Table S1: List of Genes Significantly Modified by CPA During a 12H Follow-Up Period Assuming

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Table 1 List of genes significantly modified by CPA during a 12-h follow-up period, assuming a false discovery rate of 6%

GAN / Gene name/Functional group / CPA 2 h / CPA 6 h / CPA 12 h / CPA 6h + 3 h recovery
1.0 Metabolism
1.1 Metabolism/Carbohydrates
NM_012495 / Aldolase A / 0.9±0.02 / 0.91±0.01** / 0.99±0.04 / 0.92±0.05
M13979 / Glucose transporter type 1 (GLUT1) / 0.96±0.04 / 0.92±0.03 / 0.84±0.03* / 0.95±0.03
L28126 / Glucose transporter type 2 (GLUT2) a / 1.03±0.03 / 0.95±0.08 / 0.86±0.02* / 0.95±0.06
NM_032080 / Glycogen synthase kinase 3 beta (GSK3) / 1.03±0.03 / 1.13±0.02* / 1.13±0.002*** / 1.15±0.003***
Y08355 / Alpha-d-galactosidase / 1.07±0.02 / 1.37±0.03** / 1.6±0.15* / 1.3±0.09
NM_017033 / Phosphoglucomutase / 1.46±0.03** / 1.7±0.09** / 1.64±0.1* / 0.97±0.06
NM_053826 / Pyruvate dehydrogenase kinase 1 (Pdk1) / 0.94±0.05 / 0.82±0.06 / 0.71±0.04* / 0.81±0.04*
1.2 Arginine metabolism and NO formation
J02720 / Arginase / 0.98±0.07 / 0.6±0.03* / 0.4±0.02** / 0.57±0.02**
E03424 / GTP cyclohydrolase I / 1.01±0.03 / 0.86±0.12 / 0.87±0.01** / 0.98±0.08
NM_017216 / l-Type neutral amino acid transporter / 1.04±0.02 / 1±0.03 / 0.97±0.004* / 0.98±0.01
J04792 / Ornithine decarboxylasea / ND / 1.28±0.05* / 1.57±0.08* / 1.47±0.03**
1.3 Metabolism/Aminoacids (other than arginine)
NM_012569 / Glutaminase / 1.02±0.03 / 1±0.04 / 0.76±0.04* / 0.94±0.02
NM_012545 / l-Amino acid decarboxylase / 0.92±0.004** / 0.89±0.02* / 0.8±0.01*** / 0.89±0.04
NM_031127 / Sulfite oxidasea / 0.84±0.08 / 0.64±0.02** / 0.6±0.06* / 0.8±0.07
1.4 Metabolism/Lipids
NM_057197 / 2,4-Dienoyl-CoA reductase / 0.98±0.05 / 0.78±0.01*** / 0.76±0.02** / 0.82±0.02*
NM_016986 / Acyl coenzyme A dehydrogenase / 0.98±0.05 / 1.26±0.06* / 1.48±0.04** / 1.41±0.07*
AB004329 / Acyl coenzyme A carboxylase betaa / 0.92±0.03 / 0.7±0.02** / 0.53±0.01** / 0.74±0.04*
L27075 / ATP-citrate lyase / 0.93±0.02 / 0.86±0.02* / 0.77±0.04* / 0.92±0.03
NM_019170 / Carbonyl reductase / 0.96±0.01* / 0.93±0.01* / 0.83±0.02* / 0.85±0.04
J05470 / Carnitine palmitoyltranferase II / 0.84±0.06 / 0.66±0.04* / 0.52±0.04* / 0.6±0.03*
AB062759 / Diacylglycerol acyltransferase / 1.16±0.07 / 1.38±0.01*** / 1.31±0.07* / 1.23±0.08
NM_019238 / Hepatic squalene synthasea / 1.85±0.27* / 1.36±0.03** / 1.08±0.04 / 0.65±0.07*
NM_012592 / Isovaleryl-CoA dehydrogenase / 1.1±0.05 / 1.1±0.04 / 1.25±0.02** / 1.06±0.02
