Table. Clinical Characteristics of Patients with Disease Due to Rapidly Growing Mycobacteria
Supplementary material
Table. Clinical characteristics of patients with disease due to rapidly growing mycobacteria (n= 32)
Case / Year / Age, gender / Underlying conditions / Location / RGM specie / PC/PA / Treatment / Outcome1 / 1998 / 67, F / Breast cancer (RDT), COPD, Past TB / Pulmonary disease / M. chelonae / 6/0 / First treatment: Cla (12 m), Tob (13 m)
Second treatment: Tob inhaled (9 m) / Cured with Tob inhaled after relapsing with the first treatment.
2 / 2003 / 68, M / COPD, HBV / Pulmonary disease / M. fortuitum / 5/4 / Cla, Am & Cip (5 m) / Died during treatment
3 / 2003 / 82, F / COPD / Pulmonary disease / M. fortuitum / 10/0 / Cla (9 m), Am (4 m), Cip (9 m) / Cured after relapse
4 / 2004 / 65, M / D. mellitus, COPD, lung cancer / Pulmonary disease / M. fortuitum / 2/0 / Cla (6 m), Am &, Cip (8 m) / Cured
5 / 2004 / 61, M / Lung cancer / Cavity of pneumectomy / M. abscessus / 10/4 / Cla (14 m), Lev (6 m) / Died during treatment
6 / 2006 / 82, F / Sjögren syndrome / Pulmonary disease / M. mucogenicum / 3/2 / Cla & Cip (24 m) / Cured
7 / 2006 / 72, M / D. mellitus, COPD / Pulmonary disease / M. chelonae / 4/1 / Cla & Cip (6 m) / Cured
8 / 2007 / 65, M / COPD, M. kansasii past disease / Pulmonary disease / M. abscessus / 38/23 / Cla (17 m), Am (11 m) / No response after 17 months of therapy.
Died during treatment
9 / 2008 / 77, M / COPD, D. mellitus, past TB / Pulmonary disease / M. chelonae / 2/2 / Cla (6 m), Am & Cip (8 m) / Died during treatment
10 / 2008 / 36, F / Steroids / Pulmonary disease / M. fortuitum / 11/1 / Cla (2 m), Az (5 m), Am (10 m), Cip (13 m) / Cured
11 / 2010 / 45, F / Breast cancer (RDT) / Pulmonary disease / M. abscessus / 6/0 / Cla, Am, Cip & Lz (8 m) / Cured
12 / 2011 / 49, F / Steroids, past TB / Pulmonary disease / M. abscessus / 12/7 / Cla (9 m), Am (1 m), Tig (2 m), Lz (7 m) / Cured
13 / 2011 / 62, F / Steroids, M. kansasii past disease / Pulmonary disease / M. abscessus / 10/2 / Cla, Am & Cip (12 m) / Cured
14 / 2013 / 71, M / D. mellitus, COPD, lung cancer / Pulmonary disease / M. abscessus / 3/0 / Cla (7 m), Am (6 m), Cip (7 m) / Cured
15 / 2014 / 69, M / COPD / Pulmonary disease / M. chelonae / 1/2 / Cla (12 m), Am (4 m) / Cured
16 / 1997 / 57, F / Finger traumatic wound / SSTI / M. fortuitum / 1/0 / Cla (6 m), E (1 m), R (6 m) / Cured
17 / 1998 / 59, F / Steroids / Ureter and kidney infection / M. fortuitum / 2/0 / Surgery / Cured
18 / 2005 / 68, F / Surgery (grid to treat eventration) / Infection of abdominal grid / M. fortuitum / 4/1 / Cla (6 m), Am (3 m), SXT (9 m) + grid removal / Cured
19 / 2006 / 67, M / D. mellitus, COPD, lung cancer / SSTI / M. chelonae / 2/0 / Surgery / Cured
20 / 2009 / 49, M / Surgery / Deep surgical site infection / M. fortuitum / 6/3 / Lev & Am (3 m), Mox (2 m) + Surgery / Cured
21 / 2012 / 77, F / COPD, endotracheal prosthesis / Infection of the endotracheal prosthesis / M. chelonae / 2/2 / Cla (12 m), Am (3 m), Lz (12 m) + Prosthesis removal / Cured
22 / 2012 / 55, M / Polytrauma / SSTI / M. fortuitum / 1/0 / Surgery / Cured
23 / 2013 / 80, M / COPD, steroids / Disseminated SSTI / M. chelonae / 4/4 / Cla & Tob (3 weeks) / Died during treatment
24 / 2013 / 80, M / Eye surgery / Corneal infection / M. chelonae / 1/0 / Cla (3 m) / Cured
25 / 2013 / 77, F / D. mellitus, obesity, OSA, limbs edema / SSTI / M. chelonae / 1/1 / No treatment / Died
26 / 2014 / 41, F / Surgery (breast prosthesis) / Mastitis / M. abscessus / 2/0 / Cla (3 m), Am (2 weeks), Lz (3 m) + prosthesis removal / Cured
27 / 2014 / 61, M / D. mellitus, Limb amputation / SSTI (stump infection) / M. chelonae / 1/0 / Surgery / Cured
28 / 2015 / 70, M / D. mellitus, RA, steroids, cancer / SSTI (skin ulcer) / M. chelonae / 1/0 / Cla (4 days), Tig (3 weeks), Dox (2 m) / Cured
29 / 2015 / 82, F / D. mellitus, CLD / SSTI (sporotrichoid lesion) / M. chelonae / 1/0 / Cip (3 m) / Cured
30 / 2015 / 63, M / Crohn’s disease, tunneled catheter / SSTI (Catheter infection) / M. chelonae / 1/0 / Cla (2 weeks), Cip (3.5 m), Doxi (3 m) + catheter removal / Cured
31 / 2015 / 46, F / Chronic renal failure, catheter for peritoneal dialysis / SSTI (Catheter infection) / M. mucogenicum / 1/0 / Cla (2 m), Lev (3 m) + catheter removal / Cured
32 / 2015 / 53, M / Liver transplant, immunosuppression,
grid to treat eventration / Infection of abdominal grid / M. fortuitum / 4/0 / Cip, Doxi + grid removal / Still on treatment
OSA= Obstructive sleep apnea; RDT= Radiotherapy; CLD= Chronic liver disease; SSTI, skin and soft tissue infection PC/PA: Positive culture/ Positive AFB stain, M: Male, F: Female, A: Amikacin, AZ: Azithromycin, CI: Ciprofloxacin, Cla: Clarithromycin, D: Doxycycline, E: Ethambutol, I: Isoniazid, IM: Imipenem, LE: Levofloxacin, L: Linezolid, ME: Meropenem, MO: Moxifloxacin, O: Ofloxacin, P: Pyrazinamide, R: Rifampicin, SXT: Cotrimoxazole, T: Tigecycline, TO: Tobramycin
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