Table S 1. Gene-set genes (testing and replication sample) and replicated gene-set genes

Gene-set genes significantly associated with aversive memory#
Long term depression / Neuroactive ligand receptor interaction
GRIA1 / GRIA1
GNAO1 / HRH1
PRKG1 / GRIN3A
IGF1R / TSHR
ITPR1 / GABRG2
PLCB1 / PARD3
GRID2 / THRB
GUCY1A2 / BDKRB2
GRIA2 / VIPR2
GRM1 / HTR1E
PLA2G4A / ADORA3
GUCY1A3 / GRM7
GNAS / GRID1
PLA2G5 / GABRG3
GNA12 / GRIK4
KRAS / FPR1
ITPR3 / NTSR1
NOS1 / GLP1R
PLA2G2A / GLRB
PPP2R2B / GRIN2A
PRKCA / GRID2
NOS3 / GRIK2
BRAF / PRLR
GRM5 / GRIA2
RYR1 / GRIK1
PPP2R2C / GRM1
ITPR2 / NPFFR2
GUCY1B3 / GRM8
PLA2G3 / GABRA1
PPP2R1A / TAAR2
RAF1 / TRPV1
CACNA1A / CHRM2
GNA11 / CHRM5
DRD3
GRM4

Table S 1.Cont’d

GHRHR
GRM3
GRIN2B
GHR
GRIA4
HTR2A
AVPR1A
P2RX4
HRH4
GABRP
HCRTR2
GABRB1
P2RY14
PTGFR
VIPR1
GABRB3
FSHR
GRM5
MTNR1A
GABBR2
GABRB2
SCTR
TACR1
NTSR2
GRIK3
PTH2R
GABRA5
CALCR
PTGER3
LHCGR
RXFP2
P2RY6
PRSS3
CHRM3

Table S 1.Cont’d

Gene-set genes not associated with aversive memory#
Long term depression / Neuroactive ligand receptor interaction
PLCB4 / GHSR
NPR2 / GABRR1
GNAI1 / MTNR1B
PRKG2 / GPR156
PPP2CA / HTR4
PLA2G2D / DRD2
CRHR1 / F2RL1
GUCY2C / GLP2R
PLA2G1B / P2RY2
GNAI3 / GLRA3
PPP2R1B / OPRM1
PLA2G2E / EDNRA
C7orf16 / ADORA1
LYN / LEPR
MAPK1 / GABRG1
PPP2CB / ADRA1A
PPP2R2A / GABRR2
MAP2K1 / HTR7
GNAQ / ADCYAP1R1
GNA13 / GABRA6
PLA2G6 / NMUR1
GNAZ / EDNRB
PRKCG / CRHR2
PLCB2 / DRD1
NRAS / GLRA1
PLA2G2F / CNR2
GUCY2D / P2RY1
IGF1 / F2RL2
MAP2K2 / GRIN1
NPR1 / TACR3
PLA2G12A / CRHR1
HRAS / GRIN2C
GNAI2 / P2RX1
PLCB3 / GABRA4
HTR2B
OPRL1

Table S 1.Cont’d

CCKAR
P2RX7
GABRA2
GRIK5
RXFP1
OPRD1
OXTR
GRIN2D
P2RY11
GPR35
PRL
BDKRB1
SSTR4
CNR1
CALCRL
NR3C1
PTGIR
MC2R
HTR5A
LEP
TSPO
MCHR2
SSTR2
CHRM1
TAAR1
OPRK1
HRH2
NMUR2
TSHB
ADRA1B
THRA
F2R
PRSS1
F2
AGTR1
TAAR9
HTR1B
TRHR
ADRA2A
PTAFR
HCRTR1

Table S 1.Cont’d

GPR63
PTGDR
GRM6
NMBR
ADORA2B
HTR6
P2RX3
NPY1R
MCHR1
GALR1
P2RY13
TACR2
P2RX5
CCKBR
PPYR1
GNRHR
NPY5R
CTSG
SSTR3
NPFFR1
MC3R
MAS1
GPR83
C5AR1
MC5R
NPY2R
FSHB
GZMA
CGA

Table S 1.Cont’d

Unmapped gene-set genes#
Long term depression / Neuroactive ligand receptor interaction
ARAF / ADORA2A
CRH / ADRA2B
GRIA3 / ADRA2C
GUCY2F / ADRB1
MAPK3 / ADRB2
NOS2A / ADRB3
PLA2G10 / AGTR2
PLA2G12B / AGTRL1
PRKCB1 / AVPR1B
AVPR2
BRS3
C3AR1
CHRM4
CYSLTR1
CYSLTR2
DRD4
DRD5
EDG1
EDG2
EDG3
EDG4
EDG5
EDG6
EDG7
EDG8
F2RL3
FPRL1
FPRL2
GABRA3
GABRD
GABRE
GABRQ
GALR2
GALR3
GCGR
GH1