NM_057186 / l-3-Hydroxyacyl-CoA dehydrogenasea / 0.93±0.04 / 0.67±0.01** / 0.47±0.02** / 0.66±0.03**
NM_031740 / Lactosylceramide synthase / 1.01±0.03 / 1.25±0.09 / 1.38±0.07* / 1.24±0.1
NM_012598 / Lipoprotein lipase / 0.92±0.03 / 0.89±0.01** / 0.95±0.05 / 0.99±0.07
NM_031841 / Stearol-CoA desaturase 2a / 1.52±0.22 / 2.37±0.31* / 1.68±0.12* / 1.41±0.13
NM_013013 / Sulfated glycoprotein 1 / 0.95±0.13 / 0.85±0.08 / 0.66±0.04* / 0.83±0.07
AB010743 / Uncoupling protein 2 (UCP 2) / 0.96±0.04 / 0.83±0.02* / 0.74±0.02** / 0.85±0.07
NM_013155 / Very-low-density lipoprotein receptora / 1.2±0.02* / 2.03±0.16* / 1.77±0.07** / 1.26±0.08
1.5 ATP production and processing
AA859827 / Uridine kinase / 1.03±0.04 / 1.18±0.04* / 1.23±0.03* / 1.18±0.06
1.6 Metabolism/miscellaneous
NM_022508 / C-1-tetrahydrofolate synthase / 0.89±0.04 / 0.83±0.02* / 0.61±0.04* / 0.68±0.06
NM_022594 / Peroxisomal enoyl hydase-like proteina / 0.95±0.04 / 1.16±0.05 / 1.28±0.03* / 1.1±0.09
2.0 Protein synthesis, modification and secretion
NM_031107 / Ribosomal protein S6 kinase polypeptide 1 / 0.87 ± 0.04 / 0.61 ± 0.02 ** / 0.59 ± 0.02 ** / 0.69 ± 0.01 **
AJ000485 / Cytoplasmic linker protein 115 (CLIP115) / 0.97±0.06 / 0.89±0.02* / 0.77±0.02* / 0.77±0.06
AA893080 / Selenocysteine lyase / 1.07±0.02 / 1.03±0.02 / 0.96±0.01* / 0.94±0.04
XM_216792 / Kinesin light chain-C / 0.97±0.02 / 1.24±0.1 / 1.33±0.02** / 1.22±0.09
M83745 / Prohormone convertase-1 / 0.99±0.03 / 0.78±0.004*** / 0.51±0.03** / 0.72±0.05*
NM_012746 / Prohormone convertase-2a / 0.94±0.03 / 0.78±0.03* / 0.51±0.01*** / 0.69±0.04*
U72995 / Rab 3 GDP/GTP exchange protein / 1±0.03 / 0.99±0.01 / 1.13±0.02* / 1.05±0.02
X06889 / Rab 3A / 0.78±0.16 / 0.34±0.02** / 0.25±0.03** / 0.36±0.04*
NM_023950 / Rab 7 (ras related protein 23) / 0.95±0.03 / 0.84±0.02* / 0.83±0.02* / 0.91±0.02
J03627 / S-100 related protein / 0.98±0.01 / 0.9±0.03 / 0.83±0.03* / 0.89±0.02*
NM_019277 / Sec 15 / 1.09±0.03 / 0.86±0.02* / 0.82±0.03* / 0.87±0.02*
NM_031693 / Synaptotagmin IVa / 1.13±0.11 / 1.91±0.08** / 2.2±0.06** / 1.64±0.08*
NM_175838 / Translation elongation factor 1 alpha 1a / 1.01±0.08 / 1.02±0.08 / 1.23±0.01** / 1.19±0.09
M24105 / Vesicle associated membrane protein 2 (VAMP2) / 1.07±0.04 / 1.24±0.004*** / 0.99±0.05 / 0.95±0.05
3.0 Ionic channels, ion transporters and related proteins
XM_217190 / Nedd4 / 0.85±0.02* / 0.77±0.04* / 0.64±0.05* / 0.71±0.03*
J05510 / Inositol-1,4,5-triphosphate receptor / 0.79±0.01** / 0.46±0.02** / 0.41±0.04* / 0.5±0.02**
NM_013119 / Brain sodium channel IIIa / 1.06±0.02 / 0.78±0.02** / 0.74±0.05* / 0.94±0.05
