TableS1 –Gene ontology analysis of genes nearest H3K27me3 peaks.
Each portion of H3K27me3 depicted in the Venn diagram in Fig. 3b was analyzed for enriched biological process categories (by hypergeometric test adjusted for multiple measurements, p<0.01).
Intersection of WT and KOGO ID / GO Term / Definition / p-value / Count in dataset / Count in Genome / Enrichment / Total term in dataset / Total term in genome / BH adjusted p-value
GO:0033555 / multicellular organismal response to stress / Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). / 1.34E-05 / 20 / 50 / 40.0% / 106639 / 718880 / 0.00587
GO:0031644 / regulation of neurological system process / Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system. / 2.38E-07 / 63 / 224 / 28.1% / 106639 / 718880 / 0.001052
GO:0050804 / regulation of synaptic transmission / Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. / 3.72E-06 / 53 / 192 / 27.6% / 106639 / 718880 / 0.002281
GO:0051969 / regulation of transmission of nerve impulse / Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. / 2.11E-06 / 57 / 208 / 27.4% / 106639 / 718880 / 0.001762
GO:0007268 / synaptic transmission / The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. / 1.55E-06 / 95 / 399 / 23.8% / 106639 / 718880 / 0.001581
GO:0044057 / regulation of system process / Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. / 2.81E-06 / 94 / 399 / 23.6% / 106639 / 718880 / 0.001915
GO:0019226 / transmission of nerve impulse / The neurological system process in which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation. / 1.43E-06 / 110 / 478 / 23.0% / 106639 / 718880 / 0.001581
GO:0035637 / multicellular organismal signaling / The transfer of information occurring at the level of a multicellular organism. / 1.43E-06 / 110 / 478 / 23.0% / 106639 / 718880 / 0.001581
GO:0048858 / cell projection morphogenesis / The process in which the anatomical structures of a cell projection are generated and organized. / 1.72E-05 / 91 / 400 / 22.8% / 106639 / 718880 / 0.007053
GO:0032990 / cell part morphogenesis / The process in which the anatomical structures of a cell part are generated and organized. / 2.72E-05 / 92 / 410 / 22.4% / 106639 / 718880 / 0.009817
GO:0000902 / cell morphogenesis / The developmental process in which the size or shape of a cell is generated and organized. / 2.30E-06 / 131 / 597 / 21.9% / 106639 / 718880 / 0.001762
GO:0022610 / biological adhesion / The attachment of a cell or organism to a substrate or other organism. / 3.43E-07 / 161 / 741 / 21.7% / 106639 / 718880 / 0.001052
GO:0007155 / cell adhesion / The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. / 5.31E-07 / 159 / 735 / 21.6% / 106639 / 718880 / 0.001087
GO:0032989 / cellular component morphogenesis / The process in which cellular structures, including whole cells or cell parts, are generated and organized. / 1.08E-05 / 136 / 643 / 21.2% / 106639 / 718880 / 0.005243
GO:0030182 / neuron differentiation / The process in which a relatively unspecialized cell acquires specialized features of a neuron. / 7.62E-06 / 151 / 723 / 20.9% / 106639 / 718880 / 0.004248
GO:0048699 / generation of neurons / The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. / 1.11E-05 / 164 / 802 / 20.4% / 106639 / 718880 / 0.005243
GO:0022008 / neurogenesis / Generation of cells within the nervous system. / 1.94E-05 / 172 / 856 / 20.1% / 106639 / 718880 / 0.00742
WT Only
GO ID / GO Term / Definition / p-value / Count in dataset / Count in Genome / Enrichment / Total term in dataset / Total term in genome / BH adjusted p-value
GO:0031644 / regulation of neurological system process / Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system. / 2.28E-07 / 63 / 224 / 28.1% / 106521 / 718880 / 0.000627
GO:0050804 / regulation of synaptic transmission / Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. / 3.60E-06 / 53 / 192 / 27.6% / 106521 / 718880 / 0.002769
GO:0051969 / regulation of transmission of nerve impulse / Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. / 2.04E-06 / 57 / 208 / 27.4% / 106521 / 718880 / 0.002656
GO:0030155 / regulation of cell adhesion / Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. / 2.71E-05 / 53 / 205 / 25.9% / 106521 / 718880 / 0.009196
GO:0045860 / positive regulation of protein kinase activity / Any process that activates or increases the frequency, rate or extent of protein kinase activity. / 2.21E-05 / 66 / 270 / 24.4% / 106521 / 718880 / 0.009012
GO:0044057 / regulation of system process / Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. / 2.68E-06 / 94 / 399 / 23.6% / 106521 / 718880 / 0.002734
GO:0007268 / synaptic transmission / The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. / 4.82E-06 / 93 / 399 / 23.3% / 106521 / 718880 / 0.002946
