Introduction
There are two groups of blood vessels
Pulmonary circuit
Blood goes to and from the lungs
Systemic circuit
Blood goes to the rest of the body and back to the heart
Blood goes to both circuits at the same time with each heartbeat
Histological Organization of Blood Vessels
The walls of the vessels consist of three layers
The layered walls give the vessels tremendous strength
The vessel walls are thick
The walls themselves are supplied with blood
These blood vessels are called vasavasorum
Histological Organization of Blood Vessels
Characteristics of the Three Layers
Intima (innermost layer)
Also called tunica intima
Makes up the endothelium of the vessel
Media (middle layer)
Also called tunica media
Consists of smooth muscle
Involved in vasoconstriction and vasodilation
Adventitia (outermost layer)
Also called tunica adventitia
Fibers of the adventitia anchor the blood vessels
Histological Organization of Blood Vessels
Distinguishing Arteries from Veins
Most arteries and veins run parallel to each other
Arteries carry blood away from the heart
Veins carry blood toward the heart
Walls of arteries are thicker than veins
Arteries maintain their circular shape and veins typically collapse when cut
Endothelial lining of arteries have pleated folds—endothelial lining of veins do not
Histological Organization of Blood Vessels
Arteries
As blood leaves the heart, it travels through:
Elastic arteries
Muscular arteries
Arterioles
Histological Organization of Blood Vessels
Elastic Arteries
Large vessels up to 2.5 cm in diameter
Very resilient
Examples are:
Aorta
Brachiocephalic
Pulmonary trunk
Common carotid
Subclavian
Common iliac
Histological Organization of Blood Vessels
Muscular Arteries
Medium-sized arteries up to 0.4 cm diameter
Examples are:
Radial and ulnar
External carotid
Brachial
Femoral
Mesenteric
Histological Organization of Blood Vessels
Arterioles
Small arteries around 30 microns in diameter
Poorly defined adventitia
Control blood flow between arteries and capillaries
Histological Organization of Blood Vessels
Capillaries
Smallest of all vessels
Most delicate of all vessels
Walls are thin enough to permit exchange of gases between the blood and the interstitial fluid
The diameter is about 8 microns
A red blood cell diameter is also about 8 microns
Histological Organization of Blood Vessels
Types of Capillaries
Continuous
Endothelial lining is complete
Fenestrated
Endothelial lining is not complete
These capillaries have pores in their lining
Histological Organization of Blood Vessels
Capillaries (continued)
There are four mechanisms regarding the passage of material across the walls of capillaries
Material can diffuse across the endothelial lining
Material can diffuse through gaps between adjacent cells of the lining
Material can diffuse through pores
Material can move via endocytosis
Histological Organization of Blood Vessels
Capillary Beds
Capillaries do not function as individual units
Capillaries form an interconnected network of capillaries (capillarybeds)
The capillary bed consists of vessels connecting arterioles with venules
There are precapillarysphincters involved in regulating blood flow through the capillaries
Histological Organization of Blood Vessels
Capillary Beds (continued)
In areas such as the brain, heart, and stomach, a continuous, rich flow of blood is required
In these areas, more than one artery supplies a specific area
These arteries (collateralarteries) typically fuse forming an arterialanastomosis
If one arteriole is blocked, the other one will supply blood to the capillary bed
Histological Organization of Blood Vessels
Capillary Beds (continued)
In areas such as the joints or visceral organs, bloodflow through some vessels may be hindered due to body movement
In order to accommodate this, there must be a direct connection between arterioles and venules
This direct connection is called an arteriovenousanastomosis
Histological Organization of Blood Vessels
Veins
Veins collect blood from tissues and return the blood to the heart
As blood leaves the tissue and travels to the heart, it travels through the following vessels:
Capillary beds
Capillaries
Venules
Medium-sized veins
Large veins
Histological Organization of Blood Vessels