Table S 1.Cont’d

GH2
GIPR
GLRA2
GPR23
GPR50
GRIA3
GRIN3B
GRM2
GRPR
HRH3
HTR1A
HTR1D
HTR1F
HTR2C
KISS1R
LHB
LTB4R
LTB4R2
MC1R
MC4R
MLNR
NPBWR1
NPBWR2
P2RX2
P2RXL1
P2RY10
P2RY4
P2RY5
P2RY8
PRLHR
PRSS2
PTGER1
PTGER2
PTGER4
PTHR1
SSTR1
SSTR5
TAAR5
TAAR6
TAAR8
TBXA2R

Table S 1.Cont’d

UTS2R

# Definition of terms:“Gene-set genes significantly associated with aversive memory”: genes mapped with at least one of the top 5% of all nominally significant SNPs (see also Methods)

“Gene-set genes not associated with aversive memory”: gene-set genes not mapped with at least one of the top 5% of all nominally significant SNPs

“Unmapped gene-set genes”: gene-set genes not tagged by intragenic SNPs and therefore not included in the i-GSEA analysis

Table S 1. Cont’d: Gene-set genes (replication sample)

Gene-set genes significantly associated with aversive memory#
Long term depression overlapping pathways
(Poverlap < 10-8) / Neuroactive ligand receptor interaction
overlapping pathways
(Poverlap < 10-8)
ADCY1 / ABCA1
ADCY2 / ACCN1
ADCY3 / ACCN4
ADCY4 / ACVR1B
ADCY8 / ADCY1
ADCY9 / ADCY2
ADORA2B / ADCY3
ADRA1A / ADCY4
ADRA1D / ADCY8
ATP2B2 / ADCY9
BDKRB1 / ADORA2B
BDKRB2 / ADRA1A
CACNA1A / ADRA1D
CACNA1B / AKR1C1
CACNA1C / APP
CACNA1D / AQP9
CACNA1E / ATP2B2
CACNA1G / ATP6V1B1
CACNA1I / BARD1
CACNA1S / BCL2
CALM2 / BDKRB1
CAMK2D / BDKRB2
CAMK4 / C5AR1
CHRM2 / CACNA1A
CHRM3 / CACNA1B
CHRM5 / CACNA1C
CHRNA7 / CACNA1D
EGFR / CACNA1E
ERBB2 / CACNA1G
ERBB4 / CACNA1I
GNA11 / CACNA1S
GNA14 / CACNA2D1
GNA15 / CACNB1
GNAL / CACNB2
GNAQ / CACNG2
GRIN2A / CALM2

Table S 1.Cont’d

GRM1 / CAMK2D
GRM5 / CAMK4
HRH1 / CASR
HTR2A / CCR6
HTR4 / CD55
HTR7 / CDH23
ITPR1 / CDK6
ITPR2 / CFTR
LHCGR / CHRM2
NTSR1 / CHRM3
OXTR / CHRM5
P2RX1 / CHRNA7
P2RX3 / CLCA1
PDE1C / CLCN2
PDGFRB / CLCN3
PLCB1 / CLN6
PLCD4 / CNGB1
PLCE1 / CUL5
PLCG2 / CXCL13
PLN / DFNB31
PPP3CA / DYRK3
PPP3CC / EGFR
PRKCA / EGLN1
RYR2 / ERBB2
RYR3 / ERBB4
SLC8A1 / ETS1
SLC8A3 / GCM2
TACR1 / GLRB
TACR3 / GNA11
TNNC2 / GNA14
GNA15
GNAL
GNAQ
GPR98
GRIN2A
GRM1
GRM5
HRH1
HTR2A
HTR4
HTR7

Table S 1.Cont’d

IL6
IL7
IQCB1
ITPR1
ITPR2
KCNA10
KCNA6
KCNB2
KCNC4
KCND3
KCNH1
KCNJ1
KCNJ12
KCNJ15
KCNJ3
KCNJ6
KCNK1
KCNK10
KCNK5
KCNMB2
KCNMB4
KCNN2
KCNN3
KCNQ1
KCNQ3
KCNQ5
KCNS3
KNG1
LARGE
LHCGR
LYN
NTSR1
OXTR
P2RX1
P2RX3
PCDH15
PCSK9
PDE1C
PDGFRB
PKD2
PLCB1

