Hivert et al.
Online Appendix
Online supplementary figure 1: Linkage disequilibrium (LD) plot across the RETN locus plus 20 kb upstream and 10 kb downstream for the CEU population. The horizontal black line depicts the 30 kb DNA segment of chromosome 19p13 analyzed in our sample, with the RETN gene displayed by the purple horizontal line above it. Gene MCEMP1 (RefSeq number LOC199675) is also shown here in purple on the 3’ side of RETN. The locations of the 27 SNPs included in this analysis are indicated below the black line, with the 21 tag SNPsin black hash marks above their rs number designations. An LD plot is in the bottom part of the figure based on the measure D’: each square represents the magnitude of LD for a single pair of markers, with red color indicating LD that is strong and statistically significant. Figure prepared using the program LocusView 2.0 (T. Petryshen, A. Kirby, M. Ainscow).
Online supplementary figure 2: Linkage disequilibrium (LD) plot across the RETN locus plus 20 kb upstream and 10 kb downstream for the Framingham population. The horizontal black line depicts the 30 kb DNA segment of chromosome 19p13 analyzed in our sample, with the RETN gene displayed by the purple horizontal line above it. Gene MCEMP1 (RefSeq numberLOC199675) is also shown here in purple on the 3’ side of RETN.An LD plot is in the bottom part of the figure based on the measure D’: each square represents the magnitude of LD for a single pair of markers, with red color indicating LD that is strong and statistically significant. Figure prepared using the program LocusView 2.0 (T. Petryshen, A. Kirby, M. Ainscow).
SupplementaryTable 1: Capture of common variants in RETN by selected tag SNPs
SNP to capture / MAF in CEU / Position(NCBI 35) / tag SNP / MAF in FOS / r2
rs794070 / 0.31 / 7620814 / rs794070 / 0.21 / 1
rs4804761 / 0.12 / 7621056 / rs11883223 / 0.17 / 0.8
rs12985273 / 0.17 / 7622041 / rs10413807 / 0.21 / 0.941
rs11883223 / 0.14 / 7628636 / rs11883223 / 0.17 / 1
rs2081075 / 0.31 / 7629461 / rs2081075 / 0.29 / 1
rs12610253 / 0.33 / 7630185 / rs10418380 / 0.32 / 1
rs10418380 / 0.31 / 7630540 / rs10418380 / 0.32 / 1
rs10413807 / 0.16 / 7630628 / rs10413807 / 0.21 / 1
rs4804762 / 0.14 / 7635195 / rs11883223 / 0.17 / 0.745
rs6603114 / 0.17 / 7636302 / rs11883223 / 0.17 / 0.825
rs12460483 / 0.15 / 7636594 / rs12460483 / 0.12 / 1
rs2161490 / 0.32 / 7637954 / rs2081075 / 0.28 / 0.962
rs12459044 / 0.14 / 7638406 / rs12459044 / 0.14 / 1
rs7408174 / 0.19 / 7638955 / rs7408174 / 0.31 / 1
rs1862513 / 0.35 / 7639793 / rs1862513 / 0.29 / 1
rs3219177 / 0.21 / 7640369 / rs3219177 / 0.21 / 1
rs3745367 / 0.27 / 7640511 / rs3745367 / 0.24 / 1
rs3219178 / 0.38 / 7640951 / rs3219178 / 0.42 / 1
rs10402265 / 0.23 / 7641089 / rs10402265 / 0.14 / 1
rs3745368 / 0.07 / 7641297 / rs3745368 / 0.002 / 1
rs3745369 / 0.41 / 7641475 / rs3745369 / 0.50 / 1
rs1477341 / 0.48 / 7642799 / rs1477341 / 0.44 / 1
rs4804765 / 0.34 / 7643840 / rs4804765 / 0.33 / 1
rs1423096 / 0.14 / 7645177 / rs1423096 / 0.09 / 1
rs10401670 / 0.46 / 7648802 / rs10401670 / 0.43 / 1
rs11882592 / 0.16 / 7649975 / rs11882592 / 0.18 / 1
rs10411016 / 0.46 / 7651043 / rs10411016 / 0.49 / 1
SNP: single nucleotide polymorphism identified by their rs number
MAF in CEU: minor allele frequency in the CEU population
MAF in FOS: minor allele frequency in the Framingham Offspring Study (numbers in grey are the MAF for the tagging SNP, not to be compared directly to the MAF in CEU on the same row)
r²: measure of linkage disequilibrium between captured SNP and tag SNP
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Hivert et al.
Supplementary Table 2: Diabetes incidence analyses for SNPs in RETN over 28 years of follow up in the Framingham Offspring Study
SNP / PositionNCBI 35 / allele / HR [95% CI] / P value* / Pvalue†
(BMI adj)
rs10401670 / 7648802 / T / 1.21 [0.98-1.49] / 0.08 / 0.27
