Thrombosis and Vascular Biology2011; 31: 2813-2819.

17.Lu H, Balakrishnan A, Howatt DA et al. Comparative effects of different modes of renin angiotensin system inhibition on hypercholesterolemia-induced atherosclerosis. British Journal of Pharmacology2012; 165: 2000-2008.

18.Wang S, Subramanian V, Lu H et al.Deficiency of receptor-associated protein attenuates angiotensin II-induced atherosclerosis in hypercholesterolemic mice. Atherosclerosis. 2012; 220: 375-380

19.Lu H, Meléndez GC, Levick SP, Janicki JS.Volume overload has differential effects on the initial phase of cardiac remodeling in female rats with and without ovariectomy. American Journal of Physiology Heart and Circulatory Physiology2012; 302: H811-817.

20.Li J,*, Lu H,* Plante E et al. Stem cell factor is responsible for the rapid response in mature mast cell density in the acutely stresses heart. Journal of Molecular and Cellular Cardiology2012; 53: 469-474.(* equal contribution)

21.Xie X, Lu H, Moorleghen JJ et al. Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice. PLoS ONE 2012; 7: e46411.

22.Lu H, Wu C-Q, Howatt DA et a. Differential effects of dietary sodium intake on blood pressure and atherosclerosis. Journal of Nutritional Biochemistry 2013; 24: 49-53.

23.Chen X, Lu H, Zhao M et al. Contributions of leukocyte angiotensin-converting enzyme to development of atherosclerosis.Arteriosclerosis, Thrombosis and Vascular Biology. 2013;33: 2075-2080.

24.Du F, Yu F, Wang Y, Hui Y, Carnevale K, Fu M, Lu H, Fan D. microRNA-155 deficiency results in decreased macrophage inflammation and attenuated atherogenesis in apoE -/- mice.Arteriosclerosis, Thrombosis and Vascular Biology. 2014; 34: 759-767.

25.Wu C-Q, Xu Y, LuHet al. Cys18-Cys137 disulfide bond in mouse angiotensinogen does not affect AngII-dependent functions in vivo.

Hypertension. 2015; 65: 800-805.

26.Lu H, Howatt DA, Balakrishnan A et al. Subcutaneous angiotensin II infusion using osmotic pumps induces aortic aneurysms in mice. JoVE 2015 In Press.

27.Liu J,*Lu H,* Howatt DA et al. ApoB-containing Lipoproteins Augment AngII-

induced Abdominal Aortic Aneurysms in Male Mice. Arteriosclerosis, Thrombosis

and Vascular Biology2015 In Press.(* equal contribution)

Manuscripts in Preparation:

1.Wu C-Q,* Lu H,* Howatt DA, et al. Angiotensinogen has unique functions

independent of its role on generating angiotensin peptides. Will submit to Journal of Clinical Investigation (* equal contribution).

2.Chen X, Cassis LA, Daugherty A, Hong Lu. ACE deficiency in vascular smooth

muscle cells reduces AngI-induced ascending aortic aneurysms. Will submit to Arteriosclerosis, Thrombosis and Vascular Biology.

Reviews:

1.Lu H, Cassis LA, Daugherty A. The role of the renin-angiotensin system in vascular aneurysm formation. Current Hypertension Reports; 2008; 10: 99 - 106.

2.Daugherty A, Rateri DL, Lu H, Balakrishnan A. Measuring blood pressure in mice using volume pressure recording, a tail-cuff method. J Vis Exp; 2009; 27: 1291.

3.Daugherty A, Lu H, Rateri DL, Cassis LA. Augmentation of the renin angiotensin system by hypercholesterolemia promotes vascular diseases. Future Lipidol 2008; 3: 625-636.(PMID 19802341; PMC2636897)

4.Daugherty A, Lu H, Howatt DA, Rateri DL. Modes of defining atherosclerosis in mouse models: relative merits and evolving standards. Methods in Molecular Medicine 2009; 573: 1-15.