AA799276 / Ca++ ATPase type 2 (ATP2C1) / 1.09±0.04 / 1.42±0.02** / 1.26±0.05* / 1.3±0.05*
NM_012504 / Na/K ATPase alpha 1 polypeptide / 0.95±0.04 / 0.95±0.02 / 0.86±0.02* / 0.97±0.04
AF112256 / Ryanodine receptor type 1 / 1.38±0.15 / 1.94±0.27* / 1.63±0.06** / 1.05±0.003**
AF130881 / Ryanodine receptor type 3 / 2.04±0.44 / 2.83±0.64* / 2.24±0.08** / 1.06±0.02
NM_031353 / Voltage dependent anion channel / 0.93±0.09 / 0.77±0.04* / 0.88±0.02* / 0.89±0.04
4.0 Hormones, growth factor and related proteins
NM_012842 / Epidermal growth factor (Egf) / 1.03±0.01 / 0.88±0.03 / 0.9±0.01* / 0.93±0.08
M11596 / Calcitonin gene-related peptide 2 precursor / 1.12±0.02* / 1.49±0.06** / 1.59±0.19 / 1.34±0.16
NM_012714 / Gastric inhibitory peptidea / 0.97±0.02 / 0.85±0.07 / 0.58±0.02** / 0.63±0.05*
NM_017094 / Growth hormone receptor (Ghr)a / 0.94±0.04 / 0.9±0.05 / 0.83±0.02* / 0.99±0.08
NM_019130 / Insulin 2a / 0.62±0.12 / 0.28±0.08* / 0.24±0.03** / 0.44±0.09
D13965 / Insulin receptor-related receptor alternatively spliced product / 0.86±0.05 / 0.68±0.04* / 0.62±0.05* / 0.7±0.06
NM_012998 / Iodothyronine 5-monodeiodinasea / 1.03±0.06 / 1.3±0.07* / 1.43±0.07* / 1.25±0.07
Y07534 / Mitochondrial vitamin D(3) / 1.03±0.01 / 0.94±0.01* / 0.9±0.01** / 0.99±0.07
NM_012801 / Platelet-derived growth factor- chain / 1.2±0.06 / 1.32±0.03** / 1.32±0.08* / 0.98±0.06
NM_021655 / Prechromogranin Aa / 0.9±0.1 / 0.82±0.03* / 0.56±0.03* / 0.66±0.05*
M74152 / Prolactin receptor / 1.13±0.01** / 0.83±0.05 / 0.65±0.01*** / 0.83±0.05
NM_012882 / Somatostatin receptor subtype 5 / 0.97±0.05 / 1.09±0.003** / 1±0.01 / 1.01±0.001**
5.0 Cytokines, chemokines and related receptors
NM_030845 / CINC-1 / 2.45±0.03*** / 2.75±0.21** / 3.47±0.33** / 1±0.08
NM_012586 / Islet amyloid polypeptide (IAPP) / 0.84±0.1 / 0.62±0.02** / 0.44±0.05* / 0.7±0.08
NM_031512 / Interleukin-1 beta (IL-1)a / 1.03±0.02 / 1.04±0.04 / 1.12±0.02* / 1.09±0.03
NM_012589 / Interleukin 6 (IL-6) / 0.98±0.02 / 0.65±0.02** / 0.51±0.03** / 0.73±0.11
U69272 / Interleukin 15 (IL-15) / 0.9±0.03 / 0.8±0.07 / 0.73±0.04* / 0.92±0.06
U68272 / Interferon gamma receptor 1 / 1.56±0.17 / 2.64±0.45* / 2.9±0.1** / 2.4±0.15**
NM_053647 / Macrophage inflammatory protein 2 precursor (MIP2) / 0.99±0.02 / 1.18±0.04* / 1.43±0.09* / 1.26±0.13
NM_031116 / RANTES (chemokine (C-C motif) ligand 5)a / 0.76±0.09 / 0.32±0.04** / 0.29±0.03* / 0.45±0.02**
X66539 / TNF-alpha / 1.11±0.07 / 1.04±0.04 / 1.21±0.04* / 1.12±0.05
NM_080769 / TNF-beta / 0.99±0.04 / 1.04±0.06 / 1.18±0.02* / 1.18±0.07