rs10402265 / 7641089 / G / 1.23 [0.94-1.62] / 0.14 / 0.15
rs10411016 / 7651043 / T / 0.84 [0.68-1.02] / 0.08 / 0.07
rs10413807 / 7630628 / G / 0.99 [0.77-1.27] / 0.93 / 0.44
rs10418380 / 7630540 / G / 1.05 [0.85-1.29] / 0.66 / 0.33
rs11882592 / 7649975 / A / 1.28 [0.98-1.68] / 0.07 / 0.05
rs11883223 / 7628636 / G / 0.96 [0.73-1.26] / 0.78 / 0.44
rs12459044 / 7638406 / G / 1.05 [0.78-1.42] / 0.73 / 0.76
rs12460483 / 7636594 / A / 1.16 [0.85-1.56] / 0.35 / 0.57
rs1423096 / 7645177 / A / 1.08 [0.77-1.50] / 0.66 / 0.95
rs1477341 / 7642799 / T / 1.18 [0.96-1.44] / 0.11 / 0.24
rs1862513 / 7639793 / C / 1.22 [0.98-1.51] / 0.07 / 0.15
rs2081075 / 7629461 / A / 1.03 [0.83-1.29] / 0.77 / 0.84
rs3219177 / 7640369 / T / 1.20 [0.94-1.52] / 0.14 / 0.38
rs3219178 / 7640951 / C / 1.00 [0.81-1.22] / 0.98 / 0.93
rs3745367 / 7640511 / A / 1.25 [1.00-1.56] / 0.05 / 0.14
rs3745369 / 7641475 / C / 0.90 [0.74-1.10] / 0.31 / 0.43
rs4804765 / 7643840 / T / 1.11 [0.89-1.38] / 0.37 / 0.36
rs7408174 / 7638955 / T / 0.95 [0.76-1.19] / 0.66 / 0.56
rs794070 / 7620814 / C / 1.05 [0.81-1.35] / 0.72 / 0.60
HR: hazard ratio to develop diabetes over follow up
CI: confidence interval
*Adjustment for sex, age and age²
† Adjustment for sex, age, age² and BMI
Supplementary Table 3: Results of the longitudinal and exam 7 metabolic trait associations in the Framingham Offspring Study
SNP / Position / N / Alleles M/m / MAF (allele) / Mean ± SDM/M / Mean ± SD
M/m / Mean ± SD
m/m / Nominal P value* / Empiric
P value* / Nominal P value†
BMI-adj / Empiric
P value† BMI-adj
Mean fasting blood glucose over exam 3 to 7‡ (mg/dL)
rs794070 / 7620814 / 2429 / T/C / 0.21 (C) / 99.34 ± 20.32 / 99.41 ± 20.7 / 98.89 ± 19.52 / 0.67 / 1.0 / 0.88 / 1.0
rs11883223 / 7628636 / 2456 / G/A / 0.17 (A) / 99.24 ± 20.77 / 99.37 ± 19.48 / 101.92 ± 22.9 / 0.36 / 1.0 / 0.46 / 1.0
rs2081075 / 7629461 / 2428 / G/A / 0.29 (A) / 99.01 ± 19.87 / 99.43 ± 20.78 / 101.22 ± 22.52 / 0.49 / 1.0 / 0.61 / 1.0
rs10418380 / 7630540 / 2345 / A/G / 0.32 (G) / 99.6 ± 19.62 / 99.32 ± 21.01 / 98.95 ± 23.14 / 0.07 / 0.6 / 0.17 / 0.9
rs10413807 / 7630628 / 2453 / G/C / 0.21 (C) / 99.61 ± 19.87 / 98.83 ± 21.68 / 96.18 ± 12.33 / 0.05 / 0.6 / 0.22 / 1.0
rs12460483 / 7636594 / 2484 / G/A / 0.12 (A) / 99.1 ± 19.76 / 99.61 ± 21.49 / 106.31 ± 32.77 / 0.99 / 1.0 / 0.90 / 1.0
rs12459044 / 7638406 / 2455 / C/G / 0.14 (G) / 99.06 ± 19.72 / 99.94 ± 21.63 / 106.25 ± 36.09 / 0.89 / 1.0 / 0.91 / 1.0
rs7408174 / 7638955 / 2423 / T/C / 0.31 (C) / 99.06 ± 20.17 / 99.79 ± 21.74 / 99.55 ± 17.13 / 0.42 / 1.0 / 0.62 / 1.0
rs1862513 / 7639793 / 2486 / G/C / 0.29 (C) / 98.58 ± 18.41 / 99.9 ± 21.61 / 100.29 ± 23.95 / 0.59 / 1.0 / 0.65 / 1.0
rs3219177 / 7640369 / 2475 / C/T / 0.21 (T) / 98.87 ± 19.22 / 99.48 ± 21.01 / 104.16 ± 28 / 0.45 / 1.0 / 0.58 / 1.0
rs3745367 / 7640511 / 2475 / G/A / 0.24 (A) / 98.6 ± 18.56 / 100.08 ± 22.18 / 100.31 ± 22.07 / 0.27 / 1.0 / 0.41 / 1.0
rs3219178 / 7640951 / 2421 / C/G / 0.42 (G) / 99.22 ± 20.55 / 99.98 ± 21.73 / 97.04 ± 14.75 / 0.48 / 1.0 / 0.62 / 1.0
rs10402265 / 7641089 / 2466 / C/G / 0.14 (G) / 98.88 ± 19.39 / 100.19 ± 22.02 / 104 ± 32.07 / 0.26 / 1.0 / 0.31 / 1.0
rs3745369 / 7641475 / 2469 / G/C / 0.5 (C) / 99.09 ± 18.97 / 99.4 ± 20.51 / 99.25 ± 21.07 / 0.32 / 1.0 / 0.29 / 1.0
rs1477341 / 7642799 / 2474 / A/T / 0.44 (T) / 98.28 ± 18.83 / 99.69 ± 20.64 / 99.69 ± 21.65 / 0.005 / 0.08 / 0.007 / 0.1
rs4804765 / 7643840 / 2433 / G/T / 0.33 (T) / 98.48 ± 18.16 / 100.15 ± 22.2 / 99.55 ± 21.66 / 0.12 / 0.9 / 0.07 / 0.7
rs1423096 / 7645177 / 2462 / G/A / 0.09 (A) / 99.44 ± 20.97 / 98.75 ± 18.2 / 101.11 ± 15.33 / 0.04 / 0.5 / 0.11 / 0.8
rs10401670 / 7648802 / 2455 / C/T / 0.43 (T) / 97.97 ± 18.41 / 100.25 ± 21.67 / 99.06 ± 19.6 / 0.0009 / 0.02 / 0.0007 / 0.01
rs11882592 / 7649975 / 2441 / C/A / 0.18 (A) / 98.89 ± 19.39 / 100.25 ± 22.39 / 96.95 ± 14.76 / 0.22 / 1.0 / 0.28 / 1.0
