Translational Clinical Research Partnership for Duke-Nus/Singhealth Academic Clinical

TRANSLATIONAL CLINICAL RESEARCH PARTNERSHIP FOR DUKE-NUS/SINGHEALTH ACADEMIC CLINICAL PROGRAMME

TRANSLATIONAL CLINICAL RESEARCH PARTNERSHIP (TCRP) GRANT CALL 2012 FOR DUKE-NUS/SINGHEALTH ACADEMIC CLINICAL PROGRAMME (ACP)

Grant Application Form

CLOSING DATE: 15 October 2012, 5pm

IMPORTANT: EVERY SECTION AND FIELD MUST BE COMPLETED. PLEASE INDICATE ‘NA’ WHERE A PARTICULAR SECTION OR FIELD IS NOT APPLICABLE. INCOMPLETE APPLICATIONS WILL BE REJECTED.

Application must be submitted by the above closing date.

Also submit one duly signed original hardcopy to BMRC through your Office of Research to:

Biomedical Research Council

20 Biopolis Way, Centros, #08-01

Singapore 138668

Tel: 68266111 Fax: 64789580

E-mail:

This document contains NINETEEN(19) separate sections.

Please complete ALL sections.

Please use Font: Arial 10 pt, SINGLE spacing for your text

SECTION / DESCRIPTION
I. / TITLE OF RESEARCH PROJECT
II. / FUNDING
III. / DETAILS OF CO-PRINCIPAL INVESTIGATORS (CO-PIs) AND COLLABORATORS
IV. / FIELD OF RESEARCH
V. / ETHICAL CONSIDERATIONS AND CONTAINMENT
VI. / SCIENTIFIC ABSTRACT OF PROPOSED RESEARCH PROJECT
VII. / LAY ABSTRACT OF PROPOSED RESEARCH PROJECT
VIII. / MAIN OBJECTIVES OF PROPOSED RESEARCH AND DESCRIPTION OF PROJECT
IX. / VALUE OF THE COLLABORATION
X. / POTENTIAL APPLICATIONS/EXPLOITATION
XI. / DESCRIPTION OF PLANS FOR INTERACTION AMONG PERSONNEL INVOLVED IN THE COLLABORATION
XII. / WORK CONTRIBUTION OF TEAM MEMBERS
XIII. / CURRICULUM VITAE
XIV. / BUDGET OUTLINE & JUSTIFICATIONS
XV. / MILESTONES AND PERFORMANCE INDICATORS
XVI. / OTHER SUPPORT
XVII. / SUGGESTED NAMES OF INTERNATIONAL REVIEWERS
XVIII. / DECLARATION BY CO-PRINCIPAL INVESTIGATORS
XIX. / ENDORSEMENT BY HOST INSTITUTIONS

I.TITLE OF RESEARCH PROJECT

II.FUNDING

Tier 1 capped at $1.5M/3 years (including 20% indirect costs)

Tier 2 capped at $3M/3 years (including 20% indirect costs)

Total amount of funds applied for : SGD

Period of Support requested : years

(up to 3 years)

III.DETAILS OF CO-PRINCIPAL INVESTIGATORS (CO-PIs) AND COLLABORATORS

Each proposal must involve a demonstrable collaboration between 2 Co-Principal Investigators, at least one must be a faculty member holding a primary appointment at Instructor level or above with Duke-NUS, and the other holding a primary appointment with a SingHealth entity as well as a current or pending faculty appointment, either regular rank or adjunct, with Duke-NUS.
The Duke-NUS PI will be the designated primary point of contact for the collaboration to coordinate submissions of progress and final reports.
The Co-PIs will be responsible for leading and managing a particular aspect of the collaborative effort.His role will be to coordinate research activities carried out by the research team.

A. Co-PIs

Title / Name / Research Institution / E-mail address / Contact number
DUKE-NUS CO- PI
SINGHEALTH ACP CO-PI

B. Collaborators

Any funding allocated to a Singapore-based collaborator needs to be accommodated within the budget of a Co-PI. International collaborators are not entitled to receive (directly or indirectly) any portion of the grant.Please add more rows if required.

