UCSF Lab Standard Operating Procedure s7

UCSF Lab Standard Operating Procedure

Chemical Process, Name or Hazard Class:

Anthraquinone

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Type of SOP: ☐ Process ☒Hazardous Chemical ☐ Hazardous Class

Purpose

Anthraquinone is an aromatic organic compound that may be harmful if inhaled, ingested, or absorbed through the skin. It may cause irritation to the gastrointestinal tract, respiratory tract, skin, and eyes. It may cause an allergic skin reaction. It is a suspected carcinogen according to California Prop 65. Anthraquinone is a naturally occurring compound found in certain plants, fungi, and insects. It is used in the synthesis of dyes, in the production of paper pulp and hydrogen peroxide, as a bird repellant, and in the pharmaceuticals industry.

Physical & Chemical Properties/Definition of Chemical Group

CAS#: 84-65-1

Class: Skin sensitizer, carcinogen

Molecular Formula: C14H8O2

Form (physical state): Solid

Color: Light yellow, green

Boiling point: 379 - 381 °C

Potential Hazards/Toxicity

Anthraquinone may be harmful if inhaled, ingested, or absorbed through the skin. It may cause irritation to the respiratory tract, gastrointestinal tract, skin, and eyes irritation. It may cause an allergic skin reaction. Chronic exposure may cause allergic dermatitis, blood effects, and damage to liver, kidney, and spleen. It is a suspected carcinogen according to California Prop 65.

Engineering Controls

Chemical fume hood. Adequate exhaust and capture filtration.

Personal Protective Equipment (PPE)

Respirator Protection

If lab personnel would like to use respirator on a voluntary basis, they must be trained and fit-tested by EH&S. This is a regulatory requirement. (http://or.ucsf.edu/ehs/8193-DSY/version/default/part/4/data/)

Hand Protection

Handle with gloves. Nitrile gloves are recommended.

NOTE: Consult with your preferred glove manufacturer to ensure that the gloves you plan on using are compatible with anthraquinone.

Refer to glove selection chart from the links below:

http://www.ansellpro.com/download/Ansell_8thEditionChemicalResistanceGuide.pdf

OR

http://www.allsafetyproducts.biz/page/74172

OR

http://www.showabestglove.com/site/default.aspx

OR

http://www.mapaglove.com/

Eye Protection

ANSI approved, tight-fitting glasses/goggles. Face shields are recommended.

Skin and Body Protection

Appropriately-fitting lab coat, long pants, closed-toe shoes.

Hygiene Measures

Avoid contact with skin, eyes, and clothing. Wash hands before breaks and after handling.

First Aid Procedures

If inhaled

Move person into fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Consult a physician.

In case of skin contact

Flush with plenty of water for at least 15 minutes while removing contaminated clothing. Consult a physician.

In case of eye contact

Flush eyes with plenty of water for at least 15 minutes lifting upper and lower eyelids and removing contact lenses. Consult a physician.

If swallowed

Do not induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Special Handling and Storage Requirements

Precautions for safe handling: Avoid contact with skin, eyes, and clothing. Avoid inhalation and ingestion. Avoid dust formation. Provide adequate exhaust ventilation.

Conditions for safe storage: Keep container tightly closed in a cool, dry, and well-ventilated area. Avoid oxidizing agents.

Spill and Accident Procedure

Chemical Spill Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206-8522 (SFGH only)

Spill – Assess the extent of danger. Assist contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.).

Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic bags, label and take to the next chemical waste pick-up.

Large (>1 L) – Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206-8522 (SFGH only) for assistance.

Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working hours and weekends.

Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water for 15 minutes by forcibly holding the eye open. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working hours and weekends.

Medical Emergency Dial 9-911 (campus phone) or 476-6911 (cell phone)

Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.

Non-Life Threatening Emergency– Go to Occupational Health Programs (OHP) Clinic, 415-885-7580, 2330 Post Street, Suite 460 Hours of Operation for Appointments: Monday - Friday 7:30 a.m. - 4:00 p.m. (except Holidays).

Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.

Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick nurse by dialing 415-353-7842 (STIC).

Decontamination/Waste Disposal Procedure

Clean contaminated surfaces with soap and water and paper towels. Dispose of the paper towels as hazardous waste.

Safety Data Sheet (SDS) Location

Online SDS can be accessed at http://or.ucsf.edu/ehs/7241-DSY/msds.html

Protocol/Procedure

Quantities covered by this SOP:

______(g , ml) to ______(g, ml)

Temperature range covered by this SOP:

__ °C – __ °C

General Overview and Purpose:

Enter the experimental purpose

Procedure:

Enter experimental procedure. You can copy procedure from your lab notebook or from literature.

NOTE

Any deviation from this SOP requires approval from the Principal Investigator.

Anthraquinone 4 Date: Click here to enter a date.

Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)