rs10411016 / 7651043 / 2441 / T/G / 0.49 (G) / 100.68 ± 22.02 / 98.5 ± 19.49 / 99.46 ± 20.6 / 0.22 / 1.0 / 0.44 / 1.0
Fasting blood glucose at exam 7‡ (mg/dL)
rs794070 / 7620814 / 2145 / T/C / 0.21 (C) / 104.39 ± 27.08 / 104.17 ± 24.47 / 104.97 ± 31.33 / 0.62 / 1.0 / 0.66 / 1.0
rs11883223 / 7628636 / 2172 / G/A / 0.17 (A) / 104.25 ± 26.32 / 103.88 ± 25.75 / 110.56 ± 34.9 / 0.06 / 0.6 / 0.10 / 0.8
rs2081075 / 7629461 / 2142 / G/A / 0.29 (A) / 103.94 ± 25.49 / 103.81 ± 25.13 / 109.51 ± 36.53 / 0.08 / 0.7 / 0.11 / 0.8
rs10418380 / 7630540 / 2070 / A/G / 0.32 (G) / 104.11 ± 23.19 / 104.53 ± 29 / 103.61 ± 24.73 / 0.02 / 0.2 / 0.06 / 0.6
rs10413807 / 7630628 / 2174 / G/C / 0.21 (C) / 104.7 ± 25.86 / 103.34 ± 27.54 / 101.79 ± 18.75 / 0.001 / 0.02 / 0.008 / 0.1
rs12460483 / 7636594 / 2195 / G/A / 0.12 (A) / 103.68 ± 24.71 / 105.88 ± 31.22 / 111.1 ± 31.29 / 0.40 / 1.0 / 0.38 / 1.0
rs12459044 / 7638406 / 2170 / C/G / 0.14 (G) / 103.72 ± 24.93 / 105.93 ± 30.27 / 108.32 ± 28.28 / 0.26 / 1.0 / 0.24 / 1.0
rs7408174 / 7638955 / 2136 / T/C / 0.31 (C) / 103.74 ± 25.64 / 105.24 ± 28.26 / 103.62 ± 22.61 / 0.12 / 0.8 / 0.19 / 1.0
rs1862513 / 7639793 / 2197 / G/C / 0.29 (C) / 103.45 ± 24.98 / 104.76 ± 26.93 / 105.99 ± 29.5 / 0.57 / 1.0 / 0.72 / 1.0
rs3219177 / 7640369 / 2186 / C/T / 0.21 (T) / 103.56 ± 25.29 / 104.81 ± 27.39 / 110.63 ± 30.95 / 0.28 / 1.0 / 0.53 / 1.0
rs3745367 / 7640511 / 2187 / G/A / 0.24 (A) / 103.44 ± 24.82 / 105.13 ± 28.18 / 105.99 ± 26.27 / 0.17 / 0.9 / 0.38 / 1.0
rs3219178 / 7640951 / 2142 / C/G / 0.42 (G) / 103.41 ± 23.67 / 105 ± 28.11 / 102.8 ± 24.04 / 0.57 / 1.0 / 0.94 / 1.0
rs10402265 / 7641089 / 2179 / C/G / 0.14 (G) / 103.63 ± 25 / 105.72 ± 29.45 / 108.8 ± 32.49 / 0.22 / 1.0 / 0.22 / 1.0
rs3745369 / 7641475 / 2180 / G/C / 0.5 (C) / 104.64 ± 28.21 / 104.61 ± 26.93 / 103.15 ± 22.81 / 0.75 / 1.0 / 0.78 / 1.0
rs1477341 / 7642799 / 2187 / A/T / 0.44 (T) / 103.4 ± 24.21 / 104.66 ± 26.24 / 104.24 ± 29.1 / 0.008 / 0.1 / 0.004 / 0.08
rs4804765 / 7643840 / 2147 / G/T / 0.33 (T) / 103.86 ± 24.58 / 104.74 ± 26.87 / 104.56 ± 32.09 / 0.17 / 0.9 / 0.07 / 0.6
rs1423096 / 7645177 / 2177 / G/A / 0.09 (A) / 104.32 ± 26.88 / 103.7 ± 23.39 / 110.33 ± 30.95 / 0.003 / 0.05 / 0.007 / 0.1
rs10401670 / 7648802 / 2168 / C/T / 0.43 (T) / 102.56 ± 21.56 / 105.2 ± 26.95 / 104.23 ± 29.15 / 0.006 / 0.1 / 0.001 / 0.01
rs11882592 / 7649975 / 2158 / C/A / 0.18 (A) / 103.94 ± 25.66 / 104.66 ± 26.09 / 103.46 ± 24.31 / 0.88 / 1.0 / 0.85 / 1.0
rs10411016 / 7651043 / 2158 / T/G / 0.49 (G) / 106.81 ± 29.9 / 102.78 ± 23.67 / 104.78 ± 27.84 / 0.37 / 1.0 / 0.59 / 1.0
Fasting insulin levels at exam 7‡ (µU/ml)
rs794070 / 7620814 / 2105 / T/C / 0.21 (C) / 14.65 ± 8.19 / 15.16 ± 9.55 / 14.33 ± 8.42 / 0.71 / 1.0 / 0.62 / 1.0
rs11883223 / 7628636 / 2133 / G/A / 0.17 (A) / 14.78 ± 8.71 / 14.85 ± 8.22 / 15.87 ± 11.04 / 0.33 / 1.0 / 0.54 / 1.0
rs2081075 / 7629461 / 2104 / G/A / 0.29 (A) / 14.89 ± 9.04 / 14.71 ± 8.23 / 15.17 ± 8.78 / 0.61 / 1.0 / 0.95 / 1.0
rs10418380 / 7630540 / 2030 / A/G / 0.32 (G) / 15.03 ± 9.31 / 14.68 ± 8.14 / 14.58 ± 7.85 / 0.23 / 1.0 / 0.61 / 1.0
rs10413807 / 7630628 / 2134 / G/C / 0.21 (C) / 14.84 ± 8.26 / 14.58 ± 8.12 / 14.83 ± 8.27 / 0.29 / 1.0 / 0.92 / 1.0
rs12460483 / 7636594 / 2155 / G/A / 0.12 (A) / 14.86 ± 8.82 / 14.65 ± 8.09 / 14.12 ± 5.36 / 0.65 / 1.0 / 0.51 / 1.0
rs12459044 / 7638406 / 2130 / C/G / 0.14 (G) / 14.86 ± 8.9 / 14.72 ± 8.04 / 14 ± 4.95 / 0.81 / 1.0 / 0.70 / 1.0
rs7408174 / 7638955 / 2097 / T/C / 0.31 (C) / 14.8 ± 8.75 / 14.91 ± 8.78 / 14.83 ± 8.17 / 0.86 / 1.0 / 0.95 / 1.0
rs1862513 / 7639793 / 2157 / G/C / 0.29 (C) / 14.58 ± 8.11 / 15.18 ± 9.49 / 14.49 ± 7.37 / 0.98 / 1.0 / 0.61 / 1.0
rs3219177 / 7640369 / 2146 / C/T / 0.21 (T) / 14.61 ± 8.3 / 15.19 ± 9.43 / 14.78 ± 6.82 / 0.36 / 1.0 / 0.89 / 1.0
rs3745367 / 7640511 / 2147 / G/A / 0.24 (A) / 14.65 ± 8.38 / 15.11 ± 9.27 / 14.51 ± 7.04 / 0.56 / 1.0 / 0.77 / 1.0
