Supplementary Table 2: List of Genes Differentially Expressed in NNK-Induced Mouse Lung Tumors

Supplementary Table 2: List of genes differentially expressed in NNK-induced mouse lung tumors

Gene Symbol / Entrez Gene Name / Fold Change / False Discovery Rate (q-value) / Location / Type(s) / Drug(s)
1300002K09Rik / RIKEN cDNA 1300002K09 gene / 2.702 / 1.32E-02 / Other / other
5430421N21Rik / keratin 83 / 8.572 / 2.70E-02 / Cytoplasm / other
A530076I17Rik / RIKEN cDNA A530076I17 gene / 7.97 / 2.83E-02 / Other / other
Aass / aminoadipate-semialdehyde synthase / 2.468 / 1.46E-03 / Cytoplasm / enzyme
Acta1 / actin, alpha 1, skeletal muscle / -6.125 / 2.85E-02 / Cytoplasm / other
Actc1 / actin, alpha, cardiac muscle 1 / -2.642 / 1.35E-02 / Cytoplasm / enzyme
Adamts4 / ADAM metallopeptidase with thrombospondin type 1 motif, 4 / 5.237 / 4.32E-03 / Extracellular Space / peptidase
Adm2 / adrenomedullin 2 / 9.597 / 6.03E-03 / Extracellular Space / other
Agt / angiotensinogen (serpin peptidase inhibitor, clade A, member 8) / -3.364 / 1.46E-02 / Extracellular Space / growth factor
Alas2 / aminolevulinate, delta-, synthase 2 / -3.229 / 1.79E-02 / Cytoplasm / enzyme
Aldh1l2 / aldehyde dehydrogenase 1 family, member L2 / 4.641 / 3.18E-06 / Cytoplasm / enzyme
Ank1 / ankyrin 1, erythrocytic / -2.132 / 1.91E-02 / Plasma Membrane / other
Ankrd1 / ankyrin repeat domain 1 (cardiac muscle) / -2.202 / 3.56E-02 / Cytoplasm / transcription regulator
Ankrd22 / ankyrin repeat domain 22 / 10.419 / 4.37E-06 / Nucleus / transcription regulator
Ankrd34b / ankyrin repeat domain 34B / 5.336 / 1.69E-02 / Nucleus / transcription regulator
Apobec2 / apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 / -3.846 / 4.73E-02 / Other / enzyme
Areg / amphiregulin / 4.042 / 6.79E-04 / Extracellular Space / growth factor
Arg2 / arginase 2 / 4.72 / 4.63E-08 / Cytoplasm / enzyme
Arnt2 / aryl-hydrocarbon receptor nuclear translocator 2 / 3.055 / 3.59E-03 / Nucleus / transcription regulator
Art1 / ADP-ribosyltransferase 1 / -5.08 / 1.45E-02 / Plasma Membrane / enzyme
Asgr1 / asialoglycoprotein receptor 1 / -2.208 / 2.33E-02 / Plasma Membrane / transmembrane receptor
Asprv1 / aspartic peptidase, retroviral-like 1 / 5.738 / 1.13E-02 / Other / peptidase
Atp13a5 / ATPase type 13A5 / 3.205 / 2.78E-02 / Other / transporter
Atp6v0a4 / ATPase, H+ transporting, lysosomal V0 subunit a4 / 2.957 / 4.68E-02 / Cytoplasm / transporter
Atp6v1g3 / ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 / 5.478 / 5.95E-04 / Cytoplasm / transporter
Awat1 / acyl-CoA wax alcohol acyltransferase 1 / 35.725 / 6.22E-08 / Other / other
BC023105 / cDNA sequence BC023105 / 11.116 / 1.87E-03 / Other / other
BC030867 / chromosome 17 open reading frame 53 / 7.426 / 6.46E-04 / Other / other
Bcl2l15 / BCL2-like 15 / 7.967 / 1.30E-10 / Nucleus / other
Bhlha15 / basic helix-loop-helix family, member a15 / 3.394 / 6.46E-04 / Nucleus / transcription regulator
C130080G10Rik / RIKEN cDNA C130080G10 gene / -5.659 / 7.28E-03 / Other / other
C5ar2 / complement component 5a receptor 2 / 2.506 / 4.75E-03 / Plasma Membrane / G-protein coupled receptor
Camsap3 / calmodulin regulated spectrin-associated protein family, member 3 / 2.03 / 9.28E-04 / Cytoplasm / other
Capn13 / calpain 13 / -2.842 / 3.77E-02 / Other / other
Capn6 / calpain 6 / -2.711 / 5.92E-04 / Cytoplasm / peptidase
Casq2 / calsequestrin 2 (cardiac muscle) / -3.674 / 1.22E-02 / Cytoplasm / other
Ccl8 / chemokine (C-C motif) ligand 8 / 3.731 / 2.42E-02 / Extracellular Space / other
Cd101 / CD101 molecule / 2.335 / 3.16E-02 / Plasma Membrane / other