Venules
Smallest of the veins
Collect blood from the capillaries
Lack or have thin tunica media
Histological Organization of Blood Vessels
Medium-Sized Veins
The adventitia (tunica externa) is the largest of the layers
Contains elastic fibers
Histological Organization of Blood Vessels
Large Veins
All three layers are relatively thick
Examples of large veins are:
Superior vena cava
Inferior vena cava
Histological Organization of Blood Vessels
Venous Valves
Blood in the veins returning to the heart from the lower extremities has to go against gravity
To assist in this process, many veins have valves (venousvalves)
These valves compartmentalize the blood in the veins thus acting as one-way valves
Valves prevent backflow of blood
Histological Organization of Blood Vessels
Blood in the veins from the lower extremities has to ascend to the heart
Blood in the veins returning to the heart from the lower extremities has to go against gravity
The skeletal muscles of the legs help to propel the blood back to the heart
Changes in thoracic pressure helps to move the blood through the venae cavae back to the heart
The Distribution of Blood
The total blood volume is distributed unevenly within the vessels of the body
Arteries and capillaries contain 30–35 percent of the volume
Veins contain 65–70 percent of the volume
Veins are more distensible than arteries
Based on blood pressure, a vein can expand about 8 times as much as a parallel artery
Blood Vessel Distribution
Blood vessels can be divided into two circuits
Pulmonary circuit
Composed of arteries and veins that transport blood between the heart and the lungs
Arteries and veins travel relatively short distances
Systemic circuit
Composed of arteries and veins that transport oxygenated blood between the heart and all other tissues
Arteries and veins travel longer distances
Blood Vessel Distribution
There are functional and structural differences between the vessels in the two circuits
Blood pressure in the pulmonary circuit is lower than in the systemic circuit
Walls of the pulmonary arteries are thinner than the walls of systemic arteries
Blood Vessel Distribution Vessel Distribution
Functional patterns of the pulmonary and systemic circuits
The distribution of arteries and veins is the same on the left side of the body as it is on the right side of the body except for the venae cavae and the aorta
A single vessel will have different names according to specific anatomical boundaries
Arteries and veins often anastomose
The Pulmonary Circuit
Blood on the right side of the heart is on its way through the pulmonary circuit
Deoxygenated blood leaves the heart by passing through the pulmonaryvalve
Enters the pulmonary trunk
Enters the left and right pulmonaryarteries
Blood arrives at the lungs to drop off carbon dioxide and pick up oxygen
Oxygenated blood returns to the heart via the pulmonaryveins
Blood enters the left atrium of the heart
Systemic Arteries
Blood on the left side of the heart is on its way through the system circulation
Oxygenated blood leaves the heart by passing through the aorticvalve
Enters the ascending aorta
At the base of the ascending aorta are the branches of the coronary vessels
Enters the aorticarch
From the aortic arch, blood branches into numerous vessels
Systemic Arteries
Blood in the aortic arch branches into the following vessels:
Brachiocephalic trunk
Then the right common carotid and right subclavian arteries
Left common carotid artery
Left subclavian artery
Descending aorta
Systemic Arteries
The Ascending Aorta
Begins at the aortic valve
Left and right coronary arteries branch off the base of the ascending aorta
Aortic arch
Forms an arch going toward the left and posterior side of the heart
Branching off the aortic arch are three elastic arteries
Systemic Arteries
Branches of the Aortic Arch
Brachiocephalic trunk
Gives rise to the right common carotid artery
And gives rise to the right subclavian artery, which supplies blood to the right side of the head and brain and to the right subclavian artery (supplies blood to the right arm)
Left common carotid artery
Supplies blood to the left side of the head and brain
Left subclavian artery
Supplies blood to the left arm
Systemic Arteries
