Table S1 Reactions and Parameter Values

Table S1 Reactions and parameter values

Reaction / Reaction rate / Parameter a / Initial value / Adjusted value / Ref.
1 / VIII -> VIIIa (IIa) / v1=Vmax1∙IIa∙[VIII]Km1+[IIa] / Vmax1
Km1 / 70
10 / --
-- / 1, 2
2 / IX -> IXa (XIa) / v2=Vmax2∙XIa∙[IX]Km2+[XIa] / Vmax2
Km2 / 7
10 / --
-- / 3, 4
3 / XI -> XIa (XIIa) / v3=Vmax3∙XIIa∙[XI]Km3+[XIIa] / Vmax3
Km3 / 70
1 / --
-- / 5
4 / XI -> XIa (IIa) / v4=Vmax4∙IIa∙[XI]Km4+[IIa] / Vmax4
Km4 / 10
10 / --
-- / 6
5 / VII -> VIIa (IIa) / v5=Vmax5∙IIa∙[VII]Km5+[IIa] / Vmax5
Km5 / 1
10 / --
-- / 5
6 / X -> Xa (IXa) / v6=Vmax6∙IXa∙[X]Km6+[IXa] / Vmax6
Km6 / 3
178 / --
-- / 2, 5, 7
7 / X -> Xa (IXa:VIIIa) / v7=Vmax7∙IXa:VIIIa∙[X]Km7+[IXa:VIIIa] / Vmax7
Km7 / 74
10 / --
-- / 2, 5, 7
8 / X -> Xa (VIIa) / v8=Vmax8∙VIIa∙[X]Km8+[VIIa] / Vmax8
Km8 / 1×10-3
10 / --
-- / 5
9 / V -> Va (IIa) / v9=Vmax9∙IIa∙[V]Km9+[IIa] / Vmax9
Km9 / 70
10 / --
-- / 5
10 / II -> IIa (Xa:Va) / v10=Vmax10∙Xa:Va∙[II]Km10+[Xa:Va] / Vmax10
Km10 / 70
10 / --
-- / 8
11 / II -> IIa (Xa) / v11=Vmax11∙Xa∙[II]Km11+[Xa] / Vmax11
Km11 / 7
10 / --
-- / 8, 9
12 / Fg -> F (IIa) / v12=Vmax12∙IIa∙[Fg]Km12+[IIa] / Vmax12
Km12 / 7
10 / 3000
-- / assumed
5
13 / Fg -> DP (P) / v13=Vmax13∙[P]∙[Fg]Km13+[P] / Vmax13
Km13 / 7
100 / --
-- / 5
14 / F -> XF (XIIIa) / v14=Vmax14∙[XIIIa]∙[F]Km14+[XIIIa] / Vmax14
Km14 / 7
10 / --
-- / 5
15 / F -> DP (P) / v15=Vmax15∙[P]∙[F]Km15+[P] / Vmax15
Km15 / 7
10 / --
-- / 5
16 / XF -> DP (P) / v16=Vmax16∙[P]∙[XF]Km16+[P] / Vmax16
Km16 / 7
1 / --
-- / 5
17 / XIII -> XIIIa (IIa) / v17=Vmax17∙[IIa]∙[XIII]Km17+[IIa] / Vmax17
Km17 / 7
1 / --
-- / 5
18 / Pg -> P (IIa) / v18=Vmax18∙[IIa]∙[Pg]Km18+[IIa] / Vmax18
Km18 / 7
1 / --
-- / 5
19 / Pg -> P (F) / v19=Vmax19∙[F]∙[Pg]Km19+[F] / Vmax19
Km19 / 70
1 / --
-- / 5
20 / VIIIa + IXa -> IXa:VIIIa / v20=VIIIa∙[IXa]c20 / c20 / 1×10-2 / -- / 10
21 / Xa + Va -> Xa:Va / v21=Xa∙[Va]c21 / c21 / 0.5 / -- / 10
22 / VIIa + TF -> VIIa:TF / v22=VIIa∙[TF]c22 / c22 / 0.5 / -- / 10
23 / VII + TF -> VII:TF / v23=VII∙[TF]c23 / c23 / 0.1 / -- / 10
24 / Xa:TFPI + VIIa:TF -> VIIa:TF:Xa:TFPI / v24=Xa:TFPI∙[VIIa:TF]c24 / c24 / 0.5 / -- / 10
