Supplementary Table 1 - Summary of Single Nucleotide Polymorphisms Analyzed for Pro- and Anti-inflammatory Cytokine Genes and Trait and State Anxiety Scores

Gene / SNP / MAF / Alleles / Trait Anxiety / State Anxiety
Statistica / p-value / Model / Statistica / p-value / Model
IFNG1 / rs2069728 / .079 / G>A / 0.33 / .717 / A / 0.43 / .652 / A
IFNG1 / rs2069727 / .411 / A>G / 3.22 / .042 / A / 3.27 / .002 / R
IFNG1 / rs2069718 / .442 / C>T / 0.06 / .945 / A / 0.41 / .664 / A
IFNG1 / rs1861493 / .264 / A>G / 0.37 / .691 / A / 0.55 / .577 / A
IFNG1 / rs1861494 / .279 / T>C / 0.53 / .589 / A / 0.64 / .527 / A
IFNG1 / rs2069709 / .008 / G>T / n/a / n/a / n/a / n/a / n/a / n/a
IFNG1 / HapA3 / 0.37 / .691 / 0.55 / .577
IFNG1 / HapA5 / 3.22 / .042 / 4.69 / .010
IFNGR1 / rs9376268 / .246 / G>A / 1.45 / .237 / A / 2.19 / .114 / A
IL1B / rs1071676 / .198 / G>C / 0.86 / .427 / A / 0.88 / .415 / A
IL1B / rs1143643 / .331 / G>A / 0.69 / .501 / A / 0.42 / .660 / A
IL1B / rs1143642 / .095 / C>T / 0.33 / .716 / A / 0.27 / .762 / A
IL1B / rs1143634 / .196 / C>T / 1.04 / .354 / A / 1.00 / .370 / A
IL1B / rs1143633 / .345 / G>A / 0.15 / .863 / A / 0.21 / .808 / A
IL1B / rs1143630 / .103 / C>A / 0.43 / .648 / A / 0.36 / .701 / A
IL1B / rs3917356 / .432 / A>G / -2.03 / .043 / R / 0.33 / .720 / A
IL1B / rs1143629 / .353 / T>C / -2.54 / .012 / D / 1.91 / .150 / A
IL1B / rs1143627 / .390 / T>C / -2.39 / .018 / D / 1.81 / .167 / A
IL1B / rs16944 / .380 / G>A / -2.31 / .022 / D / 1.25 / .288 / A
IL1B / rs1143623 / .248 / G>C / -1.99 / .048 / R / 2.03 / .134 / A
IL1B / rs13032029 / .428 / C>T / 2.02 / .045 / D / 0.20 / .820 / A
IL1B / HapA1 / 1.43 / .241 / 0.44 / .644
IL1B / HapA3 / 0.01 / .925 / 0.01 / .915
IL1B / HapA4 / 0.82 / .443 / 0.38 / .686
IL1B / HapA5 / 1.04 / .356 / 1.01 / .366
IL1B / HapB1 / 0.72 / .486 / 0.89 / .412
IL1B / HapB7 / 2.31 / .102 / 2.42 / .092
IL1B / HapB9 / 1.90 / .151 / 0.18 / .835
IL1B / HapB11 / 0.37 / .691 / 0.36 / .698
IL1R1 / rs949963 / .213 / G>A / 0.12 / .890 / A / 0.46 / .635 / A
IL1R1 / rs2228139 / .066 / C>G / 0.48 / .620 / A / 1.19 / .307 / A
IL1R1 / rs3917320 / .068 / A>C / 0.37 / .543 / A / 0.00 / .967 / A
IL1R1 / rs2110726 / .333 / C>T / 0.24 / .789 / A / 0.30 / .740 / A
IL1R1 / rs3917332 / .124 / T>A / 0.80 / .449 / A / 0.58 / .560 / A
IL1R2 / rs4141134 / .401 / T>C / 2.17 / .031 / D / 2.65 / .009 / D
IL1R2 / rs11674595 / .233 / T>C / 0.02 / .977 / A / 0.91 / .406 / A
IL1R2 / rs7570441 / .393 / G>A / 2.17 / .117 / A / -2.63 / .009 / D
IL1R2 / HapA1 / 0.98 / .375 / 0.25 / .782
IL1R2 / HapA2 / 3.72 / .026 / 3.23 / .041
IL1R2 / HapA4 / 2.76 / .065 / 4.42 / .013
IL2 / rs1479923 / .302 / C>T / 0.52 / .595 / A / 1.12 / .327 / A
IL2 / rs2069776 / .244 / T>C / 0.71 / .495 / A / 1.61 / .202 / A
IL2 / rs2069772 / .238 / A>G / 1.59 / .206 / A / 2.53 / .082 / A
IL2 / rs2069777 / .054 / C>T / 1.27 / .262 / A / 0.00 / .954 / A
IL2 / rs2069763 / .287 / T>G / 0.90 / .407 / A / 0.60 / .550 / A
IL2 / HapA1 / 0.33 / .716 / 1.37 / .255
IL2 / HapA2 / 1.59 / .206 / 2.43 / .090