The Subclavian Arteries
The subclavian arteries
Continue to form the axillaryarteries
Prior to forming the axillary arteries, the subclavians form three branches:
Thyrocervical trunk
Supplies muscles of the neck, head, and upper back
Internal thoracic artery
Supplies the pericardium and anterior wall of the chest
Vertebral artery
Supplies the brain and spinal cord
Systemic Arteries
The Flow of Blood from the Subclavians to the Arms
Axillary artery
Brachial artery
Radial and ulnar arteries
Arteries anastomose at the wrist forming the superficial palmar arch and deep palmar arch
Systemic Arteries
The Carotid Arteries and the Blood Supply to the Brain
The common carotids ascend the neck
Divide to form the internal carotids and external carotids
The carotid sinus is at the base of the internal carotid artery consisting of baroreceptors and chemoreceptors
Systemic Arteries
The Internal and External Carotid Arteries
External carotids
Supply the neck and outside of the skull
Branches to form:
Lingual artery
Facial artery
Occipital artery
Superficial temporal artery
Systemic Arteries
The Internal and External Carotid Arteries
Internal carotids
Enter the skull to deliver blood to the brain
Branches to form:
Ophthalmic artery (supplies the eyes)
Anterior cerebral artery (supplies frontal and parietal lobes of the brain)
Middle cerebral artery (supplies the midbrain and lateralsurfaces of the brain)
Systemic Arteries
Blood Supply to the Brain
Blood in the vertebral arteries reaches the brain via:
Left and right vertebral arteries fuse to form the basilar artery
Basilar artery branches many times in the area of the pons
Basilar artery eventually forms the vessels of the cerebralarterial circle (circle of Willis)
Systemic Arteries
The Descending Aorta
A continuation of the aortic arch
Divided into thoracic aorta and abdominal aorta at the diaphragm area
Systemic Arteries
The Thoracic Aorta
Branches to form the following vessels:
Bronchial arteries
Pericardial arteries
Mediastinal arteries
Esophageal arteries
Intercostal arteries
Superior phrenic arteries
Systemic Arteries
The Abdominal Aorta
Branches to form the following vessels:
Celiac trunk
Superior mesenteric artery
Inferior mesenteric artery
Inferior phrenic arteries
Suprarenal arteries
Renal arteries
Gonadal arteries
Lumbar arteries
Right and left common iliac arteries
Systemic Arteries
The Celiac Trunk
Supplies the following organs:
Liver
Stomach
Esophagus
Gallbladder
Duodenum
Pancreas
Spleen
Systemic Arteries
The Celiac Trunk
Branches to form the left gastric artery
Supplies the stomach
Branches to form the splenic artery
Supplies the spleen
Branches to form the left gastroepiploic artery to supply the stomach
Branches to form the pancreatic arteries to supply the pancreas
Systemic Arteries
The Celiac Trunk
Branches to form the common hepatic artery
Branches to form:
Hepatic artery proper
Supplies the liver
Right gastric artery
Supplies the stomach
Cystic artery
Supplies the gallbladder
Gastroduodenal artery
Supplies the duodenum
Systemic Arteries
Superior Mesenteric Artery
Branches to supply
Pancreas
Inferior pancreaticoduodenal artery
Duodenum
Inferior pancreaticoduodenal artery
Small intestine
Intestinal arteries
Large intestine
Right colic artery
Middle colic artery
Ileocolic arteries
Systemic Arteries
Inferior Mesenteric Artery
Branches to supply
Terminal portion of the large intestine
Left colic artery
Sigmoid arteries
Rectum
Rectal arteries
Systemic Arteries
Five paired arteries branch off the descending aorta
Inferior phrenic arteries
Suprarenal arteries
Renal arteries
Gonadal arteries
Lumbar arteries
Systemic Arteries
The five paired arteries supply:
Inferior phrenic arteries
Supply inferior portion of esophagus and diaphragm
Suprarenal arteries
Supply the suprarenal glands
Renal arteries
Supply the right and left kidneys
Systemic Arteries
The five paired arteries supply (continued)
Gonadal arteries
Supply testes, scrotum, ovaries, uterine tubes, uterus
Lumbar arteries
Supply vertebrae, spinal cord, abdominal wall
Systemic Arteries
Arteries of the Pelvis and Lower Limbs
The descending aorta branches to form:
The common iliac arteries branch to form:
The internal iliac artery (supplies the urinary bladder, walls of the pelvis, external genitalia, and the medial side of the thigh)
