Meyer et al., The MLL recombinome

Table 2: The MLL recombinome

# Cytogenetic abnormality Gene name Reference AL-Type

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1. t(1;11)(p32;q23) EPS15 Bernard et al. (1994) AML, CML

2. t(1;11)(p36;q23) n/a Douet-Guilbert, (2005) AML

3. t(1;11)(q21;q23) AF1Q Tse et al. (1995) AML

4. t(1;11)(q31;q23) n/a Harrison et al. (1998) AML

5. t(1;11)(q32;q23) n/a Harrison et al. (1998) t-AML, AML

6. t(2;11)(p21;q23) n/a Feder et al. (1985) AML,ALL,MDS

7. t(2;11)(q11.2–12;q23) LAF4 von Bergh et al. (2003) ALL

8. t(2;11)(q37;q23) n/a DeLozier-Blanchet et al. (1985) AML, t-AML

9. t(3;11)(p13;q23) n/a Harrison et al. (1998) AML

10. t(3;11)(p21;q23) NCKIPSD Sano et al. (2000) t-AML

11. t(3;11)(q21.3;q23) SELB Meyer et al (2005) ALL

12. t(3;11)(q24;q23) GMPS Pegram et al. (2000) t-AML

13. t(3;11)q27-q28;q23) LPP Daheron et al. (2001) t-AML

14. t(4;11)(p11;q23) n/a Harrison et al. (1998) t-AML

15. t(4;11)(q21.1;q23) SEPT11 Kojima et al. (2004) CML

16. t(4;11)(q21;q23) MLLT2 (AF4) Gu et al. (1992) ALL, t-AML, AML

17. t(4;11)(q35.1;q23) ARGBP2 Tonelli et al. (2004) AML

18. complex abnormalities FKSG14 Taki et al. (1996) AML

19. ins(5;11)(q31;q13q23) AF5Q31 Taki et al. (1999) ALL

20. t(5;11)(q31;q23) ARHGAP26 Borkhardt et al. (2000) JMML

21. t(6;11)(q12-13;q23) SMAP1 Meyer et al (2005) AML

22. t(6;11)(q21;q23) FOXO3A Hillion et al. (1997) t-AML

23. t(6;11)(q13;q23) n/a Harrison et al. (1998) AML

24. t(6;11)(q27;q23) MLLT4 (AF6) Prasad et al. (1993) AML, t-AML, ALL

25. t(7;11)(p15;q23) n/a Kobayashi et al. (1993) CML, AML

26. t(4;7;11)(q21;q21-22;q23) CDK6 Raffini et al. (2002) t-ALL

27. t(7;11)(q22;q23) n/a Lai et al. (1995) ALL, AML

28. t(7;11)(q32;q23) n/a Huret (2003) n/a

29. t(8;11)(q11;q23) n/a Huret (2003) n/a

30. t(8;11)(q21;q23) n/a Harrison et al. (1998) AL

31. t(8;11)(q24;q23) n/a Aventin et al. (1999) AML

32. t(9;11)(p11;q23); n/a Fan et al. 1988 ALL

33. t(9;11)(p22;q23) MLLT3 (AF9) Nakamura et al. (1993) AML, t-AML, ALL

34. t(9;11)(q33;q23); n/a Huret (2003) n/a

35. t(9;11)(q33.1-q33.3;q23); DAB2IP von Bergh et al. (2004) AML

36. ins(11;9)(q23;q34)inv(11)(q13)(q23) FNBP1 Fuchs et al. (2001) AML

37. t(10;11)(p11.2;q23) ABI1 Taki et al. (1998) AML

38. ins(10;11)(p12;q23q13) MLLT10 (AF10) Chaplin et al. (1995) AML, t-AML, ALL

39. t(10;11)(q21;q23) CXXC6 Ono et al. (2002) AML

40. t(10;11)(q25;q23) n/a Harrison et al. (1998) AML

41. t(11;11)(q11;q23) n/a Harrison et al. (1998) ALL, CLL

42. t(11;11)(q13;q23) n/a Harrison et al. (1998) t-AML

43. t(11;11)(q13.4;q23) ARHGEF17 Teuffel et al. (2005) AML

44. del(11)(q13.3q23) RPS3 Lo Nigro et al. (2003) AML

45. inv(11)(q14q23) PICALM Wechsler et al. (2003) AML

46. t(11;11)(q21;q23) n/a Harrison et al. (1998) ALL

47. del(11)(q23q23.3) ARHGEF12 Kourlas et al. (2000) AML

48 del(11)(q23;q23.3) BCL9L Attarbashi et al. (2005) ALL

49. del(11)(q23q23.3) CBL Fu et al. (2003) AML

50. del(11)(q23q24.2) TIRAP Meyer et al (2005) AML

51. del(11)(q23q24.2) DCPS Meyer et al (2005) AML

52. t(11;12)(q23;p13) n/a Raimondi et al. (1991) t-AML, AML, ALL

53. t(11;12)(q23;q13) n/a Bentz et al. (1995) AML, CLL

54. t(11;12)(q23;q13.2) CIP29 Hashii et al. (2004) AML

55. t(11;12)(q23;q24) n/a Schoch et al. 2003 AML

56. t(4;13;11)(q21;q34;q23) n/a Harrison et al. (1998) ALL, AML

57. t(11;14)(q23;q11) n/a Ziemin-van der Poel et al. (1992) ALL

