TIMOTHY J. YEATMAN, M.D.PAGE 1 Updated 12/21/18

TIMOTHY J. YEATMAN, M.D.PAGE 1
Updated 12/21/18

CURRICULUM VITAE

NAME:

Timothy J. Yeatman, M.D., F.A.C.S.

HOME ADDRESS:TELEPHONE:

17341 Morris Bridge Road(813) 782-3008

Thonotosassa, FL 33592

OFFICE ADDRESS:TELEPHONE:

H. LeeMoffittCancerCenter and Research Institute(813) 745-7292

A NationalCancerInstituteComprehensiveCancerCenter

12902 Magnolia Drive – SRB-TCC

Tampa, FL 33612

PRESENT TITLE AND AFFILIATION:

Executive Vice President, Translational Research,

H. Lee Moffitt Cancer Center and Research Institute

Section Head, Hepatobiliary disease

University of South Florida

Tampa, Florida

Professor of Surgery

University of South Florida

Tampa, Florida

Senior Member, Biochemistry and Molecular Biology

University of South Florida

Tampa, Florida

President & Chief Scientific Officer,

M2Gen

DATE AND PLACE OF BIRTH:

6/10/1958, Cheverly, MD

EDUCATION:

Duke University

Durham, North Carolina

B.S. (Double Major: Zoology, Psychology)

Phi Beta Kappa, Summa Cum Laude, 1980

EmoryUniversitySchool of Medicine

Atlanta, Georgia

M.D., 1984

POST GRADUATE TRAINING:

University of Florida, College of Medicine

Gainesville, Florida

Internship, July 1984 June 1985

University of Florida, College of Medicine

Gainesville, Florida

General Surgery Residency, July 1985 June 1990

University of Texas M.D. Anderson Cancer Center

Houston, Texas

Fellow in Surgical Oncology, July 1990 June 1992

AACR Post-Graduate Course

Workshop in Molecular Biology

Aspen, CO, July 1993

Stint in Laboratory of Arthur Pardee, Ph.D.

Dana Farber Cancer Institute

Boston, MA, August 1993

LICENSURES:

Licensed Physician and Surgeon

State of Florida, 1985

Certificate # 47461

Licensed Physician and Surgeon

State of Alabama, 1990

Certificate # 15488

Licensed Physician and Surgeon

State of Texas, 1990

Certificate # H9450

BOARD CERTIFICATIONS:

1985 National Board of Medical Examiners

Certificate # 295636

1991 Diplomate, American Board of Surgery

Certificate # 36060

ACADEMIC AND PROFESSIONAL APPOINTMENTS:

Animal Caretaker

National Institutes of Health

Building 10

Bethesda, MD

Summer, 1976

Teaching Assistant

Department of Zoology

DukeUniversity

Durham, North Carolina

September 1978 May 1979

Biologist

National Institutes of Health

Bethesda, Maryland

1977 1984 Consecutive Summer Appointments

Junior Faculty Associate

UT M.D.AndersonCancerCenter

Department of General Surgery

Houston, Texas

July 1990 June 1992

Assistant Professor of Surgery

University of SouthFlorida

College of Medicine

Department of Surgery, Department of Biochemistry & Molecular Biology

Tampa, Florida

July 1992 - 1996

Associate Professor of Surgery

University of South Florida

College of Medicine

Department of Surgery, Department of Biochemistry & Molecular Biology

Tampa, Florida

July 1996 – June 2000

Program Leader, GI Tumor Program

H. LeeMoffittCancerCenter and Research Institute

at the University of South Florida

Tampa, Florida

May 1999 – August 2003

Professor of Surgery

University of SouthFlorida

College of Medicine

Department of Surgery, Department of Biochemistry & Molecular Biology

Tampa, Florida

July 2000 - Present

Associate Chair of Education, Department of

Interdisciplinary Oncology

H. Lee Moffitt Comprehensive Cancer Center & Research Institute

At the University of South Florida

Tampa, Florida

August 2001-present

InterimAssociateCenter Director for

Clinical Investigations

H. Lee Moffitt Comprehensive Cancer Center & Research Institute

At the University of South Florida

Tampa, Florida

November 2002-August 2003

AssociateCenter Director for

Clinical Investigations

H. Lee Moffitt Comprehensive Cancer Center & Research Institute

At the University of South Florida

Tampa, Florida

August 2003-August 2005

Director of Total Cancer Care

H. Lee Moffitt Comprehensive Cancer Center & Research Institute

At the University of South Florida

Tampa, Florida

August 2005-present

Executive Vice President, Translational Research, MCC

President & Chief Scientific Officer, M2Gen

February 2007-present

Total Cancer Care is a broad initiative in personalized cancer care. Leveraging an international network of 20 hospitals systems (Total Cancer Care Consortium), clinical and molecular data are collected longitudinally from thousands of patients to identify molecular signatures in cancer diagnosis, prognosis, and prediction response to therapy. Patients are consented for lifetime follow-up with the promise of re-contact for the purpose of a therapeutic clinical trial. The outcome is personalized cancer therapy that will aid in linking patients and proper therapy. To date, more than 50,000 patients have consented to participate, and 15,000 eligible snap frozen tumor tissue samples have been collected. More than 12,000 tumor samples have been profiled with a whole genome microarray analysis. Total Cancer Care holds promise to revolutionize the performance of clinical trials through digital trial matching and gene-based trial matching and to improve the quality and standard of care for cancer patients.

M2GEN (Moffitt 2nd Generation) is a wholly-owned, for-profit subsidiary of the non-for profit MCC parent corporation funded by 45M from the State of Florida, Hillsborough County, and the City of Tampa to become an “economic multiplier” for these entities. It is a personalized medicine company that manages the Total Cancer Care Initiative, specializing in tissue and data collection that will be used to help speed the delivery of novel therapeutics translational clinical trials. The company is anticipated to incubate and spin off new entities such as a contract research organization capable of personalized medicine clinical trials.

COMPETITIVE GRANT SUPPORT:

Southern Medical Association

CoInvestigator

"Membrane changes associated with 5fluorouracil resistance

of colon cancer cells"

July 1987 June 1988

$ 2,500

American Cancer Society

CoInvestigator

"Tumorspecific interactions with hepatocyte receptors as a mechanism

for organspecific metastasis of human colorectal cancer"

July 1987 June 1988

$ 5,500

Immunomedics, Inc.

Principal Investigator

"A pilot study examining the feasibility of using immunolymphoscintigraphy to detect and quantify breast cancer lymph node metastases: staging the axilla preoperatively using the Tc99mlabeled Fab' fragment of the antiCEA antibody Immu4"

January 1992 January 1993

$75,000

University of South Florida

Principal Investigator

"A study of the endogenous phospholipases governing CEA release by human colorectal cancer cells"

February 1993 - June 1994

$6,000

University of SouthFlorida Creative Scholarship Award Grant

Principal Investigator

"Detection of genes associated with human colorectal liver metastasis by the differential display method"

January 1994 - January 1995

$7,500

University of South Florida, Department of Surgery Seed Grant

Principal Investigator

"Detection of genes associated with human colorectal liver metastasis by the differential display method"

1994

$5,000

American Cancer Society ACS 6120069LO

Principal Investigator

"Detection of genes associated with human colorectal liver metastasis by the differential display method"

February 1994 - January 1995

$8,000

National Institutes of Health, National Cancer Institute

Principal Investigator

K-11 Physician Scientist's AwardCA65512-01

"Analysis of Colon Cancer Liver Metastasis mRNA's"

May 1995 - May 1998

$713,787

American Cancer Society, National

Co-Investigator

RPG-97-031-01DHP

“Electrochemotherapy for the Treatment of Liver Malignancies"

January 1997 - December 1998

$187,000

American Cancer Society, National

Principal Investigator

RPG-MGO-97551

“Src Activation in Colon Cancer"

January 1999 - December 2001

$299,000

National Institutes of Health, National Cancer Institute

Co-Investigator

P20-CA91353-03 (PI, Pledger) 05/2001 – 04/2003

“Puerto Rico Partnership”

Partnership between the H. Lee Moffitt Cancer Center and the Puerto RicoCancerCenter to share expertise and enhance development.