25 / Xa + TFPI -> Xa:TFPI / v25=Xa∙[TFPI]c25 / c25 / 0.5 / -- / 10
26 / VII:TF -> VIIa:TF (Xa) / v26=Vmax26∙[Xa]∙[VII:TF]Km26+[Xa] / Vmax26
Km26 / 70
1 / --
-- / 10
27 / X -> Xa (VIIa:TF) / v27=Vmax27∙[VIIa:TF]∙[X]Km27+[VIIa:TF] / Vmax27
Km27 / 9×102
2×102 / --
-- / 10
28 / IX -> IXa (VIIa:TF) / v28=Vmax28∙[VIIa:TF]∙[IX]Km28+[VIIa:TF] / Vmax28
Km28 / 70
1 / --
-- / 10
29 / VII:TF -> VIIa:TF (TF) / v29=Vmax29∙[TF]∙[VII:TF]Km29+[TF] / Vmax29
Km29 / 1×103
1 / --
-- / 10
30 / VII -> VIIa (Xa) / v30=Vmax30∙[Xa]∙[VII]Km30+[Xa] / Vmax30
Km30 / 1
10 / --
-- / 10
31 / VII -> VIIa (VIIa:TF) / v31=Vmax31∙[VIIa:TF]∙[VII]Km31+[VIIa:TF] / Vmax31
Km31 / 1
10 / --
-- / 10
32 / VII -> VIIa (IXa) / v32=Vmax32∙[IXa]∙[VII]Km32+[IXa] / Vmax32
Km32 / 0.2
10 / --
-- / 10
33 / XII -> XIIa (CA) / v33=Vmax33∙[CA]∙[XII]Km33+[CA] / Vmax33
Km33 / 7
1 / --
-- / 10
34 / XII -> XIIa (K) / v34=Vmax34∙[K]∙[XII]Km34+[K] / Vmax34
Km34 / 70
1 / --
-- / 10
35 / PK -> K (XIIa) / v35=Vmax35∙[XIIa]∙[PK]Km35+[XIIa] / Vmax35
Km35 / 7
1 / --
-- / 10
36 / ATIII + Xa -> Xa:ATIII / v36=ATIII∙[Xa]c36 / c36 / 5.4×10-3 / -- / 11
37 / IXa + ATIII -> IXa:ATIII / v37=IXa∙[ATIII]c37 / c37 / 1.76×10-3 / -- / 11
38 / ATIII + IIa -> IIa:ATIII / v38=ATIII∙[IIa]c38 / c38 / 2.56×10-2 / -- / 11
39 / VIIa:TF + ATIII -> VIIa:TF:ATIII / v39=VIIa:TF∙[ATIII]c39 / c39 / 8.28×10-4 / -- / 11
40 / XIIa + ATIII -> XIIa:ATIII / v40=XIIa∙[ATIII]c40 / c40 / 7.78×10-5 / -- / 12
41 / XIa + ATIII -> XIa:ATIII / v41=XIa∙[ATIII]c41 / c41 / 1.15×10-3 / -- / 13
42 / XII -> null / v42=k42∙[XII] / k42 / 1.2×10-2 / -- / 14
43 / XIIa -> null / v43=k43∙[XIIa] / k43 / 20 / -- / 5, 15
44 / XI -> null / v44=k44∙[XI] / k44 / 9.9×10-3 / -- / 5
45 / XIa -> null / v45=k45∙[XIa] / k45 / 20 / -- / 5
46 / VIII -> null / v46=k46∙[VIII] / k46 / 5.8×10-2 / -- / 16
47 / VIIIa -> null / v47=k47∙[VIIIa] / k47 / 20 / -- / 7
48 / IX -> null / v48=k48∙[IX] / k48 / 2.9×10-2 / -- / 18
49 / IXa -> null / v49=k49∙[IXa] / k49 / 20 / -- / 5
50 / IXa:VIIIa -> null / v50=k50∙[IXa:VIIIa] / k50 / 20 / -- / 5