Cd164l2 / CD164 sialomucin-like 2 / 2.268 / 3.62E-02 / Other / other
Cd177 / CD177 molecule / 4.664 / 4.16E-02 / Cytoplasm / other
Cd300ld / CD300 molecule-like family member d / 2.704 / 1.27E-02 / Plasma Membrane / other
Cd33 / CD33 antigen / 2.456 / 1.10E-02 / Plasma Membrane / other
Cd74 / CD74 molecule, major histocompatibility complex, class II invariant chain / 2.294 / 9.00E-08 / Plasma Membrane / transmembrane receptor
Cdh23 / cadherin-related 23 / 2.771 / 4.59E-02 / Plasma Membrane / transporter
Celf4 / CUGBP, Elav-like family member 4 / 2.203 / 5.84E-03 / Nucleus / translation regulator
Ch25h / cholesterol 25-hydroxylase / 2.058 / 4.86E-02 / Cytoplasm / enzyme
Chad / chondroadherin / -2.802 / 3.63E-03 / Extracellular Space / other
Cideb / cell death-inducing DFFA-like effector b / 2.476 / 7.03E-03 / Cytoplasm / other
Ckm / creatine kinase, muscle / -5.03 / 1.60E-02 / Cytoplasm / kinase
Cldn2 / claudin 2 / 4.05 / 1.27E-03 / Plasma Membrane / other
Clec4d / C-type lectin domain family 4, member D / 4.279 / 2.58E-03 / Plasma Membrane / other
Cmya5 / cardiomyopathy associated 5 / -2.048 / 3.57E-04 / Cytoplasm / other
Corin / corin, serine peptidase / 2.987 / 2.42E-02 / Plasma Membrane / peptidase
Cox7a1 / cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) / -2.276 / 5.68E-03 / Cytoplasm / enzyme
Cox8b / cytochrome c oxidase subunit VIIIb / -3.087 / 6.35E-03 / Cytoplasm / enzyme
Cpne2 / copine II / 2.373 / 1.11E-11 / Other / other
Csf2rb / colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) / 2.188 / 8.21E-04 / Plasma Membrane / transmembrane receptor / sargramostim, EPO/sargramostim, rituximab/sargramostim
Csf3r / colony stimulating factor 3 receptor (granulocyte) / 3.922 / 3.84E-04 / Plasma Membrane / transmembrane receptor / cladribine/cytarabine/filgrastim, cytarabinerastim
Csmd1 / CUB and Sushi multiple domains 1 / 6.921 / 1.08E-05 / Plasma Membrane / other
Ctla4 / cytotoxic T-lymphocyte-associated protein 4 / 3.72 / 1.45E-02 / Plasma Membrane / transmembrane receptor / ipilimumab, ticilimumab
Ctsk / cathepsin K / 2.085 / 1.21E-02 / Cytoplasm / peptidase
Cxcl9 / chemokine (C-X-C motif) ligand 9 / 8.168 / 2.10E-03 / Extracellular Space / cytokine
Cxcr1 / chemokine (C-X-C motif) receptor 1 / 4.008 / 1.43E-03 / Plasma Membrane / G-protein coupled receptor / repertaxin, SB-265610
Cxcr2 / chemokine (C-X-C motif) receptor 2 / 6.379 / 4.63E-03 / Plasma Membrane / G-protein coupled receptor / repertaxin, SB-265610
Cyp1a1 / cytochrome P450, family 1, subfamily A, polypeptide 1 / -14.738 / 6.83E-04 / Cytoplasm / enzyme
Cyp2e1 / cytochrome P450, family 2, subfamily E, polypeptide 1 / -3.615 / 6.46E-04 / Cytoplasm / enzyme
Cyp4a12a / cytochrome P450, family 4, subfamily A, polypeptide 22 / 7.005 / 3.37E-02 / Cytoplasm / enzyme
D10Bwg1379e / KIAA1244 / 2.026 / 4.16E-04 / Other / other
D330050G23Rik / RIKEN cDNA D330050G23 gene / 8.686 / 1.57E-03 / Other / other
Dhrs9 / dehydrogenase/reductase (SDR family) member 9 / 2.602 / 5.49E-03 / Cytoplasm / enzyme
Dpyd / dihydropyrimidine dehydrogenase / -2.164 / 3.10E-03 / Cytoplasm / enzyme / eniluracil
Dusp4 / dual specificity phosphatase 4 / 2.785 / 4.29E-05 / Nucleus / phosphatase
E030013I19Rik / RIKEN cDNA E030013I19 gene / -2.028 / 4.66E-02 / Other / other
Ebf2 / early B-cell factor 2 / -13.03 / 1.49E-02 / Nucleus / other
Egr1 / early growth response 1 / 2.84 / 7.42E-04 / Nucleus / transcription regulator
Emilin2 / elastin microfibril interfacer 2 / 2.318 / 2.45E-03 / Extracellular Space / other
