Supplementary Table I. Amyotrophic Lateral Sclerosis Signaling Pathway Targets and Drugs*

Supplementary Table I. Amyotrophic Lateral Sclerosis Signaling Pathway Targets and Drugs*

Target(s) / Drug(s)
AKT3 / enzastaurin
Bcl-2 / oblimersen, (-)-gossypol
CCS / Unknown
NOS1 / GW 273629, omega-N-methylarginine
PPP3CA / ISAtx-247, tacrolimus, pimecrolimus, cyclosporin A
SLC1A2 / riluzole
VEGF / bevacizumab

* only targets with a known drug are represented.

Supplementary Table II. Cell Cycle G2/M DNA Damage Checkpoint Regulation Pathway Targets and Drugs*

Target(s) / Drug(s)
Cdc2 / flavopiridol
CDK7 / BMS-387032, flavopiridol
Chk1 / UCN-01
Plk1 / BI 2536
Topo II / Etoposide, doxorubicin

* only targets with a known drug are represented.

Supplementary Table III. Glucocorticoid Receptor Signaling Pathway Targets and Drugs*

Target(s) / Drug(s)
ADRB2 / articaine/epinephrine, bupivacaine/epinephrine, carteolol, dipivefrin, arbutamine, carbetapentane/chlorpheniramine/ephedrine/phenylephrine, epinephrine, dobutamine meluadrine, epinephrine/prilocaine, epinephrine/lidocaine, KUR 1246, KUL 7211, arformoterol, PYM-50018, budesonide/formoterol, nebivolol, fluticasone/salmeterol, ipratropium/albuterol, carvedilol, ephedrine, guanethidine, levalbuterol, propranolol, pindolol, esmolol, metoprolol, salmeterol, dorzolamide/timolol, fluoxetine/olanzapine, guanadrel, bendroflumethiazide/nadolol, isoxsuprine, hydrochlorothiazide/propranolol, hydrochlorothiazide/timolol, isoproterenol, sotalol, nadolol, timolol, isoetharine, ritodrine, olanzapine, venlafaxine, labetalol, formoterol, bitolterol, albuterol, terbutaline, pirbuterol, metaproterenol sulfate,
AR / estradiol valerate/testosterone enanthate, estradiol cypionate/testosterone cypionate, bicalutamide, flutamide, nandrolone decanoate, testosterone cypionate, medroxyprogesterone acetate, oxandrolone, danazol, stanozolol, spironolactone, testosterone, oxymetholone, testosterone propionate, testosterone enanthate
Bcl-2 / oblimersen, (-)-gossypol
c-Raf / sorafenib
ER / 17-alpha-ethinylestradiol, fulvestrant, beta-estradiol, estradiol 17beta-cypionate, estrone, estradiol valerate, 3-(4-methoxy)phenyl-4-((4-(2-(1-piperidinyl)ethoxy)phenyl)methyl)-2H-1-benzopyran-7-ol, bazedoxifene, estradiol valerate/testosterone enanthate, TAS-108, ethinyl estradiol/ethynodiol diacetate, estradiol acetate, esterified estrogens, estradiol cypionate/medroxyprogesterone acetate, conjugated estrogens/meprobamate, estradiol/norethindrone acetate, synthetic conjugated estrogens, A, estradiol cypionate/testosterone cypionate, synthetic conjugated estrogens, B, CC8490, MITO-4509, ethinyl estradiol/desogestrel, ethinyl estradiol/drospirenone, premarin, ethinyl estradiol/norelgestromin, ethinyl estradiol/norethindrone, ethinyl estradiol/levonorgestrel, ethinyl estradiol/norgestrel, ethinyl estradiol/norgestimate, conjugated estrogen/medroxyprogesterone acetate, diethylstilbestrol, FC1271A, toremifene, tamoxifen, raloxifene, arzoxifene, clomiphene, estramustine phosphate, diethylstilbestrol diphosphate, estropipate
FGG / thrombin
GR / rimexolone, medrysone, clocortolone pivalate, diflorasone diacetate, fluorometholone, dexamethasone phosphate, cortisone acetate, halcinonide, flurandrenolide, desoximetasone, desonide, prednisolone, clobetasol propionate, fluocinolone acetonide, prednisone, hydrocortisone, triamcinolone, dexamethasone 21-acetate, 11beta hydrocortisone acetate, betamethasone, dexamethasone, budesonide, fluticasone, beclomethasone dipropionate, acetic acid/hydrocortisone, betamethasone acetate/betamethasone phosphate, betamethasone acetate, triamcinolone acetonide, ciprofloxacin/hydrocortisone, dexamethasone/neomycin/polymyxin B, ciprofloxacin/dexamethasone, ORG 34517, ciclesonide, betamethasone dipropionate/calcipotriene, fluticasone furoate, budesonide/formoterol, difluprednate, clotrimazole/betamethasone dipropionate, fluticasone/salmeterol, dexamethasone/tobramycin, clotrimazole/betamethasone, miconazole, prednisolone acetate, clioquinol/hydrocortisone, methylprednisolone acetate, mometasone furoate, amcinonide, methylprednisolone succinate, betamethasone phosphate, fluocinonide, prednicarbate, hydrocortisone cypionate, hydrocortisone succinate, prednisolone phosphate, betamethasone valerate, betamethasone benzoate, fludrocortisone acetate, prednisolone tebutate, betamethasone dipropionate, hydrocortisone buteprate, alclometasone dipropionate, hydrocortisone butyrate, fluorometholone acetate, hydrocortisone valerate, nystatin/triamcinolone acetonide, loteprednol etabonate, hydrocortisone phosphate, methylprednisolone, halobetasol propionate, flunisolide
HSP90 / CNF2024, SNX5422, IPI-504
IL-1β / IL-1 trap
IL-6 / tocilizumab
iNOS / GW 273629, omega-N-methylarginine
MR / hydrochlorothiazide/spironolactone, fludrocortisone acetate, drospirenone, spironolactone, eplerenone
p65/RelA / NF-kappaB decoy
PAI-1 / drotrecogin alfa
PGR / misoprostol, dienogest, HRP-2000, asoprisnil, ethynodiol diacetate, norethindrone acetate, ethinyl estradiol/ethynodiol diacetate, estradiol cypionate/medroxyprogesterone acetate, tosagestin, estradiol/norethindrone acetate, ZK 230211, nestorone, ethinyl estradiol/desogestrel, ethinyl estradiol/drospirenone, ethinyl estradiol/norelgestromin, ethinyl estradiol/norethindrone, ethinyl estradiol/levonorgestrel, ethinyl estradiol/norgestrel, ethinyl estradiol/norgestimate, conjugated estrogen/medroxyprogesterone acetate, mometasone furoate, megestrol acetate, drospirenone, medroxyprogesterone acetate, norgestrel, desogestrel, levonorgestrel, norelgestromin, norethindrone, norgestimate, progesterone
TNFα / adalimumab, etanercept, infliximab, CDP870, golimumab, thalidomide