IL2 / HapA3 / 0.71 / .495 / 1.57 / .210
IL2 / HapA5 / 0.52 / .595 / 1.12 / .327
IL4 / rs2243248 / .101 / T>G / 0.49 / .613 / A / 1.40 / .250 / A
IL4 / rs2243250 / .260 / C>T / n/a / n/a / n/a / n/a / n/a / n/a
IL4 / rs2070874 / .219 / C>T / 1.65 / .194 / A / 0.81 / .446 / A
IL4 / rs2227284 / .399 / C>A / 0.57 / .568 / A / 0.72 / .487 / A
IL4 / rs2227282 / .401 / C>G / 0.49 / .614 / A / 0.55 / .579 / A
IL4 / rs2243263 / .124 / G>C / 0.00 / .998 / A / 0.07 / .794 / A
IL4 / rs2243266 / .203 / G>A / 0.86 / .426 / A / 0.40 / .669 / A
IL4 / rs2243267 / .205 / G>C / 0.75 / .475 / A / 0.38 / .686 / A
IL4 / rs2243274 / .262 / G>A / 0.22 / .800 / A / 0.03 / .970 / A
IL4 / HapA1 / 0.38 / .685 / 0.67 / .512
IL4 / HapA10 / 1.09 / .339 / 0.71 / .491
IL6 / rs4719714 / .196 / A>T / 2.12 / .122 / A / 1.02 / .364 / A
IL6 / rs2069827 / .071 / G>T / 1.91 / .150 / A / 0.25 / .779 / A
IL6 / rs1800796 / .095 / G>C / n/a / n/a / n/a / n/a / n/a / n/a
IL6 / rs1800795 / .355 / C>G / 2.06 / .129 / A / 2.36 / .097 / A
IL6 / rs2069835 / .066 / T>C / 1.97 / .162 / A / 0.37 / .542 / A
IL6 / rs2066992 / .091 / G>T / n/a / n/a / n/a / n/a / n/a / n/a
IL6 / rs2069840 / .308 / C>G / 2.18 / .115 / A / 0.57 / .567 / A
IL6 / rs1554606 / .405 / T>G / 0.52 / .595 / A / 0.53 / .588 / A
IL6 / rs2069845 / .405 / G>A / 0.52 / .595 / A / 0.53 / .588 / A
IL6 / rs2069849 / .039 / C>T / n/a / n/a / n/a / n/a / n/a / n/a
IL6 / rs2069861 / .083 / C>T / 0.95 / .332 / A / 4.87 / .028 / A
IL6 / rs35610689 / .242 / A>G / 2.69 / .070 / A / 1.21 / .301 / A
IL6 / HapA4 / 2.00 / .138 / 0.52 / .598
IL6 / HapA6 / 2.38 / .094 / 3.28 / .039
IL8 / rs4073 / .498 / T>A / 0.24 / .786 / A / 0.51 / .600 / A
IL8 / rs2227306 / .366 / C>T / 0.83 / .435 / A / 0.55 / .580 / A
IL8 / rs2227543 / .374 / C>T / 0.27 / .765 / A / 0.51 / .604 / A
IL8 / HapA1 / 0.49 / .611 / 0.54 / .583
IL8 / HapA3 / 0.83 / .435 / 0.55 / .580
IL8 / HapA4 / 0.24 / .786 / 0.51 / .600
IL10 / rs3024505 / .138 / C>T / 0.09 / .915 / A / 0.08 / .927 / A
IL10 / rs3024498 / .236 / A>G / 0.05 / .952 / A / 0.06 / .943 / A
IL10 / rs3024496 / .459 / T>C / 0.31 / .738 / A / 0.86 / .426 / A
IL10 / rs1878672 / .452 / G>C / 0.17 / .846 / A / 0.75 / .472 / A
IL10 / rs3024492 / .207 / A>T / 0.13 / .874 / A / 0.00 / .996 / A
IL10 / rs1518111 / .267 / G>A / 1.94 / .147 / A / 0.48 / .619 / A
IL10 / rs1518110 / .267 / G>T / 1.94 / .147 / A / 0.48 / .619 / A
IL10 / rs3024491 / .448 / T>G / 0.23 / .792 / A / 0.72 / .490 / A
IL10 / HapA5 / 0.61 / .544 / 0.11 / .895
IL10 / HapA6 / 2.00 / .138 / 0.52 / .595
IL10 / HapA8 / 0.18 / .837 / 0.01 / .992
IL10 / HapA9 / 0.07 / .929 / 0.08 / .922
IL13 / rs1881457 / .192 / A>C / 0.22 / .805 / A / 0.26 / .773 / A
IL13 / rs1800925 / .227 / C>T / 0.67 / .510 / A / 0.92 / .401 / A
IL13 / rs2069743 / .021 / A>G / n/a / n/a / n/a / n/a / n/a / n/a
IL13 / rs1295686 / .252 / G>A / 0.51 / .602 / A / 0.33 / .717 / A
IL13 / rs20541 / .174 / C>T / 0.35 / .706 / A / 0.39 / .676 / A
IL13 / HapA1 / 0.50 / .605 / 0.32 / .727
IL13 / HapA4 / 0.33 / .721 / 0.52 / .597