1. / Title and name
Affiliation (i.e. Dept, Faculty and Home Institution/Organization)
Email address and contact no.
Postal Address
Role in proposed project
2. / Title and name
Affiliation (i.e. Dept, Faculty and Home Institution/Organization)
Email address and contact no.
Role in proposed project

IV.FIELD OF RESEARCH

Neurology and Mental Health

Inflammatory and Infectious Diseases

Cardiovascular and Metabolic Diseases

Molecular Pathology and Biomarker Discovery

V.ETHICAL CONSIDERATIONS AND CONTAINMENT

Fund disbursement is subjected to ethics approval if the project involves any of the below.

Please tick accordingly if project involves any of the following: / (if yes, please state all participating institutions/centres)
a) / Human Subject / Yes / No
b) / Use of Human/Material/Animal Tissues or Cells from Primary Donors (i.e. subject/volunteers recruited for project) / Yes / No
c) / Use of Commercially Available Human Material/Animal Tissues or Cells / Yes / No
d) / Animal Experimentation / Yes / No
e) / Requirement for Containment / Yes / No
f) / Multi-centre trials(s) / Yes / No

A copy of the ethics approval is attached:

YesNo

VI.SCIENTIFIC ABSTRACT OF PROPOSED RESEARCH PROJECT

In no more than 300 words, concisely describe the specific aims, hypotheses, methodology and approach of the research proposal including its importance to the furtherance of medical science, in particular clinical significance. The abstract must be self-contained so that it can serve as a succinct and accurate description of the research proposal. Note that the scientific abstract may be disclosed to other funding agencies.

VII.LAY ABSTRACT OF PROPOSED RESEARCH PROJECT

In no more than 300 words, concisely describe the specific aims, hypotheses, methodology and approach of the research proposal including its importance to the furtherance of medical science, in particular clinical significance. The abstract must be self-contained so that it can serve as a succinct and accurate description of the research proposal. Note that the lay abstract may be disclosed to the media for the purpose of the announcement of the grant call results.

VIII.MAIN OBJECTIVES OF PROPOSED RESEARCH AND DESCRIPTION OF PROJECT

List main objectives in order of priority.

Describe the project clearly and succinctly

Describe the main methodology and innovative approaches.

Please do NOT exceed seven (7) pages for this section. Page limit excludes the reference section.

Aim

Hypothesis

Methodology

IX.VALUE OF THE COLLABORATION

Demonstrate how the research could not be done without the joint inputs of all the Co-PIs in this research team for the full term of the project.

X.POTENTIALAPPLICATIONS/EXPLOITATION

State clearly the likely applications of the work (technological, social, scientific, and economic) and when these applications are likely to occur.

Technological –

Social –

Scientific –

Economic –

XI.DESCRIPTION OF PLANS FOR INTERACTION AMONG PERSONNEL INVOLVED IN THE COLLABORATION

Briefly describe the plans for interaction among the team member(s)
Include a qualitativedescription of the team member(s)’ commitment to the project.

XII.WORK CONTRIBUTION OF TEAM MEMBERS

Provide the expected percentage effort within the project, as well as within his/her other work commitments for the Co-PIs and Collaborator(s).Each Co-PI must have a minimum of 30% effort within this project, and this should be reflected in the total project’s budget.

Name

Role in project (e.g. Co-PIs and Collaborators)

Institution

% effort within project[1]

% effort within own work commitments[2]

Total

100%

XIII.CURRICULUM VITAE

In no more than 1 page per team member, please provide the following information on all the Co-Principal Investigators and Collaborator(s):

Name

Current position and past employment history (Please provide full details,eg,joint appointments, percentage of time spent in Singapore every year, if applicable)

Academic qualifications (indicate institution’s name and year degree awarded)

Latest 10 publications

Patents held (related or unrelated to study)

Recent awards (Scientific awards)

Current and previous support from A*STAR/BMRC/NMRC/NRF or other sources

Research outcomes from other grants (e.g. publications, patents, awards, etc.)

