Table 1: Innovative New Approaches from Our Body of Work

Table 1: Innovative New Approaches from Our Body of Work

Output 1: Summary of multiplier funding linked to the ESRC/DFID grant Theobald-Cuevas RES-167-25-0387

The ESRC DFID study “Identifying barriers to tuberculosis diagnosis and treatment under a new rapid diagnostic scheme” (RES-167-25-0387) involved research in Ethiopia, Yemen, Nepal and Nigeria. These are all countries with a high burden of tuberculosis, where patients often abandon the diagnostic process and fail to initiate treatment. We used multi-country and multi-stage surveys to describe the costs incurred accessing tuberculosis diagnostic services across these contexts and patients’ perception of the disease and services. These results were used to develop models to identify populations at risk of high expenditure for tuberculosis diagnosis and treatment. Complementary qualitative methods in Yemen and Ethiopia elicited participants’ perceptions of diagnostic and treatment processes, the barriers people face in accessing services and how services could be modified to improve access.

The multi-method approach deployed generated strong evidence across these contexts of the multiple challenges people with symptoms of tuberculosis face in accessing diagnosis through the classic passive approach to tuberculosis case finding (reliant on patients paying multiple visits to a health centre). Accessing services resulted in significant costs, especially clinic fees and transport and in particular among accompanied adults and from rural areas. Most participants (particularly women) attended the services with companions and were unprepared for the duration of the process. Besides costs, women faced many other particular difficulties in accessing services. The findings highlight how poverty, geography (distance from health centre), gender and age interplay to shape barriers to accessing tuberculosis diagnostic services at central level. This evidence (together with other evidence generated through accompanying studies and experience) has been pivotal in the development of a body of work that has taken forward the conceptualisation of equity and social justice in tuberculosis diagnosis processes. This body of work has promoted creative thinking about piloting different approaches to bring tuberculosis services closer to communities in Ethiopia, Yemen and Nigeria to increase the access of poor and marginalised groups to vital lifesaving tuberculosis diagnostic services. We have been very successful in testing several approaches described in the impacts section and have generated over £3,026,976 of research income to support further operational and intervention research to test out new approaches that bring the diagnosis closer to the communities in these country contexts. The table below details the grants linked to this ESRC/DFID grant and the last column describes how the evidence generated was used in developing the concepts. Key to these awards is the development of new and creative ways to bring tuberculosis diagnosis closer to communities to address and minimise the multiple barriers patients face accessing formal care.

Table 1: Innovative new approaches from our body of work

Grant / Amount / Funder and dates / Concepts and application
Innovative community-based approaches for enhanced tuberculosis case finding and treatment outcome in Southern Ethiopia (PIs Mohammed Yassin and Sally Theobald) / US$689,163
(£428,379) / TB REACH, 2010-12 / Bringing TB diagnosis to the doorstep at the village level through partnership with female Health Extension Workers (HEWs) who collect sputum and produce smears at community level (either at the patients’ house or at the health post). If found positive patients can initiate and be supported in their treatment at home or the local community health post.
HEWs are part of the Health Extension Programme (HEP) launched in 2003. Two salaried HEWsprovide services in each kebele (the lowest administrative unit).
Innovative community-based approaches for enhanced tuberculosis case finding and treatment outcome in Southern Ethiopia (PIs Mohammed Yassin and Sally Theobald) / US$ 654,721
(£406,970) / TB REACH, 2012-13
Scaling up innovative community-based approaches to improve TB diagnosis and treatment among vulnerable and high risk populations (PIs Luis Cuevas & Daniel Datiko) / US $999,560
(£621,319) / TB REACH 2013-14
A PPP to increase access to quality TB diagnosis and treatment to slum populations of Abuja through active case finding and diagnostic technologies (PIs Luis Cuevas and Saddiq Abdurrahman) / US$ 878537
(£546,092) / TB REACH 2011-12 / Bringing TB diagnosis to the doorstep at the slum populations of the Federal Capital Territory of Abuja. Teams of HEWs sensitize the community and visits households of the slums surrounding the metropolitan area. If considered positive, then patients are initiated treatment at the nearest health post.
Year 1 and 2 were proof of concept years and years 3 (and expected year 4) aim to demonstrate the scalability of the approaches.
Continuation phase for ‘A PPP to increase access to quality TB diagnosis and treatment to slum populations of Abuja through active case finding and diagnostic technologies (PIs Luis Cuevas and Saddiq Abdurrahman’) / US$96,000
(£59,672) / TB REACH 2012-13 / Transition fund to allow the National TB Control Programme to take over the project activities into the National Programme and to apply for extension funds to the Global Fund
Increased detection of children, women and elderly individuals with smear-positive TB in Yemen (PIs Najla Al-Sonboli & Sally Theobald) / US$ 287,621
(£178,783) / TB REACH, 2010-11 / Increasing access to TB diagnosis for secondary cases identified at household level (particularly women, children and older people)
Innovative approaches to diagnose and monitor patients with TB to facilitate conducting clinical trials for the community based treatment of MDR TB
(PIs Luis Cuevas, Daniel Gemechu Datiko) / €848,469
(£726,264)
/ EDCTP, 2012-2014 / Increasing human resource capacity for the evaluation of new interventions to increase accessibility to diagnosis in Ethiopia and Nigeria
Grand challenges Canada
(PIs Daniel Gemechu Datiko and Luis Cuevas) / CAN$ 100,000
(£59,497) / Grand Challenges Canada 2013-2014 / We are assessing whether the identification of children with TB is increased through the implementation of active case finding at community level and evaluating if screening children using innovative approaches to test specimens with new diagnostic technologies increases the proportion of children with microbiological confirmation.
Total amount of new awards generated / £3,026,976