Supplementary Table 1. Quality evaluation, Inclusion criteria for AD cases and controls in selected studies investigating the association between rs9349407 polymorphism and AD

Study / Country / Ethnicity / Quality evaluation / Inclusion criteria for AD cases / Inclusion criteria for controls
Tan 2013 (1) / China / East Asian / 9 / NINCDS-ADRDA / A consensus clinical diagnosis of probable AD was established by at least two neurologists according to the criteria of the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association
Miyashita 2013 (2) / Japan / East Asian / 9 / NINCDS-ADRDA / Elders living in an unassisted manner in the local community with no signs of dementia were used as controls.
Omoumi 2014 (3) / Canada / Canadian / 8 / DSM, NINCDS-ADRDA / subjects were deemed as normal or no cognitive impairment if they did not have any of the Diagnostic and Statistical Manual of Mental Disorders, version III, revised, criteria for dementia after clinical and neuropsychological assessments
Logue 2011 (4) / United States / American / 8 / NINCDS-ADRDA / NA
Carrasquillo 2011 (5) / Jacksonville / American / 8 / NA / NA
Carrasquillo 2011 (5) / Rochester / American / 8 / NA / NA
Carrasquillo 2011 (5) / Autopsy / American / 8 / NA / NA
Carrasquillo 2011 (5) / Norway / European ancestry / 8 / NA / NA
Carrasquillo 2011 (5) / Poland / European ancestry / 8 / NA / NA
Carrasquillo 2011 (5) / ARUK / European ancestry / 8 / NA / NA
Naj 2011 (6) / ADGC-stage 1 / European ancestry / 9 / NINCDS-ADRDA, DSM or CERAD / NA
Naj 2011 (6) / ADGC-stage 2 / European ancestry / 9 / NINCDS-ADRDA, DSM or CERAD / NA
Hollingworth 2011 (7) / GERAD1 / European ancestry / 9 / NINCDS-ADRDA, DSM or CERAD / MMSE, TICS-M, Geriatric mental schedule, cognitive performance scale, SIDAM or clinical dementia rating scale
Hollingworth 2011 (7) / EADI1 / European ancestry / 9 / NINCDS-ADRDA, DSM or CERAD / MMSE, TICS-M, Geriatric mental schedule, cognitive performance scale, SIDAM or clinical dementia rating scale
Hollingworth 2011 (7) / deCODE / European ancestry / 9 / NINCDS-ADRDA, DSM or CERAD / MMSE, TICS-M, Geriatric mental schedule, cognitive performance scale, SIDAM or clinical dementia rating scale

ADGC, the Alzheimer’s Disease Genetic Consortium; EADI1, European Alzheimer’s Disease Initiative 1; GERAD1, the Genetic and Environmental Risk in Alzheimer's Disease 1;NINCDS-ADRDA, the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorder Association; DSM-IV, Diagnostic and Statistical Manual of Mental Disorders version IV; DSM III, Diagnostic and Statistical Manual of Mental Disorders version III; The Quality Score of includedstudies were scored based on the criteria developed by Clark et al (8) to evaluate the quality of genetic association studies. NA, not available

References

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6Naj, A.C., Jun, G., Beecham, G.W., Wang, L.S., Vardarajan, B.N., Buros, J., Gallins, P.J., Buxbaum, J.D., Jarvik, G.P., Crane, P.K. et al. (2011) Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet, 43, 436-441.

7Hollingworth, P., Harold, D., Sims, R., Gerrish, A., Lambert, J.C., Carrasquillo, M.M., Abraham, R., Hamshere, M.L., Pahwa, J.S., Moskvina, V. et al. (2011) Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet, 43, 429-435.

8Clark, M.F. and Baudouin, S.V. (2006) A systematic review of the quality of genetic association studies in human sepsis. Intensive care medicine, 32, 1706-1712.

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