(ABS) / Extinction Coefficient
(Red) / Instability index protein
1 / GPR22 / 433 / 7068 / 9.43 / 49265.4 / 39140 / 38390 / 42.65
2 / GPR21 / 349 / 5551 / 7.87 / 39515.1 / 63340 / 62340 / 37.29
3 / BB3 / 399 / 6311 / 8.99 / 44410.8 / 49110 / 48360 / 42.98
4 / GPR33 / 333 / 5449 / 9.57 / 38231.9 / 59150 / 58900 / 31.75
5 / GPR34 / 381 / 6256 / 9.89 / 43846.01 / 53455 / 52830 / 45.78
6 / GPR62 / 368 / 5435 / 10.99 / 37618.61 / 38430 / 37930 / 62.99
7 / GPR63 / 419 / 6802 / 9.6 / 47577.73 / 64330 / 63830 / 42.18
8 / GPR68 / 365 / 5772 / 7.87 / 41076.64 / 55320 / 54320 / 40.46
9 / GPR42 / 346 / 5465 / 7.55 / 38695.1 / 69620 / 68870 / 39.02
10 / GPR79 / 0 / 0 / 0 / 0 / 0 / 0 / 0
11 / GPR82 / 336 / 5470 / 9.21 / 38409.47 / 50935 / 50310 / 37.99
12 / GPR87 / 358 / 5898 / 9.55 / 41435.7 / 49445 / 48820 / 55.61
13 / GPR153 / 609 / 9165 / 7.9 / 65360.91 / 97245 / 96370 / 63.24
14 / GPR160 / 338 / 5694 / 8.84 / 39786.6 / 69175 / 68300 / 41.64
15 / GPR174 / 333 / 5447 / 8.73 / 38502.63 / 58175 / 57300 / 52.13
16 / GPR183 / 361 / 5861 / 9.31 / 41224.03 / 38235 / 37360 / 37.52
17 / MAS1 / 378 / 6048 / 8.71 / 42410.6 / 60150 / 58900 / 34.16
18 / MAS1L / 378 / 6048 / 8.71 / 42410.6 / 60150 / 58900 / 34.16
19 / MRGPRG / 289 / 4520 / 9.59 / 31517.6 / 62170 / 61420 / 43.99
20 / MRGPRX4 / 322 / 5233 / 9 / 36460.5 / 54150 / 53400 / 37.6
21 / OPN3 / 402 / 6405 / 9.3 / 44873 / 86455 / 85830 / 32.95
22 / OPN4 / 478 / 7422 / 9.35 / 52635.27 / 105935 / 105310 / 60.07
23 / MRGPRX3 / 322 / 5225 / 8.83 / 36479.4 / 60680 / 59930 / 47.14
24 / P2RY10 / 339 / 5489 / 9.26 / 38774.1 / 60820 / 59820 / 47.12
25 / TAAR9 / 348 / 5483 / 6.22 / 39016.4 / 62185 / 61310 / 32.29
26 / TAAR8 / 342 / 5395 / 6.41 / 38028.8 / 60695 / 59820 / 33.55
27 / TAAR6 / 345 / 5412 / 8.28 / 38451.1 / 59330 / 58330 / 41.68
28 / TAAR4 / 347 / 5491 / 8.36 / 38904.1 / 52785 / 51910 / 42.97
29 / TAAR3 / 343 / 5496 / 8.7 / 39064.9 / 60110 / 59360 / 36.33
30 / TAAR2 / 306 / 4937 / 8.85 / 34952.5 / 57590 / 56840 / 36.44
31 / GPR158 / 1212 / 158710 / 8.57 / 135213.8 / 160335 / 158710 / 47.85
32 / GPR156 / 814 / 12433 / 7.74 / 89083 / 93860 / 92360 / 63.2
33 / GPR179 / 2367 / 35794 / 5.53 / 257344.4 / 301450 / 297700 / 56.27
34 / GPRC5A / 357 / 5717 / 8.39 / 40251.1 / 63745 / 63370 / 38.69
35 / GPRC5B / 403 / 6393 / 8.56 / 44794.9 / 71430 / 70930 / 43.2
36 / GPRC5C / 486 / 7461 / 9.14 / 52934.4 / 91955 / 91330 / 45.72
37 / GPRC5D / 345 / 5508 / 4.87 / 38790.9 / 58410 / 57410 / 36.61
38 / CD97 / 835 / 12771 / 6.5 / 91899.3 / 124810 / 121810 / 40.62
39 / CELSR2 / 2923 / 44065 / 5.14 / 317452.5 / 274565 / 269190 / 46.39
40 / CELSR1 / 3014 / 45848 / 5.59 / 329486.2 / 273200 / 267700 / 45.16
41 / CELSR3 / 3312 / 49824 / 6.23 / 358185.4 / 296675 / 291300 / 46.47
42 / ELTD1 / 690 / 10880 / 7.81 / 77810.7 / 90700 / 88700 / 42.37
43 / EMR1 / 886 / 13528 / 6.53 / 97680.2 / 110550 / 106800 / 47.4
44 / EMR2 / 823 / 12603 / 6.47 / 90505.8 / 113685 / 110810 / 39.92
45 / EMR3 / 652 / 10198 / 8.33 / 72593 / 92050 / 90300 / 33
46 / EMR4P / 457 / 7206 / 8.7 / 50902.8 / 70830 / 69330 / 35.59
47 / GPR56 / 693 / 10982 / 8.79 / 77738 / 100685 / 99810 / 46.39
48 / GPR64 / 1003 / 15506 / 7.17 / 110072.7 / 85185 / 83310 / 45.61
49 / VLGR1 / 6306 / 97469 / 4.53 / 693069.4 / 564455 / 562330 / 40.33
50 / GPR110 / 910 / 14378 / 8.91 / 101364.6 / 135800 / 134300 / 36.82
51 / GPR111 / 708 / 11150 / 8.45 / 78568.5 / 101755 / 100380 / 45.87
52 / GPR112 / 3080 / 46929 / 5.83 / 333424.7 / 239565 / 237440 / 40.17
53 / GPR113 / 1079 / 16417 / 7.44 / 116341 / 156280 / 153780 / 53.64
54 / GPR114 / 569 / 8919 / 8.6 / 63254.4 / 99320 / 98320 / 46.65
55 / GPR115 / 752 / 11891 / 9.2 / 83830 / 91090 / 89840 / 45.1
56 / GPR116 / 1346 / 20947 / 6.23 / 149479.5 / 197330 / 194580 / 43.99
57 / GPR124 / 1331 / 19922 / 8.75 / 141961.6 / 172210 / 169710 / 52.77
58 / GPR125 / 1321 / 20479 / 8.8 / 146150 / 166810 / 164560 / 44.76
59 / GPR126 / 1165 / 18123 / 6.26 / 129721.3 / 175065 / 172690 / 36.38
60 / GPR128 / 797 / 12577 / 8.77 / 88908.5 / 111030 / 109780 / 35.02
61 / GPR133 / 906 / 14032 / 8.28 / 99983.6 / 159263 / 158140 / 33.96
62 / GPR144 / 963 / 14694 / 8.33 / 104087.3 / 181150 / 179900 / 52.39
63 / LPHN1 / 1474 / 22718 / 6.17 / 162716.8 / 212985 / 210860 / 48.67
64 / LPHN2 / 1459 / 22792 / 6.02 / 163348.9 / 207735 / 205360 / 36.96
65 / LPHN3 / 1469 / 22931 / 6.06 / 164580.4 / 207485 / 205360 / 42.19
Table S2- 65sequences of orphan GPCRs were used as testing data set