Supplementary Table 1. Narrowly Expressed Genes with Different Activity in Polyploid Vs

Supplementary Table 1. Narrowly expressed genes with different activity in polyploid vs. diploid heart and liver: main specific functions, regulation of transcription and metabolism.

Entrez Gene ID) / Name, organ and functional group* / Gene Function ** / Expression levels ratio (polyploid to diploid organs)
HEART / Heart (human to mouse ratio)
Contractile proteins
4625 / Myosin, heavy polypeptide 7, cardiac muscle, beta / Microfilament motor activity (GO:0000146) / 272.35
4635 / Myosin, light polypeptide 4 / Striated muscle contraction (GO:0006941) / 136.89
4653 / Myocilin / Structural molecule activity (GO:0005198) / 3.40
6525 / Smoothelin / Smooth muscle contraction (GO:0006939) / 5.28
7134 / Troponin C / Calcium ion binding (GO:0005509); muscle development (GO:0007517) / 3.60
7135 / Troponin I, skeletal, slow / Tropomyosin binding (GO:0005523) / 10.67
9080 / Claudin 9 / Structural molecule activity (GO:0005198) / 4.53
51412 / Actin-like 6 / Motor activity (GO:0003774) / 3.18
58498 / Myosin, light polypeptide 7, regulatory / Actin filament-based movement (GO:0030048) / 4.25
29109 / Formin homology 2 domain containing 1 / Actin binding (GO:0003779); cytokinesis (GO:0016288) / 15.75
80206 / Formin homology 2 domain containing 3 / Actin binding (GO:0003779) / 15.24
9499 / Myotilin / Structural constituent of muscle (GO:0008307) / 0.06
10324 / Kelch repeat and BTB (POZ) / Striated muscle contraction (GO:0006941) / 0.03
29765 / Tropomodulin 4 (muscle) / Tropomyosin binding (GO:0005523) / 0.10
4624 / Myosin, heavy polypeptide 6, cardiac muscle, alpha / Striated muscle contraction (GO:0006941) / 0.16
Reglation of contraction
10677 / Advillin / Actin modulating activity (GO:0003790) / 2.52
6262 / Ryanodine receptor 2 (cardiac) / Calcium ion binding (GO:0005509) / 3.47
54207 / Potassium channel, subfamily K, member 10 / Voltage-gated ion channel activity (GO:0005244) / 2.82
3757 / Potassium voltage-gated channel, subfamily H (eag-related), member 2 / Muscle contraction (GO:0006939) / 4.44
29780 / Parvin, beta / Actin binding (GO:0003779);cell adhesion (GO:0007155) / 6.66
3764 / Potassium inwardly-rectifying channel, subfamily J, member 8 / ATP-activated inward rectifier potassium channel activity (GO:0015272) / 4.13
4892 / Nebulin-related anchoring protein / Actin binding (GO:0003779) / 0.18
56203 / Leiomodin 3 (fetal) / Tropomyosin binding (GO:0005523) / 0.03
5506 / Protein phosphatase 1, regulatory (inhibitor) / Myosin phosphatase activity (GO:0017018) / 0.30
91807 / Myosin light chain kinase (MLCK) / ATP binding (GO:0005524);protein amino Acid phosphorylation (GO:0006468); / 0.01
10345 / Triadin / Muscle contraction (GO:0006936) / 0.01
51778 / Myozenin 2 / Calcineurin-binding (IPR008438) / 0.11
781 / Calcium channel, voltage-dependent / Calcium channel activity (GO:0005262) / 0.24
84665 / Myopalladin / Sarcomeric protein [EG]
Immunoglobulin C-2 type (IPR003598) / 0.04
93649 / Myocardin / Sarcomeric protein [EG]; DNA binding (GO:0003677); bipartite nuclear localization signal (IPR001472) / 0.09