Ereg / epiregulin / 23.915 / 6.32E-08 / Extracellular Space / growth factor
Etv4 / ets variant 4 / 13.761 / 2.49E-13 / Nucleus / transcription regulator
F830016B08Rik / RIKEN cDNA F830016B08 gene / 3.937 / 2.30E-02 / Other / other
Fabp3 / fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) / -2.91 / 5.44E-03 / Cytoplasm / transporter
Fam102b / family with sequence similarity 102, member B / 2.07 / 7.62E-07 / Other / other
Fam150a / family with sequence similarity 150, member A / 2.131 / 6.58E-03 / Other / other
Fam64a / family with sequence similarity 64, member A / -2.535 / 3.32E-02 / Nucleus / other
Fam83a / family with sequence similarity 83, member A / 5.68 / 7.90E-05 / Other / other
Fasn / fatty acid synthase / 2.096 / 1.74E-05 / Cytoplasm / enzyme / orlistat, cerulenin
Fbp2 / fructose-1,6-bisphosphatase 2 / 4.956 / 7.80E-08 / Cytoplasm / phosphatase
Fbxl16 / F-box and leucine-rich repeat protein 16 / 2.455 / 3.62E-02 / Cytoplasm / other
Fgf12 / fibroblast growth factor 12 / -3.712 / 3.15E-02 / Extracellular Space / other
Fgf7 / fibroblast growth factor 7 / -2.163 / 1.20E-02 / Extracellular Space / growth factor
Fmo4 / flavin containing monooxygenase 4 / 3.135 / 1.44E-03 / Cytoplasm / enzyme
Fmo6 / flavin containing monooxygenase 6 / -4.368 / 6.87E-03 / Other / other
Fndc5 / fibronectin type III domain containing 5 / -2.609 / 3.31E-02 / Other / other
Fos / FBJ murine osteosarcoma viral oncogene homolog / 2.303 / 1.37E-03 / Nucleus / transcription regulator
Foxp3 / forkhead box P3 / 4.067 / 2.35E-02 / Nucleus / transcription regulator
Frem2 / FRAS1 related extracellular matrix protein 2 / -2.745 / 1.49E-04 / Extracellular Space / other
Frmpd1 / FERM and PDZ domain containing 1 / 2.412 / 5.80E-03 / Cytoplasm / other
Fut2 / fucosyltransferase 2 (secretor status included) / 2.627 / 6.29E-03 / Cytoplasm / enzyme
Fut4 / fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) / 2.146 / 1.39E-03 / Cytoplasm / enzyme
Galnt5 / polypeptide N-acetylgalactosaminyltransferase 5 / -2.084 / 2.00E-02 / Cytoplasm / enzyme
Gdf15 / growth differentiation factor 15 / 2.373 / 8.04E-04 / Extracellular Space / growth factor
Gdnf / glial cell derived neurotrophic factor / 2.284 / 7.07E-06 / Extracellular Space / growth factor
Gdpd2 / glycerophosphodiester phosphodiesterase domain containing 2 / 2.617 / 6.90E-03 / Plasma Membrane / enzyme
Gja3 / gap junction protein, alpha 3, 46kDa / 8.476 / 4.39E-02 / Plasma Membrane / transporter
Gjb1 / gap junction protein, beta 1, 32kDa / 2.778 / 6.10E-03 / Plasma Membrane / transporter
Gjb3 / gap junction protein, beta 3, 31kDa / 3.808 / 4.63E-08 / Plasma Membrane / transporter
Gjb4 / gap junction protein, beta 4, 30.3kDa / 7.242 / 1.85E-06 / Plasma Membrane / transporter
Gm10863 / predicted gene 10863 / 5.409 / 4.71E-03 / Other / other
Gm12171 / predicted gene 12171 / -44.517 / 8.75E-03 / Other / other
Gm14548 / leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 / 2.103 / 1.43E-02 / Plasma Membrane / transmembrane receptor
Gm15401 / predicted gene 15401 / 10.718 / 1.28E-03 / Other / other
Gm21188 / predicted gene, 21188 / 3.254 / 2.40E-02 / Other / other
Gp49a / leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 / 2.067 / 9.61E-03 / Plasma Membrane / other
Grik2 / glutamate receptor, ionotropic, kainate 2 / 2.926 / 2.32E-02 / Plasma Membrane / ion channel
H19 / H19, imprinted maternally expressed transcript (non-protein coding) / -3.048 / 1.46E-02 / Cytoplasm / other
H2-DMa / major histocompatibility complex, class II, DM alpha / 2.051 / 6.54E-05 / Cytoplasm / other
