Table S1. Detected amount of oxylipins (nM) and polyunsaturated fatty acid (μM) in plasma of study participants

Compound name / Internal standard / Precision (RSD%) / Inter-batch variation (RSD%) / non-MCI controls
Mean ± SD / MCI patientsMean ± SD
TXB2 / (d4) TXB2 / < 9.54 / 6.66 / 3.48 ± 9.48 / 1.21 ± 3.23
PGF2α / (d4) PGF2α / < 14.9 / 13.56 / 5.09 ± 1.88 / 5.16 ± 1.98
PGE2 / (d4) PGF2α / < 8.34 / 10.96 / 0.42 ± 0.62 / 0.16 ± 0.36
14,15-DHET / (d4) 12,13-DiHOME / < 4.07 / 2.93 / 0.57 ± 0.15 / 0.67 ± 0.18
11,12-DHET / (d4) 12,13-DiHOME / < 5.01 / 5.11 / 0.47 ± 0.13 / 0.55 ± 0.15
8,9-DHET / (d4) 12,13-DiHOME / < 6.42 / 3.22 / 0.34 ± 0.12 / 0.38 ± 0.19
20-HETE / (d8) 12-HETE / < 8.58 / 11.13 / 1.50 ± 0.83 / 1.93 ± 0.90
5,6-DHET / (d8) 12-HETE / < 8.33 / 7.68 / 0.32 ± 0.13 / 0.37 ± 0.10
15-HETE / (d8) 12-HETE / < 6.21 / 8.37 / 3.29 ± 2.78 / 2.73 ± 2.07
11-HETE / (d8) 12-HETE / < 9.14 / 10.15 / 1.18 ± 1.08 / 0.94 ± 0.53
8-HETE / (d8) 12-HETE / < 9.74 / 7.28 / 0.82 ± 0.51 / 0.80 ± 0.42
12-HETE / (d8) 12-HETE / < 3.49 / 13.78 / 20.21 ± 29.59 / 9.48 ± 16.74
5-HETE / (d8) 12-HETE / < 5.76 / 4.47 / 2.18 ± 1.07 / 2.98 ± 1.54
14,15-EET / (d4) 12,13-EpOME / < 17.01 / 15.84 / 0.31 ± 0.18 / 0.42 ± 0.28
11,12-EET / (d4) 12,13-EpOME / < 23.56 / 30.96 / 0.21 ± 0.13 / 0.28 ± 0.24
5-OxoETE / (d4) 12,13-EpOME / < 15.04 / 14.69 / 0.37 ± 0.20 / 0.46 ± 0.26
9-HETE / (d8) 12-HETE / < 4.74 / 16.33 / 0.52 ± 0.22 / 0.55 ± 0.24
PGF1α / (d4) PGF2α / < 12.42 / 14.19 / 5.44 ± 3.60 / 6.83 ± 5.97
12,13-DiHOME / (d4) 12,13-DiHOME / < 3.68 / 3.54 / 3.68 ± 1.87 / 4.55 ± 2.63
9,10-DiHOME / (d4) 12,13-DiHOME / < 3.29 / 9.71 / 3.86 ± 2.26 / 4.72 ± 3.37
13-HODE / (d4) 9-HODE / < 11.26 / 8.54 / 24.41 ± 12.48 / 29.46 ±21.08
9-HODE / (d4) 9-HODE / < 6.27 / 10.29 / 22.67 ± 9.68 / 31.65 ± 27.08
12,13-EpOME / (d4) 12,13-EpOME / < 7.94 / 8.19 / 5.50 ± 1.86 / 6.43 ± 2.53
13-HpODE / (d4) 9-HODE / < 23.21 / 24.07 / 6.41 ± 5.18 / 8.41 ± 7.56
9,10-EpOME / (d4) 12,13-EpOME / < 8.58 / 7.81 / 15.22 ± 6.42 / 18.85 ± 9.50
15-HEPE / (d8) 12-HETE / < 8.79 / 16.87 / 0.62 ± 0.69 / 0.46 ± 0.37
5-HEPE / (d8) 12-HETE / < 12.56 / 11.2 / 0.85 ± 0.58 / 1.05 ± 0.65
Arachidonic acid / (d4) 12,13-EpOME / < 10.61 / 10.56 / 6.24 ± 2.41 / 6.49 ± 2.45
Linoleic acid / (d4) 12,13-EpOME / < 9.63 / 9.34 / 74.98 ± 18.92 / 85.31 ± 22.55
Eicosapentaenoic acid / (d4) 12,13-EpOME / < 12.15 / 15.92 / 1.03 ± 0.77 / 1.08 ± 0.85
Docosahexaenoic acid / (d4) 12,13-EpOME / < 10.61 / 13.27 / 29.92 ± 11.11 / 27.12 ± 11.53

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