Regulation of transcription

1870 / E2F transcription factor 2 / Transcription from Pol II promoter (GO:0006366); plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and has a role in blood pressure regulation via a component of the endothelin system [EG] / 4.53
8538 / BarH-like homeobox 2 heart-specific / Transcription factor activity (GO:0003700) / 6.06
1482 / NK2 transcription factor related / Transcription factor activity (GO:0003700); heart development (GO:0007507); / 3.82
6943 / Transcription factor 21 / RNA polymerase II transcription factor activity (GO:0003702) / 2.13
8463 / TEA domain family member 2 / Transcription factor activity (GO:0003700) / 3.38
3211 / Homeo box B1 / Transcription factor activity (GO:0003700) / 4.98
23066 / TBP-interacting protein CMC / Homeostasis regulation and differentiation (EG) / 5.17
55798 / Methyltransferase like 2 / Methyltransferase activity (GO:0008757) / 3.31
50805 / Iroquois homeobox protein 4 / Transcription factor activity (GO:0003700) / 5.17
51027 / CGI-143 protein (cell cycle regulation) / Transcription regulator activity (GO:0030528); cell cycle regulation / 0.35
23414 / Zinc finger protein, multitype 2 GATA modulator signalling / Transcription corepressor activity (GO:0003714) / 0.31
Carbohydrate metabolism
229 / Aldolase B, fructose-bisphosphate / Fructose metabolism (GO:0006000);glycolysis (GO:0006096) / 4.64
3651 / Insulin promoter factor 1, / Energy pathways (GO:0006091) transcription factor activity (GO:0003700) / 4.73
23302 / KIAA0523 protein / Carbohydrate-binding WSC (IPR002889) / 3.46
84803 / Hypothetical protein MGC11324 / Phospholipid/glycerol acyltransferase (IPR002123) / 2.33
5967 / Regenerating islet-derived 1 alpha / Sugar binding (GO:0005529) / 5.45
8839 / WNT1 inducible pathway protein 2 / Insulin-like growth factor binding (GO:0005520) / 3.09
55066 / Pyruvate dehydrogenase phosphatase regulatory subunit / Aminomethyltransferase activity (GO:0004047) / 0.13
115701 / Heart alpha-kinase / ATP binding (GO:0005524); protein amino acid phosphorylation / 0.27
Oxidation-reduction and reserve ATP producing pathways
10873 / Malic enzyme 3, NADP(+)-dependent,(APT deficiency activated) / Oxidoreductase activity (GO:0016491); pyruvate metabolism (GO:0006090);
reserve ATP producing pathway [EG] / 6.21
55902 / Acetyl-Coenzyme A synthetase 2 / Acetate-CoA ligase activity (GO:0003987);
reserve ATP producing pathway [EG] / 4.12
364 / Aquaporin 7 / Energy pathways (GO:0006091); glycerol transport (GO:0015793) / 3.48
51751 / CLST 11240 protein HIGD1B HIG1 hypoxia inducible domain family, member 1B / 'Hypoxia induced protein conserved region (IPR007667) / 2.30
10570 / Dihydropyrimidinase-like 4 additional source of ATP / Hydrolase activity (GO:0016787); neurogenesis (GO:0007399) / 2.44
8431 / Nuclear receptor subfamily 0, group B, member 2 / Cholesterol metabolism (GO:0008203); transcription factor activity (GO:0003700) / 5.16
126410 / Cytochrome P450, family 4, / Electron transport (GO:0006118); monooxygenase activity (GO:0004497) / 0.39
Lipid metabolism
3293 / Hydroxysteroid (17-beta) dehydrogenase 3 / Steroid biosynthesis (GO:0006694) / 0.36
23590 / Trans-prenyltransferase / Isoprenoid biosynthesis (GO:0008299) / 0.45
7753 / Zinc finger protein 202 IBS / Lipid metabolism (GO:0006629) / 0.40
2168 / Fatty acid binding protein 1, liver / Fatty acid metabolism (GO:0006631) / 0.21
338322 / NACHT, leucine rich repeat / ATP binding (GO:0005524) / 0.21
10699 / Corin, serine protease / Lipid metabolism (GO:0006629) / 0.03
Amino acid and protein metabolism
10667 / Phenylalanine-tRNA synthetase 1 (mitochondrial) / Phenylalanine-tRNA ligase activity (GO:0004826) / 4.36
5129 / PCTAIRE protein kinase 3 / Protein amino acid phosphorylation (GO:0006468) / 36.76
10248 / Processing of precursor 7, ribonuclease P subunit (S. cerevisiae) / Ribonuclease P activity (GO:0004526);tRNA processing (GO:0008033) / 2.46
2160 / Coagulation factor XI (plasma thromboplastin antecedent) / Blood coagulation (GO:0007596); / 2.045
2812 / Glycoprotein Ib (platelet), beta polypeptide / Blood coagulation (GO:0007596);cell adhesion (GO:0007155) / 21.11
7079 / Tissue inhibitor of metalloproteinase 4 / Metalloendopeptidase inhibitor activity (GO:0008191) / 14.76
7092 / Tolloid-like 1 / Metallopeptidase activity (GO:0008237);proteolisis and peptidolysis (GO:0006508) / 2.29
64129 /