5.Daugherty A, Poduri A, Chen X, Lu H, Cassis LA. Genetic variants of the renin angiotensin system: effects on atherosclerosis in experimental models and humans. Curr Atheroscler Rep 2010; 12: 167-173.

6.Daugherty A, Cassis LA, Lu H. Complex pathologies of angiotensin II-induced abdominal aortic aneurysms. Journal of Zhejiang University-Biomedicine & Biotechnology2011; 12: 624-628.

7.Bruemmer D, Daugherty A, Lu H, Rateri DL. Relevance of angiotensin II-induced aortic pathologies to human aortic aneurysms. Annals of The New York Academy of Sciences2011; 1245: 7-10.

8.Wu C-Q, Lu H,Cassis LA, Daugherty A. Molecular and pathophysiological features of angiotensinogen: a mini review. North America Journal of Medical Sciences 2011; 4: 196-203.

9.Lu H, Rateri DL, Bruemmer D, Cassis LA, Daugherty A. Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms. Clin Sci 2012; 123: 531-543.

10.Lu H, Rateri DL, Bruemmer D, Cassis LA, Daugherty A. Novel mechanisms of abdominal aortic aneurysms. Curr Atheroscler Rep 2012; 14(5): 402-412.

11.Chen X, Lu H, Rateri DL, Cassis LA, Daugherty A. Conundrum of Angiotensin II and TGF-β Interactions in Aortic Aneurysms. Current Opinion in Pharmacology 2013; 13: 180-185.

12.Liu J, Daugherty A,Lu H. Angiotensin II and abdominal aortic aneurysms: an update. Curr Pharm Des 2015; In Press.

Book Chapters:

1. Lu H, Cassis LA, Daugherty A. Atherosclerosis and arterial blood pressure in mice. Current Drug Targets; Bentham Press. Editor: G.S. Getz; 2007; 8: 1181-1189.(PMID 18045096)
2. Lu H, Rateri DL, Daugherty A. Immunostaining of mouse atherosclerotic lesions. Methods in MolecularMedicine; Humana Press. Editor: N. Sreejayan, and J. Ren; 2007; 139: 77-94.(PMID 18287665)

3.Lu H, Cassis LA, Daugherty A. The renin-angiotensin system in atherosclerosis. Advances in Atherosclerosis: Treatment and Prevention. Novel Strategies for the Treatment of Atherosclerosis.Stanford Chong Publishers. Editoirs. O. Soehnlein and C. Weber. 2012.

4.Lu H, Cassis LA, Daugherty A. Angiotensin peptides. Atherosclerosis: Cellular, Molecular & Biochemical Mechanism and Therapy. Wiley Press. Editors. H. Wang and C. Patterson. 2014.

5.Huff M, Daugherty A, Lu H. Biochemistry of Lipids, Lipoproteins, and Membranes: Atherosclerosis. Elsevier. Editors: Drs. Ridgway and McLeod. In preparation.

6.Lu H, Howatt DA, Balakrishnan A et al. Angiotensin II-induced aortic aneurysms in mice. Springer. Editors: 2015 In Press

Editorials:

1.Daugherty A, Rateri DL, Lu H. As macrophages indulge, atherosclerotic lesions bulge. Circ Res; 2008, 102: 1445 - 1447.(PMID 18566308; PMC2730919)

2.Daugherty A, Lu H, Rateri DL. Atherosclerosis: cell biology and lipoproteins. Curr Opin Lipidol; 2009, 20: 260 – 261.

3.Lu H, Daugherty A. Atherosclerosis: cell biology and lipoproteins. Curr Opin Lipidol; 2009, 20: 528-529.

4.Lu H, Daugherty A. Atherosclerosis: cell biology and lipoproteins. Curr Opin Lipidol; 2010, 21: 552-553.

5.Lu H, Daugherty A. Atherosclerosis: cell biology and lipoproteins. Curr Opin Lipidol; 2011, 21: 322-323.