H2-Eb1 / major histocompatibility complex, class II, DR beta 5 / 2.053 / 1.70E-02 / Plasma Membrane / transmembrane receptor
H2-M2 / histocompatibility 2, M region locus 2 / 10.56 / 6.07E-06 / Plasma Membrane / other
H2-Q7 / major histocompatibility complex, class I, A / 2.159 / 6.38E-03 / Plasma Membrane / other
Hal / histidine ammonia-lyase / 2.61 / 2.41E-03 / Cytoplasm / enzyme
Hamp / hepcidin antimicrobial peptide / -4.855 / 4.33E-02 / Extracellular Space / other
Hbb-bt / hemoglobin, beta / -3.706 / 7.31E-03 / Cytoplasm / transporter / iron dextran
Hecw1 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 / 12.252 / 1.35E-04 / Cytoplasm / enzyme
Hfe2 / hemochromatosis type 2 (juvenile) / -5.923 / 1.93E-03 / Plasma Membrane / other
Hgfac / HGF activator / 2.257 / 7.86E-04 / Extracellular Space / peptidase
Hk2 / hexokinase 2 / 2.714 / 3.10E-04 / Cytoplasm / kinase
Hrc / histidine rich calcium binding protein / -5.057 / 4.53E-02 / Cytoplasm / other
Hs3st3a1 / heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 / 3.105 / 2.94E-02 / Cytoplasm / enzyme
Hs3st3b1 / heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 / 2.183 / 8.75E-06 / Cytoplasm / enzyme
Igdcc4 / immunoglobulin superfamily, DCC subclass, member 4 / -2.194 / 9.05E-03 / Plasma Membrane / other
Igha / immunoglobulin heavy constant alpha / 11.233 / 1.72E-10 / Plasma Membrane / other
Ighg2b / immunoglobulin heavy constant gamma 2B / 6.108 / 2.58E-02 / Extracellular Space / other
Ighg2c / immunoglobulin heavy constant gamma 2C / 7.653 / 2.16E-02 / Extracellular Space / other
Igj / immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides / 5.715 / 2.51E-05 / Extracellular Space / other
Igkc / immunoglobulin kappa constant / 4.423 / 5.07E-03 / Extracellular Space / other
Igkv1-110 / immunoglobulin kappa variable 1-110 / 10.898 / 1.69E-03 / Other / other
Igkv4-68 / immunoglobulin kappa variable 4-68 / 11.039 / 1.82E-02 / Plasma Membrane / other
Igsf6 / immunoglobulin superfamily, member 6 / 2.046 / 4.01E-02 / Plasma Membrane / transmembrane receptor
Il18rap / interleukin 18 receptor accessory protein / 2.637 / 7.26E-03 / Plasma Membrane / transmembrane receptor
Il1b / interleukin 1, beta / 2.892 / 1.57E-03 / Extracellular Space / cytokine / canakinumab, gevokizumab, canakinumab/INS, gallium nitrate
Il1f9 / interleukin 36, gamma / 5.817 / 8.04E-04 / Extracellular Space / cytokine
Il1r2 / interleukin 1 receptor, type II / 12.312 / 6.92E-04 / Plasma Membrane / transmembrane receptor
Il4i1 / interleukin 4 induced 1 / 2.69 / 4.81E-02 / Cytoplasm / enzyme
Itga9 / integrin, alpha 9 / 2.248 / 1.27E-06 / Plasma Membrane / other
Itgax / integrin, alpha X (complement component 3 receptor 4 subunit) / 2.193 / 1.95E-05 / Plasma Membrane / transmembrane receptor
Itgb1bp2 / integrin beta 1 binding protein (melusin) 2 / -2.765 / 1.27E-02 / Other / other
Kcnc3 / potassium voltage-gated channel, Shaw-related subfamily, member 3 / 2.024 / 8.75E-06 / Plasma Membrane / ion channel
Kcnf1 / potassium voltage-gated channel, subfamily F, member 1 / 2.185 / 2.17E-02 / Plasma Membrane / ion channel
Kcnj10 / potassium inwardly-rectifying channel, subfamily J, member 10 / 2.657 / 2.92E-02 / Plasma Membrane / ion channel
Kcnj2 / potassium inwardly-rectifying channel, subfamily J, member 2 / 2.212 / 6.46E-04 / Plasma Membrane / ion channel / nicorandil, amiodarone
Kcnj3 / potassium inwardly-rectifying channel, subfamily J, member 3 / -4.675 / 4.58E-04 / Plasma Membrane / ion channel
Kcnj5 / potassium inwardly-rectifying channel, subfamily J, member 5 / -3.287 / 1.27E-02 / Plasma Membrane / ion channel / minoxidil, nicorandil, amiodarone