GO:0048858 / cell projection morphogenesis / The process in which the anatomical structures of a cell projection are generated and organized. / 1.65E-05 / 91 / 400 / 22.8% / 106521 / 718880 / 0.007221
GO:0019226 / transmission of nerve impulse / The neurological system process in which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation. / 4.07E-06 / 108 / 478 / 22.6% / 106521 / 718880 / 0.002769
GO:0035637 / multicellular organismal signaling / The transfer of information occurring at the level of a multicellular organism. / 4.07E-06 / 108 / 478 / 22.6% / 106521 / 718880 / 0.002769
GO:0032990 / cell part morphogenesis / The process in which the anatomical structures of a cell part are generated and organized. / 2.61E-05 / 92 / 410 / 22.4% / 106521 / 718880 / 0.009196
GO:0000902 / cell morphogenesis / The developmental process in which the size or shape of a cell is generated and organized. / 2.17E-06 / 131 / 597 / 21.9% / 106521 / 718880 / 0.002656
GO:0022610 / biological adhesion / The attachment of a cell or organism to a substrate or other organism. / 1.97E-07 / 162 / 741 / 21.9% / 106521 / 718880 / 0.000627
GO:0007155 / cell adhesion / The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. / 3.07E-07 / 160 / 735 / 21.8% / 106521 / 718880 / 0.000627
GO:0032989 / cellular component morphogenesis / The process in which cellular structures, including whole cells or cell parts, are generated and organized. / 1.02E-05 / 136 / 643 / 21.2% / 106521 / 718880 / 0.005224
GO:0030182 / neuron differentiation / The process in which a relatively unspecialized cell acquires specialized features of a neuron. / 7.18E-06 / 151 / 723 / 20.9% / 106521 / 718880 / 0.003993
GO:0048699 / generation of neurons / The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. / 1.57E-05 / 163 / 802 / 20.3% / 106521 / 718880 / 0.007221
GO:0022008 / neurogenesis / Generation of cells within the nervous system. / 2.67E-05 / 171 / 856 / 20.0% / 106521 / 718880 / 0.009196
KO Only
GO ID / GO Term / Definition / p-value / Count in dataset / Count in Genome / Enrichment / Total term in dataset / Total term in genome / BH adjusted p-value
GO:0033555 / multicellular organismal response to stress / Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). / 1.27E-05 / 20 / 50 / 40.0% / 106290 / 718880 / 0.0063
GO:0031644 / regulation of neurological system process / Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system. / 2.11E-07 / 63 / 224 / 28.1% / 106290 / 718880 / 0.000856
GO:0050804 / regulation of synaptic transmission / Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. / 3.37E-06 / 53 / 192 / 27.6% / 106290 / 718880 / 0.002064
GO:0051969 / regulation of transmission of nerve impulse / Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. / 1.90E-06 / 57 / 208 / 27.4% / 106290 / 718880 / 0.001665
GO:0007268 / synaptic transmission / The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. / 1.34E-06 / 95 / 399 / 23.8% / 106290 / 718880 / 0.001367
GO:0044057 / regulation of system process / Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. / 2.45E-06 / 94 / 399 / 23.6% / 106290 / 718880 / 0.001871
GO:0019226 / transmission of nerve impulse / The neurological system process in which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation. / 1.23E-06 / 110 / 478 / 23.0% / 106290 / 718880 / 0.001367
GO:0035637 / multicellular organismal signaling / The transfer of information occurring at the level of a multicellular organism. / 1.23E-06 / 110 / 478 / 23.0% / 106290 / 718880 / 0.001367
GO:0000902 / cell morphogenesis / The developmental process in which the size or shape of a cell is generated and organized. / 3.18E-06 / 130 / 597 / 21.8% / 106290 / 718880 / 0.002064
GO:0022610 / biological adhesion / The attachment of a cell or organism to a substrate or other organism. / 2.80E-07 / 161 / 741 / 21.7% / 106290 / 718880 / 0.000856
GO:0007155 / cell adhesion / The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. / 4.35E-07 / 159 / 735 / 21.6% / 106290 / 718880 / 0.000888
GO:0032989 / cellular component morphogenesis / The process in which cellular structures, including whole cells or cell parts, are generated and organized. / 1.44E-05 / 135 / 643 / 21.0% / 106290 / 718880 / 0.0063
GO:0030182 / neuron differentiation / The process in which a relatively unspecialized cell acquires specialized features of a neuron. / 9.85E-06 / 150 / 723 / 20.7% / 106290 / 718880 / 0.005479
GO:0048699 / generation of neurons / The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. / 1.39E-05 / 163 / 802 / 20.3% / 106290 / 718880 / 0.0063
GO:0022008 / neurogenesis / Generation of cells within the nervous system. / 2.37E-05 / 171 / 856 / 20.0% / 106290 / 718880 / 0.009669