XIV.BUDGET OUTLINE & JUSTIFICATIONS

Instructions:

A.State the estimated funding required for the proposed research under each of the Co-PIs for categories listed in the table below.Any funding allocated to a Singapore-based collaborator needs to be accommodated within the budget of a Co-PI. International collaborators are not entitled to receive (directly or indirectly) any portion of the grant.

1.Duke-NUS Co-PI’s Budget

Manpower (EOM) /

Qualifications

/ No /

Year 1($)

Year 2($)

Year 3($)

Total ($)

Research Fellow

Research Assistant

Research Nurse

Laboratory Technician

Others (Please specify)

EOM Sub-total

Equipment (please state)

Capped at a total of $100k /

Year 1($)

Year 2($)

Year 3($)

Total ($)

Equipment Subtotal

Other Operating Expenses (OOE)

Year 1($)

Year 2($)

Year 3($)

Total ($)

Materials & Consumables

(Capped at $35k/Research Personnel/year)

Animal Cost

Local Conferences

Maintenance

Publications

Others (please state)

OOE- Overseas Travel

Year 1($)

Year 2($)

Year 3($)

Total ($)

Overseas Travel

(This is capped at $6k/year and includes overseas conference travel & overseas travel for purposes directly related to the research project)

OOE Subtotal[3]

Grand Total

2.SingHealth ACP Co-PI’s Budget

Manpower (EOM) /

Qualifications

/ No /

Year 1($)

Year 2($)

Year 3($)

Total ($)

PI EOM[4]

(capped at $100K)

Research Fellow

Research Assistant

Research Nurse

Laboratory Technician

Others (Please specify)

EOM Sub-total

Equipment (please state)

Capped at a total of $100k /

Year 1($)

Year 2($)

Year 3($)

Total ($)

Equipment Subtotal

Other Operating Expenses (OOE)

Year 1($)

Year 2($)

Year 3($)

Total ($)

Materials & Consumables

(Capped at $35k/Research Personnel/year)

Animal Cost

Local Conferences

Maintenance

Publications

Others (please state)

OOE- Overseas Travel

Year 1($)

Year 2($)

Year 3($)

Total ($)

Overseas Travel

(This is capped at $6k/year and includes overseas conference travel & overseas travel for purposes directly related to the research project)

OOE Subtotal[5]

Grand Total

b.Provide the details and justificationswhy these items are critical for the success of the research project:

Proposed budget for PI EOM
Equipment (where cap has exceeded $100k or if Co-PIs wish to pool equipment budget to purchase equipment
OOE for consumables exceeding the cap of $35k/research officer hired in the grant/year; animal costs and maintenance.

XV.Milestones and Performance Indicators

A. Propose detailed scientific milestones for the research proposal. These will be used to assess the progress of the study. The progress of the project will be taken into consideration for continued disbursements of funds.

Research
Milestones/
Deliverables / Year 1 / Year 2 / Year 3
Q1 / Q2 / Q3 / Q4 / Q1 / Q2 / Q3 / Q4 / Q1 / Q2 / Q3 / Q4
Duke-NUS Co-PI
Milestone 1
Milestone 2
Etc.
SingHealth ACP Co-PI
Milestone 1
Milestone 2
Etc.

*Please use shading for the time points

Research
Milestones/
Deliverables / Year 1 / Year 2 / Year 3
Q1 / Q2 / Q3 / Q4 / Q1 / Q2 / Q3 / Q4 / Q1 / Q2 / Q3 / Q4
Collaborator (1)
Milestone 1
Milestone 2
Etc.
Collaborators (2)
Milestone 1
Milestone 2
Etc.

B. Indicate the final expected targets for proposed research project. Please state ‘NA’ where indicator is not applicable.

Performance Indicators / Number / value
Capability Indicators / Training R&D manpower for industry / Master’s research students trained
PhD students trained
Master’s research and PhD students trained and spun out to local industry as RSEs[6]
Research staff spun out to local industry as RSEs
Post-doctoral (within 3 years of the PhD award) researchers hired
Developing long term R&D capability / Joint programs/projects with prestigious international research organisations
Joint programs/projects with local universities
Invention disclosures
Proof-of-concept studies in man
Progress to Clinical trials
Kick-start clinical treatments/therapeutics
Patents filed/granted/licensed/commercialized
Papers published in international journals
(To state impact factor)
Presentations at international conferences
External awards for research at international level
Industry Relevance Indicators / R&D collaboration / R&D projects with industry cash funding
Industry dollars received to fund R&D projects
( includes in-kind contribution )
Outcomes / Revenue from royalties and licensing agreements
Spin-off companies registered
New products/processes commercialized

XVI.OTHER SUPPORT

Provide the following details for the grants currently held or being applied for by the Co-PIs.