* only targets with a known drug are represented.

Supplementary Table IV. Glutamate Receptor Signaling Pathway Targets and Drugs*

Target(s) / Drug(s)
GRM1 / fasoracetam
GRM2 / LY-544344, fasoracetam
GRM3 / fasoracetam
GRM4 / fasoracetam
GRM5 / fasoracetam
GRM6 / fasoracetam
GRM7 / fasoracetam
GRM8 / fasoracetam

* only targets with a known drug are represented.

Supplementary Table V. p53 Signaling Pathway Targets and Drugs*

Target(s) / Drug(s)
Bcl-2 / oblimersen, (-)-gossypol
CDK2 / BMS-387032, flavopiridol
CDK4 / PD-0332991, flavopiridol
Chk1 / UCN-01
Gsk3β / enzastaurin
HDAC / tributyrin, PXD101, pyroxamide, vorinostat, FR 901228
JNK1 / aplidine
p38 MAPK / SCIO-469, RO-3201195
p53R2 / triapine, hydroxyurea

* only targets with a known drug are represented.

Supplementary Table VI. Wnt/β-catenin Pathway Targets and Drugs*

Target(s) / Drug(s)
HDAC1 / tributyrin, PXD101, pyroxamide, MGCD0103, vorinostat, FR 901228
PPARδ / GW501516
Src / dasatinib, AZM-475271

* only targets with a known drug are represented.