Lipocalin 7

/ Cysteine-type endopeptidase activity (GO:0004197) / 8.79
64180 /

Dipeptidase 3

/ Proteolisis and peptidolysis (GO:0006508) / 6.65
4224 / Meprin A, alpha / Endopeptidase activity (GO:0004175) / 0.25
115290 / F-box only protein 26 / Protein catabolism (GO:0030163) / 0.42

LIVER

/ Liver (mouse to human ratio)

Immunity

10747 / Mannan-binding lectin serine protease 2a / Antimicrobial humoral response (GO:0006960) / 2.55
10584 / Collectin sub-family member 10 / Antimicrobial peptide activity (GO:0003795) / 19.82
5624 / Protein C (inactivator of coagulation factors Va and VIIIa) / Anti-inflammatory response (GO:0030236) / 7.10
6364 / Chemokine (C-C motif) ligand 20 / Antimicrobial humoral response (GO:0019735) / 2.62
6504 / Signaling lymphocytic activation molecule family member 1 / Antimicrobial humoral response (GO:0019735) / 3.71
4153 / Mannose-binding lectin (protein C) 2, soluble / Defense/immunity protein activity (GO:0003793) / 10.37
3426 / I factor of complement cascade / Complement factor I activity (GO:0003818) / 841.56
1441 / Colony stimulating factor 3 receptor / Defense response (GO:0006952) / 3.30
1401 / C-reactive protein, pentraxin-related / Aacute-phase response (GO:0006953) / 105.42
941 / CD80 antigen / T-cell activation (GO:0042110) / 2.38
731 / Complement component 8, alpha polypeptide / Response to pathogenic bacteria (GO:0009618) / 5.18
733 / Complement component 8, gamma polypeptide / Cytolysis (GO:0019835) / 2.18
735 / Complement component 9 / Cytolysis (GO:0019835) / 150.61
131669 / Hypothetical protein FLJ31300 / Immunoglobulin/major histocompatibility complex (IPR003006) / 2.10
140836 / Chromosome 20 open reading frame 179 / Barrier to autointegration factor, BAF (IPR004122) / 4.92
11061 / Leukocyte cell derived chemotaxin 1 HIF2a - inducable gene / Antimicrobial peptide activity (GO:0003795) / 3.83
2638 / Group-specific component / Vitamin D binding (GO:0005499) (GO:0003779) / 6.52
79962 / Hypothetical protein FLJ13236 / Heat shock protein DnaJ (IPR001623) / 16.90
325 / Amyloid P component / Acute-phase response protein activity (GO:0003794) / 0.03
10261 / Immunoglobulin superfamily, member 6 / Immune response (GO:0006955), Inflammation [EG] / 0.49
10332 / CD209 antigen-like / Virus-host interaction (GO:0019048) / 0.24
4485 / Macrophage stimulating 1 (hepatocyte growth factor-like) / Trypsin activity (GO:0004295) / 0.47
2213 / Fc fragment of IgG, low affinity IIb, receptor for (CD32) / Immune response (GO:0006955) / 0.21
3456 / Interferon, beta 1, fibroblast / Response to virus (GO:0009615) / 0.37
3570 / Interleukin 6 receptor inflammm / Interleukin-6 receptor activity (GO:0004915) / 0.13
3594 / Interleukin 12 receptor, beta 1 Inflammation / Interleukin-12 receptor activity (GO:0016517); Inflammation [EG] / 0.31
3697 / Inter-alpha (globulin) inhibitor H1 / Immune cell activation (GO:0045321) / 0.34
942 / CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) / Immune response (GO:0006955) transcriptional activator activity (GO:0016563) / 0.23