58. t(11;14)(q23;q23.3) GPHN Kuwada et al. (2001) AML, t-AML

59, t(11;14)(q23;q32) n/a Huret (2003) n/a

60. t(11;15)(q23;q14) AF15Q14 Hayette et al. (2000) AML, ALL

61. t(11;15)q23;q14) ZFYVE19 Chinwalla et al. (2003) AML

62. t(11;15)q23;q15) n/a Harrison et al. (1998) AML

63. t(11;16)(q23;p13.3) CREBBP Taki et al. (1997) t-AML, t-ALL, t-CML

63. t(11;17)(q23;p13.1) GAS7 Megonigal et al. (2000) t-AML

64. t(11;17)(q23;q11) n/a Chuu et al. (1990) AML

66. ins(11;17)(q23;q21) ACACA Meyer et al (2005) AML

67. t(11;17)(q23;q21) MLLT6 (AF17) Prasad et al. (1994) AML

68. t(11;17)(q23;q21) LASP1 Strehl et al. (2003) AML

69. t(11;17)(q23;q23) n/a Berger et al. (1987) AML

70. t(11;17)(q23;q25) MSF Osaka et al. (1999) t-AML, AML

71. t(11;18)(q23;q12) n/a Bagby et al. (1978) AML, CML

72. t(11;18)(q23;q23) n/a Secker-Walker et al. (1998) AML, t-AML

73. t(11;19)q23;p13.1) ELL Thirman et al. (1994) AML, t-AML

74. t(11;19)q23;p13) SH3GL1 So et al. (1997) AML

75. t(11;19)(q23;p13.3) MLLT1 (ENL) Tkachuk et al. (1992) ALL, AML, t-AL

76. t(11;19)q23;p13.3) ASAH3 Lo Nigro et al. (2002) ALL

76. t(11;19)q23;p13.3-p13.2) MYO1F Lo Nigro et al. (2002) AML

78. t(11;20)(q23;q11.1-11.23) MAPRE1 Fu et al. (2005) ALL

79. t(11;20)(q23;q13) n/a Shippey et al. (1989) ALL, AML

80. t(11;21)(q23;q11) n/a Harrison et al. (1998) MDS, ALL

81. t(11;22)(q23;q11.21) PNUTL1 Megonigal et al. (1998) AML

82. t(11;22)(q23;q13.2) EP300 Ida et al. (1997) t-AML

83. t(Y;11)(p11;q23) n/a Bernasconi et al. (1999) AML

84. t(X;11)(q13.1;q23) MLLT7 (AFX) Parry et al. (1994) ALL,AML

85. t(X;11)(q22;q23) n/a Harrison et al. (1998) AML

86. ins(X;11)(q24;q23) SEPT6 Borkhardt et al. (2001) AML

87. ins(11;X)(q23;q28) n/a Arnaud et al. (2004) AML

Reference List for Table 2

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2. Douet-Guilbert N, Morel F, Le Bris MJ, Sassolas B, Giroux JD, De Braekeleer M. Rearrangement of MLL in a patient with congenital acute monoblastic leukemia and granulocytic sarcoma associated with a t(1;11)(p36;q23) translocation. Leuk Lymphoma 2005; 46: 143-146.

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8. DeLozier-Blanchet CD, Cabrol C, Werner-Favre C, Beris P, Engel E. Translocation 2;11 and other significant chromosome changes in acute monoblastic leukemia (M5) with clonal evolution: sequential clinical and cytogenetic studies. Cancer Genet Cytogenet 1985; 16: 95-102.

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16. Gu Y, Nakamura T, Alder H, Prasad R, Canaani O, Cimino G, Croce CM, Canaani E. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 1992; 71: 701-708.

17. Tonelli R, Luca Lo Nigro, Salvatore Serravalle, Luca Montemurro, Giancarlo Izzi, Andrea Pession. Identification of a New t(4;11) Rearrangement Involving MLL and ArgBP2 in a Case of Infant Acute Myeloid Leukemia. Abstract #4331 appeared in Blood 2004; 104.

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21. see reference 11

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23. see reference 4

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30. see reference 4

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40. see reference 4

41. see reference 4

42. see reference 4

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46. see reference 4

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50. see reference 11

51. see reference 11

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