rs3219178 / 7640951 / 2104 / C/G / 0.42 (G) / 14.67 ± 9.21 / 14.99 ± 8.46 / 14.56 ± 8.26 / 0.76 / 1.0 / 0.20 / 1.0
rs10402265 / 7641089 / 2140 / C/G / 0.14 (G) / 14.72 ± 8.79 / 15.09 ± 8.35 / 14.98 ± 7.62 / 0.37 / 1.0 / 0.51 / 1.0
rs3745369 / 7641475 / 2140 / G/C / 0.5 (C) / 14.76 ± 8.27 / 14.97 ± 9.21 / 14.57 ± 7.84 / 0.57 / 1.0 / 0.37 / 1.0
rs1477341 / 7642799 / 2147 / A/T / 0.44 (T) / 14.97 ± 8.08 / 14.86 ± 9.41 / 14.53 ± 7.58 / 0.38 / 1.0 / 0.23 / 1.0
rs4804765 / 7643840 / 2109 / G/T / 0.33 (T) / 15.23 ± 9.47 / 14.65 ± 8.28 / 14.04 ± 6.65 / 0.08 / 0.7 / 0.11 / 0.8
rs1423096 / 7645177 / 2137 / G/A / 0.09 (A) / 14.62 ± 7.97 / 15.74 ± 11.24 / 16.33 ± 8.96 / 0.07 / 0.6 / 0.22 / 1.0
rs10401670 / 7648802 / 2129 / C/T / 0.43 (T) / 14.82 ± 8.2 / 14.8 ± 9.22 / 14.86 ± 7.93 / 0.88 / 1.0 / 0.80 / 1.0
rs11882592 / 7649975 / 2119 / C/A / 0.18 (A) / 14.89 ± 8.97 / 14.67 ± 8 / 14.87 ± 8.87 / 0.67 / 1.0 / 0.47 / 1.0
rs10411016 / 7651043 / 2118 / T/G / 0.49 (G) / 15.23 ± 8.69 / 14.69 ± 8.03 / 14.39 ± 7.41 / 0.44 / 1.0 / 0.83 / 1.0
HOMA-IR at exam 7‡
rs794070 / 7620814 / 2105 / T/C / 0.21 (C) / 3.92 ± 2.98 / 4.09 ± 3.44 / 4.08 ± 4.52 / 0.67 / 1.0 / 0.57 / 1.0
rs11883223 / 7628636 / 2133 / G/A / 0.17 (A) / 3.99 ± 3.36 / 3.97 ± 2.8 / 4.38 ± 3.6 / 0.19 / 1.0 / 0.32 / 1.0
rs2081075 / 7629461 / 2104 / G/A / 0.29 (A) / 4.04 ± 3.6 / 3.9 ± 2.81 / 4.2 ± 2.96 / 0.39 / 1.0 / 0.65 / 1.0
rs10418380 / 7630540 / 2030 / A/G / 0.32 (G) / 4.05 ± 3.42 / 3.97 ± 3.18 / 3.83 ± 2.52 / 0.11 / 0.8 / 0.34 / 1.0
rs10413807 / 7630628 / 2134 / G/C / 0.21 (C) / 3.99 ± 2.96 / 3.89 ± 3.14 / 3.95 ± 2.83 / 0.10 / 0.8 / 0.46 / 1.0
rs12460483 / 7636594 / 2155 / G/A / 0.12 (A) / 4 ± 3.33 / 3.92 ± 2.77 / 4.06 ± 2.41 / 0.83 / 1.0 / 0.72 / 1.0
rs12459044 / 7638406 / 2130 / C/G / 0.14 (G) / 4 ± 3.36 / 3.97 ± 2.8 / 3.88 ± 2.24 / 0.96 / 1.0 / 0.97 / 1.0
rs7408174 / 7638955 / 2097 / T/C / 0.31 (C) / 3.95 ± 3.18 / 4.05 ± 3.32 / 4 ± 3.22 / 0.61 / 1.0 / 0.77 / 1.0
rs1862513 / 7639793 / 2157 / G/C / 0.29 (C) / 3.87 ± 2.9 / 4.12 ± 3.61 / 3.99 ± 2.8 / 0.90 / 1.0 / 0.68 / 1.0
rs3219177 / 7640369 / 2146 / C/T / 0.21 (T) / 3.92 ± 3.16 / 4.09 ± 3.38 / 4.18 ± 2.46 / 0.30 / 1.0 / 0.82 / 1.0
rs3745367 / 7640511 / 2147 / G/A / 0.24 (A) / 3.92 ± 3.18 / 4.09 ± 3.37 / 3.93 ± 2.42 / 0.41 / 1.0 / 0.94 / 1.0
rs3219178 / 7640951 / 2104 / C/G / 0.42 (G) / 3.91 ± 3.31 / 4.07 ± 3.27 / 3.84 ± 2.88 / 0.90 / 1.0 / 0.25 / 1.0
rs10402265 / 7641089 / 2140 / C/G / 0.14 (G) / 3.94 ± 3.29 / 4.11 ± 3.04 / 4.19 ± 2.67 / 0.26 / 1.0 / 0.34 / 1.0
rs3745369 / 7641475 / 2140 / G/C / 0.5 (C) / 4.01 ± 3.58 / 4.04 ± 3.27 / 3.86 ± 2.69 / 0.67 / 1.0 / 0.46 / 1.0
rs1477341 / 7642799 / 2147 / A/T / 0.44 (T) / 3.98 ± 3.11 / 4.03 ± 3.47 / 3.9 ± 2.68 / 0.95 / 1.0 / 0.80 / 1.0
rs4804765 / 7643840 / 2109 / G/T / 0.33 (T) / 4.09 ± 3.59 / 3.96 ± 3.03 / 3.75 ± 2.32 / 0.25 / 1.0 / 0.35 / 1.0
rs1423096 / 7645177 / 2137 / G/A / 0.09 (A) / 3.93 ± 3.02 / 4.24 ± 3.98 / 4.63 ± 2.96 / 0.02 / 0.2 / 0.06 / 0.6
rs10401670 / 7648802 / 2129 / C/T / 0.43 (T) / 3.9 ± 3.08 / 4.02 ± 3.36 / 3.99 ± 2.83 / 0.37 / 1.0 / 0.24 / 1.0
rs11882592 / 7649975 / 2119 / C/A / 0.18 (A) / 3.99 ± 3.24 / 3.95 ± 3.03 / 4.11 ± 3.3 / 0.71 / 1.0 / 0.50 / 1.0
rs10411016 / 7651043 / 2118 / T/G / 0.49 (G) / 4.22 ± 3.4 / 3.88 ± 2.87 / 3.88 ± 2.78 / 0.34 / 1.0 / 0.95 / 1.0
Gutt insulin sensitivity index at exam 7‡
rs794070 / 7620814 / 797 / T/C / 0.21 (C) / 21.62 ± 7.33 / 21.56 ± 7.35 / 21.82 ± 6.2 / 0.63 / 1.0 / 0.33 / 1.0
rs11883223 / 7628636 / 806 / G/A / 0.17 (A) / 21.55 ± 7.18 / 22.24 ± 7.67 / 19.17 ± 6.62 / 0.74 / 1.0 / 0.71 / 1.0
rs2081075 / 7629461 / 794 / G/A / 0.29 (A) / 21.6 ± 7.48 / 21.67 ± 7.2 / 21.86 ± 6.98 / 0.74 / 1.0 / 0.62 / 1.0
rs10418380 / 7630540 / 767 / A/G / 0.32 (G) / 21.43 ± 7.71 / 21.96 ± 7.01 / 21.84 ± 7.2 / 0.31 / 1.0 / 0.27 / 1.0
rs10413807 / 7630628 / 809 / G/C / 0.21 (C) / 21.46 ± 7.46 / 22.11 ± 6.86 / 22.24 ± 8.35 / 0.14 / 0.9 / 0.20 / 1.0