Table S 1.Cont’d

PLCD4
PLCE1
PLCG2
PLN
PPP3CA
PPP3CC
PPT1
PRKCA
PTPRC
RDH12
RYR2
RYR3
SCN11A
SCN5A
SCN9A
SCNN1B
SLC30A5
SLC8A1
SLC8A3
SRI
TACR1
TACR3
TMPRSS3
TNNC2
TRPC4
TRPM2
TRPV1
TRPV4
USH1C
USH2A
XCR1

Table S 1.Cont’d

Gene-set genes not associated with aversive memory#
Long term depression
overlapping pathways
(Poverlap < 10-8) / Neuroactive ligand receptor interaction
overlapping pathways
(Poverlap < 10-8)
ADCY7 / ABCG1
ADORA2A / ACIN1
ADRA1B / ACVR2A
AGTR1 / ADCY7
ATP2A1 / ADORA2A
ATP2A2 / ADRA1B
ATP2A3 / AGTR1
ATP2B1 / AIFM3
ATP2B4 / AKT1
AVPR1A / ANGPTL3
BST1 / APOA2
CACNA1H / APOA4
CALM1 / APOA5
CALM3 / AQP2
CAMK2A / AQP6
CAMK2B / AQP7
CAMK2G / AQP8
CCKAR / ATOX1
CCKBR / ATP1A1
CD38 / ATP1A2
CHRM1 / ATP1A4
DRD1 / ATP2A1
EDNRA / ATP2A2
EDNRB / ATP2A3
ERBB3 / ATP2B1
F2R / ATP2B4
GNAS / ATP2C1
GRIN1 / ATP7B
GRIN2C / AVPR1A
GRIN2D / BAK1
HRH2 / BAX
HTR2B / BCL10
HTR5A / BCL2L1
HTR6 / BEST1
ITPKA / BNIP3
ITPKB / BSND

Table S 1.Cont’d

ITPR3 / BST1
MYLK / CACNA1H
MYLK2 / CACNB4
NOS1 / CACNG1
NOS3 / CACNG4
P2RX4 / CALCA
P2RX5 / CALCB
P2RX7 / CALM1
PDE1A / CALM3
PDE1B / CAMK2A
PDGFRA / CAMK2B
PHKB / CAMK2G
PLCB2 / CAV1
PLCB3 / CCKAR
PLCB4 / CCKBR
PLCD1 / CCL1
PLCD3 / CCL13
PLCG1 / CCL14
PLCZ1 / CCL15
PPID / CCL19
PPP3CB / CCL3
PPP3R1 / CCL5
PPP3R2 / CCR2
PRKACB / CCR3
PRKCG / CCR4
PTAFR / CCR7
PTGER3 / CCR9
PTGFR / CD38
PTK2B / CEBPG
RYR1 / CETP
SLC8A2 / CHRM1
TACR2 / CHRNA1
TRHR / CHRNA2
TRPC1 / CHRNA3
VDAC1 / CHRNA4
VDAC2 / CHRNA6
VDAC3 / CHRNB3
CHRNB4
CHRND
CLCA2
CLCA4

Table S 1.Cont’d

CLCN1
CLDN16
CLN3
CLN5
CLRN1
CNGA3
CP
CXCL12
DERL1
DRD1
EDNRA
EDNRB
EGLN2
EP300
ERBB3
F2R
F2RL1
FOXO3
FXN
FXYD3
GCK
GCLC
GHRL
GLP1R
GLRA1
GNAS
GRIN1
GRIN2C
GRIN2D
GYLTL1B
HCLS1
HFE
HIF1A
HNF1A
HRH2
HTR2B
HTR3A
HTR3B
HTR5A
HTR6
HVCN1

Table S 1.Cont’d

IFI6
INHBA
ITPKA
ITPKB
ITPR3
KCNA1
KCNA2
KCNA5
KCNC1
KCNC3
KCNE1
KCNG2
KCNH2
KCNIP2
KCNJ10
KCNJ14
KCNJ4
KCNJ5
KCNK15
KCNK17
KCNK3
KCNK6
KCNMB1
KCNMB3
KCNN4
KCNQ2
KCNS1
LCK
MC4R
MCHR1
MPV17
MS4A2
MTL5
MYLK
MYLK2
NARFL
NDUFS1
NF1
NMUR2
NOS1
NOS3