National Institutes of Health, National Cancer Institute

Senior Leader and Scientific Director of Data Management Core and Protocol Specific Support.

P30-CA76292-06 (PI, Dalton) 02/19/98–01/31/07

“H. LeeMoffittCancerCenter and Research Institute Support Grant”

$1,832,856

Department of Defense

Co-Investigator

DAMD17-02-2-0051 (PI – Pledger)

09/01/03-03/31/06

National Functional GenomicsCenter

Prediction of Response of Gastroesophageal Junction Tumors to Neoadjuvant Chemoradiotherapy with Expression Profiling

$50,000

National Institutes of Health, National Cancer Institute

Principal Investigator

Director’s Challenge: Toward a Molecular Classification of Tumors (CA-98-027)

“Decoding Fingerprints Portending Colon Cancer Metastasis”

09/07/00 – 01/31/06 (no cost extension)

$5,469,696

National Institutes of Health, National Cancer Institute

Principal Investigator

K24 – Midcareer Investigator Award In Patient Oriented Research (PA-98-053)

“SRC as a Novel Target for Human Colon Cancer Therapy”

09/30/00 – 08/31/05

$615,545

National Institutes of Health (TPA-99-064)

Co-Investigator

K12-CA87989-02 (PI – Zuckerman)

"Clinical Scholars in Oncology"

7/1/01-6/30/06

$2,694,737

James and Esther King Agency (State of Florida)

Co-Investigator

“Functional Role of Mcm 7-Rb Interaction in Res Signaling and Yumorigenesis”

06-NIR-01

07/01/2006-06/30/2009

National Institutes of Health: Moffitt Aging and Cancer

CO- Principal Investigator

5P20CA103676-05

“Age-Related Genetic Immunological Profiles in Breast Cancer”

09/01/2007-08/31/08

National Cancer Institute

Principal Investigator

R01-CA098522

“Screening for Breast Cancer Using Molecular Signatures”

08/18/03 – 07/31/08

$3,139,402

National Cancer Institute

Collaborator

RO1 CA120316-01A1

“Mapping Gene Networks in Colon Cancer”

12/01/06 – 11/30/10

$21,527—total costs

National Cancer Institute

Principal Investigator

1 R01 CA 112215-01A2

“Chip-Based Diagnosis of Problematic Liver Tumors”

8/10/06 - 7/31/11

$2,155,00 – total costs

James and Esther King Agency/ Bankhead Coley (State of Florida)

Principal Investigator

08BR-02

“Molecular Signatures for Colon Cancer”

7/1/08- 6/30/11

$1,250,000 – total costs

OTHER GRANT SUPPORT:

Dupont Pharmaceuticals

“Alpha V Beta 3 Gene Expression in Cancer”

2000 - 2001

$5,000

Roche Laboratories

“Src Inhibitors for Cancer”

June 2000 – June 2002

$100,000

Pfizer

Principal Investigator

Molecular Analysis of Colon Cancer

EDITORIAL BOARDS

Journal of Clinical Oncology

Annals of Surgical Oncology

Cancer Control

Molecular Oncology

Clinical Cancer Research (CCR)