6.Lu H, Daugherty A. Atherosclerosis: cell biology and lipoproteins. Curr Opin Lipidol; 2012, 23: 263-264.

7.Lu H, Daugherty A. Atherosclerosis: cell biology and lipoproteins. Curr Opin Lipidol; 2013, 24: 455-456.

8.Daugherty A,Lu H. Diverse contributions from the initial discovery of mechanisms of angiotensin II-induced oxidation in smooth muscle cells. Circ Res; 2013, 113: 1283-1285.

9.Lu H, Daugherty A. Atherosclerosis: cell biology and lipoproteins. Curr Opin Lipidol; 2014; 25:157-158.

10.Lu H, Daugherty A. Atherosclerosis: cell biology and lipoproteins. Curr Opin Lipidol; 2015; 26:152-153.

11. Lu H, Daugherty A. Atherosclerosis. Arterioscler Thromb Vasc Biol; 2015; 35:489-491.

12.Lu H, Aikawa M. The many faces of matrix metalloproteinases in aortic aneurysms. Arterioscler Thromb Vasc Biol; 2015; 35: 752-754.

Abstracts:

1. Hong Lu, Toshinori Higashikata, Akihiro Inazu, Hiroshi Mabuchi. Association of estrogen receptor- gene polymorphisms, PvuII and XbaI, with coronary artery disease in patients with familial hypercholesterolemia. 33th Annual Meeting of Japan Atherosclerosis Society; July, 2001, Tokyo, Japan.
2. Hong Lu, Toshinori Higashikata, Akihiro Inazu, Hiroshi Mabuchi. Association of estrogen receptor- gene polymorphisms with coronary artery disease in patients with familial hypercholesterolemia. XIV International Symposium on Drugs Affecting Lipid Metabolism; September, 2001, New York.
3. Hong Lu, Akihiro Inazu, Hiroshi Mabuchi. Genetic analyses of cholesteryl ester transfer protein gene promoter and HDL cholesterol. 34th Annual Meeting of Japan Atherosclerosis Society; July, 2002, Kobe, Japan.
4. Hong Lu, Katsuya Tashiro, Debra L. Rateri, Lisa A. Cassis, Alan Daugherty. Definition of a macrophage renin-angiotensin system that is stimulated in a hyperlipidemic environment. 5th Annual conference on Arteriosclerosis, Thrombosis and Vascular Biology; May, 2004, San Francisco.
5. Hong Lu, Debra L. Rateri, Lisa A. Cassis, Alan Daugherty. The blockade of AT1 receptors increases angiotensinogen expression in mouse adipose tissue. 13th South East Lipid Research Conference; September, 2004, CallawayGardens, Pine Mountain, Georgia.
6. Hong Lu, Katsuya Tashiro, Debra L. Rateri, Lisa A. Cassis, Alan Daugherty. Acetylated LDL-induced lipid-loading of macrophages upregulates angiotensinogen via the AT1a receptor. 6th Annual conference on Arteriosclerosis, Thrombosis and Vascular Biology; April, 2005, Washington, DC.
7. Hong Lu, Debra L. Rateri, Lisa A. Cassis, Alan Daugherty. Renin deficiency in bone marrow-derived cells reduces hypercholesterolemia-Induced atherosclerosis. 7th Annual conference on Arteriosclerosis, Thrombosis and Vascular Biology; April, 2006, Denver.

8.Hong Lu, Lisa A. Cassis, David L Feldman, Alan Daugherty. Renin inhibition markedly reduces hypercholesterolemia-induced atherosclerosis. American Heart Association Scientific Sessions 2006, Nov, 2006, Chicago.

9.Hong Lu, Debra L. Rateri, Lisa A. Cassis, Alan Daugherty. Medial macrophages that accumulate in abdominal aortic regions prone to angiotensin II-induced aneurysms are not primarily derived from blood borne cells. 8th Annual conference on Arteriosclerosis, Thrombosis and Vascular Biology; April, 2007, Chicago, IL.