Table S 1.Cont’d

NOX5
NPC1
NPC2
NPHP3
NPR1
OPRL1
ORAI1
P2RX4
P2RX5
P2RX7
P2RY2
PDE1A
PDE1B
PDGFRA
PDPN
PHKB
PLCB2
PLCB3
PLCB4
PLCD1
PLCD3
PLCG1
PLCZ1
PPARGC1A
PPID
PPP3CB
PPP3R1
PPP3R2
PRKACB
PRKCG
PROK2
PTAFR
PTGER3
PTGFR
PTK2B
RHAG
RHCG
RHOT1
RPS6
RYR1
SCN2A

Table S 1.Cont’d

SCN2B
SCN4A
SCN4B
SCN7A
SCNN1D
SCNN1G
SFTPD
SLC40A1
SLC4A1
SLC8A2
SLC9A1
SOD1
SPI1
STC1
STX1B
TAC1
TACR2
THY1
TPP1
TRHR
TRPC1
TRPC3
TRPM1
TRPM5
TRPV2
TRPV5
TRPV6
VDAC1
VDAC2
VDAC3
XCL1
ZNF675

Table S 1.Cont’d

Unmapped gene-set genes#
Long term depression
overlapping pathways
(Poverlap < 10-8) / Neuroactive ligand receptor interaction
overlapping pathways
(Poverlap < 10-8)
ADRB1 / ABCA2
ADRB2 / ADRB1
ADRB3 / ADRB2
ATP2B3 / ADRB3
AVPR1B / ALAS2
CACNA1F / APOA1
CALML3 / APOE
CALML6 / AQP5
CHP / ATP1A3
CYSLTR1 / ATP2B3
CYSLTR2 / ATP7A
GRPR / AVPR1B
HTR2C / C3AR1
LTB4R2 / CACNA1F
MLCK / CACNB3
NOS2A / CACNG5
P2RX2 / CALML3
P2RXL1 / CALML6
PHKA1 / CALR
PHKA2 / CARTPT
PHKG1 / CCL11
PHKG2 / CCL2
PRKACA / CCL23
PRKACG / CCL7
PRKCB1 / CCR1
PRKX / CCR5
PRKY / CCR8
PTGER1 / CCT8L2
SLC25A4 / CD24
SLC25A5 / CD52
SLC25A6 / CHP
SPHK1 / CHRNB2
SPHK2 / CHRNE
TBXA2R / CLCN4
TNNC1 / CLCNKA
CLCNKB

Table S 1.Cont’d

CXCR3
CXCR4
CYSLTR1
CYSLTR2
DDIT3
EDG2
EDG3
EDG4
EDG6
EDG7
FTH1
FTL
FXYD1
GALR2
GLRA2
GLRX2
GPX1
GRK1
GRPR
HPX
HTR2C
KCNA3
KCNA4
KCNE2
KCNH3
KCNH4
KCNK4
KCNK7
LCAT
LDB1
LGICZ1
LTB4R2
MAFB
MLCK
MT2A
MYC
NOLA1
NOS2A
NOX1
NPPB
P2RX2

Table S 1.Cont’d

P2RXL1
P2RY4
PHKA1
PHKA2
PHKG1
PHKG2
PRKACA
PRKACG
PRKCB1
PRKX
PRKY
PTGER1
RGN
RHOT2
RPS19
SAA1
SCN1B
SELS
SHROOM2
SLC12A4
SLC25A4
SLC25A5
SLC25A6
SLC2A4
SLC34A3
SLC4A11
SLC9A7
SPHK1
SPHK2
TARBP2
TBXA2R
TFR2
TNNC1
TRPC5
TXNDC4
USH1G

# Definition of terms:“Gene-set genes significantly associated with aversive memory”: genes mapped with at least one of the top 5% of all nominally significant SNPs (see also Methods)

“Gene-set genes not associated with aversive memory”: gene-set genes not mapped with at least one of the top 5% of all nominally significant SNPs

“Unmapped gene-set genes”: gene-set genes not tagged by intragenic SNPs and therefore not included in the i-GSEA analysis

Table S 1. Cont’d: Replicated gene-set genes

Replicated gene-set genes significantly associated with aversive memory
LONG TERM DEPRESSION / NEUROACTIVE LIGAND RECEPTOR INTERACTION
CACNA1A / BDKRB2
GNA11 / CHRM2
GRM1 / CHRM3
GRM5 / CHRM5
ITPR1 / GLRB
ITPR2 / GRIN2A
PLCB1 / GRM1
PRKCA / GRM5
HRH1
HTR2A
LHCGR
NTSR1
TACR1
TRPV1

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