Supplementary Tablesof various Second generation drug-eluting stent comparison

Table 1.G2-DESs subtype comparison, angiographic and Lesions Characteristics of the Index procedures*:

CoCr-EESs / BESs / PtCr-EESs / P Value
Treated vessel, % (n)
LAD
LCX
RCA / 6 (27)
1 (4.5)
14 (63) / 2 (13)
2 (13)
10 (66.7) / 3 (23)
1 (7.7)
8 (61.5) / 0.95
Calcification, n (%) / 4 (18) / 0 / 3 (23) / 0.19
Angulation >45o , (n) % / 4 (18) / 3 (20) / 4 (31) / 0.68
ACC/AHA Lesion class, (n) %
Type B
Type C / 10 (45)
11 (50) / 6 (40)
8 (53) / 3 (23)
8 (61.5) / 0.74
Bifurcation lesion, (n) % / 5 (22.7) / 2 (13) / 4 (30.8) / 0.53
Kissing balloon, (n)% / 5 (22.7) / 2 (13) / 1 (7.7) / 0.56
Chronic total occlusion, (n) % / 7 (31.8) / 6 (40) / 7(53.8) / 0.5
Ostial Stenting, (n) % / 3 (13.6) / 5 (33.30 / 2 (15.4) / 0.35
Use of IVUS, % (n) / 12 (54.5) / 12 (80) / 10 (77) / 0.22
Rotablator, (n) % / 3 (13.6) / 0 / 1 (7.7) / 0.35
No. of stents / lesion / 1.45 ± 0.85 / 1.2 ± 0.4 / 1.3 ± 0.63 / 0.54
Total stent length / lesion, mm / 29 ± 22 / 25 ± 5 / 31 ± 18 / 0.62
stent diameter, mm / 2.9 ± 0.46 / 3.2 ± 0.4 / 2.9 ± 0.44 / 0.23
Maximum Balloon diameter, mm / 3.1 ± 0.65 / 3.4 ± 0.67 / 3 ± 0.31 / 0.24
Maximum inflation pressure, atm / 20 ± 6 / 21 ± 4.5 / 19.6 ± 5 / 0.71

Data are described as n (%) or mean ± SD.*Index procedures: procedures in which the

studied stents were first implanted. ACC/AHA, American College of Cardiology/American Heart Association; BESs, biolimus-eluting stents; CoCr-EESs, Cobalt-chromium everolimus-eluting stent; G2-DESs,second generation drug-eluting stent; IVUS, intravascular ultrasound; LAD, left anterior descending artery; RCA, right coronary artery; LCx, left circumflex artery;PtCr-EESs, platinum-chromium everolimus-eluting stents.

Table 3.G2-DESs subtype comparison, serial Quantitative Coronary Angiographic (QCA) Results

CoCr-EESs
(n=22) / BESs
(n=15) / PtCr-EESs
(n=13) / p value
QCA at the Index procedures *:
Lesion length, mm
Reference vessel diameter, mm
Pre-procedural MLD, mm
Post-procedural MLD, mm
Pre-procedural DS (%)
Post-procedural DS (%) / 27.6 ± 18
3 ± 0.53
0.69 ± 0.64
2.5 ± 0. 4
77 ± 20
17 ± 7 / 21 ± 7.8
3.3 ± 0.38
0.78 ± 0.69
2.9 ± 0. 4
75.5 ± 20
14 ± 6 / 28 ± 17
3 ± 0.39
0.52 ± 0.61
2.5 ± 0.4
81 ± 21
17 ± 9 / 0.42
0.31
0.57
0.02
0.77
0.41
QCA at TLR procedures:*
Lesion length, mm
Reference vessel diameter, mm
MLD, mm
Percent DS (%) / 15 ± 5.9
2.9 ± 0.55
1 ± 0.49
66 ± 13 / 16 ± 11
3.3 ± 0.49
1 ± 0.47
69.6 ± 14 / 18 ±8.8
2.9 ± 0.49
0.86 ± 0.31
69.7 ± 12.7 / 0.56
0.06
0.55
0.66
Time to Restenosis, median (quartiles) days.* / 292 (246 -613) / 614(250-623) / 244(137-245) / 0.001
Time to TLR, median (quartiles) days.* / 616 (260 - 653) / 632(554-817) / 259(154-274) / 0.001
Stent Fracture, n (%)* / 2 (9) / 2 (13) / 4 (30.8) / 0.28

Values are mean ± SD or n (%). MLD, minimum lumen diameter; %DS, percent diameter stenosis. TLR, Target lesion revascularization; other abbreviations are as Table 1.* Measurements and proportions were calculated from the number of lesions which had follow up angiography.

Table 4. OFDI Findings of various G2-DES subtypes, analysis per lesion:

CoCr-EESs
(n=22) / BESs
(n=15) / PtCr-EESs
(n=13) / p value
Qualitative Findings:
Homogeneous intima, n (%) / 11 (50) / 6 (40) / 5 (38.5) / 0.85
Heterogeneous intima, n (%)
Layered pattern, %
Patchy pattern, %
Speckeled pattern, % / 11 (50)
2(9)
8 (36.5)
1 (4.5) / 9 (60)
5 (33)
2 (13.3)
2 (13.3) / 8 (61)
4 (30.8)
4 (30.8)
0 / 0.81
0.30
Backscatter,
High, n (%)
Low, n (%) / 13 (59)
9 (40.9) / 10 (66.7)
5 (33.3) / 8 (61.5)
5 (38.5) / 0.9
Micro vessels, n (%) / 9 (41) / 5 (33.3) / 3 (23) / 0.6
Peri-strut low intensity, n (%) / 10 (45.5) / 7 (46.7) / 5 (38.5) / 0.87
Lipid rich intima (neoatherosclerosis), n (%). / 9 (41) / 6 (40) / 9 (69) / 0.22
Quantitative findings:
Minimal Lumen diameter, mm / 1.32 ± 0.32 / 1.4 ± 0.45 / 1.21 ± 0.4 / 0.47
Mean Lumen CSA, mm2 / 1.95 ± 1 / 1.89 ± 1 / 1.43 ± 0.69 / 0.35
Minimal stent diameter, mm2 / 2.69 ± 0.75 / 3 ± 0.87 / 2.79 ± 0.75 / 0.47
Mean stent CSA, mm2 / 7 ± 3.1 / 8.9 ± 3.2 / 6.7 ± 3.2 / 0.19
Stent symmetry index / 0.89 ± 0.05 / 0.90 ± 0.03 / 0.90 ± 0.05 / 0.68
Stent eccentricity index / 0.16 ± 0.12 / 0.15 ± 0.04 / 0.18 ± 0.09 / 0.86
Mean NIH area, mm2 / 5.3 ± 2.6 / 7 ± 2.8 / 5.3 ±2.7 / 0.17
Percent NIH area % / 72 ± 12 / 78 ± 9.3 / 75.5 ± 10 / 0.21
Lipid arc o / 199 ± 74 / 233 ± 55.7 / 237±75 / 0.47

Values are mean ± SD, median (interquartile range), or n (%). CSA = cross-sectional area; EEM = external elastic membrane; OFDI= optical frequency domain imaging.

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