A.Grant Support

Provide the details for all currently held or applied grantsby the Co-PIs. These include those supported by / applied to BMRC, NMRC, Universities, Clusters and other public funding agencies. Attach the scientific abstract of each grant listed below for Council’s reference.

Title of Research / Funding Agency / Amount of Fund / Support Period (Year) / Expiry Date of the grant
Approved/ Received ($) / Balance Available ($)

XVII.Suggested Names of INTERNATIONAL Reviewers

Suggest names of reviewers who may be suitable to review the proposed project, and state the relationship with the PI(s). Reviewers who are co-authors with the PI(s) in publications are generally not to be included. Note that reviewers must not have conflict of interest or involvement (direct and indirect) with the proposed project. BMRC has the final discretion whether to select the suggested reviewers for the evaluation of the grant proposal.

S/N / Title / Names of Reviewers / Details of contacts
(Please provide mailing address,
e-mail address, tel and fax numbers.) / Relationship to Principal Investigator
1
2
3
4
5

The application should not be sent to the following reviewers.

XVIII.DECLARATIONBY CO-PRINCIPAL INVESTIGATORS

We declare that the facts stated in this application and the accompanying information are true and thatthis is an original proposal.In signing the Grant Application, we UNDERTAKE, on any Grant Award, to the following:

Not send similar versions or part(s) of this proposal to other agencies for funding.

Submit supporting documents of ethics approval obtained from the relevant Institutional Review Board (IRB) and Animal Ethics Committee for studies involving human subjects/human tissues or cells, and animals/animal tissues or cells respectively.

Be actively engaged in the execution of the research and comply with all laws, rules and regulations pertaining to animal and human ethics, including the Singapore Good Clinical Practice guidelines.

Ensure that BMRC’s funding is acknowledged in all publications.

Ensure that all publications arising from research wholly or partly funded by BMRC will be forwarded to BMRC.

Co-operate with BMRC to develop interests in biomedical sciences among students and teachers.

Obtain approval from BMRC before engaging in any commercial activity that will exploit the findings of the research funded by Council.

Signature / Date
Duke-NUS
Co-Principal Investigator
SingHealth ACP
Co-Principal Investigator

XIX.ENDORSEMENT BY HOST INSTITUTIONS

In signing the Grant Application, the Institution UNDERTAKES, on any Grant Award, to:

Provide appropriate support during the grant period.

Ensure that the funds provided are used for the appropriate purposes.

Ensure that the study complies with all laws, rules and regulations pertaining to animal and human ethics, including the Singapore Good Clinical Practice guidelines.

Ensure that approval from BMRC has been obtained before engaging in any commercial activity that will exploit the findings of the research funded by the Councils.

Have in place a code of practice for research integrity and procedures to deal with unethical research practices.

Name and Signature / Date
Head/Director of Dept of Duke-NUS (pls specify):
Head/Director of Dept of SingHealthInstitute (pls specify):

TCRP DUKE-NUS/SINGHEALTH ACP

[1]NOTE: Represents percentage effort spent by the team members in the project relative to his/her other team members. The total in this column must add up to 100%.

[2]NOTE: Represents percentage effort spent by the team members on this project out of total work commitments (eg. other grants, other teaching and administrative responsibilities, clinical work, etc).

[3]OOE Subtotal shouldinclude that of OOE and OOE- Overseas Travel expenses.

[4]EOM will befunded proportionate to the amount of time spent on this project within own work commitments. This EOM component is capped at 30% of current salary or $100k/year; whichever is lower.

[5]OOE Subtotal shouldinclude that of OOE and OOE- Overseas Travel expenses.

[6]RSE: Research Scientist and Engineer