IL17A / rs4711998 / .293 / G>A / 0.52 / .593 / A / 1.85 / .159 / A
IL17A / rs8193036 / .255 / T>C / 0.42 / .660 / A / 0.10 / .906 / A
IL17A / rs3819024 / .374 / A>G / 1.57 / .210 / A / 0.04 / .966 / A
IL17A / rs2275913 / .345 / G>A / 1.82 / .164 / A / 0.24 / .787 / A
IL17A / rs3804513 / .027 / A>T / n/a / n/a / n/a / n/a / n/a / n/a
IL17A / rs7747909 / .225 / G>A / 3.18 / .005 / R / 3.04 / .006 / R
NFKB1 / rs3774933 / .444 / T>C / 0.52 / .596 / A / 0.43 / .649 / A
NFKB1 / rs170731 / .397 / T>A / 0.74 / .476 / A / 0.88 / .417 / A
NFKB1 / rs17032779 / .023 / T>C / n/a / n/a / n/a / n/a / n/a / n/a
NFKB1 / rs230510 / .366 / T>A / 0.78 / .462 / A / 0.11 / .897 / A
NFKB1 / rs230494 / .477 / A>G / 1.03 / .360 / A / 0.99 / .374 / A
NFKB1 / rs4648016 / .017 / C>T / n/a / n/a / n/a / n/a / n/a / n/a
NFKB1 / rs4648018 / .025 / G>C / n/a / n/a / n/a / n/a / n/a / n/a
NFKB1 / rs3774956 / .479 / C>T / 0.50 / .605 / A / 1.03 / .360 / A
NFKB1 / rs10489114 / .025 / A>G / n/a / n/a / n/a / n/a / n/a / n/a
NFKB1 / rs4648068 / .366 / A>G / 0.27 / .761 / A / 0.93 / .398 / A
NFKB1 / rs4648095 / .052 / T>C / 0.02 / .901 / A / 0.05 / .827 / A
NFKB1 / rs4648110 / .205 / T>A / 0.06 / .939 / A / 0.23 / .793 / A
NFKB1 / rs4648135 / .060 / A>G / 0.01 / .933 / A / 0.01 / .910 / A
NFKB1 / rs4648141 / .188 / G>A / 0.38 / .684 / A / 0.56 / .571 / A
NFKB1 / rs1609798 / .337 / C>T / 0.82 / .443 / A / 1.26 / .286 / A
NFKB1 / HapA1 / 0.70 / .496 / 0.15 / .860
NFKB1 / HapA9 / 0.59 / .555 / 0.62 / .541
NFKB2 / rs12772374 / .157 / A>G / 1.21 / .300 / A / 1.21 / .299 / A
NFKB2 / rs7897947 / .229 / T>G / 2.32 / .021 / D / 2.13 / .034 / D
NFKB2 / rs11574849 / .085 / G>A / 0.35 / .706 / A / 0.63 / .531 / A
NFKB2 / rs1056890 / .317 / C>T / 0.13 / .880 / A / 0.18 / .837 / A
TNFA / rs2857602 / .360 / T>C / 0.89 / .413 / A / 1.36 / .260 / A
TNFA / rs1800683 / .388 / G>A / 0.10 / .909 / A / 1.31 / .271 / A
TNFA / rs2239704 / .370 / G>T / 1.26 / .287 / A / 1.45 / .238 / A
TNFA / rs2229094 / .256 / T>C / 1.59 / .207 / A / 1.03 / .360 / A
TNFA / rs1041981 / .388 / C>A / 0.10 / .909 / A / 1.31 / .271 / A
TNFA / rs1799964 / .202 / T>C / 0.89 / .411 / A / 0.10 / .909 / A
TNFA / rs1800750 / .019 / G>A / n/a / n/a / n/a / n/a / n/a / n/a
TNFA / rs1800629 / .157 / G>A / 5.16 / .006 / A / 2.69 / .008 / D
TNFA / rs1800610 / .105 / C>T / 0.98 / .378 / A / 1.07 / .343 / A
TNFA / rs3093662 / .072 / A>G / 0.71 / .492 / A / 0.54 / .586 / A
TNFA / HapA1 / 0.24 / .790 / 1.89 / .154
TNFA / HapA5 / 1.30 / .275 / 0.32 / .726
TNFA / HapA8 / 0.86 / .427 / 1.54 / .217

aAnalysis of variance (ANOVA) was used to test for additive models; t-tests were used to test for dominant and recessive models

Abbreviations: A = Additive model, Chr = chromosome, D = Dominant model, Hap = haplotype, IFNG = interferon gamma, IL = interleukin, MAF = minor allele frequency, n/a = not assayed because SNP violated Hardy-Weinberg expectations (p<.001) or because MAF<.05, NFKB = nuclear factor kappa beta, R = Recessive model, SNP = single nucleotide polymorphism, TNFA = tumor necrosis factor alpha