NATIONAL COMMITTEES

The Society of Surgical Oncology Scientific Program Committee – 2005-present

American Cancer Society Colorectal Task Force – 1999-present

The Society of Surgical Oncology Examination Committee- 1996-present

The Society of Surgical Oncology Web Site Committee - 1996-present

NCCN Gastrointestinal Tumor Group - 1999-2002

AD HOC REVIEWER

Nature Genetics

Cancer Cell

Cancer Research

Clinical Cancer Research

Journal of Surgical Research

Gastroenterology

Annals of Surgical Oncology

Cancer: Interdisciplinary International Journal of the American Cancer Society

Clinical and Experimental Metastasis Journal

Cancer Control Journal: Journal of the H. LeeMoffittCancerCenter

British Journal of Surgery

British Journal of Cancer

VA Merit Review

International Journal of Cancer

Nucleic Acids Research

Oncogene

SOCIETY OFFICES

Association for Academic Surgery -

Program Committee 1998-2000

Committee on Issues 1999-2001

Nominating Committee 2001-2002

Society of Surgical Oncology –

Vice Chair, Scientific Program Committee 2006-2007

Scientific Program Committee 2005-2006

Education Committee 1998-2000

Website Development Committee 1999-2002

HONORS AND AWARDS:

Washington Heart Association

Outstanding Student Scholarship Award, 1975

American Cancer Society

Competitive Scientific Scholarship Award, 1976

Phi Beta Kappa, Summa Cum Laude

DukeUniversity

Durham, North Carolina, 1980

American Cancer Society

Clinical Research Fellowship Award

$ 7,000 1987 – 1988

Outstanding Resident Research Award

University of Florida, College of Medicine

Gainesville, Florida, 1989

American Cancer Society

Research Training Grant Recipient Twoyear recipient

$ 30,000 July 1990 – 1992

Center Director's Award for Outstanding Research

H. Lee Moffitt Cancer Center & Research Institute

Tampa, Florida, 1995

James Ewing Foundation Trainee Award

Society of Surgical Oncology, 1997

Center Director's Award for Outstanding Research

H. Lee Moffitt Cancer Center & Research Institute

Tampa, Florida, 1997

Center Director's Award for Outstanding Research

H. Lee Moffitt Cancer Center & Research Institute

Tampa, Florida, 1998

James IV Association of Surgeons

Travelling Fellowship

Europe, 2001

SSO Bakers Travel Award

March, 2002

Excellence in Research Award

American College of Surgeons

Jimmy Sung, Surgical Resident

University of South Florida-Mentored resident

2005

TEACHING:

Clinical Instructor - Surgical Residents

College of Medicine, Department of Surgery

University of SouthFlorida

Tampa, Florida

Clinical Instructor - Medical students

College of Medicine/Gene Therapy

University of SouthFlorida

Tampa, Florida

Instructor - Medical Students

College of Medicine, Department of Biochemistry

& Molecular Biology

University of SouthFlorida

Tampa, Florida

Clinical Instructor Core Lectures

Physician’s Assistant Program

University of Florida, College of Medicine

Gainesville, Florida, 1988

Clinical Instructor Core Lectures

Department of Physical Therapy

University of Florida, College of Medicine

Gainesville, Florida, 1988

Laboratory Instructor

Introductory Zoology

DukeUniversity

Durham, North Carolina

September 1978 May 1979

Students Mentored

Jonathan Hernandez, M.D. – Surgical Resident

Alexander Li, B.S. – HarvardUniversityCollege of Medicine

James Huang, M.D. – Surgical Resident

Emilia Dauway, M.D. – Surgical Oncology Fellow

Nicole Nicosia – University of SouthFlorida

Rosalyn Irby, Ph.D. - Post Doctoral Fellow

Weiguang Mao, M.D. - Post Doctoral Fellow

Anneris Paredes, M.D.- Pathology Fellow

Leigh Judah - University of SouthFlorida

Priya Naman - YaleUniversity

David R. Lane - SwarthmoreCollege

Jimmy Kang - HarvardUniversity

Jimmy Sung – Surgical Resident, University of South Florida, 2005

Quan Ly – Surgical Resident, University of South Florida, present

Michael Alvarado - Post Doctoral Fellow, University of South Florida, present

Eric Jensen - Post Doctoral Fellow, University of South Florida, present

Cindy Timme - Doctoral Student, MCC, present

PROFESSIONAL AFFILIATIONS

American Association for Cancer Research

AmericanCollege of Surgeons

American Association for Advancement of Science

Association for Academic Surgery

The Society of Surgical Oncology

The Society for Surgery of the Alimentary Tract

American Society of Clinical Oncology

The Society of University Surgeons

TampaBay Surgical Society

UNIVERSITY RELATED SERVICES

USF Search Advisory Committee for the Vice President for Health Sciences

and Dean, College of Medicine - 2004

Chair, Department of Surgery Research Committee - 1999

Scientific Review Committee –1995

Infectious Disease Committee -1994

College Of Medicine Faculty Affairs Committee-1994

Laboratory Animal Medicine Ethics Committee -1993

PUBLICATIONS

Attallah AM, Yeatman TJ, Noguchi PD, Petricciani JC. Is DNA synthesis a requisite for the differentiation of B lymphocytes into immunoglobulinsecreting plasma cells? Int Arch Allergy Appl Immun. 1979;60(2):132139.

Attallah AM, Fleisher T, Neefe JR, Kazakis A, Noguchi PD, Yeatman TJ. Differential effect of human interferon on normal and neoplastic T and B cell lymphocytes. Ann NY Acad Sci. 1980;350:245253.

Attallah AM, Yeatman TJ, Noguchi PD, Johnson JB. Antibodydependent cellmediated cytotoxicity detected by automated flow cytometry with ultramicro techniques. Science. 1980 Jul;209(4454):404406.

Attallah AM, Lewis FA, UrritiaShaw A, Folks T, Yeatman TJ. Natural killer cells (NK) and antibodydependent cellmediated cytotoxicity (ADCC) components of Schistosoma mansoni infection. Int Arch Allergy Appl Immun.1980;63(3):351354.

Attallah AM, UrritiaShaw A, Yeatman TJ, Folks T. Effect of the new immuno-suppressive agent cyclosporinA on natural killer cell and ADCC activity. Int Arch Allergy Appl Immunol. 1981;65(4):465469.

Attallah AM, Yeatman TJ. ADCC analysis with the Coulter counter: a highly sensitive, ultramicro assay suitable for clinical and experimental application. J Immunol Methods. 1981;43(2):121129.

Attallah AM, Zoon K, Folks T, Yeatman TJ. Multiple biological activities of homogenous human alpha interferon. Infect and Immunol. 1981 Dec;34(3):10681070.

Attallah AM, Yeatman TJ. Is there a role for biotechnology and genetic engineering in Egypt’s future. In: Galal S, ed. The five conferences of Egypt in the year 2000. Cairo, Egypt: Al-Ahram Press;1982.

Attallah AM, Yeatman TJ, Johnson RP, Petricciani JC. Biological response modifiers and their promise in clinical medicine. Pharmacol and Ther. 1982;19(3):435454.

Attallah AM, Yeatman TJ. Determination of surface antigens using the Coulter counter: a simple, highlysensitive method. Diagn Immunol. 1983;1(1):3942.

Yeatman TJ. Emphysematous cholecystitis: an insidious variant of acute cholecystitis. Am J Emer Med. 1986 Mar;4(2):163166.

Yeatman TJ, Smith VC. Thymoma. Surg Rounds 1986;9(2):121124.

Yeatman TJ, SeagleMB, CassisiNJ. A rare manifestation of metastatic adenocarcinoma. The Laryngoscope. 1986 Jun;96(6):6924.

Yeatman TJ, Sharp JV, KimuraAK. Can susceptibility to carcinoid tumors be inherited? Cancer. 1989 Jan;63(2):390393.

Yeatman TJ, Bland KI, Copeland EM, III, KimuraAK. Tumor cellsurface galactose correlates with the degree of colorectal liver metastasis. J Surg Res. 1989 Jun;46(6):567571.

Yeatman TJ, Bland KI, Copeland EM, III, Hollenbeck JI, Vogel SB, Souba WW, Kimura AK. Relationship between colorectal liver metastases and CEA levels in gallbladder bile. Ann Surg. 1989;210(4):505512.

Yeatman TJ, Bland KI. Sphinctersaving procedures for distal carcinoma of the rectum. Ann Surg. 1989 Jan;209(1):118.

