Supplementary Tables

Supplementary Table S1. Sample characteristics.

Diagnosis / WHO grade / Ki-67 / p53 / MGMT a / 1p & 19q / Radiotherapy
Recurrent AO / III / 10% / positive / <1% negative / 1p deletion / CCRT b 55.8 Gy

aMGMT, O6-methylguanine–DNA methyltransferase.

bCCRT, Concurrent chemoradiotherapy, temozolomide based.

Supplementary Table S3. The proteins of anti-apoptosis identified in recurrent AO.

Accesions / Gene_Symbol / Gene product
IPI00000760 / DDAH2 / dimethylargininedimethylaminohydrolase 2
IPI00003362 / HSPA5 / heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IPI00003815 / ARHGDIA / Rho GDP dissociation inhibitor (GDI) alpha
IPI00007765 / HSPA9 / heat shock 70kDa protein 9 (mortalin)
IPI00012011 / CFL1 / cofilin 1 (non-muscle)
IPI00021263 / YWHAZ / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
IPI00021369 / CRYAB / crystallin, alpha B
IPI00021842 / APOE / apolipoprotein E
IPI00022314 / SOD2 / superoxide dismutase 2, mitochondrial
IPI00025512 / HSPB1 / heat shock 27kDa protein 1
IPI00027230 / HSP90B1 / heat shock protein 90kDa beta (Grp94), member 1
IPI00027350 / PRDX2 / peroxiredoxin 2
IPI00071059 / BAX / BCL2-associated X protein
IPI00218733 / SOD1 / superoxide dismutase 1, soluble
IPI00219757 / GSTP1 / glutathione S-transferase pi 1
IPI00220740 / NPM1 / nucleophosmin (nucleolar phosphoprotein B23, numatrin)
IPI00220766 / GLO1 / glyoxalase I
IPI00329801 / ANXA5 / annexin A5
Accesions / Gene_Symbol / Gene product
IPI00000874 / PRDX1 / peroxiredoxin 1
IPI00003479 / MAPK1 / mitogen-activated protein kinase 1
IPI00007926 / C6orf108 / chromosome 6 open reading frame 108
IPI00013004 / PDXK / pyridoxal (pyridoxine, vitamin B6) kinase
IPI00015148 / RAP1B / RAP1B, member of RAS oncogene family
IPI00021304 / KRT2 / keratin 2
IPI00021347 / UBE2L3 / ubiquitin-conjugating enzyme E2L 3
IPI00021841 / APOA1 / apolipoprotein A-I
IPI00022744 / CSE1L / CSE1 chromosome segregation 1-like (yeast)
IPI00027350 / PRDX2 / peroxiredoxin 2
IPI00215747 / FABP7 / fatty acid binding protein 7, brain
IPI00218493 / HPRT1 / hypoxanthine phosphoribosyltransferase 1
IPI00299399 / S100B / S100 calcium binding protein B
IPI00784154 / HSPD1 / heat shock 60kDa protein 1 (chaperonin)

Supplementary Table S4. The proteins of cell proliferation identified in recurrent AO.

Supplementary Table S5.The protein of cell adhesion identifiedin recurrent AO.

Accesions / Gene_Symbol / Gene product
IPI00013303 / LSAMP / limbic system-associated membrane protei
IPI00019502 / MYH9 / myosin, heavy chain 9, non-muscle
IPI00022892 / THY1 / Thy-1 cell surface antigen
IPI00159927 / NCAN / neurocan
IPI00160552 / TNR / tenascin R (restrictin, janusin)
IPI00177817 / ATP2A2 / ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
IPI00215629 / VCAN / versican
IPI00298994 / TLN1 / talin 1
IPI00376427 / NCAM2 / neural cell adhesion molecule 2
IPI00411478 / NCAM1 / neural cell adhesion molecule 1
IPI00456623 / BCAN / brevican
Accesions / Gene_Symbol / Gene product
IPI00019502 / MYH9 / myosin, heavy chain 9, non-muscle
IPI00021304 / KRT2 / keratin 2
IPI00021841 / APOA1 / apolipoprotein A-I
IPI00025512 / HSPB1 / heat shock 27kDa protein 1
IPI00027493 / SLC3A2 / solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
IPI00031370 / TUBB2B / tubulin, beta 2B class IIb
IPI00160552 / TNR / tenascin R (restrictin, janusin)
IPI00419585 / PPIA / peptidylprolyl isomerase A (cyclophilin A)
IPI00974544 / YWHAE / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

Supplementary Table S6.The protein of cell migration identifiedin recurrent AO.

Supplementary Table S7. The proteins associated with EGFR signaling identified in recurrent AO.

Accesions / Gene_Symbol / Gene product
IPI00004838 / CRK / v-crk sarcoma virus CT10 oncogene homolog (avian)
IPI00012011 / CFL1 / cofilin 1 (non-muscle)
IPI00014230 / C1QBP / complement component 1, q subcomponent binding protein
IPI00021369 / CRYAB / crystallin, alpha B
IPI00021439 / ACTB / actin, beta
IPI00024067 / CLTC / clathrin, heavy chain (Hc)
IPI00071059 / BAX / BCL2-associated X protein
IPI00289499 / ATIC / 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
IPI00395769 / ATP5C1 / ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
IPI00414123 / CRMP1 / collapsin response mediator protein 1
IPI00456623 / BCAN / brevican
IPI00456969 / DYNC1H1 / dynein, cytoplasmic 1, heavy chain 1
PI00465436 / CAT / catalase
IPI00465439 / ALDOA / aldolase A, fructose-bisphosphate
IPI00844578 / DHX9 / DEAH (Asp-Glu-Ala-His) box polypeptide 9