rs12460483 / 7636594 / 812 / G/A / 0.12 (A) / 21.84 ± 7.52 / 21.12 ± 6.47 / 23.48 ± 8.69 / 0.48 / 1.0 / 0.67 / 1.0
rs12459044 / 7638406 / 803 / C/G / 0.14 (G) / 21.87 ± 7.47 / 20.89 ± 6.67 / 20.95 ± 6.09 / 0.08 / 0.7 / 0.13 / 0.9
rs7408174 / 7638955 / 790 / T/C / 0.31 (C) / 21.27 ± 7.09 / 22.23 ± 7.46 / 20.87 ± 7.13 / 0.44 / 1.0 / 0.31 / 1.0
rs1862513 / 7639793 / 814 / G/C / 0.29 (C) / 22.08 ± 7.37 / 21.26 ± 7.26 / 21.54 ± 7.31 / 0.09 / 0.7 / 0.18 / 0.9
rs3219177 / 7640369 / 811 / C/T / 0.21 (T) / 21.99 ± 7.35 / 21.15 ± 7.13 / 21.33 ± 7.96 / 0.13 / 0.9 / 0.51 / 1.0
rs3745367 / 7640511 / 811 / G/A / 0.24 (A) / 22.07 ± 7.33 / 21.13 ± 7.21 / 21.43 ± 7.57 / 0.05 / 0.5 / 0.18 / 1.0
rs3219178 / 7640951 / 794 / C/G / 0.42 (G) / 21.92 ± 7.33 / 21.17 ± 7.31 / 22.56 ± 7.18 / 0.60 / 1.0 / 0.89 / 1.0
rs10402265 / 7641089 / 808 / C/G / 0.14 (G) / 21.89 ± 7.43 / 21.2 ± 7.15 / 21.26 ± 5.94 / 0.29 / 1.0 / 0.38 / 1.0
rs3745369 / 7641475 / 809 / G/C / 0.5 (C) / 21.48 ± 6.97 / 21.82 ± 7.45 / 21.71 ± 7.38 / 0.99 / 1.0 / 0.75 / 1.0
rs1477341 / 7642799 / 812 / A/T / 0.44 (T) / 21.77 ± 7.04 / 21.76 ± 7.76 / 21.46 ± 6.63 / 0.48 / 1.0 / 0.47 / 1.0
rs4804765 / 7643840 / 800 / G/T / 0.33 (T) / 22.08 ± 7.4 / 21.29 ± 7.46 / 21.64 ± 6.49 / 0.31 / 1.0 / 0.21 / 1.0
rs1423096 / 7645177 / 807 / G/A / 0.09 (A) / 21.5 ± 7.21 / 22.47 ± 7.85 / 20.62 ± 7.37 / 0.54 / 1.0 / 0.42 / 1.0
rs10401670 / 7648802 / 805 / C/T / 0.43 (T) / 21.6 ± 7.19 / 21.78 ± 7.58 / 21.59 ± 6.89 / 0.81 / 1.0 / 0.85 / 1.0
rs11882592 / 7649975 / 803 / C/A / 0.18 (A) / 21.81 ± 7.3 / 21.19 ± 7.47 / 25.06 ± 6.07 / 0.86 / 1.0 / 0.83 / 1.0
rs10411016 / 7651043 / 797 / T/G / 0.49 (G) / 21.36 ± 7.72 / 21.88 ± 7.16 / 21.55 ± 7.05 / 0.47 / 1.0 / 0.94 / 1.0
A1c levels at exam 7‡ (%)
rs794070 / 7620814 / 1974 / T/C / 0.21 (C) / 5.66 ± 1.01 / 5.68 ± 0.92 / 5.53 ± 0.94 / 0.96 / 1.0 / 0.95 / 1.0
rs11883223 / 7628636 / 1997 / G/A / 0.17 (A) / 5.66 ± 0.98 / 5.65 ± 0.97 / 5.76 ± 1.11 / 0.27 / 1.0 / 0.35 / 1.0
rs2081075 / 7629461 / 1978 / G/A / 0.29 (A) / 5.63 ± 0.87 / 5.67 ± 0.99 / 5.78 ± 1.37 / 0.57 / 1.0 / 0.71 / 1.0
rs10418380 / 7630540 / 1914 / A/G / 0.32 (G) / 5.64 ± 0.83 / 5.67 ± 1.04 / 5.75 ± 1.19 / 0.51 / 1.0 / 0.65 / 1.0
rs10413807 / 7630628 / 1999 / G/C / 0.21 (C) / 5.65 ± 0.95 / 5.67 ± 1 / 5.58 ± 0.74 / 0.55 / 1.0 / 0.82 / 1.0
rs12460483 / 7636594 / 2023 / G/A / 0.12 (A) / 5.64 ± 0.87 / 5.7 ± 1.21 / 6.07 ± 1.74 / 0.62 / 1.0 / 0.55 / 1.0
rs12459044 / 7638406 / 1995 / C/G / 0.14 (G) / 5.64 ± 0.88 / 5.69 ± 1.16 / 5.73 ± 1.1 / 0.11 / 0.8 / 0.11 / 0.8
rs7408174 / 7638955 / 1971 / T/C / 0.31 (C) / 5.64 ± 0.97 / 5.69 ± 1.03 / 5.65 ± 0.81 / 0.08 / 0.7 / 0.10 / 0.8
rs1862513 / 7639793 / 2024 / G/C / 0.29 (C) / 5.62 ± 0.86 / 5.69 ± 1.05 / 5.7 ± 1.15 / 0.93 / 1.0 / 0.96 / 1.0
rs3219177 / 7640369 / 2013 / C/T / 0.21 (T) / 5.63 ± 0.89 / 5.67 ± 1.07 / 5.83 ± 1.27 / 0.97 / 1.0 / 0.81 / 1.0
rs3745367 / 7640511 / 2014 / G/A / 0.24 (A) / 5.62 ± 0.88 / 5.68 ± 1.06 / 5.73 ± 1.16 / 0.48 / 1.0 / 0.66 / 1.0
rs3219178 / 7640951 / 1974 / C/G / 0.42 (G) / 5.65 ± 0.94 / 5.68 ± 1.03 / 5.56 ± 0.8 / 0.45 / 1.0 / 0.56 / 1.0
rs10402265 / 7641089 / 2006 / C/G / 0.14 (G) / 5.64 ± 0.88 / 5.68 ± 1.16 / 5.95 ± 1.39 / 0.44 / 1.0 / 0.43 / 1.0
rs3745369 / 7641475 / 2007 / G/C / 0.5 (C) / 5.68 ± 1.02 / 5.64 ± 0.97 / 5.65 ± 0.93 / 0.45 / 1.0 / 0.44 / 1.0
rs1477341 / 7642799 / 2014 / A/T / 0.44 (T) / 5.65 ± 0.92 / 5.67 ± 0.98 / 5.63 ± 1.01 / 0.33 / 1.0 / 0.34 / 1.0
rs4804765 / 7643840 / 1982 / G/T / 0.33 (T) / 5.65 ± 0.91 / 5.66 ± 0.98 / 5.69 ± 1.2 / 0.43 / 1.0 / 0.35 / 1.0
rs1423096 / 7645177 / 2004 / G/A / 0.09 (A) / 5.68 ± 1.01 / 5.58 ± 0.79 / 5.52 ± 1 / 0.82 / 1.0 / 0.63 / 1.0
rs10401670 / 7648802 / 1997 / C/T / 0.43 (T) / 5.63 ± 0.88 / 5.67 ± 0.98 / 5.63 ± 1.01 / 0.29 / 1.0 / 0.27 / 1.0
rs11882592 / 7649975 / 1988 / C/A / 0.18 (A) / 5.65 ± 0.94 / 5.65 ± 1 / 5.56 ± 0.74 / 0.11 / 0.8 / 0.09 / 0.7