Yeatman TJ, Bland KI. Colorectal liver metastasis. Postgrad Gen Surg. 1989;1(8):4551.

Yeatman TJ, Bland KI. The basis for surgical decisions in the management of insitu breast cancer. Comprehen Ther. 1990 May;16(5):1217.

Yeatman TJ, Bland KI, Copeland EM, III, KimuraAK. Rapid Analysis of Carcinoembryonic Antigen Levels in Gallbladder Bile: Identification of Patients at High Risk for Colorectal Liver Metastasis. Ann Surg. 1991 Feb;213(2):113-117.

Yeatman TJ, Vogel SV, Bland KI. Hepatic resection: when? why? how? In: Levine BA, Maier RV, Bland KI, eds. Perspectives Gen Surg. St. Louis, Missouri: Quality Medical Publishing, Inc; 1991:2(1):5776.

Yeatman TJ, Risley GL, BrunsonMT. Depletion of dietary arginine inhibits growth of metastatic tumor. Arch Surg. 1991Nov;126(11):13761382.

Yeatman TJ, Weber RS, Balch CM. The contemporary management of skin cancers. In: Levine BA, Copeland EM, III, Warshaw AL, Howard RJ, Sugerman H, eds. Current Practice of Surgery.New York: Churchill-Livingstone; 1992.

Tressler RJ, Updyke TV, Yeatman TJ, Nicolson GL. Extracellular annexin II is associated with divalent cationdependent tumor cellendothelial cell adhesion of metastatic RAW 117 largecell lymphoma cells. J Cell Biol. 1993;53:265-276.

Yeatman TJ, Updyke TV, Dedman JR, Nicolson GL. Expression of annexins on the surfaces of non-metastatic and metastatic human and rodent tumor cells. Clin Exp Metastasis. 1993 Jan;11(1):37-44.

Yeatman TJ, Nicolson GL. Molecular Basis of Tumor Progression: Mechanism of Organ-specific Tumor Metastasis. Semin Surg Onc. 1993 May-Jun;9(3):256-263.

Nicolson GL, Yeatman TJ, Tressler RJ, Updyke TV, Hamada J, Cavanaugh PG. Tumor cell-endothelial cell interactions during blood-borne metastasis: role of specific adhesion, motility, and growth molecules. In: Hemler ME, Mihich E, eds. Pezcoller Foundation Sympsia Series.New York: Plenum Press; 1993:221-243.

Kim EE, Podoloff DA, Moulopoulos LA, Hortobagyi GH, Yeatman TJ, Singletary SE. Magnetic Resonance Imaging, Positron Emission Tomography, and Radioimmunoscintigraphy of Breast Cancer. Cancer Bulltn. 1993;45(6):500-505.

Yeatman TJ, Duan C, Mao W, Karl RC, Djeu J. Augmentation of Carcinoembryonic Antigen Release from Intact, Viable, Tumor Cells by a Factor in Human Serum. Ann Surg Oncol. 1995 Jul;2(4):336-342.

Yeatman TJ, Mao W, Karl RC, Djeu J. Phospholipase C - gamma1 is present on the surface of human colorectal cancer cells. Biochem Biophys Res Commun. 1994 Jun:201(2);1043-49.

Tressler RJ, Yeatman TJ, Nicolson GL. Extracellular annexin VI expression is associated with divalent cation-dependent endothelial cell adhesion of metastatic RAW 117 large-cell lymphoma cells. Exp Cell Res. 1994:215;395-400.

Yeatman TJ. The natural history of locally advanced primary breast carcinoma and metastatic disease. In: Bland KI (ed). Surgical Oncology Clinics of North America. 1995 Oct;4 (4):569-89.

Yeatman TJ, Karl RC. Molecular basis for chemoprevention of colorectal carcinogenesis. J Fla Med Assoc. 1995 May;82(5):360-3.

Yeatman TJ, Cantor AB, Smith TJ, et al. Tumor biology of infiltrating lobular carcinoma.