SupplTable 2: List of ERα regulated genes downregulated in ICI treated early stage C-CAFs

Sl. No / GeneName / Description / Entrez ID / logFC / P.Value
1 / HS3ST2 / heparan sulfate (glucosamine) 3-O-sulfotransferase 2 / 9956 / -3.11437 / 0.024
2 / ADCY8 / adenylatecyclase 8 (brain) / 114 / -2.49948 / 0.014
3 / KYNU / kynureninase (L-kynurenine hydrolase) / 8942 / -2.45283 / 0.015
4 / MPHOSPH1 / M-phase phosphoprotein 1 / 9585 / -1.94493 / 0.048
5 / SHC4 / SHC (Src homology 2 domain containing) family, member 4 / 399694 / -1.91943 / 0.001
6 / ITPR3 / inositol 1,4,5-triphosphate receptor, type 3 / 3710 / -1.64181 / 0.027
7 / ORC1L / origin recognition complex, subunit 1-like (yeast) / 4998 / -1.62698 / 0.034
8 / CTSK / cathepsin K / 1513 / -1.40763 / 0.015
9 / SHC3 / SHC (Src homology 2 domain containing) transforming protein 3 / 53358 / -1.33932 / 0.035
10 / SERPINE1 / serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 / 5054 / -1.32318 / 0.044
11 / ADCY4 / adenylatecyclase 4 / 196883 / -1.30631 / 0.0004
12 / ESPL1 / extra spindle pole bodies homolog 1 (S. cerevisiae) / 9700 / -1.0823 / 0.022
13 / INPP4B / inositol polyphosphate-4-phosphatase, type II, 105kDa / 8821 / -1.05589 / 0.017
14 / FKBP5 / FK506 binding protein 5 / 2289 / -0.95283 / 0.038
15 / UGCGL1 / UDP-glucose ceramideglucosyltransferase-like 1 / 56886 / -0.90863 / 0.008
16 / NRAS / neuroblastoma RAS viral (v-ras) oncogene homolog / 4893 / -0.90753 / 0.043
17 / CISH / cytokine inducible SH2-containing protein / 1154 / -0.86629 / 0.049
18 / NFKBIL2 / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 / 4796 / -0.78668 / 0.042
19 / MAP2K1 / mitogen-activated protein kinase kinase 1 / 5604 / -0.6982 / 0.030
20 / MAPK1 / mitogen-activated protein kinase 1 / 5594 / -0.68772 / 0.029
21 / CALML3 / calmodulin-like 3 / 810 / -0.65453 / 0.048
22 / HSPA1L / heat shock 70kDa protein 1-like / 3305 / -0.60834 / 0.037