rs10411016 / 7651043 / 1989 / T/G / 0.49 (G) / 5.66 ± 0.98 / 5.66 ± 0.95 / 5.65 ± 1.03 / 0.79 / 1.0 / 0.51 / 1.0
BMI at exam 7 (kg/m²)
rs794070 / 7620814 / 2338 / T/C / 0.21 (C) / 28.15 ± 5.31 / 28.33 ± 5.47 / 27.37 ± 5.18 / 0.94 / 1.00 / na / na
rs11883223 / 7628636 / 2362 / G/A / 0.17 (A) / 28.1 ± 5.29 / 28.37 ± 5.58 / 28.29 ± 4.79 / 0.53 / 1.00 / na / na
rs2081075 / 7629461 / 2335 / G/A / 0.29 (A) / 28.03 ± 5.29 / 28.33 ± 5.48 / 28.58 ± 5.32 / 0.23 / 0.98 / na / na
rs10418380 / 7630540 / 2257 / A/G / 0.32 (G) / 28.29 ± 5.54 / 28.17 ± 5.26 / 27.94 ± 5.34 / 0.43 / 1.00 / na / na
rs10413807 / 7630628 / 2361 / G/C / 0.21 (C) / 28.34 ± 5.46 / 27.94 ± 5.21 / 27.35 ± 5.01 / 0.06 / 0.60 / na / na
rs12460483 / 7636594 / 2390 / G/A / 0.12 (A) / 28.11 ± 5.37 / 28.23 ± 5.14 / 30.28 ± 6.82 / 0.29 / 1.00 / na / na
rs12459044 / 7638406 / 2361 / C/G / 0.14 (G) / 28.12 ± 5.38 / 28.2 ± 5.18 / 29.23 ± 6.19 / 0.47 / 1.00 / na / na
rs7408174 / 7638955 / 2330 / T/C / 0.31 (C) / 28.1 ± 5.24 / 28.21 ± 5.52 / 28.4 ± 5.17 / 0.74 / 1.00 / na / na
rs1862513 / 7639793 / 2391 / G/C / 0.29 (C) / 28.03 ± 5.26 / 28.23 ± 5.38 / 28.76 ± 5.8 / 0.28 / 0.99 / na / na
rs3219177 / 7640369 / 2380 / C/T / 0.21 (T) / 28.01 ± 5.29 / 28.29 ± 5.34 / 29.69 ± 6.12 / 0.09 / 0.74 / na / na
rs3745367 / 7640511 / 2380 / G/A / 0.24 (A) / 28.02 ± 5.26 / 28.21 ± 5.37 / 29.35 ± 6.02 / 0.08 / 0.70 / na / na
rs3219178 / 7640951 / 2329 / C/G / 0.42 (G) / 28.33 ± 5.39 / 28.13 ± 5.3 / 27.93 ± 5.48 / 0.26 / 0.99 / na / na
rs10402265 / 7641089 / 2371 / C/G / 0.14 (G) / 28.14 ± 5.43 / 28.19 ± 4.96 / 29.3 ± 7.07 / 0.43 / 1.00 / na / na
rs3745369 / 7641475 / 2374 / G/C / 0.5 (C) / 28.21 ± 5.59 / 28.14 ± 5.15 / 28.21 ± 5.52 / 0.98 / 1.00 / na / na
rs1477341 / 7642799 / 2378 / A/T / 0.44 (T) / 28.15 ± 5.25 / 28.21 ± 5.33 / 28.11 ± 5.61 / 0.93 / 1.00 / na / na
rs4804765 / 7643840 / 2338 / G/T / 0.33 (T) / 28.33 ± 5.29 / 28.11 ± 5.52 / 28.06 ± 5.22 / 0.53 / 1.00 / na / na
rs1423096 / 7645177 / 2369 / G/A / 0.09 (A) / 28.1 ± 5.31 / 28.52 ± 5.49 / 28.36 ± 6.19 / 0.28 / 0.99 / na / na
rs10401670 / 7648802 / 2360 / C/T / 0.43 (T) / 28.25 ± 5.46 / 28.19 ± 5.22 / 28.01 ± 5.62 / 0.76 / 1.00 / na / na
rs11882592 / 7649975 / 2348 / C/A / 0.18 (A) / 28.19 ± 5.32 / 28.19 ± 5.45 / 28.41 ± 6.05 / 0.59 / 1.00 / na / na
rs10411016 / 7651043 / 2347 / T/G / 0.49 (G) / 28.31 ± 5.21 / 28.26 ± 5.39 / 27.84 ± 5.43 / 0.08 / 0.70 / na / na
Waist circumference at exam 7 (inches)
rs794070 / 7620814 / 2321 / T/C / 0.21 (C) / 39.26 ± 5.55 / 39.5 ± 5.59 / 38.44 ± 5.71 / 0.80 / 1.00 / 0.25 / 0.99
rs11883223 / 7628636 / 2345 / G/A / 0.17 (A) / 39.28 ± 5.58 / 39.31 ± 5.56 / 39.91 ± 5.5 / 0.98 / 1.00 / 0.27 / 0.99
rs2081075 / 7629461 / 2318 / G/A / 0.29 (A) / 39.14 ± 5.57 / 39.47 ± 5.61 / 39.77 ± 5.65 / 0.21 / 0.96 / 0.92 / 1.00
rs10418380 / 7630540 / 2241 / A/G / 0.32 (G) / 39.35 ± 5.72 / 39.37 ± 5.46 / 39.08 ± 5.8 / 0.93 / 1.00 / 0.17 / 0.94
rs10413807 / 7630628 / 2344 / G/C / 0.21 (C) / 39.49 ± 5.65 / 39 ± 5.46 / 38.53 ± 5.36 / 0.07 / 0.66 / 0.94 / 1.00
rs12460483 / 7636594 / 2373 / G/A / 0.12 (A) / 39.17 ± 5.57 / 39.63 ± 5.38 / 40.52 ± 7.72 / 0.08 / 0.71 / 0.18 / 0.94
rs12459044 / 7638406 / 2344 / C/G / 0.14 (G) / 39.2 ± 5.58 / 39.5 ± 5.41 / 39.91 ± 7.17 / 0.19 / 0.96 / 0.24 / 0.98
rs7408174 / 7638955 / 2313 / T/C / 0.31 (C) / 39.28 ± 5.66 / 39.29 ± 5.6 / 39.53 ± 5.12 / 0.80 / 1.00 / 0.91 / 1.00
rs1862513 / 7639793 / 2374 / G/C / 0.29 (C) / 39.08 ± 5.37 / 39.44 ± 5.69 / 39.81 ± 6.17 / 0.18 / 0.95 / 0.68 / 1.00
rs3219177 / 7640369 / 2363 / C/T / 0.21 (T) / 39.07 ± 5.44 / 39.47 ± 5.66 / 41.15 ± 6.32 / 0.04 / 0.48 / 0.63 / 1.00
rs3745367 / 7640511 / 2363 / G/A / 0.24 (A) / 39.11 ± 5.39 / 39.36 ± 5.72 / 40.59 ± 6.13 / 0.06 / 0.59 / 0.87 / 1.00
rs3219178 / 7640951 / 2312 / C/G / 0.42 (G) / 39.36 ± 5.53 / 39.36 ± 5.66 / 38.99 ± 5.4 / 0.45 / 1.00 / 0.61 / 1.00