6.0 Cytokines processing and signal transduction
XM_231067 / Tnf receptor-associated factor 2 / 1.07±0.02 / 0.78±0.03* / 0.72±0.04* / 0.81±0.06
NM_057103 / A kinase anchor protein 12 (Akap12) / 1.13±0.04 / 1.47±0.03** / 1.57±0.14* / 1.33±0.09
XM_213869 / 5-hydroxytryptamine receptor b / 1.1±0.01** / 1.29±0.02** / 1.28±0.04* / 1.11±0.05
XM_236690 / MyD88 / 1.01±0.04 / 1.1±0.01** / 1±0.08 / 1.07±0.09
NM_032063 / Delta1 / 1.01±0.06 / 0.83±0.08 / 0.89±0.02* / 0.92±0.08
U18942 / Double-stranded RNA-specific adenosine deaminase / 0.96±0.05 / 0.77±0.03* / 0.62±0.02** / 0.73±0.03*
NM_139193 / G-coupled protein receptor 10 (GRP10) / 0.94±0.07 / 0.97±0.04 / 0.88±0.01* / 0.95±0.06
AA892287 / GPRC5C (G-protein-coupled-receptors) / ND / 1±0.02 / 1.15±0.01** / 1.06±0.04
NM_019242 / Interferon-related developmental regulator 1 / 0.99±0.02 / 1.16±0.01** / 1.09±0.14 / 1±0.07
NM_053777 / Islet brain 1 / 0.94±0.05 / 0.76±0.02** / 0.61±0.05* / 0.76±0.04*
AF051895 / Lipocortin V, Annexin V / 0.95±0.01 / 0.83±0.03* / 0.72±0.02** / 0.81±0.04
NM_053842 / Mitogen activated protein kinase 1 (Mapk1/MEK1)a / 1.03±0.03 / 1.22±0.03* / 1.33±0.06* / 1.17±0.06
NM_133578 / MAP-kinase phosphatase (cpg21) / 1.09±0.02 / 1.2±0.02** / 1.04±0.04 / 1.14±0.2
X57405 / Notch 1 / 0.94±0.02 / 0.88±0.01** / 0.92±0.07 / 0.91±0.02
NM_012800 / P2Y purinoreceptor (P2ry1) / 1.41±0.06* / 0.95±0.07 / 0.8±0.03* / 0.93±0.02
NM_133307 / Protein kinase C delta (PKCδ)a / 0.86±0.06 / 0.64±0.02** / 0.43±0.02** / 0.67±0.04*
X99267 / Presenilin-2 / 1.03±0.04 / 1.12±0.05 / 1.14±0.03* / 1±0.05
NM_053769 / Protein tyrosine phosphatasea / 0.77±0.06 / 0.53±0.03** / 0.41±0.03** / 0.56±0.02**
NM_017214 / Regulator of G-protein signaling 4 (RGS4)a / 1.02±0.05 / 0.72±0.02** / 0.7±0.02** / 0.86±0.02*
NM_019232 / Serum/glucocorticoid-regulated kinase 1 / 0.91±0.03 / 0.84±0.02* / 0.61±0.04* / 0.69±0.07
AF075382 / Suppressor of cytokine signaling-2 (SOCS2) / 1±0.01 / 0.78±0.05 / 0.65±0.01** / 0.83±0.05
NM_013082 / Syndecan-2 / 0.89±0.04 / 0.81±0.03* / 0.7±0.03* / 0.89±0.04
NM_020306 / TNF- converting enzyme (TACE) / 1.79±0.14* / 2.13±0.19* / 2.21±0.17* / 1.06±0.16
NM_021589 / Tyrosine kinase receptor / 0.87±0.06 / 0.78±0.02** / 0.57±0.04* / 0.67±0.05*
7.0 MHC and related genes
XM_215962 / Proteasome subunit alpha type 7 (Psma7) / 0.92±0.01* / 0.88±0.01* / 0.92±0.03 / 0.95±0.06
AI170268 / -2 Microgobulin / 1.03±0.02 / 0.69±0.04* / 0.69±0.05* / 0.87±0.07
M36151 / MHC class II A-beta RT1, B-b-beta gene / 0.99±0.01 / 1.12±0.06 / 1.12±0.02* / 1±0.05
