Thep-Values Are Fromtheoverall Testof Significance of Eachcovariate Inthe Model

Table S1:MultivariateOverallSurvival Analysis

Covariate / AHR / 95%CI / p*
Age(years)† / 1.02 / 1.00–1.03 / 0.008
BMI(kg/m2)‡ / 0.99 / 0.93–1.05 / 0.640
Race/Ethnicity / 0.449
White / 1.00 / referent
Black / 1.29 / 0.74–2.27
other / 0.72 / 0.35–1.50
Performancestatus / 0.453
0 / 1.00 / referent
1 / 1.11 / 0.80–1.55
2 / 1.40 / 0.82–2.40
Grade(differentiation) / 0.113
good / 1.00 / referent
moderate / 1.58 / 1.01–2.46
poor / 1.45 / 0.94–2.24
notgraded / 0.68 / 0.21–2.19
Histology / 0.001
serous / 1.00 / referent
endometrioid / 0.74 / 0.49–1.13
mixedepithelial / 1.17 / 0.76–1.79
clear-cell / 3.69 / 1.99–6.85
other / 0.91 / 0.56–1.48
Grossresidualdisease / 0.001
no / 1.00 / referent
yes / 1.72 / 1.31–2.26
TSIC(days)§ / 0.99 / 0.96–1.02 / 0.342

∗Thep-values are fromtheoverall testof significance of eachcovariate inthe model.

†TheAHRdenotesthechangeinriskofprogressionordeathassociatedwithanincreaseof1yearofage.

‡TheAHRdenotesthechangeinriskofprogressionordeathassociatedwitha10%increaseinBMI(kg/m2).

§TheAHRdenotesthechangeinriskofprogressionordeathassociatedwitha10%increaseinTSIC(days).

Table S2:ResultsofalinearmodelforlogTSICasafunctionofcovariates(Waldstatistics)

d.f. / PartialSS / MS / F / P
Age / 1 / 0.044 / 0.044 / 0.33 / 0.5635
BMI / 1 / 0.807 / 0.807 / 6.15 / 0.0136
Race / 2 / 0.026 / 0.013 / 0.10 / 0.9074
Performance status / 2 / 0.023 / 0.0117 / 0.09 / 0.9153
Grade / 3 / 0.321 / 0.107 / 0.82 / 0.4856
Histology / 4 / 0.648 / 0.1620 / 1.23 / 0.2956
Residual disease / 1 / 1.702 / 1.7028 / 12.97 / 0.0004
Protocol number / 1 / 94.623 / 94.623 / 720.87 / 0.0001
REGRESSION / 15 / 155.357 / 10.357 / 78.90 / 0.0001
ERROR / 404 / 53.030 / 0.131

TableS3: MultivariateProgression-FreeSurvivalAnalysis(GOG-0172)

Covariate / AHR / 95% CI / p*
Age(years)† / 1.00 / 0.98–1.01 / 0.718
BMI(kg/m2)‡ / 0.98 / 0.90–1.07 / 0.702
Race/Ethnicity / 0.641
White / 1.00 / referent
Black / 1.25 / 0.50–3.11
other / 0.73 / 0.33–1.61
Grade(differentiation) / 0.257
good / 1.00 / referent
moderate / 1.34 / 0.74–2.42
poor / 1.43 / 0.81–2.53
notgraded / 3.92 / 0.98–15.71
Histology / 0.100
serous / 1.00 / referent
endometrioid / 0.60 / 0.28–1.27
mixedepithelial / 1.49 / 0.75–2.95
clear-cell / 2.14 / 1.01–4.52
other / 0.87 / 0.31–2.43
Grossresidualdisease / 0.001
no / 1.00 / referent
yes / 1.98 / 1.33–2.96
TSIC(days)§ / 0.97 / 0.94–1.00 / 0.086

∗Thep-values are fromtheoverall testof significance of eachcovariate inthe model.

†TheAHRdenotesthechangeinriskofprogressionordeathassociatedwithanincreaseof1yearofage.

‡TheAHRdenotesthechangeinriskofprogressionordeathassociatedwitha10%increaseinBMI(kg/m2).

§TheAHRdenotesthechangeinriskofprogressionordeathassociatedwitha10%increaseinTSIC(days).