UCSF Lab Standard Operating Procedure s11

UCSF Lab Standard Operating Procedure

Chemical Process, Name or Hazard Class:

4,4'-Methylenedianiline

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Type of SOP: ☐ Process ☒Hazardous Chemical ☐ Hazardous Class

Purpose

4,4'-Methylenedianiline (abbreviated MDA) is a potential carcinogen that may cause liver damage, heart damage, nervous system effects, and dermatitis with prolonged exposure. It can be harmful if ingested, inhaled, or absorbed through the skin. It can cause respiratory tract, digestive tract, and eye irritation. It can cause skin irritation leading to skin sensitization and allergy. 4,4'-Methylenedianiline is used mainly in the production of polyurethane foams. It is also used in the preparation of impact-resistant resins, polyimides, hydraulic fluids, fungicide stabilizers, and sensitizers for explosives.

Physical & Chemical Properties/Definition of Chemical Group

CAS#: 101-77-9

Class: Carcinogen, toxic

Molecular Formula: C13H14N2

Form (physical state): Solid, powder

Color: White, beige

Boiling point: 398-399 °C

Potential Hazards/Toxicity

4,4'-Methylenedianiline is a potential carcinogen that can be harmful if ingested or inhaled. May cause irritation of the digestive tract. It may be fatal if absorbed through the skin. Causes respiratory tract, skin, and eye irritation. The material may cause skin sensitization, skin allergy, and photosensitive skin reactions. Produces yellow staining of skin, nail, and sometimes hair. Symptoms of exposure include loss of appetite, jaundice, dark urine, fever, upper abdominal pain, fatigue, severe headache, nausea, muscular pain, respiratory paralysis, and death. MDA is a blood toxin. Absorption can lead to the formation of methemoglobin which can then cause cyanosis. Prolonged exposure can cause dermatitis, liver damage, heart damage, and nervous system effects.

Engineering Controls

Chemical fume hood. Adequate exhaust and capture filtration.

Personal Protective Equipment (PPE)

Respirator Protection

If lab personnel would like to use respirator on a voluntary basis, they must be trained and fit-tested by EH&S. This is a regulatory requirement. (http://or.ucsf.edu/ehs/8193-DSY/version/default/part/4/data/)

Hand Protection

Handle with gloves. Nitrile gloves are recommended.

NOTE: Consult with your preferred glove manufacturer to ensure that the gloves you plan on using are compatible with 4,4'-methylenedianiline.

Refer to glove selection chart from the links below:

http://www.ansellpro.com/download/Ansell_8thEditionChemicalResistanceGuide.pdf

OR

http://www.allsafetyproducts.biz/page/74172

OR

http://www.showabestglove.com/site/default.aspx

OR

http://www.mapaglove.com/

Eye Protection

ANSI approved, tight-fitting glasses/goggles.

Skin and Body Protection

Appropriately-fitting lab coat, long pants, closed-toe shoes.

Hygiene Measures

Avoid contact with skin, eyes, and clothing. Wash hands before breaks and after handling.

First Aid Procedures

If inhaled

Move person into fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Consult a physician.

In case of skin contact

Flush with plenty of water for at least 15 minutes while removing contaminated clothing. Consult a physician.

In case of eye contact

Flush eyes with plenty of water for at least 15 minutes. Consult a physician.

If swallowed

Do not induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Special Handling and Storage Requirements

Precautions for safe handling: Avoid contact with skin, eyes, and clothing. Avoid inhalation and ingestion. Minimize dust formation. Use with adequate exhaust ventilation. Wash contaminated clothing before reuse.

Conditions for safe storage: Keep container tightly closed in a cool, dry, and well-ventilated area away from incompatible substances. Avoid strong oxidizing agents.

Spill and Accident Procedure

Chemical Spill Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206-8522 (SFGH only)

Spill – Assess the extent of danger. Assist contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.).

Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic bags, label and take to the next chemical waste pick-up.

Large (>1 L) – Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206-8522 (SFGH only) for assistance.

Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working hours and weekends.

Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water for 15 minutes by forcibly holding the eye open. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working hours and weekends.

Medical Emergency Dial 9-911 (campus phone) or 476-6911 (cell phone)

Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.

Non-Life Threatening Emergency– Go to Occupational Health Programs (OHP) Clinic, 415-885-7580, 2330 Post Street, Suite 460 Hours of Operation for Appointments: Monday - Friday 7:30 a.m. - 4:00 p.m. (except Holidays).

Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.

Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick nurse by dialing 415-353-7842 (STIC).

Decontamination/Waste Disposal Procedure

Clean contaminated surfaces with soap and water and paper towels. Dispose of the paper towels as hazardous waste.

Safety Data Sheet (SDS) Location

Online SDS can be accessed at http://or.ucsf.edu/ehs/7241-DSY/msds.html

Protocol/Procedure

Quantities covered by this SOP:

______(g , ml) to ______(g, ml)

Temperature range covered by this SOP:

__ °C – __ °C

General Overview and Purpose:

Enter the experimental purpose

Procedure:

Enter experimental procedure. You can copy procedure from your lab notebook or from literature.

NOTE

Any deviation from this SOP requires approval from the Principal Investigator.

4,4'-Methylenedianiline 4 Date: Click here to enter a date.

Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)