Table S1 -Overview of large retrospective series of pancreatoduodenectomy and randomized trials comparing pancreatogastrostomy and pancreatojejunostomy.

Abbreviations: POPF postoperative pancreatic fistula. MC multicenter, UMC university medical center, na not assessed, mortality given as the reported relative perioperative mortality (varying definitions).

Author / Year / Center / Period / total n / POPF
% / Mortality %
Retrospective Series
Fong1 / 2014 / Boston MGH / 2002-2012 / 1173 / 14% / 1.8%
Kimura2 / 2014 / Japan MC / 2011 / 8575 / 13% / 2.8%
Correa-Gallego 3 / 2013 / Memorial Sloan Kettering / 2006-2011 / 739 / 17% / na
Leichtle4 / 2013 / ACS-NSQIP / 2005-2010 / 6989 / na / 2.4%
Wellner5 / 2013 / Freiburg UMC / 1994-2012 / 729 / na / 2.6%
Castillo6 / 2012 / Boston MGH / 1940-2011 / 2050 / 13% / 2.4%
Gebauer7 / 2012 / Hamburg UMC / 1992-2009 / 1966 / 11% / na
Kawai8 / 2011 / Japan MC / 2005-2009 / 1239 / 14% / 1.0%
Wu9 / 2014 / Johns Hopkins Baltimore / 1995-2011 / 1144 / 4% / 0.7%
Venkat10 / 2011 / Johns Hopkins Baltimore / 1998-2009 / 1976 / na / 3.7%
Winter11 / 2008 / Johns Hopkins Baltimore / 1981-2007 / 3029 / 11% / 1.6%
Cameron12 / 2006 / Johns Hopkins Baltimore / 1969-2003 / 1000 / 12% / 1.0%
Hashimoto13 / 2010 / Seattle MC / 1988-2008 / 507 / 10% / 1.0%
Schmidt14 / 2010 / Indiana USM / 1980-2007 / 1003 / 14% / 3.2%
Vin15 / 2008 / MSKCC New York / 2000-2005 / 680 / 18% / na
Welsch16 / 2011 / Heidelberg UMC / 2001-2008 / 796 / na / na
Welsch17 / 2010 / Heidelberg UMC / 2001-2008 / 764 / na / 2.5%
Randomized Controlled Trials
RECOPANC / 2014 / Germany MC / 2011-2013 / 320 / 21% / 5.6%
El Nakeeb18 / 2014 / Cairo / 2011-2013 / 90 / 12% / 7.8%
Figueras19 / 2013 / Girona/Valencia UMC / 2008-2012 / 123 / 24% / 4.9%
Topal20 / 2013 / Belgium MC / 2009-2012 / 329 / 14% / 3.6%
Wellner21 / 2012 / Freiburg UMC / 2006-2011 / 116 / 11% / 1.7%
Fernández-Cruz22 / 2008 / Barcelona UMC / 2005-2007 / 108 / 11% / 0.0%
Bassi23 / 2005 / Verona UMC / 2002-2004 / 151 / 15% / 0.7%
Duffas24 / 2005 / France MC / 1995-1999 / 149 / 18% / 11.4%
Yeo25 / 1995 / Johns Hopkins Baltimore / 1993-1995 / 145 / 12% / 0.0%

References for Table S1

1. Fong ZV, Ferrone CR, Thayer SP, et al. Understanding hospital readmissions after pancreaticoduodenectomy: can we prevent them?: a 10-year contemporary experience with 1,173 patients at the Massachusetts General Hospital. J Gastrointest Surg Off J Soc Surg Aliment Tract 2014;18(1):137–144; discussion 144–145.

2. Kimura W, Miyata H, Gotoh M, et al. A pancreaticoduodenectomy risk model derived from 8575 cases from a national single-race population (Japanese) using a web-based data entry system: the 30-day and in-hospital mortality rates for pancreaticoduodenectomy. Ann Surg 2014;259(4):773–80.

3. Correa-Gallego C, Brennan MF, Dʼangelica M, et al. Operative drainage following pancreatic resection: analysis of 1122 patients resected over 5 years at a single institution. Ann Surg 2013;258(6):1051–8.

4. Leichtle SW, Kaoutzanis C, Mouawad NJ, et al. Classic Whipple versus pylorus-preserving pancreaticoduodenectomy in the ACS NSQIP. J Surg Res 2013;183(1):170–6.

5. Wellner UF, Kulemann B, Lapshyn H, et al. Postpancreatectomy hemorrhage-incidence, treatment, and risk factors in over 1,000 pancreatic resections. J Gastrointest Surg 2014;18(3):464–75.

6. Castillo CF, Morales-Oyarvide V, McGrath D, et al. Evolution of the Whipple procedure at the Massachusetts General Hospital. Surgery 2012;152(3 0 1):S56–S63.

