Table e-2. Demographic, clinical and clinical genetic features of examined family members

Subject / Sex/
Age(yr)/
Age at onset (yr) / Profession / Handed-ness / Type of dystonia / Site of dystonia / Possible trigger (last 6 months before onset) / Disease course / Benefit from sensory trick / Reported focal task specific dystonia / BIDS / Therapy (last 6 months)
FH+1.II.1 / F/69/? / Housewife / R / Multifocal Dystonia(+) / none / Stable / none / none / pos / none
FH+1.III.2 / M/41/20 / Tubist / R / MD / Mouth / Pain syndrom, Increased practice / Progressive / none / Index patient / not done / unspecific exercises
FH+1.III.3 / F/32/19 / Pollice Officer / R / MD / Mouth / none / Stable / none / yes / not done / none
FH+1.III.4 / F/39/25 / Clarinettist / R / MD(+) / Hands / none / Stable / none / none / pos / none
FH+2.III.2 / M/43/35 / Flutist / Ambi-dextrous / MD / Hand (L) / none / Stable before BT / none / Index patient / not done / BT: improvement
FH+2.III.3 / M/43/26 / Flutist / R / MD / Hand (L) / none / Stable before BT / none / yes / not done / BT: improvement
FH+3.III.2 / M/72/66 / Pianist, Music Teacher / R / MD(+) / Hand (R) / none / Stable before BT / none / Index patient / not done / BT: improvement
FH+3.IV.1 / M/39/28 / Panflutist / R / MD (possible) / Neck / Increased practice / Improvement / none / yes / not done / unspecific exercises
FH+4.II.9 / F/65/- / Housewife / R / none / none / yes / not done
FH+4.III.11 / F/41/39 / Oboist / R / MD(+) / Hand (R) / none / Stable before BT / yes / Index patient / not done / BT: improvement
FH+5.III.2 / M/47/36 / Clarinettist / Ambi-dextrous / MD(+) / Hands / none / Stable / none / Index patient / not done / none
FH+5.III.4 / F/43/20 / Governess / R / WC (possible) / Hand (R) / none / Stable / none / yes / not done / none
FH+6.II.5* / F/74/28 / Pianist, Medical doctor / R / WC(+) / Arm (R) / Increased practice / Progressive / none / yes / not done / none
FH+6.III.3* / M/40/27 / Pianist, Medical doctor / R / MD(+) / Hand (R) / Pain syndrome / Progressive / Use of glove / Index patient / not done / none
FH+6.III.4* / F/42/30 / Teacher / R / WC / Arm (R) / Increased practice / Progressive / none / yes / not done / none
FH+7.II.6 / M/68/41 / Music Teacher / R / MD(+) / Hand (L) / none / Stable / none / yes / not done / none
FH+7.III.1 / F/38/37 / Violinist / R / MD(+) / Hand (L) / none / Improvement / none / Index patient / not done / unspecific exercises
FH+8.II.1 / F/64/22 / Teacher / Ambi-dextrous / MD(+) / Hand (R) / Increased practice / Stable / none / yes / not done / none
FH+8.III.1 / M/31/16 / Correpetitor / Ambi-dextrous / MD(+) / Hands / none / Stable before BT / none / Index patient / not done / BT: improvement
FH+9.II.2* / M/71/20 / Commercial clerk / R / WC(+) / Hand (R) / none / Stable / none / none / pos / none
FH+9.III.1* / M/45/23 / Guitarist, Medical doctor / R / MD / Hands / none / Stable / none / Index patient / not done / none
FH+9.III.2* / F/46/33 / Art historian / Ambi-dextrous / WC(+) / Arms / Increased practice / Progressive / none / yes / not done / none
FH+10.II.8 / M/84/55 / Commercial clerk / R / WC(+) / Hand (R) / none / Stable / none / yes / not done / none
FH+10.III.1 / M/48/31 / Piano Teacher / R / MD(+) / Hand (R)
Arm (L) / none / Progressive / none / Index patient / not done / BT: improvement
FH+11.III.11 / F/27/22 / Clarinettist / R / MD(+) / Hand (R) / Increased practice / Progressive / none / Index patient / not done / none
FH+11.III.12 / F/25/21 / Music Teacher / R / MD / Hand (R) / none / Stable / none / yes / not done / none