10.Hong Lu, Lisa A. Cassis, Alan Daugherty. Exogenous angiotensin II directly promotes abdominal aortic aneurysms in hypercholesterolemic mice. Angiotensin Gordon Research Conference; February, 2008, Ventura, CA.

11.Hong Lu, Lisa A. Cassis, Alan Daugherty.Dietary sodium regulates blood pressure and the systemic renin angiotensin system independent of atherogenesis. 9th Annual conference on Arteriosclerosis, Thrombosis and Vascular Biology; April, 2008, Atlanta.

12.Hong Lu, Lisa A. Cassis, Alan Daugherty. Exogenous angiotensin II directly promotes abdominal aortic aneurysms in hypercholesterolemic mice. 9th Annual conference on Arteriosclerosis, Thrombosis and Vascular Biology; April, 2008, Atlanta.

13.Hong Lu, Lisa A. Cassis, Alan Daugherty. Infusion of the AngII precursor, AngI, induces atherosclerosis and aneurysms via an ACE dependent mechanism. 9th Annual conference on Arteriosclerosis, Thrombosis and Vascular Biology; April, 2008, Atlanta.

14.Hong Lu, Lisa A. Cassis, Alan Daugherty. Low dietary sodium augments hypercholesterolemia-induced atherosclerosis. 10th Annual conference on Arteriosclerosis, Thrombosis and Vascular Biology; April, 2009, Washington, DC.

15.Xiaofeng Chen, Hong Lu, Lisa A. Cassis, Alan Daugherty. Angiotensinogen Deficiency in bone marrow-derived cells does not reduce hypercholesterolemia-induced atherosclerosis. 11th Annual conference on Arteriosclerosis, Thrombosis and Vascular Biology; April, 2010, San Francisco, CA.

16.Congqing Wu, Lisa A. Cassis, Alan Daugherty, Hong Lu.Attenuation ofendogenous angiotensinogen reduces abdominal aortic aneurysms induced by exogenous Angiotensin II. 11th Annual conference on Arteriosclerosis, Thrombosis and Vascular Biology; April, 2010, San Francisco, CA.

17.Hong Lu, Anju Balakrishnan, Deborah A. Howatt, Richard Charnigo, Gene Liau, Lisa A. Cassis, Alan Daugherty. Comparative effects of different modes of renin angiotensin system inhibition on hypercholesterolemia-induced atherosclerosis.12th Annual conference on Arteriosclerosis, Thrombosis and Vascular Biology; April, 2011, Chicago, IL.

18.Congqing Wu, Lisa A. Cassis, Alan Daugherty, Hong Lu.Hepatocyte-specific

angiotensinogen deficiency markedly reduces hypercholesterolemia-induced

atherosclerosis and diet-induced obesity in mice. AmericanHeartAssociation Scientific Sessions 2011, Nov, 2011, Orlando, FL.

19.Congqing Wu, Lisa A. Cassis, Alan Daugherty, Hong Lu.Angiotensinogen influences metabolic rates and metabolome in plasma and hepatic tissue. 13th Annual conference on Arteriosclerosis,Thrombosis and Vascular Biology; April, 2012, Chicago, IL.

20.Congqing Wu,Hong Lu, Jessica J. Moorleghen, Deborah A. Howatt, Anju Balakrishnan, Lisa A. Cassis, Alan Daugherty. Adeno-associated virus-mediated restoration of angiotensinogen function in mice with hepatocyte-specific deficiency. 14th Annual conference on Arteriosclerosis, Thrombosis and Vascular Biology; May, 2013, Orlando, FL.

21.Anju Balakrishnan, Deborah A. Howatt, Hong Lu, Mark J. Graham, Adam E. Mullick, Rosanne M. Crooke, David Feldman, Lisa A. Cassis, Alan Daugherty. Comparative effects of angiotensinogen versus renin inhibition on established atherosclerosis and obesity in hypercholesterolemic mice.14th Annual conference on Arteriosclerosis,Thrombosis and Vascular Biology; May, 2013, Orlando, FL.