NM_022921 / MHC-I RT1 class Ib / 0.99±0.05 / 1.01±0.05 / 0.76±0.03* / 0.93±0.03
8.0 Cell adhesion, cytoskeleton and related genes
NM_012977 / 36 kD Beta galactoside binding lectin / 1.06±0.08 / 1.11±0.02* / 1.09±0.01* / 1.03±0.08
NM_020071 / Fibrinogen B beta chaina / 0.92±0.05 / 0.92±0.01* / 0.8±0.02* / 0.87±0.05
AA859740 / Heparan sulphate 6-O sulfotransferase-1 / 0.91±0.02* / 0.85±0.04 / 0.59±0.02** / 0.67±0.06*
NM_019284 / Neuroglycan C precursor / ND / 1.05±0.04 / 1.06±0.01** / 1.1±0.03
NM_017354 / Neurotrimin / 1.07±0.07 / 1.05±0.03 / 1.1±0.01** / 1.18±0.05
NM_021699 / MAP/microtubule affinity-regulating kinase 2 (Mark2) / 1.98±0.21* / 2.57±0.38* / 2.87±0.12** / 1.05±0.08
9.0 Transcription factor and related genes
S66024 / CREM transcriptional repressor / 1.09±0.05 / 0.84±0.01** / 0.86±0.03* / 1.1±0.04
NM_013086 / cAMP responsive element modulator (Crem), transcript variant 1 / 1.2±0.06 / 0.77±0.05 / 0.86±0.02* / 1.2±0.02**
NM_012669 / Hepatocyte nuclear factor 1 (HNF-1)a / 0.96±0.04 / 1.02±0.09 / 0.72±0.03* / 0.82±0.01**
X55955 / Hepatocyte nuclear factor 3 (HNF-3) / 1.02±0.03 / 0.88±0.05 / 0.8±0.01** / 0.94±0.06
NM_024359 / Hypoxia-inducible factor 1 (HIF1)a / 1.03±0.05 / 0.88±0.17 / 0.84±0.03* / 1.02±0.09
XM_219857 / IkappaB kinase alpha (IKK) / 1.02±0.04 / 0.95±0.09 / 0.78±0.03* / 0.9±0.08
XM_219769 / IkappaB kinase  subunit (Nemo) / 0.87±0.03 / 0.58±0.03* / 0.52±0.03** / 0.63±0.01**
S69329 / Isl-1 / 0.98±0.02 / 0.83±0.08 / 0.83±0.02* / 0.98±0.04
D14448 / Max / 1.31±0.05* / 1.77±0.09** / 2.31±0.22* / 1.52±0.12*
NM_012551 / Nerve growth factor-induced gene / 0.99±0.04 / 0.83±0.01** / 0.68±0.02** / 0.79±0.05
NM_031626 / Orphan nuclear receptora / 1.15±0.13 / 1.69±0.06** / 1.81±0.2* / 1.44±0.14
S67435 / PDX-1 / 0.86±0.02* / 0.67±0.03* / 0.71±0.03* / 0.98±0.01
NM_021764 / Protein kinase C-binding protein Beta15 / 1.04±0.11 / 1.33±0.08* / 1.34±0.03** / 1.1±0.04
NM_053328 / Enhancer of split and hairy related protein 2 (Sharp2) / 1.19±0.05 / 1.31±0.06* / 1.31±0.02** / 1.08±0.09
AA892553 / STAT-1 / 0.92±0.04 / 0.88±0.04 / 0.75±0.03* / 0.9±0.05
AA800613 / TIS 11 / 1.07±0.004** / 1.24±0.09 / 1.34±0.02** / 1.22±0.07
NM_031777 / USF-1 / 0.99±0.01 / 1.16±0.07 / 1.13±0.02* / 0.93±0.06
NM_022856 / Transcriptional repressor NAB 1 / 0.94±0.05 / 0.82±0.02* / 0.71±0.02** / 0.81±0.02**
NM_052801 / VHL proteina / 1.09±0.03 / 1.13±0.03* / 1.15±0.02* / 1.09±0.01*
NM_031642 / Zinc finger protein 9 / 1.55±0.03** / 1.3±0.03** / 1.11±0.05 / 0.89±0.06
AF031657 / Zinc finger protein 94 / 1.44±0.11* / 1.64±0.2 / 1.71±0.09** / 1.09±0.07
