Supplementary Table S5: The top-20 genes for which expression levels were inversely correlated with miR-365 expression in 37 children with BCP-ALL and the identification of these genes by publicly available target prediction algorithms and/or of validated miRNA-mRNA interactions.

# / Gene symbol / miRNA-mRNA association P value / Microcosm / pita / TargetScan / miRecords / miRtarbase
1 / MYBL2 / 0.000 / TRUE / FALSE / FALSE / FALSE / FALSE
2 / CSMD1 / 0.000 / FALSE / FALSE / TRUE / FALSE / FALSE
3 / UGT8 / 0.000 / TRUE / FALSE / FALSE / FALSE / FALSE
4 / FGF9 / 0.000 / TRUE / FALSE / FALSE / FALSE / FALSE
5 / PITPNM2 / 0.001 / FALSE / FALSE / TRUE / FALSE / FALSE
6 / HDAC4 / 0.001 / FALSE / FALSE / TRUE / FALSE / FALSE
7 / SPON2 / 0.002 / TRUE / FALSE / FALSE / FALSE / FALSE
8 / PLEKHB2 / 0.002 / FALSE / FALSE / TRUE / FALSE / FALSE
9 / CHD4 / 0.003 / TRUE / FALSE / FALSE / FALSE / FALSE
10 / SLC15A1 / 0.003 / TRUE / FALSE / FALSE / FALSE / FALSE
11 / AFAP1L1 / 0.004 / TRUE / FALSE / TRUE / FALSE / FALSE
12 / MCOLN2 / 0.005 / TRUE / FALSE / FALSE / FALSE / FALSE
13 / DNAH12 / 0.006 / TRUE / FALSE / FALSE / FALSE / FALSE
14 / ZAP-70 / 0.006 / TRUE / FALSE / FALSE / FALSE / FALSE
15 / SLC6A15 / 0.008 / TRUE / FALSE / FALSE / FALSE / FALSE
16 / FAM60A / 0.008 / TRUE / FALSE / TRUE / FALSE / FALSE
17 / EPAS1 / 0.011 / FALSE / TRUE / TRUE / FALSE / FALSE
18 / KCNA7 / 0.012 / FALSE / FALSE / TRUE / FALSE / FALSE
19 / SEMA6D / 0.014 / FALSE / TRUE / FALSE / FALSE / FALSE
20 / SSTR3 / 0.014 / TRUE / FALSE / FALSE / FALSE / FALSE

The possibility of miRNA-mRNA binding was calculated using three commonly used tools for target prediction: TargetScan version 6.1 (www.targetscan.org), microCosm version 5 (formerly miRBase Targets, http://www.ebi.ac.uk/enright-srv/microcosm/cgi-bin/targets/v5/search.pl), and PITA version from 2007 (http://genie.weizmann.ac.il/pubs/mir07/mir07_data.html). In addition, two databases containing validated targets were selected: miRecords version November 25, 2010 (http://mirecords.biolead.org/), and miRTarBase release 3.5 (http://mirtarbase.mbc.nctu.edu.tw/). TRUE indicates the possibility of miRNA binding to the candidate target gene and FALSE means there was no predicted binding site for the miRNA in 3’ UTR of candidate target gene.