FH+12.III.2 / M/63/30 / Clarinettist / R / MD(+) / Hand (L) / none / Stable / none / Index patient / not done / none
FH+12.III.3 / M/65/59 / Trombonist / R / MD(+) / Mouth / none / Stable / none / yes / not done / none
FH+13.II.3 / M/66/46 / Croupier / R / Croupier’s cramp(+) / Hand (R) / none / Stable / none / yes / not done / none
FH+13.III.1 / F/38/32 / Flutist / R / MD(+) / Hand (R) / Increased practice / Improvement / none / Index patient / not done / BT: improvement
FH+14.II.6 / F/62/44 / Housewife / R / WC(+) (possible) / Hand (R) / Pain syndrome / Stable / none / yes / not done / none
FH+14.III.3 / M/32/28 / Flutist / R / MD(+) / Mouth / Increased practice / Stable / none / Index patient / not done / unspecific exercises
FH-1.III.5 / M/31/28 / Pianist / R / MD(+) / Hand (R) / none / Improvement / none / Index patient / not done / Phenytoin: improvement
FH-2.III.2 / M/49/32 / Saxophonist / R / MD(+) / Hand (R) / none / Stable / none / Index patient / not done / none
FH-3.II.1* / F/79/75 / Housewife / R / ‘Handicraft’ dystonia (+) / Hands / none / Stable / none / none / pos / none
FH-3.III.1* / M/46/30 / Guitarist / R / MD / Hand (R) / Increased practice / Stable before BT / none / Index patient / not done / BT: improve-ment
FH-3.III.4* / M/54/20 / Businessman, Watchmaker / R / Brachial Dystonia(+) / Arm (R) / none / Stable / none / none / pos / none
FH-3.III.5* / F/45/35 / Pianist / R / WC(+) / Hand (R) / none / Stable / none / none / pos / none
FH-4.III.3 / F/37/27 / Clarinettist / R / MD(+) / Hand (R) / Increased practice / Improvement / none / Index patient / not done / none
FH-5.III.1 / M/45/38 / Pianist / R / MD(+) / Hand (L) / none / Stable / none / Index patient / not done / none
FH-5.III.4 / M/47/? / Gardener / R / WC (possible) / Hand (R) / none / Stable / none / none / pos / none
FH-6.III.1 / M/27/25 / Hornist / R / MD / Mouth / Pain syndrome / Improvement / none / Index patient / not done / unspecific exercises
FH-7.III.4 / F/47/35 / Oboist / R / MD(+) / Hand (R) / none / Stable / none / Index patinet / not done / none
FH-8.II.2 / F/69/- / Medical doctor / R / none / none / none / pos
FH-8.III.1 / M/42/25 / Pianist / R / MD / Hand (R) / Increased practice / Improvement / none / Index patient / not done / Phenytoin: improvement
FH-9.III.1 / M/74/60 / Pianist, Music Teacher / R / MD(+) / Hand (R) / none / Stable / none / Index patient / not done / none
FH-9.III.9 / F/75/45 / Pensioner / R / WC(+) / Hand (R) / none / Improvement / none / none / pos / none
FH-10.III.4 / M/35/22 / Clarinettist / R / MD(+) / Hand (L) / none / Stable before BT / none / Index patient / not done / BT: improvement
FH-11.III.3 / F/41/27 / Violinist / R / MD / Hand (L) / none / Stable / none / Index patient / not done / unspecific exercises
FH-11.III.4 / F/47/42 / Music Teacher / R / MD(+) / Hand (R) / Increased practice / Stable / yes / none / pos / none
FH-12.III.2 / F/27/20 / Oboist, Medical doctor / R / MD(+) / Hand (R) / none / Improvement / none / Index patient / not done / none
FH-13.III.1 / M/44/39 / Tubist / R / MD / Mouth / none / Stable / none / Index patient / not done / none
FH-14III.1 / M/63/35 / Clarinettist / R / MD(+) / Hands / none / Progressive / none / Index patient / not done / BT: improvement

FH+ = reported positive family history of focal task-specific dystonia (FTSD); FH- = no known family history; MD = musician’s dystonia; WC = writer’s cramp; (+) = additional dystonias or additional other movement disorders definitely, probably or possibly present; BIDS = Beth Israel Dystonia Screen; BT = botulinum toxin; R = right; L = left; pos = positive.

* = previously published in (12)