10.0 RNA synthesis and splicing factor
NM_053563 / ATP-dependent RNA helicase DDX39 / 0.79±0.04* / 0.6±0.03* / 0.5±0.06* / 0.6±0.04*
11.0 Cell cycle
XM_234132 / Similar to 14-3-3 protein sigma (Stratifin) / 1.02±0.01 / 0.99±0.02 / 0.92±0.01** / 1.05±0.03
D14014 / Cyclin D1 / 1.21±0.34 / 0.57±0.05* / 0.54±0.06* / ND
NM_030989 / p53 / 1±0.01 / 1.3±0.03* / 1.07±0.06 / 1.06±0.08
NM_033230 / Thymoma viral (v-akt) oncogene homolog 1 (Akt1) / 1.17±0.04* / 1.22±0.01** / 1.33±0.11 / 1.08±0.08
NM_017093 / Thymoma viral (v-akt) oncogene homolog 2 (Akt2) / 0.99±0.02 / 1.11±0.05 / 1.19±0.02** / 1.13±0.08
12.0 Defence repair
NM_031971 / Heat shock 70kD protein 1A (Hspa1a)a / 0.94±0.05 / 0.83±0.04 / 0.74±0.04* / 0.86±0.02*
NM_031510 / Cytosolic NADP-dependent isocite dehydrogenase 1 / 1.04±0.03 / 0.98±0.03 / 0.95±0.01* / 0.9±0.04
U77829 / Growth arrest specific 6 (Gas-6) / 1.25±0.05* / 1.89±0.09** / 2.05±0.09** / 1.61±0.1*
NM_057100 / Growth arrest specific 5 (Gas-5)a / 0.9±0.05 / 0.94±0.02 / 0.85±0.01** / 1.02±0.02
NM_012796 / Glutathione S-transferase subunit Yrs / 1.02±0.03 / 1.06±0.05 / 1.26±0.03* / 1.07±0.1
L32591 / Growth arrest DNA damage 45a (Gadd 45a) / 1.56±0.14* / 2.47±0.1** / 1.44±0.04** / 0.94±0.02
NM_012580 / Heme oxygenasea / 0.92±0.03 / 0.98±0.03 / 1.23±0.02** / 1.21±0.03*
M11794 / Metallothionein / 1.23±0.02** / 1.8±0.21* / 1.89±0.06** / 1.55±0.06**
AI176456 / Metallothionein 2 / 1.06±0.05 / 1.03±0.05 / 1.1±0.02* / 0.95±0.05
Y00497 / Manganese superoxide dysmutase (MnSOD) / 1.18±0.02* / 1.39±0.03** / 1.34±0.05* / 1.06±0.03
13.0 Apoptosis/ER stress
AF252627 / Activating transcription factor 4 (ATF4) / 2.14±0.23* / 2.48±0.18** / 2.59±0.24* / 0.92±0.03
M63282 / Activating transcription factor 3 (ATF3) / 1.57±0.14* / 2.75±0.17** / 2.1±0.34* / 0.95±0.06
M14050 / BiP / 1.5±0.04** / 2.6±0.31* / 3.07±0.27** / 2.59±0.22**
NM_017326 / Calmodulin 2 (Calm2)a / 1.03±0.02 / 0.73±0.03* / 0.65±0.05* / 0.83±0.07
NM_031984 / Calbindin d28ka / 1.1±0.02* / 0.91±0.02* / 0.8±0.03* / 0.88±0.03
L18889 / Calnexin / 1.02±0.02 / 1.08±0.03 / 1.26±0.05* / 1.06±0.003**
S69315 / Grp 94 (Endoplasmin) / 1.12±0.06 / 1.49±0.26 / 2.09±0.28* / 1.49±0.07*
X02918 / Protein disulphide isomerase (PDI) / 0.99±0.01 / 1.26±0.07 / 1.42±0.05** / 1.24±0.07
U30186 / C/EBP homologous protein (Chop/Gadd 153)a / 2.54±0.17** / 3.58±0.22** / 3±0.03*** / 1.14±0.04
NM_016993 / Bcl-2 / 0.77±0.03* / 0.47±0.03** / 0.41±0.03** / 0.52±0.02**
S76511 / Baxa / 1.02±0.04 / 1.14±0.03* / 1.2±0.04* / 1.04±0.05
