Table 1 - Studies in Set up and Potentially Looking for More Sites

Rheumatology Studies in Scotland – July 2017

Table 1 - Studies in set up and potentially looking for more sites

Please see contacts for more details

Phase 3 study in participants with RA (FINCH 3)

CCX168 - Avacopan in patients with Vasculitis (ADVOCATE study)

The role of the immune system in diseases

Condition / Study Title / Funder/lead / Contact
Biosimilar Network / A register of investigators/sites that would be interested in conducting Phase 4 clinical trials on biosimilars in the future / Covance
(commercially funded) / If you are interested in becoming a member of this network, follow the link below

Juvenile-onset systemic lupus erythematosus (JSLE) / BPSU JSLE study-
investigating the incidence of JSLE in patients <18 years in the UK and Ireland / British Paediatric Surveillance Unit (BPSU)
Liverpool /
OA / A Study to Determine the Efficacy and Safety of Fasinumab for the Treatment of Adults With Chronic Low Back Pain
Click here for more details / Regeneron Pharmaceuticals
(commercially funded) /
Osteogenesis Imperfecta / Treatment of Osteogenesis Imperfecta with Parathyroid hormone and Zoledronic acid (TOPAZ) / University of Edinburgh
Efficacy and Mechanism Evaluation (EME) Program
Eli Lilly
(Eligibly funded) / CI Prof Stuart Ralston

Polymyositis and dermatomyositis / Investigating genes in patients with polymyositis and dermatomyositis
Click here for more details / Arthritis Research UK, Myositis Support Group
University of Manchester
(Eligibly funded) / CI Prof WER Ollier

PsA / ScOttish Psoriatic artHritis Observational Study (SOPHOS) / Glasgow University
(Eligibly funded) / CI Dr Stefan Seibert

RA / Inhibition of Co-Stimulation in Rheumatoid Arthritis (ICoSRA) / Glasgow University
(Eligibly funded) /
RA / A randomized, double-blind, pragmatic (effectiveness and safety) clinical trial on low-dose glucocorticoids (GC) in adult patients with rheumatoid arthritis (RA). / EU
(Eligibly funded) /
RA / Stratification of Biologic Therapies for RA by Pathobiology (STRAP): A randomised, open-labelled biopsy-driven stratification trial in DMARD inadequate responder patients randomised to Etanercept, Tocilizumab or Rituximab
Click here for more details / Medical Research Council
Queen Mary University of London
(Eligibly funded) / CI Prof ConstantinoPitzalis

Please note -
Sites required to have capacity to conduct arthroscopic or ultrasound-guided synovial biopsies
RA / FOCOS RA - Foot Orthoses- Custom v Off-the-shelf in Rheumatoid Arthritis / University of East London
Dr William. M Scholl Fund
(Non eligibly funded) / CI Dr Kellie Gibson

Please note-
Podiatry involvement required
Spondyloarthritis / Do NSAIDs mask bone marrow oedema on MRI in spondyloarthritis? Dynamism / Arthritis Research UK
University of Aberdeen
(Eligibly funded) /
Please note-
Requires research nurse, MRI scanner (scans are paid for) and training (will be provided).
SLE / BILAG Biologics Prospective Cohort: The Use of Novel Biological Therapies in the Treatment of Systemic Lupus Erythematosus (SLE)
Click here for more details / F.Hoffmann-La Roche Ltd
University of Manchester
(Eligibly funded) / CI Prof Ian Bruce

SLE / A randomized, placebo-controlled, patient and investigator blinded, Proof of Concept study investigating the safety, tolerability, pharmacokinetics and preliminary efficacy of multiple doses of CFZ533 on patients with moderately active proliferative lupus nephritis / Commercially funded
Novartis /
SLE / SLE Prospective Observational Cohort Study (SPOCS): a prospective observational cohort of patients with moderate-to-severe SLE to characterize disease activity, treatment patterns, outcomes, healthcare resource utilization, and associated quality of life in the general population of moderate and severe SLE patients, and also by the type I Interferon gene expression status / Commercially funded
Quintiles/ Astra Zeneca /
Systemic sclerosis / 1199.214 Nintedanib vs placebo in scleroderma related lung fibrosis
click here for more details / BoehringerIngelheim Ltd
(commercially funded) / CI Christopher Denton

Vasculitis / DCVAS - ACR/EULAR endorsed study to develop new classification and diagnostic criteria for primary systemic vasculitis
Click here for more details / American College of Rheumatology (ACR), European League Against Rheumatism (EULAR), Vasculitis Foundation
(Eligibly funded) / CI Dr Raashid Luqmani