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Tables
Table 1: Distribution of vaginal pH score of clinically eligible pregnant women
pH / Frequency / (%)3.5 / 17 / 1.00%
4 / 478 / 28.13%
4.5 / 620 / 36.49%
5 / 424 / 24.96%
5.5 / 152 / 8.95%
6 / 8 / 0.47%
N / 1699 / 100.00%
Table 2: Distribution of Nugent scores (pH>=4.5)
Nugent Score / Frequency / (%)0 / 80 / 6.67%
1 / 256 / 21.35%
2 / 136 / 11.34%
3 / 52 / 4.34%
4 / 36 / 3.00%
5 / 49 / 4.09%
6 / 113 / 9.42%
7 / 156 / 13.01%
8 / 234 / 19.52%
9 / 60 / 5.00%
10 / 27 / 2.25%
N / 1199 / 100.00%
Table 3: Distribution of patients with vaginal pH> = 4.5 according to the Nugent classification
Nugent Score / Frequency / (%)Normal / 524 / 43.70%
Intermediate / 198 / 16.51%
BacterialVaginosis / 477 / 39.78%
N / 1199 / 100.00%
Table 4: Changes in Nugent class after 8 weeks
Table 5: Cross tabulation of vaginal pH level and Nugent class of pregnant women, pH score >= 4.5
Nugent / TotalBV / Interm. / Normal
pH / 4.5 / Count / 87 / 92 / 438 / 617
% withinpH / 14.1% / 14.9% / 71.0% / 100.0%
% withinNugent / 18.2% / 46.5% / 83.6% / 51.5%
% of Total / 7.3% / 7.7% / 36.5% / 51.5%
5.0 / Count / 271 / 81 / 71 / 423
% withinpH / 64.1% / 19.1% / 16.8% / 100.0%
% withinNugent / 56.8% / 40.9% / 13.5% / 35.3%
% of Total / 22.6% / 6.8% / 5.9% / 35.3%
5.5 / Count / 111 / 25 / 15 / 151
% withinpH / 73.5% / 16.6% / 9.9% / 100.0%
% withinNugent / 23.3% / 12.6% / 2.9% / 12.6%
% of Total / 9.3% / 2.1% / 1.3% / 12.6%
6.0 / Count / 8 / 0 / 0 / 8
% withinpH / 100.0% / .0% / .0% / 100.0%
% withinNugent / 1.7% / .0% / .0% / .7%
% of Total / .7% / .0% / .0% / .7%
Total / Count / 477 / 198 / 524 / 1199
% withinpH / 39.8% / 16.5% / 43.7% / 100.0%
% withinNugent / 100.0% / 100.0% / 100.0% / 100.0%
% of Total / 39.8% / 16.5% / 43.7% / 100.0%
Table 6 -Sensitivity and specificity of vaginal pH to predict BV status.
a)Cutoff value: pH=4.5
Colunas1 / BV+ / BV- / TotalpH < 4.5 / 0 / 499 / 499
pH >=4.5 / 480 / 724 / 1204
Total / 480 / 1223 / 1703
Sensitivity: 480/480 = 100%
Specificity: 499/1223 = 41%
Accuracy: 57.5%
b) Cutoff value: pH 5.0
Colunas1 / BV+ / BV- / Total
pH< 5 / 95 / 1029 / 1124
pH≥5 / 385 / 194 / 579
Total / 480 / 1223 / 1703
Sensitivity: 385/480 = 80%
Specificity: 1029/1223 = 84%
Accuracy: 83%
Table 7- Selected maternal data related to cases of
a)spontaneous preterm delivery 34 weeks’ gestation
Case / Vaginal pH / Nugent score / Modified / Birth weight (kg) / GA at birth (USG)Donders' score
1 / 5.0 / 10 / 3 / 2.010 / 30w, 6d *1
2 / 5.5 / 6** / 3** / 1.695 / 33w, 2d
3 / 4.5 / 9 / 3 / 1.580 / 31w, 4d
4 / 5.0 / 8 / 3 / 2.305 / 33w,6d *2
*1,2 The GA estimated by neonatologists were 33w 6d and 35w5d, respectively.
** Results are not reliable due to insufficient material for analysis.
b)abortion
5 / 5.0 / 7 / 2 / - / 12w,3dc)spontaneous preterm deliveries between 34-<37 weeks’ gestation.
Case / Vaginal pH / Nugent score / ModifiedDonders' score / Birthweight (kg) / GA at birth (USG)
1 / 4.5 / 8 / 3 / 2.925 / 36w,0d
2 / 5.5 / 8 / 4 / 2.555 / 36w,6d
3 / 5.0 / 7 / 2 / 2.300 / 35w,5d
4 / 5.0 / 8 / 3 / 2.665 / 36w,6d
5 / 4.5 / 5 / 3 / 2.220 / 36w,6d*
6 / 5.0 / 8 / 4 / 2.435 / 35w,1d
7 / 5.5 / 7 / 3 / 2.720 / 35w,5d
* The GA based on neonatologists estimate was 34w,6d.
** LMP and neonatologist’s estimate (no USG available)
Table 8– Spontaneous Preterm deliveries according to BV status of asymptomatic pregnant women with vaginal pH>=4.5.
a)<34weeks’ gestation
BV status / < 34 wks / >= 34 wks / TotalBV+ / 3a* / 236c / 239
BV Int / 1b** / 98d / 99
Total / 4 / 334 / 338
**Insufficient material
RR= 1,24
Two sided-p value (Fisher’s exact test)= 1.00 , n.s.
b)34-<37 weeks’ gestation
BV status / SPD 34-37 wks / Deliveries >= 37 wks / TotalBV+ / 6a / 230c / 236
BV Int / 1b / 97d / 98
Total / 7 / 327 / 334
RR=2.47
Two sided-p value (Fisher’s exact test)= 0.68, ns.
c)<37 weeks’ gestation
BV status / SPD*< 37wks / Deliveries >= 37wks / TotalBV+ / 3+6a / 230c / 239
BV Int / 1+1b / 97d / 99
Total / 11 / 327 / 338
*spontaneous preterm delivery; elective preterm deliveries were not considered.
RR= 1,86 Two sided-p value (Fisher’s exact test)= 0.52, ns.