rs10402265 / 7641089 / 2354 / C/G / 0.14 (G) / 39.23 ± 5.63 / 39.48 ± 5.24 / 39.86 ± 7.09 / 0.30 / 1.00 / 0.55 / 1.00
rs3745369 / 7641475 / 2357 / G/C / 0.5 (C) / 39.25 ± 5.57 / 39.27 ± 5.53 / 39.42 ± 5.64 / 0.39 / 1.00 / 0.05 / 0.53
rs1477341 / 7642799 / 2361 / A/T / 0.44 (T) / 39.21 ± 5.51 / 39.37 ± 5.53 / 39.26 ± 5.81 / 0.32 / 1.00 / 0.11 / 0.81
rs4804765 / 7643840 / 2321 / G/T / 0.33 (T) / 39.4 ± 5.6 / 39.29 ± 5.61 / 39.16 ± 5.57 / 0.88 / 1.00 / 0.12 / 0.84
rs1423096 / 7645177 / 2352 / G/A / 0.09 (A) / 39.24 ± 5.53 / 39.58 ± 5.72 / 38.9 ± 6.11 / 0.38 / 1.00 / 0.60 / 1.00
rs10401670 / 7648802 / 2344 / C/T / 0.43 (T) / 39.36 ± 5.67 / 39.33 ± 5.44 / 39.1 ± 5.86 / 0.73 / 1.00 / 0.22 / 0.97
rs11882592 / 7649975 / 2331 / C/A / 0.18 (A) / 39.29 ± 5.55 / 39.36 ± 5.66 / 39.29 ± 6.11 / 0.50 / 1.00 / 0.42 / 1.00
rs10411016 / 7651043 / 2330 / T/G / 0.49 (G) / 39.5 ± 5.45 / 39.35 ± 5.62 / 38.98 ± 5.61 / 0.05 / 0.52 / 0.24 / 0.98
Subcutaneous adipose tissue (cm³)
rs794070 / 7620814 / 976 / T/C / 0.21 (C) / 2955.7 ± 1296.8 / 3081.1 ± 1364.2 / 2595.8 ± 1192.9 / 0.69 / 1.00 / na / na
rs11883223 / 7628636 / 997 / G/A / 0.17 (A) / 2995.8 ± 1310.9 / 2912.9 ± 1313.9 / 2933.2 ± 1222.1 / 0.45 / 1.00 / na / na
rs2081075 / 7629461 / 977 / G/A / 0.29 (A) / 2983.5 ± 1322.6 / 2971.1 ± 1289.6 / 2928.4 ± 1390.2 / 0.83 / 1.00 / na / na
rs10418380 / 7630540 / 921 / A/G / 0.32 (G) / 2952.4 ± 1310.6 / 3013.7 ± 1309.3 / 3082.7 ± 1381.5 / 0.22 / 0.97 / na / na
rs10413807 / 7630628 / 993 / G/C / 0.21 (C) / 2962.9 ± 1317.7 / 3000.3 ± 1311.7 / 2975.6 ± 1289.4 / 0.83 / 1.00 / na / na
rs12460483 / 7636594 / 1005 / G/A / 0.12 (A) / 2973.6 ± 1312.7 / 2931.7 ± 1244.2 / 3736.1 ± 1854.7 / 0.15 / 0.91 / na / na
rs12459044 / 7638406 / 990 / C/G / 0.14 (G) / 2969.7 ± 1312.1 / 2948.7 ± 1245.1 / 4554.0 ± 2008.3 / 0.09 / 0.74 / na / na
rs7408174 / 7638955 / 972 / T/C / 0.31 (C) / 2964 ± 1308.4 / 2946.2 ± 1272.2 / 3110.0 ± 1402.8 / 0.58 / 1.00 / na / na
rs1862513 / 7639793 / 1006 / G/C / 0.29 (C) / 2966.4 ± 1330.0 / 2956.0 ± 1243.3 / 3162.4 ± 1523.6 / 0.38 / 1.00 / na / na
rs3219177 / 7640369 / 1000 / C/T / 0.21 (T) / 2964.9 ± 1317.9 / 2967.0 ± 1261.8 / 3277.8 ± 1515.6 / 0.22 / 0.97 / na / na
rs3745367 / 7640511 / 1001 / G/A / 0.24 (A) / 2950.8 ± 1319.9 / 2979.8 ± 1247.4 / 3291.3 ± 1564.2 / 0.19 / 0.96 / na / na
rs3219178 / 7640951 / 982 / C/G / 0.42 (G) / 3028.8 ± 1348.9 / 2940.4 ± 1263.6 / 2989.0 ± 1392.3 / 0.49 / 1.00 / na / na
rs10402265 / 7641089 / 996 / C/G / 0.14 (G) / 3001.1 ± 1333.4 / 2854.2 ± 1180.2 / 3596.5 ± 1859.3 / 0.84 / 1.00 / na / na
rs3745369 / 7641475 / 1000 / G/C / 0.5 (C) / 2953.0 ± 1344.1 / 2970.0 ± 1267.7 / 3048.6 ± 1364.3 / 0.33 / 1.00 / na / na
rs1477341 / 7642799 / 1000 / A/T / 0.44 (T) / 2954.1 ± 1273.4 / 2941.3 ± 1270.5 / 3128.1 ± 1467.2 / 0.27 / 0.99 / na / na
rs4804765 / 7643840 / 979 / G/T / 0.33 (T) / 2975.8 ± 1331.2 / 2946.8 ± 1271.7 / 3116.9 ± 1401.5 / 0.58 / 1.00 / na / na
rs1423096 / 7645177 / 998 / G/A / 0.09 (A) / 2955.0 ± 1268.6 / 3082.2 ± 1442.2 / 2905.8 ± 1396.5 / 0.76 / 1.00 / na / na
rs10401670 / 7648802 / 993 / C/T / 0.43 (T) / 2945.4 ± 1320.3 / 2980.8 ± 1275.1 / 3048.6 ± 1396.1 / 0.61 / 1.00 / na / na
rs11882592 / 7649975 / 985 / C/A / 0.18 (A) / 2976.9± 1340.6 / 3010.5 ± 1229.8 / 2893.0 ± 1465.4 / 0.94 / 1.00 / na / na
rs10411016 / 7651043 / 985 / T/G / 0.49 (G) / 3016.4 ± 1368.1 / 2961.5 ± 1273.6 / 2960.8 ± 1335.7 / 0.55 / 1.00 / na / na
Visceral adipose tissue (cm³)
rs794070 / 7620814 / 976 / T/C / 0.21 (C) / 2134.4 ± 1096.1 / 2172.3 ± 1135.7 / 1905.4 ± 942.7 / 0.64 / 1.00 / na / na
rs11883223 / 7628636 / 997 / G/A / 0.17 (A) / 2155.4 ± 1115.2 / 2069.8 ± 1063.7 / 2333.6 ± 1192.9 / 0.42 / 1.00 / na / na
rs2081075 / 7629461 / 977 / G/A / 0.29 (A) / 2141.1 ± 1109.6 / 2107.2 ± 1069.0 / 2285.3 ± 1307.3 / 0.71 / 1.00 / na / na
rs10418380 / 7630540 / 921 / A/G / 0.32 (G) / 2157.2 ± 1082.5 / 2100.5 ± 1074.1 / 2156.6 ± 1305.6 / 0.68 / 1.00 / na / na