Klk13 / kallikrein-related peptidase 13 / 2.486 / 1.83E-04 / Extracellular Space / peptidase
Klk14 / kallikrein-related peptidase 14 / 3.73 / 1.15E-05 / Extracellular Space / peptidase
Klra17 / killer cell lectin-like receptor, subfamily A, member 17 / 4.498 / 3.64E-02 / Plasma Membrane / other
Klra9 / killer cell lectin-like receptor, subfamily A, member 4 / 7.538 / 3.37E-02 / Plasma Membrane / transmembrane receptor
Kng2 / kininogen 1 / 21.206 / 3.08E-02 / Extracellular Space / other
Lbp / lipopolysaccharide binding protein / 2.018 / 6.67E-06 / Plasma Membrane / transporter
Lcn2 / lipocalin 2 / 4.457 / 7.62E-07 / Extracellular Space / transporter
Ldb3 / LIM domain binding 3 / -2.679 / 3.96E-02 / Cytoplasm / transporter
Lif / leukemia inhibitory factor / 2.159 / 2.78E-02 / Extracellular Space / cytokine
Lingo1 / leucine rich repeat and Ig domain containing 1 / -2.807 / 2.94E-02 / Plasma Membrane / other
Lmod2 / leiomodin 2 (cardiac) / -3.43 / 1.77E-04 / Other / other
Lrat / lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) / -2.676 / 4.84E-03 / Cytoplasm / enzyme
Lrg1 / leucine-rich alpha-2-glycoprotein 1 / 2.482 / 5.75E-05 / Extracellular Space / other
Ltbp2 / latent transforming growth factor beta binding protein 2 / 2.846 / 1.30E-10 / Extracellular Space / other
Lum / lumican / -2.667 / 3.02E-02 / Extracellular Space / other
Ly6g / lymphocyte antigen 6 complex, locus A / 51.494 / 4.81E-02 / Plasma Membrane / other
Ly6k / lymphocyte antigen 6 complex, locus K / 11.107 / 1.46E-02 / Nucleus / other
Lypd2 / Ly6/Plaur domain containing 2 / -2.463 / 8.04E-03 / Other / other
Mafb / v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B / 2.505 / 1.49E-04 / Nucleus / other
Malt1 / mucosa associated lymphoid tissue lymphoma translocation gene 1 / 2.03 / 1.51E-02 / Cytoplasm / peptidase
Mapk10 / mitogen-activated protein kinase 10 / -2.932 / 1.71E-02 / Cytoplasm / kinase
Mc5r / melanocortin 5 receptor / 4.401 / 2.50E-02 / Plasma Membrane / G-protein coupled receptor
Meg3 / maternally expressed 3 / 20.147 / 3.25E-06 / Other / other
Mfsd2a / major facilitator superfamily domain containing 2A / 2.056 / 7.49E-03 / Other / other
Mgam / maltase-glucoamylase (alpha-glucosidase) / 2.987 / 3.75E-02 / Plasma Membrane / enzyme / miglitol, celgosivir, voglibose, acarbose
Mirg / miRNA containing gene / 16.157 / 1.53E-04 / Other / other
Mlana / melan-A / 2.881 / 1.42E-02 / Plasma Membrane / other
Mmp12 / matrix metallopeptidase 12 (macrophage elastase) / 4.433 / 1.47E-03 / Extracellular Space / peptidase / marimastat
Mmp25 / matrix metallopeptidase 25 / 3.657 / 6.25E-03 / Plasma Membrane / peptidase / marimastat
Mmp8 / matrix metallopeptidase 8 (neutrophil collagenase) / 5.452 / 4.71E-03 / Extracellular Space / peptidase / marimastat
Mmp9 / matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) / 4.354 / 4.71E-03 / Extracellular Space / peptidase
Mrgpra2b / MAS-related GPR, member X3 / 22.402 / 6.98E-04 / Plasma Membrane / G-protein coupled receptor
Mybpc3 / myosin binding protein C, cardiac / -2.853 / 5.84E-03 / Cytoplasm / other
Myh13 / myosin, heavy chain 13, skeletal muscle / 4.223 / 1.09E-05 / Cytoplasm / other
Myh6 / myosin, heavy chain 6, cardiac muscle, alpha / -2.725 / 1.75E-03 / Cytoplasm / enzyme
Myl1 / myosin, light chain 1, alkali; skeletal, fast / -7.114 / 1.14E-04 / Cytoplasm / other
Myl3 / myosin, light chain 3, alkali; ventricular, skeletal, slow / -5.839 / 6.46E-04 / Cytoplasm / other
