The internal diseases, the hematology cycle - Y year course.
The plan of practical classes
№ / The theme / The content / The hours1. / Introductory class. The revising of base knowledge about cells of blood, hemopoeitic organs and hematopoeisis. Skill control of physical examination. / The cells of blood: the quantity, the biological function, the life span. The parameters of complete blood count (CBC), the different WBC count in cases of norm and pathology. Algorithm of estimation of complete blood count in the patients with blood diseases. The hematopoeitic organs, hematopoiesis: hematopoeitic stem cells, myelopoeisis and lymphopoeisis, the specific lines of the cell’s differentiation.
The four main hematological syndromes: anemia, bleeding, immunodeficiency with inflammatory and hyperplasic syndrome: the pathogenesis, the signs and objective symptoms, the date of CBC. The physical examination the patients with blood disease. The acquaintanceship with the working of the hematological department. / 5
2. / Deficiency anemias. Iron deficiency anemia. Megaloblastic anemia: Cobalamin Deficiency and Folate Deficiency. / Iron deficiency anemia. (IDA): the definition, the iron metabolism, the courses of iron deficit, the syndromes in clinical picture, the diagnostic criteria’s, the differential diagnosis of microcytic anemias, the treatment.
Megaloblastic anemias: normoblast, magaloblast, reticulocute. Vitamin B12 deficiency anemia: the definition, the vitamin B12 metabolism, the courses of vitamin B12 deficit, the syndromes in clinical picture, the diagnostic criteria’s, the treatment. Folic acid deficiency anemia, the common and differences with vitamin B12 deficiency anemia. The differential diagnosis of macrocytic anemias
The examination of the patients with anemias, the clinical parsing. / 5
3. / Oncohematology diseases.
Acute myeloid leukemia. / The WHO classification of the tumors of hematopietic and lymphoid tissue. Myeloid leukemias: acute myeloid leukemia (AML), the definition, FAB classification of nonlymphoid leukemias, the pathogenesis of acute leukemia, the syndromes in clinical picture, the stages (the first attack, remission, early death, resistance), the treatment (support therapy and chemotherapy).
The examination of the patients with AML, the clinical parsing / 5
4. / Chronic Leukemia: chronic lymphoid leukemia, Chronic myeloid leukemia. / The WHO classification of the tumors of hematopietic and lymphoid tissue. Myeloid leukemias: chronic myeloid leukemia (CML), the definition, the pathogenesis of CML, the specific cytogenetic abnormality – Philadelphia chromosome – t(9;22), the syndromes in clinical picture, the stages (the chronic phase, the accelerative phase, the blast crisis) , the treatment and its possible effects..
Chronic lymphoid leukemia (CLL): the definition, the pathogenesis of CLL, the syndromes in clinical picture, the stages acoding Rai classification, the treatment and its possible effects.
The examination of the patients with chronic leukemias, the clinical parsing / 5
5. / The hemostaisis. Hemophilia
Credit. / The hemostasis: the primary (platelets) and the secondary (coagulation blood) mechanisms, the five types of hemorrhagic syndromes (the capillary, the hematomal, the mixed, the vascular, the teleangioactesial): the clinical picture, the screening and specific laboratory tests. The hemophilia: the definition, the pathogenesis, the clinical picture, the diagnostic criteria’s, the treatment.
The examination of the patients with hemophilia, the clinical parsing / 5