51 / VIIa + Xa -> VIIa:Xa / v51=VIIa∙[Xa]c51 / c51 / 0.5 / -- / 10
52 / VII -> null / v52=k52∙[VII] / k52 / 0.12 / -- / 18
53 / VIIa -> null / v53=k53∙[VIIa] / k53 / 20 / -- / 5
54 / TF -> null / v54=k54∙[TF] / k54 / 5×10-2 / -- / 10
55 / VII:TF -> null / v55=k55∙[VII:TF] / k55 / 0.7 / -- / 10
56 / VIIa:TF -> null / v56=k56∙[VIIa:TF] / k56 / 20 / -- / 10
57 / Xa:TFPI -> null / v57=k57∙[Xa:TFPI] / k57 / 20 / -- / 10
58 / VIIa:TF:Xa:TFPI -> null / v58=k58∙[VIIa:TF:Xa:TFPI] / k58 / 20 / -- / 10
59 / X -> null / v59=k59∙[X] / k59 / 1.8×10-2 / -- / 18,17
60 / Xa -> null / v60=k60∙[Xa] / k60 / 20 / -- / 7
61 / V -> null / v61=k61∙[V] / k61 / 4.3×10-2 / -- / 18,17
62 / Va -> null / v62=k62∙[Va] / k62 / 20 / -- / 5
63 / Xa:Va -> null / v63=k63∙[Xa:Va] / k63 / 20 / -- / 5
64 / TFPI -> null / v64=k64∙[TFPI] / k64 / 20 / -- / 10
65 / II -> null / v65=k65∙[II] / k65 / 1×10-2 / -- / 18,16
66 / IIa -> null / v66=k66∙[IIa] / k66 / 67.4 / -- / 17
67 / XIII -> null / v67=k67∙[XIII] / k67 / 3.6×10-3 / -- / 16
68 / XIIIa -> null / v68=k68∙[XIIIa] / k68 / 0.69 / -- / 17
69 / Pg -> null / v69=k69∙[Pg] / k69 / 5×10-2 / -- / 5
70 / P -> null / v70=k70∙[P] / k70 / 20 / -- / 5
71 / PK -> null / v71=k71∙[PK] / k71 / 5×10-2 / -- / 10
72 / K -> null / v72=k72∙[K] / k72 / 20 / -- / 10
73 / Fg -> null / v73=k73∙[Fg] / k73 / 6.4×10-3 / -- / 5
74 / F -> null / v74=k74∙[F] / k74 / 5×10-2 / -- / 5
75 / XF -> null / v75=k75∙[XF] / k75 / 5×10-2 / -- / 5
76 / DP -> null / v76=k76∙[DP] / k76 / 3.5 / -- / 5
77 / ATIII -> null / v77=k77∙[ATIII] / k77 / 1×10-2 / -- / 18
78 / Xa:ATIII -> null / v78=k78∙[Xa:ATIII] / k78 / 8.3 / -- / 19
79 / IXa:ATIII -> null / v79=k79∙[IXa:ATIII] / k79 / 1.4 / -- / 20
80 / XIa:ATIII -> null / v80=k80∙[XIa:ATIII] / k80 / 1 / -- / assumed
81 / XIIa:ATIII -> null / v81=k81∙[XIIa:ATIII] / k81 / 1 / -- / assumed
82 / IIa:ATIII -> null / v82=k82∙[IIa:ATIII] / k82 / 0.2 / -- / 5

a Units for Vmax values=1/h, for Km values=nM, for c values=nM*h, and for k=1/h.

Species -> null, the degradation reaction of species.

See the legend of Figure 2 for the abbreviations.

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