Myl4 / myosin, light chain 4, alkali; atrial, embryonic / -4.805 / 2.23E-03 / Cytoplasm / other
Myl7 / myosin, light chain 7, regulatory / -4.399 / 1.20E-02 / Cytoplasm / enzyme
Mylk3 / myosin light chain kinase 3 / -3.086 / 3.38E-04 / Cytoplasm / kinase
Myo3b / myosin IIIB / 2.416 / 9.08E-04 / Plasma Membrane / kinase
Myom2 / myomesin 2 / -2.757 / 2.69E-02 / Cytoplasm / other
Nov / nephroblastoma overexpressed / 3.141 / 3.74E-03 / Extracellular Space / growth factor
Nppa / natriuretic peptide A / -4.534 / 2.35E-02 / Extracellular Space / other
Npy2r / neuropeptide Y receptor Y2 / 159.316 / 4.27E-11 / Plasma Membrane / G-protein coupled receptor / peptide YY 3-36
Nrap / nebulin-related anchoring protein / -2.484 / 1.75E-02 / Cytoplasm / other
Nrn1 / neuritin 1 / 2.416 / 8.07E-04 / Cytoplasm / other
Ntrk1 / neurotrophic tyrosine kinase, receptor, type 1 / -4.136 / 2.01E-02 / Plasma Membrane / kinase / regorafenib
Oas1g / 2'-5'-oligoadenylate synthetase 1, 40/46kDa / 2.726 / 1.08E-02 / Cytoplasm / enzyme
Oas3 / 2'-5'-oligoadenylate synthetase 3, 100kDa / 3.86 / 1.30E-02 / Cytoplasm / enzyme
Olfm4 / olfactomedin 4 / 3.798 / 4.14E-02 / Extracellular Space / other
Olfr98 / olfactory receptor 97 / 85.322 / 1.61E-04 / Plasma Membrane / G-protein coupled receptor
Ovgp1 / oviductal glycoprotein 1, 120kDa / 2.925 / 1.21E-04 / Extracellular Space / enzyme
Pabpc4l / poly(A) binding protein, cytoplasmic 4-like / -3.296 / 3.56E-02 / Other / other
Padi4 / peptidyl arginine deiminase, type IV / 3.411 / 9.92E-03 / Cytoplasm / enzyme
Parm1 / prostate androgen-regulated mucin-like protein 1 / 2.991 / 6.94E-06 / Extracellular Space / other
Pcdhb11 / protocadherin beta 11 / -2.511 / 4.99E-03 / Plasma Membrane / other
Pde1c / phosphodiesterase 1C, calmodulin-dependent 70kDa / 2.737 / 1.50E-02 / Cytoplasm / enzyme
Pde4c / phosphodiesterase 4C, cAMP-specific / 3.107 / 5.47E-03 / Cytoplasm / enzyme / dyphylline, nitroglycerin, caffeine/ergotamine, arofylline, tetomilast, L 869298, ibudilast, aminophylline, anagrelide, cilomilast, milrinone, dipyridamole, L-826,141, ketotifen, roflumilast, tolbutamide, theophylline, pentoxifylline, caffeine
Pgam2 / phosphoglycerate mutase 2 (muscle) / -2.55 / 7.02E-03 / Cytoplasm / phosphatase
Pik3r5 / phosphoinositide-3-kinase, regulatory subunit 5 / 2.026 / 6.79E-04 / Cytoplasm / kinase
Piwil4 / piwi-like RNA-mediated gene silencing 4 / 2.694 / 6.26E-04 / Cytoplasm / other
Pkib / protein kinase (cAMP-dependent, catalytic) inhibitor beta / 2.171 / 1.58E-03 / Other / other
Pln / phospholamban / -8.613 / 2.92E-04 / Cytoplasm / other
Pon1 / paraoxonase 1 / -2.324 / 3.18E-06 / Extracellular Space / phosphatase
Pram1 / PML-RARA regulated adaptor molecule 1 / 7.833 / 1.75E-03 / Other / other
Prmt8 / protein arginine methyltransferase 8 / 3.079 / 4.06E-03 / Nucleus / enzyme
Prnd / prion protein 2 (dublet) / 10.012 / 3.19E-03 / Plasma Membrane / other
Psrc1 / proline/serine-rich coiled-coil 1 / 3.919 / 1.35E-05 / Cytoplasm / other
Ptn / pleiotrophin / -2.337 / 4.49E-02 / Extracellular Space / growth factor
Ptprn2 / protein tyrosine phosphatase, receptor type, N polypeptide 2 / 5.223 / 2.50E-05 / Plasma Membrane / phosphatase
Rab3c / RAB3C, member RAS oncogene family / 2.735 / 1.94E-02 / Cytoplasm / enzyme
Rap1gap / RAP1 GTPase activating protein / 2.033 / 7.02E-03 / Cytoplasm / other
Rasd2 / RASD family, member 2 / 2.791 / 6.94E-06 / Cytoplasm / enzyme
Rbm20 / RNA binding motif protein 20 / -3.169 / 1.72E-02 / Nucleus / other
Retnlg / resistin like gamma / 8.361 / 1.48E-03 / Extracellular Space / other