The external iliac artery (supplies blood to the legs)
Systemic Arteries
Arteries of the Thigh and Leg
External iliac arteries form the:
Deep femoral artery
Femoral artery
Continues to form the popliteal artery
The popliteal bifurcates to form anterior tibial and posterior tibial arteries
The posterior tibial artery gives rise the fibular artery
Systemic Arteries
Arteries of the Foot
The anterior tibial artery forms:
Dorsalispedis artery
The posterior tibial artery forms:
Medial and lateral plantar arteries
Systemic Veins
Systemic Veins
Veins collect blood from the body tissues and return it to the heart
Blood returns to the heart from the lower extremities
Via the inferior vena cava to the right atrium
Blood returns to the heart from the upper extremities
Via the superior vena cava to the right atrium
Blood returns to the heart from the lungs
Via the pulmonary veins to the left atrium
Systemic Veins
The Superior Vena Cava
All veins drain into the superior vena cava and the inferior vena cava except:
Cardiac veins
Superior vena cava receives blood from:
The head
The neck
The chest
The shoulders
The upper limbs
Systemic Veins
Venous Return from the Cranium
The superficial cerebral veins drain into:
Superior and inferior sagittal sinuses
Petrosal sinuses
Occipital sinus
Left and right transverse sinuses
Straight sinus
Venous blood from the cranium drains into the internal jugular veins, which drain into the brachiocephalic veins
Systemic Veins
Venous Return from the Cranium (continued)
Venous blood from the posterior skull and the cervical spinal cord drain into:
The vertebral veins
Drain into brachiocephalic veins
Systemic Veins
Superficial Veins of the Head and Neck
Veins from the head converge to form the:
Temporal vein
Drains into the external jugular vein then into the subclavian vein
Maxillary veins
Drain into the external jugular vein then into the subclavian veins
Facial vein
Drains into the internal jugular vein then into the subclavian veins
Systemic Veins
Venous Return from the Upper Limb
Blood returns to the heart from the hands in the following sequence
Digital veins
Superficial and deep palmar veins
The superficial palmar veins drain into the cephalic vein
Subclavian vein
Brachiocephalic vein
Superior vena cava
Right atrium
Systemic Veins
Venous Return from the Upper Limb
Blood can also return to the heart from the hands in the following sequence
The superficial palmar veins drain into the cephalic vein
Median cubital vein
Basilic vein
Axillary vein
Subclavian vein
Brachiocephalic vein
Superior vena cava
Right atrium
Systemic Veins
Venous Return from the Upper Limb
Blood can also return to the heart from the hands in the following sequence
The superficial palmar veins drain into the basilic vein
Axillary vein
Subclavian vein
Brachiocephalic vein
Superior vena cava
Right atrium
Systemic Veins
Venous Return from the Upper Limb
Blood can also return to the heart from the hands in the following sequence
The deep palmar veins drain into the radial and ulnar veins
Those veins will unite to form the brachial vein
Axillary vein
Subclavian vein
Brachiocephalic vein
Superior vena cava
Right atrium
Systemic Veins
The Formation of the Superior Vena Cava
The following veins drain into the superior vena cava, which then drains into the right atrium
Azygos veins
Brachiocephalic veins
Subclavian veins drain into the brachiocephalic veins
Internal thoracic veins drain into the brachiocephalic veins
Systemic Veins
The Inferior Vena Cava
The following veins drain into the inferior vena cava, which drains into the right atrium
Common iliac veins
Lumbar veins
Gonadal veins:
The right gonadal vein drains into the inferior vena cava, the left gonadal vein drains into the left renal vein and then into the inferior vena cava
Hepatic veins
Systemic Veins
Veins Draining the Pelvis
The following veins drain into the internal iliac and then into the common iliac and then into the IVC
Gluteal veins
Internal pudendal veins
Obturator veins
Lateral sacral veins
Median sacral veins drain into the left common iliac
Systemic Veins
Veins Draining the Abdomen
The abdominal portion of the inferior vena cava collects blood from: