Topic 11.1: Antibody Production and Vaccination
Topic 11.1: Antibody Production and Vaccination
Essential Idea: Immunity is based on recognition of self and destruction of foreign material.
Statements & Objectives:
11.1.U1 Every organism has unique molecules on the surface of its cells.
Define antigen.
(Define Give the precise meaning of a word, phrase, concept or physical quantity.)
List example antigen molecules.
(List Give a sequence of brief answers with no explanation.)
11.1.U2 B-lymphocytes are activated by T lymphocytes in mammals.
Explain the “challenge and response” mechanism of specific immunity.
(Explain: Give a detailed account including reasons or causes)
Describe activation of helper T lymphocytes by the macrophage.
(Describe Give a detailed account or picture of a situation, event, pattern or process.)
Describe activation of B cell lymphocytes by the helper T cells.
(Describe Give a detailed account or picture of a situation, event, pattern or process.)
11.1.U3 Plasma cells secrete antibodies.
Outline the structure and function of plasma B cells.
(Outline Give a brief account or summary.)
11.1U4 Activated B cells multiply to form clones of plasma cells and memory cells.
Describe clonal selection of plasma B cells.
(Describe Give a detailed account or picture of a situation, event, pattern or process.)
11.4.U5 Antibodies aid the destruction of pathogens.
Outline four modes of antibody action.
(Outline Give a brief account or summary.)
11.1.U6 Immunity depends upon the persistence of memory cells.
Define immunity.
(Define Give the precise meaning of a word, phrase, concept or physical quantity.)
State two mechanisms of immunity.
(State Give a specific name, value or other brief answer without explanation or calculation.)
Explain the differences between the primary and secondary immune responses.
(Explain: Give a detailed account including reasons or causes)
11.1.U7 Vaccines contain antigens that trigger immunity but do not cause the disease.
Explain the principle of vaccination.
(Explain: Give a detailed account including reasons or causes)
11.1.U8 Pathogens can be species-specific although others can cross species barriers.
Outline mechanisms that prevent some pathogens from crossing species.
(Outline Give a brief account or summary.)
Define zoonosis.
(Define Give the precise meaning of a word, phrase, concept or physical quantity.)
List three examples of zoonotic diseases.
(List Give a sequence of brief answers with no explanation.)
11.1.U9 White cells release histamine in response to allergens.
State the source and function of histamine proteins.
(State Give a specific name, value or other brief answer without explanation or calculation.)
11.1.U10 Histamines cause allergic symptoms.
List allergic symptoms caused by histamines.
(List Give a sequence of brief answers with no explanation.)
State the function of an anti-histamine.
(State Give a specific name, value or other brief answer without explanation or calculation.)
11.1.U11 Fusion of a tumor cell with an antibody-producing plasma cell creates a hybridoma cell.
Explain the production of hybridoma cells.
(Explain: Give a detailed account including reasons or causes)
11.1.U12 Monoclonal antibodies are produced by hybridoma cells.
Define “monoclonal antibody.”
(Define Give the precise meaning of a word, phrase, concept or physical quantity.)
Describe the production of monoclonal antibodies in hybridoma cells.
(Describe Give a detailed account or picture of a situation, event, pattern or process.)
Outline the use of monoclonal antibodies in diagnosis and treatment.
(Outline Give a brief account or summary.)
11.1.A1 Antigens on the surface of red blood cells stimulate antibody production in a person with a different blood group.
Outline the difference between the ABO blood antigens.
(Outline Give a brief account or summary.)
State the fours human ABO blood types
(State Give a specific name, value or other brief answer without explanation or calculation.)
Describe the consequence of mismatched blood transfusions, including agglutination and hemolysis.
(Describe Give a detailed account or picture of a situation, event, pattern or process.)
11.1.A2 Smallpox was the first infectious disease of humans to have been eradicated by vaccination.
Describe the global initiative used to eradicate smallpox.
(Describe Give a detailed account or picture of a situation, event, pattern or process.)
11.1.A3 Monoclonal antibodies to HCG are used to pregnancy test kits.
Describe a pregnancy test strip works, including the role of free and immobilized monoclonal antibodies.
(Describe Give a detailed account or picture of a situation, event, pattern or process.)
11.1.S1 Analysis of epidemiological data related to vaccination programs.
Define epidemiology.
(Define Give the precise meaning of a word, phrase, concept or physical quantity.)
Outline the role of an epidemiologist in vaccination programs.
(Outline Give a brief account or summary.)
11.1.NOS Consider ethical implications of research- Jenner tested his vaccine for smallpox in a child.
Describe how Jenner tested his smallpox vaccine.
(Describe Give a detailed account or picture of a situation, event, pattern or process.)
List reasons when Jenner’s test would not be approved today.
(List Give a sequence of brief answers with no explanation.)
Key Terms
Antibody
memory cells
primary immunity
zoonosis
hybridoma cells
hemolysis
epidemiology
myeloma cells
immunity
B-lymphocytes
secondary immunity
histamine
ABO blood antigens
smallpox
Jenner
Antigen
T lymphocytes
vaccination
anti-histamine
red blood cells
eradicate
opsonization
challenge and response
helper T cells
pathogen
allergic symptoms
monoclonal antibody
pregnancy
blood transfusion
macrophage
plasma B cells
crossing species
tumor cell
agglutination
HCG
toxin