AF027954 / Bcl-2-related ovarian killer protein (Bok) / 0.97±0.01 / 0.99±0.03 / 1.07±0.01* / 1.01±0.03
NM_139258 / Bcl-2 modifying factor (Bmf) / 0.99±0.06 / 0.84±0.04 / 0.7±0.01** / 0.81±0.07
XM_216640 / IPAF / 0.99±0.03 / 0.92±0.04 / 0.79±0.02** / 0.83±0.05
NM_133561 / Brain protein 44-like (Brp44l)a / 0.96±0.04 / 0.9±0.05 / 0.91±0.01* / 0.98±0.02
XM_226743 / Neuronal apoptosis inhibitory protein / 1.02±0.1 / 0.99±0.05 / 0.9±0.01* / 0.93±0.04
U40627 / Apoptosis repressor ARC / 0.9±0.05 / 0.79±0.02** / 0.68±0.03* / 0.73±0.03*
NM_023987 / Inhibitor of apoptosis protein 1 (Birc2) / 1.07±0.05 / 1.07±0.04 / 1.28±0.05* / 1.1±0.03
NM_021752 / Apoptosis inhibitor 2 (Api2)a / 0.89±0.05 / 0.65±0.02** / 0.46±0.01*** / 0.69±0.05*
NM_022522 / Caspase 2 / 0.93±0.004** / 0.84±0.01** / 0.84±0.03* / 0.91±0.06
NM_012922 / Caspase 3 / 0.96±0.08 / 0.88±0.07 / 0.73±0.04* / 0.81±0.03*
NM_022260 / Caspase 7a / 1.12±0.1 / 1.29±0.11 / 1.47±0.11* / 1.12±0.04
AF317633 / Caspase 12 / 1.14±0.02* / 1.86±0.19* / 2.28±0.2* / 1.87±0.11**
NM_053353 / CD40 ligand / 1±0.05 / 0.94±0.04 / 0.81±0.02* / 0.87±0.03
AF244366 / FLIP / 0.94±0.11 / 0.93±0.18 / 0.76±0.03* / 0.78±0.02*
NM_139096 / Lectin, galactoside-binding, soluble, 3 binding protein / 0.97±0.01 / 0.93±0.02 / 0.87±0.01** / 0.89±0.07
M96630 / Sec 61 / 1.04±0.04 / 1.32±0.05* / 1.6±0.05** / 1.43±0.07*
XM_231740 / Transformer-2 protein homologue (TRA-2 alpha) / 0.92±0.01* / 0.76±0.05 / 0.58±0.05* / 0.78±0.06
NM_031120 / TRAP-complex gamma subunit / 1.04±0.04 / 1.13±0.02* / 1.21±0.02** / 1.13±0.04
NM_145681 / Tumour necrosis factor ligand (TRAIL) / 1.09±0.01* / 0.81±0.03* / 0.77±0.04* / 0.8±0.05
14.0 Miscellaneous
NM_013097 / Deoxyribonuclease I (Dnase1) / 0.99±0.04 / 0.8±0.02** / 0.85±0.08 / 0.94±0.12
NM_130741 / Globulin alpha 2u - related protein / 0.94±0.01* / 0.84±0.02* / 0.67±0.05* / 0.72±0.03*
X52713 / Mx3 / 0.77±0.06 / 0.59±0.06* / 0.49±0.07* / 0.65±0.05*
NM_012623 / P glycoprotein 1 / 1.03±0.02 / 1.16±0.01** / 1.18±0.02* / 1.13±0.06
AA799803 / Complement component 1 / 0.93±0.07 / 0.78±0.01** / 0.82±0.07 / 0.84±0.03*

The data shown are the means of three independent experiments, expressed as fold change ± SEM vs control (DMSO).

*p<0.05, ** p<0.01, *** p<0.001, Student’s t test (one sample hypothesis, ratio different from one)

CPA-induced differences in genes expression were considered present when the q value calculated was ≤0.06 for at least one of the time points studied

a Genes represented by more than one probe

ND non-detectable, GAN GeneBank accession number