Rhbdl2 / rhomboid, veinlet-like 2 (Drosophila) / 4.576 / 4.24E-06 / Plasma Membrane / peptidase
Rian / RNA imprinted and accumulated in nucleus / 12.643 / 6.81E-06 / Nucleus / other
Rims1 / regulating synaptic membrane exocytosis 1 / 4.122 / 4.34E-02 / Plasma Membrane / other
Rims2 / regulating synaptic membrane exocytosis 2 / 3.207 / 2.35E-02 / Plasma Membrane / other
Rnf223 / ring finger protein 223 / 5.712 / 2.35E-02 / Other / other
Ros1 / c-ros oncogene 1 , receptor tyrosine kinase / 5.799 / 2.56E-08 / Plasma Membrane / kinase / ceritinib
Rtl1 / retrotransposon-like 1 / 41.663 / 2.88E-02 / Other / other
Runx3 / runt-related transcription factor 3 / 2.402 / 4.05E-02 / Nucleus / transcription regulator
S100a8 / S100 calcium binding protein A8 / 7.293 / 1.73E-02 / Cytoplasm / other
S100a9 / S100 calcium binding protein A9 / 7.772 / 1.70E-02 / Cytoplasm / other
Scd1 / stearoyl-CoA desaturase (delta-9-desaturase) / 2.805 / 3.02E-08 / Cytoplasm / enzyme
Sec1 / secretory blood group 1 / 2.629 / 2.32E-05 / Cytoplasm / enzyme
Sema4d / sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D / 2.037 / 1.23E-02 / Plasma Membrane / transmembrane receptor
Sema6b / sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B / 2.007 / 1.49E-02 / Plasma Membrane / other
Serpinb5 / serpin peptidase inhibitor, clade B (ovalbumin), member 5 / 25.137 / 2.83E-04 / Extracellular Space / other
Sesn2 / sestrin 2 / 2.31 / 1.07E-05 / Cytoplasm / other
Sgca / sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) / -3.063 / 1.28E-02 / Plasma Membrane / other
Shisa6 / shisa family member 6 / 4.818 / 1.39E-04 / Other / other
Siglec1 / sialic acid binding Ig-like lectin 1, sialoadhesin / 2.463 / 1.20E-04 / Plasma Membrane / other
Siglece / sialic acid binding Ig-like lectin 9 / 2.186 / 3.39E-02 / Plasma Membrane / other
Slc15a1 / solute carrier family 15 (oligopeptide transporter), member 1 / 2.159 / 4.89E-02 / Plasma Membrane / transporter
Slc16a14 / solute carrier family 16, member 14 / 4.644 / 2.94E-02 / Other / other
Slc16a6 / solute carrier family 16, member 6 / 2.429 / 9.23E-07 / Plasma Membrane / transporter
Slc17a7 / solute carrier family 17 (vesicular glutamate transporter), member 7 / -3.776 / 3.19E-03 / Plasma Membrane / transporter
Slc25a34 / solute carrier family 25, member 34 / -3.338 / 1.61E-02 / Cytoplasm / other
Slc26a3 / solute carrier family 26 (anion exchanger), member 3 / -3.195 / 1.86E-02 / Plasma Membrane / transporter
Slc26a9 / solute carrier family 26 (anion exchanger), member 9 / 2.504 / 4.63E-08 / Plasma Membrane / transporter
Slc2a3 / solute carrier family 2 (facilitated glucose transporter), member 3 / 2.177 / 2.30E-02 / Plasma Membrane / transporter
Slc35f1 / solute carrier family 35, member F1 / 8.067 / 7.71E-03 / Other / other
Slc6a20a / solute carrier family 6 (proline IMINO transporter), member 20 / 4.905 / 8.39E-14 / Plasma Membrane / transporter
Slc7a11 / solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 / 2.118 / 4.05E-02 / Plasma Membrane / transporter
Slc7a5 / solute carrier family 7 (amino acid transporter light chain, L system), member 5 / 2.623 / 1.81E-03 / Plasma Membrane / transporter
Slfn4 / schlafen family member 12-like / 5.158 / 1.07E-03 / Other / enzyme
Smarca1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 / -2.401 / 1.08E-02 / Nucleus / transcription regulator
Smyd1 / SET and MYND domain containing 1 / -2.034 / 1.73E-02 / Nucleus / transcription regulator
Snca / synuclein, alpha (non A4 component of amyloid precursor) / -3.718 / 3.77E-02 / Cytoplasm / other