22.Jing Liu, Hong Lu, Deborah A. Howatt, Anju Balakrishnan, Lisa A. Cassis, Alan Daugherty. The effects of hypercholesterolemia and lipoprotein-cholesterol concentrations on angiotensin II-induced abdominal aortic aneurysms. 14th Annual conference on Arteriosclerosis,Thrombosis and Vascular Biology; May, 2013, Orlando, FL.

23.Yinchuan Xu, Hong Lu, Deborah A. Howatt, Anju Balakrishnan, Jessica J.

Moorleghen, Lisa A. Cassis, Alan Daugherty. Nicotine infusion fails to induce abdominal aortic aneurysms in LDL receptor deficient mice. 14th Annual conference on Arteriosclerosis,Thrombosis and Vascular Biology; May, 2013, Orlando, FL.

24.Jing Liu, Hong Lu, Deborah A. Howatt, Anju Balakrishnan, Mary Sorci-Thomas, Lisa A. Cassis, Alan Daugherty. ApoB-containing lipoproteins contribute to augmentation of AngII-induced abdominal aortic aneurysms. 15th Annual conference on Arteriosclerosis,Thrombosis and Vascular Biology; May, 2014, Toronto, Canada.

25.Anju Balakrishnan, Deborah A. Howatt, Hong Lu, Mark J. Graham, Adam E. Mullick, Rosanne M. Crooke, Lisa A. Cassis, Alan Daugherty. Angiotensinogen inhibition reduces atherosclerosis and body weight gain induced by high carbohydrate diet.15th Annual conference on Arteriosclerosis,Thrombosis and Vascular Biology; May, 2014, Toronto, Canada.

26.Xiaofeng Chen, Deborah A. Howatt, Anju Balakrishnan, Jessica J. Moorleghen, Lisa A. Cassis, Alan Daugherty,Hong Lu. Smooth muscle cell-specific deficiency of ACE attenuates AngI-induced ascending aortic dilation in male LDL receptor -/- mice. 15th Annual conference on Arteriosclerosis,Thrombosis and Vascular Biology; May, 2014, Toronto, Canada.

27.Xiaofeng Chen, Deborah A. Howatt, Anju Balakrishnan, Jessica J. Moorleghen,

Lisa A. Cassis, Alan Daugherty,Hong Lu. Deficiency of angiotensin-converting enzyme in vascular smooth muscle cells reduces hypercholesterolemia-induced atherosclerosis.American HeartAssociation Scientific Sessions 2014. Conference will be held in Nov, 2014, Chicago, IL.

28.Anju Balakrishnan, Deborah A. Howatt, Lisa A. Cassis, Alan Daugherty Hong

Lu. Hypercholesterolemia induced by a PCSK9 gain-of-function mutation augments AngII-induced AAAs in C57BL/6 mice.16th Annual conference on Arteriosclerosis,Thrombosis and Vascular Biology; May, 2015, San Francisco, CA.

29.Jing Liu, Hong Lu, Jessica Moorleghen, Deborah A. Howatt, Anju Balakrishnan, Lisa A. Cassis, Alan Daugherty. Reductions of apoB-containing lipoproteins prevented progression of established AAAs in AngII infused mice.16th Annual conference on Arteriosclerosis,Thrombosis and Vascular Biology; May, 2015, San Francisco, CA.

Acknowledgments in Publications:

1.Rateri DL, Moorleghen JJ, Balakrishnan A et al. Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice. Circ Res 2011; 108: 574-581.

2.UchidaHA, PoduriA, SubramanianV et al. uPA Deficiency in Bone Marrow-derived Cells Augments Rupture of Angiotensin II-induced Abdominal Aortic Aneurysms. Arteriosclerosis, Thrombosis and Vascular Biology2011; 52: 2272-2278.

3.Poduri A, Owens AP 3rd, Howatt DA et al. Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms. PLoS ONE 2012; 7: e48462.