7. Gebauer F, Kloth K, Tachezy M, et al. Options and limitations in applying the fistula classification by the International Study Group for Pancreatic Fistula. Ann Surg 2012;256(1):130–8.

8. Kawai M, Kondo S, Yamaue H, et al. Predictive risk factors for clinically relevant pancreatic fistula analyzed in 1,239 patients with pancreaticoduodenectomy: multicenter data collection as a project study of pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepato-Biliary-Pancreat Sci 2011;18(4):601–8.

9. Wu W, He J, Cameron JL, et al. The Impact of Postoperative Complications on the Administration of Adjuvant Therapy Following Pancreaticoduodenectomy for Adenocarcinoma. Ann Surg Oncol 2014;

10. Venkat R, Puhan MA, Schulick RD, et al. Predicting the risk of perioperative mortality in patients undergoing pancreaticoduodenectomy: a novel scoring system. Arch Surg Chic Ill 1960 2011;146(11):1277–84.

11. Winter JM, Cameron JL, Yeo CJ, Lillemoe KD, Campbell KA, Schulick RD. Duodenojejunostomy leaks after pancreaticoduodenectomy. J Gastrointest Surg Off J Soc Surg Aliment Tract 2008;12(2):263–9.

12. Cameron JL, Riall TS, Coleman J, Belcher KA. One Thousand Consecutive Pancreaticoduodenectomies. Ann Surg 2006;244(1):10–5.

13. Hashimoto Y, Traverso LW. Incidence of pancreatic anastomotic failure and delayed gastric emptying after pancreatoduodenectomy in 507 consecutive patients: use of a web-based calculator to improve homogeneity of definition. Surgery 2010;147(4):503–15.

14. Schmidt CM, Turrini O, Parikh P, et al. Effect of hospital volume, surgeon experience, and surgeon volume on patient outcomes after pancreaticoduodenectomy: a single-institution experience. Arch Surg Chic Ill 1960 2010;145(7):634–40.

15. Vin Y, Sima CS, Getrajdman GI, et al. Management and outcomes of postpancreatectomy fistula, leak, and abscess: results of 908 patients resected at a single institution between 2000 and 2005. J Am Coll Surg 2008;207(4):490–8.

16. Welsch T, Eisele H, Zschäbitz S, Hinz U, Büchler MW, Wente MN. Critical appraisal of the International Study Group of Pancreatic Surgery (ISGPS) consensus definition of postoperative hemorrhage after pancreatoduodenectomy. Langenbecks Arch Surg Dtsch Ges Für Chir 2011;396(6):783–91.

17. Welsch T, Borm M, Degrate L, Hinz U, Buchler MW, Wente MN. Evaluation of the International Study Group of Pancreatic Surgery definition of delayed gastric emptying after pancreatoduodenectomy in a high-volume centre. Br J Surg 2010;97(7):1043–50.

18. El Nakeeb A, Hamdy E, Sultan AM, et al. Isolated Roux loop pancreaticojejunostomy versus pancreaticogastrostomy after pancreaticoduodenectomy: a prospective randomized study. HPB 2014;16(8):713–22.

19. Figueras J, Sabater L, Planellas P, et al. Randomized clinical trial of pancreaticogastrostomy versus pancreaticojejunostomy on the rate and severity of pancreatic fistula after pancreaticoduodenectomy. Br J Surg 2013;100(12):1597–605.

20. Topal B, Fieuws S, Aerts R, et al. Pancreaticojejunostomy versus pancreaticogastrostomy reconstruction after pancreaticoduodenectomy for pancreatic or periampullary tumours: a multicentre randomised trial. Lancet Oncol 2013;14(7):655–62.

21. Wellner UF, Sick O, Olschewski M, Adam U, Hopt UT, Keck T. Randomized controlled single-center trial comparing pancreatogastrostomy versus pancreaticojejunostomy after partial pancreatoduodenectomy. J Gastrointest Surg Off J Soc Surg Aliment Tract 2012;16(9):1686–95.

22. Fernández-Cruz L, Cosa R, Blanco L, López-Boado MA, Astudillo E. Pancreatogastrostomy with gastric partition after pylorus-preserving pancreatoduodenectomy versus conventional pancreatojejunostomy: a prospective randomized study. Ann Surg 2008;248(6):930–8.

23. Bassi C, Falconi M, Molinari E, et al. Reconstruction by pancreaticojejunostomy versus pancreaticogastrostomy following pancreatectomy: results of a comparative study. Ann Surg 2005;242(6):767–71, discussion 771–3.

24. Duffas J-P, Suc B, Msika S, et al. A controlled randomized multicenter trial of pancreatogastrostomy or pancreatojejunostomy after pancreatoduodenectomy. Am J Surg 2005;189(6):720–9.

25. Yeo CJ, Cameron JL, Maher MM, et al. A prospective randomized trial of pancreaticogastrostomy versus pancreaticojejunostomy after pancreaticoduodenectomy. Ann Surg 1995;222(4):580–92.