rs10413807 / 7630628 / 993 / G/C / 0.21 (C) / 2170.5 ± 1096.1 / 2053.5 ± 1091.5 / 2191.8 ± 1306.8 / 0.53 / 1.00 / na / na
rs12460483 / 7636594 / 1005 / G/A / 0.12 (A) / 2126.5 ± 1095.8 / 2136.8 ± 1072.7 / 2545.9 ± 1718.3 / 0.89 / 1.00 / na / na
rs12459044 / 7638406 / 990 / C/G / 0.14 (G) / 2132.2 ± 1096.5 / 2162.6 ± 1106.9 / 2290.6 ± 1074.0 / 0.57 / 1.00 / na / na
rs7408174 / 7638955 / 972 / T/C / 0.31 (C) / 2165.0 ± 1172.0 / 2091.3 ± 1074.3 / 2116.6 ± 937.2 / 0.45 / 1.00 / na / na
rs1862513 / 7639793 / 1006 / G/C / 0.29 (C) / 2080.4 ± 1103.6 / 2206.1 ± 1050.3 / 2111.0 ± 1337.9 / 0.44 / 1.00 / na / na
rs3219177 / 7640369 / 1000 / C/T / 0.21 (T) / 2106.3 ± 1105.3 / 2169.5 ± 1043.5 / 2304.1 ± 1350.4 / 0.48 / 1.00 / na / na
rs3745367 / 7640511 / 1001 / G/A / 0.24 (A) / 2100.3 ± 1109.2 / 2168.0 ± 1023.7 / 2274.3 ± 1382.2 / 0.20 / 0.96 / na / na
rs3219178 / 7640951 / 982 / C/G / 0.42 (G) / 2105.9 ± 1064.3 / 2175.2 ± 1114.6 / 2057.5 ± 1164.3 / 0.78 / 1.00 / na / na
rs10402265 / 7641089 / 996 / C/G / 0.14 (G) / 2142.0 ± 1096.7 / 2098.3 ± 1066.5 / 2281.7 ± 1608.6 / 0.62 / 1.00 / na / na
rs3745369 / 7641475 / 1000 / G/C / 0.5 (C) / 2151.3 ± 1153.4 / 2128.0 ± 1062.1 / 2143.0 ± 1119.6 / 0.48 / 1.00 / na / na
rs1477341 / 7642799 / 1000 / A/T / 0.44 (T) / 2126.0 ± 1069.8 / 2149.3 ± 1107.0 / 2141.8 ± 1160.5 / 0.40 / 1.00 / na / na
rs4804765 / 7643840 / 979 / G/T / 0.33 (T) / 2140.7 ± 1098.8 / 2131.2 ± 1106.4 / 2187.7 ± 1179.2 / 0.50 / 1.00 / na / na
rs1423096 / 7645177 / 998 / G/A / 0.09 (A) / 2136.9 ± 1086.5 / 2165.9 ± 1166.1 / 1917.7 ± 1196.9 / 0.55 / 1.00 / na / na
rs10401670 / 7648802 / 993 / C/T / 0.43 (T) / 2083.2 ± 1046.7 / 2164.9 ± 1126.4 / 2131.9 ± 1149.9 / 0.35 / 1.00 / na / na
rs11882592 / 7649975 / 985 / C/A / 0.18 (A) / 2154.4 ± 1116.6 / 2094 ± 1058.8 / 2070.3 ± 1332.7 / 0.83 / 1.00 / na / na
rs10411016 / 7651043 / 985 / T/G / 0.49 (G) / 2144.5 ± 1065.3 / 2123.4 ± 1083.1 / 2135.7 ± 1179.7 / 0.89 / 1.00 / na / na
na: not applicable
*Adjustment for sex, age and age²
† Adjustment for sex, age, age² and BMI
‡ Analysis after exclusion of participants with diabetes
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Hivert et al.
Supplementary Table 4: Power calculation for predicting diabetes incidence in the Framingham Offspring Study
Minor Allele Frequency / Hazard ratio* per minor allele / Power to detect significant effect0.05 / 1.1 / 0.062
1.2 / 0.096
1.3 / 0.149
1.4 / 0.219
1.5 / 0.301
2 / 0.725
0.1 / 1.1 / 0.073
1.2 / 0.137
1.3 / 0.238
1.4 / 0.364
1.5 / 0.500
2 / 0.933
0.25 / 1.1 / 0.097
1.2 / 0.230
1.3 / 0.423
1.4 / 0.624
1.5 / 0.786
2 / 0.997
0.4 / 1.1 / 0.110
1.2 / 0.276
1.3 / 0.502
1.4 / 0.713
1.5 / 0.859
2 / 0.999
* using an additive model
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Hivert et al.
Supplementary Table 5: Power calculation for quantitative traits in the Framingham Offspring Study*
Percent variance explained by SNP / 0.10 / 0.5 / 1 / 2 / 5 / 10alpha=0.05 / 0.346 / 0.938 / 0.999 / >0.999 / >0.999 / >0.999
alpha=0.01 / 0.156 / 0.821 / 0.991 / >0.999 / >0.999 / >0.999
alpha=0.001 / 0.042 / 0.581 / 0.951 / >0.999 / >0.999 / >0.999
alpha=0.0001 / 0.010 / 0.347 / 0.854 / 0.999 / >0.999 / >0.999
alpha=0.00001 / 0.002 / 0.179 / 0.701 / 0.995 / >0.999 / >0.999
* using the additive model, for a minor allele frequency of 0.05 (power is greater for higher minor allele frequencies)
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Hivert et al.
Supplementary Table 6: Linkage Disequilibrium (LD) values (D’ and r2) in the Framingham population for the 4 SNPs associated with resistin levels
SNPs / rs1477341 / rs4804765 / rs1423096 / rs10401670rs1477341 / na / 0.603 / 0.104 / 0.707
rs4804765 / 1.00 / na / 0.030 / 0.563
rs1423096 / 0.970 / 0.776 / na / 0.088
rs10401670 / 0.884 / 0.918 / 0.837 / na
D’ values are shown in red
r2 values are shown in bold blue
na: non applicable
1