Sowahb / sosondowah ankyrin repeat domain family member B / 2.531 / 6.95E-05 / Nucleus / transcription regulator
Spag11b / sperm associated antigen 11B / 216.429 / 4.25E-08 / Extracellular Space / other
Spink5 / serine peptidase inhibitor, Kazal type 5 / 2.472 / 1.30E-03 / Extracellular Space / other
Spon2 / spondin 2, extracellular matrix protein / -4.016 / 7.07E-05 / Extracellular Space / other
Srl / sarcalumenin / -2.437 / 1.95E-03 / Cytoplasm / other
St8sia6 / ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 / 5.809 / 1.30E-10 / Cytoplasm / enzyme
Stac2 / SH3 and cysteine rich domain 2 / 2.899 / 4.24E-06 / Other / other
Stfa2l1 / stefin A2 / 9.586 / 6.58E-03 / Cytoplasm / other
Stk39 / serine threonine kinase 39 / 2.621 / 7.41E-06 / Nucleus / kinase
Svopl / SVOP-like / 5.555 / 3.61E-02 / Other / other
Synpo2l / synaptopodin 2-like / -3.071 / 2.94E-02 / Cytoplasm / other
Syt12 / synaptotagmin XII / 2.35 / 4.68E-02 / Plasma Membrane / transporter
Syt13 / synaptotagmin XIII / 3.871 / 2.15E-02 / Plasma Membrane / transporter
Sytl5 / synaptotagmin-like 5 / 3.28 / 8.29E-04 / Other / other
Tarm1 / T cell-interacting, activating receptor on myeloid cells 1 / 10.951 / 3.62E-02 / Other / other
Tc2n / tandem C2 domains, nuclear / 2.24 / 2.28E-05 / Nucleus / transporter
Tceal3 / transcription elongation factor A (SII)-like 6 / -5.15 / 2.46E-02 / Other / other
Tdgf1 / teratocarcinoma-derived growth factor 1 / -6.359 / 4.35E-02 / Extracellular Space / growth factor
Tff2 / trefoil factor 2 / -4.837 / 1.18E-02 / Extracellular Space / other
Tgm1 / transglutaminase 1 / 2.085 / 4.16E-02 / Plasma Membrane / enzyme
Tgtp1 / T cell specific GTPase 1 / 4.268 / 1.71E-02 / Other / enzyme
Thbs1 / thrombospondin 1 / 2.072 / 4.80E-02 / Extracellular Space / other
Thbs2 / thrombospondin 2 / 2.643 / 3.31E-02 / Extracellular Space / other
Tlr13 / toll-like receptor 13 / 2.419 / 6.50E-04 / Cytoplasm / other
Tmem213 / transmembrane protein 213 / 7.334 / 6.94E-06 / Other / other
Tnfsf9 / tumor necrosis factor (ligand) superfamily, member 9 / 9.677 / 1.72E-10 / Plasma Membrane / other
Tnnc1 / troponin C type 1 (slow) / -5.093 / 6.54E-03 / Cytoplasm / other / levosimendan, Ca2+
Tnni3 / troponin I type 3 (cardiac) / -3.806 / 1.00E-03 / Cytoplasm / transporter
Tnni3k / TNNI3 interacting kinase / -9.06 / 2.27E-03 / Cytoplasm / kinase
Tnnt2 / troponin T type 2 (cardiac) / -3.874 / 2.84E-02 / Cytoplasm / other
Trem2 / triggering receptor expressed on myeloid cells 2 / 2.095 / 2.83E-02 / Plasma Membrane / transmembrane receptor
Trim54 / tripartite motif containing 54 / -9.1 / 5.24E-04 / Cytoplasm / other
Trpm2 / transient receptor potential cation channel, subfamily M, member 2 / 6.363 / 9.16E-05 / Plasma Membrane / ion channel
Trpv6 / transient receptor potential cation channel, subfamily V, member 6 / 2.645 / 2.05E-04 / Plasma Membrane / ion channel
Tspan11 / tetraspanin 11 / 2.445 / 4.98E-04 / Other / other
Txlnb / taxilin beta / -3.623 / 7.60E-04 / Cytoplasm / other
Ubd / ubiquitin D / 31.684 / 8.40E-03 / Nucleus / other
Wdr81 / WD repeat domain 81 / 2.069 / 5.73E-03 / Plasma Membrane / other
Wfdc17 / WAP four-disulfide core domain 17 / 3.095 / 6.54E-05 / Other / other
Xdh / xanthine dehydrogenase / 2.023 / 6.58E-03 / Cytoplasm / enzyme / allopurinol, febuxostat
Xirp2 / xin actin-binding repeat containing 2 / -11.641 / 6.54E-03 / Other / other
Zfp385b / zinc finger protein 385B / 2.203 / 6.46E-04 / Nucleus / other
Zfp831 / zinc finger protein 831 / 3.044 / 9.08E-03 / Other / other
Zmat4 / zinc finger, matrin-type 4 / 2.675 / 5.83E-03 / Nucleus / other