Table S1. Lung pathology scores.

A. / Airway Disease / Vasculature / Alveoli/Parenchyma / Diffuse Alveolar Damage
Day 1 / Denudation / Debris / Inflammation / Necrosis / Perivascular Cuffing / Edema / Interstitial Septum (Infla) / Airspace Inflammation / Hyaline Membrane / Exudates / Hemorrhage
102 / 0 / 0.2 / 0 / 0 / 0.1 / 0 / 0.1 / 0 / 0 / 0 / 0
103 / 0 / 0.5 / 0.2 / 0 / 0.1 / 0 / 0 / 0 / 0 / 0 / 0
104 / 0.1 / 0.1 / 0.2 / 0 / 0.1 / 0 / 0.1 / 0.1 / 0 / 0 / 0
105 / 0.1 / 0.2 / 0.1 / 0 / 0.2 / 0 / 0 / 0 / 0 / 0 / 0
Day 2
102 / 0.2 / 0.5 / 0.1 / 0 / 0.4 / 0 / 0.1 / 0 / 0 / 0 / 0
103 / 0.6 / 0.7 / 0.4 / 0 / 1 / 0.4 / 0.3 / 0.2 / 0 / 0 / 0
104 / 0.7 / 1 / 0.5 / 0 / 0.8 / 0.6 / 0.4 / 0.2 / 0 / 0 / 0
105 / 1.1 / 1.3 / 0.2 / 0 / 0.8 / 0.8 / 0.1 / 0 / 0 / 0 / 0
Day 4
102 / 0.5 / 0.7 / 0.7 / 0 / 1.2 / 0.5 / 0.7 / 0.8 / 0 / 0.1 / 0
103 / 0.4 / 0.6 / 0.4 / 0 / 1 / 0.4 / 0.2 / 0.1 / 0 / 0.1 / 1.6
104 / 0.3 / 0.5 / 0.5 / 0 / 1.1 / 0.5 / 0.6 / 0.6 / 0 / 0.1 / 2
105 / 0.8 / 0.9 / 0.15 / 0 / 0.7 / 0.1 / 0.5 / 0.6 / 0 / 0 / 2.4
Day 7
102 / 0.2 / 0.3 / 0.65 / 0 / 1 / 0.3 / 0.6 / 0.6 / 0 / 0.5 / 0.9
103 / 0.4 / 0.6 / 1 / 0 / 1.4 / 0.4 / 1.1 / 1.1 / 0 / 0.7 / 0.8
104 / 0.4 / 0.5 / 1.1 / 0 / 1.6 / 0.5 / 1.2 / 1.4 / 0.1 / 1 / 1.6
105 / 0.5 / 0.5 / 0.8 / 0 / 1.3 / 0.5 / 1.2 / 1.5 / 0.9 / 0.8 / 4

B.

Day 4 / Denudation / Debris / Inflammation / Necrosis / Perivascular Cuffing / Edema / Interstitial Septum (Infla) / Airspace Inflammation / Hyaline Membrane / Exudates / Hemorrhage
B6 104 / 0.2 / 0.6 / 0.6 / 0 / 0.9 / 0.4 / 0.8 / 0.8 / 0 / 0.4 / 1.2
Serpine1 104 / 0.2 / 0.4 / 0.6 / 0 / 0.9 / 0.6 / 0.4 / 0.4 / 0 / 0 / 2
Day 7
B6 104 / 0.3 / 0.5 / 0.9 / 0 / 1.7 / 0.8 / 1.4 / 1.5 / 0.3 / 1.3 / 1.7
Serpine1 104 / 0.2 / 0.6 / 1 / 0 / 1.7 / 0.9 / 1.6 / 1.7 / 0.3 / 1 / 3.2

Lung pathology was scored in a blinded fashion for 3-5 mice per condition on a scale of 0, 1, 2 or 3 (none, mild, moderate, severe and observed broadly through the lung) for the dose response study (A) and Serpine1 -/- study (B). Hemorrhage scoring ranged from 0 to 4. Mean values are reported.

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