Carbohydrate metabolism

152831 / Nuclear receptor subfamily 5, / Carbohydrate metabolism (GO:0005975) / 2.47
23729 / Carbohydrate kinase-like / Carbohydrate metabolism (GO:0005975) / 4.13
9942 / Xylulokinase homolog (H. influenzae) / Carbohydrate metabolism (GO:0005975) / 22.39
8972 / Maltase-glucoamylas digestion of starch / Carbohydrate metabolism (GO:0005975) / 14.92
8987 / Genethonin 1 starch binding domain 1 / Carbohydrate metabolism (GO:0005975) / 14.85
6514 / Solute carrier family 2 (facilitated glucose transporter) / Carbohydrate metabolism (GO:0005975) / 67.85
2642 / Glucagon receptor / Glucagon receptor activity (GO:0004967) / 7.55
2645 / Glucokinase (hexokinase 4 ) / Glycolysis (GO:0006096) / 30.72
2646 / Glucokinase (hexokinase 4) regulator / Carbohydrate metabolism (GO:0005975) / 13.57
2998 / Glycogen synthase 2 (liver) / Glycogen biosynthesis (GO:0005978) / 2.80
55224 / Putative ethanolamine kinase / Choline/ethanolamine kinase (IPR002573) / 2.94
Oxidation – reduction,
xenobiotic metabolism
and reserve ATP production
23498 / 3-hydroxyanthranilate 3,4-dioxygenase / Oxidoreductase activity (GO:0016491); / 12.50
763 / Carbonic anhydrase VA, mitochondrial / One-carbon compound metabolism (GO:0006730) / 6.26
389434 / Iodotyrosine dehalogenase 1 IYD / Oxidoreductase activity (GO:0016491) / 98.47
55301 / Thioesterase domain containing 1 / Hydrolase activity, acting on ester bonds (GO:0016788) / 2.44
54363 / Hydroxyacid oxidase (glycolate oxidase) / Oxidoreductase activity (GO:0016491) / 5.92
55191 / NAD synthetase 1 / NAD+ synthase (glutamine-hydrolyzing) / 10.96
93517 / NAD(P) SDR42E1 s dehydrogenase/reductase / Oxidoreductase activity (GO:0016491); Reserve ATP production [EG] / 32.66
29958 / Dimethylglycine dehydrogenase / Oxidoreductase activity (GO:0016491);
Reserve ATP production [EG] / 74.57
2328 / Flavin containing monooxygenase 3 / Disulfide oxidoreductase activity (GO:0015036) / 12.71
121214 / Orphan short-chain dehydrogenase / reductase / Oxidoreductase activity (GO:0016491) / 3.45
64577 / Aldehyde dehydrogenase 8 family, member A1 / Oxidoreductase activity (GO:0016491) / 5.59
120227 / Cytochrome P450, family 2, subfamily R, polypeptide 1 / Electron transport (GO:0006118) / 7.31
11283 / Cytochrome P450, family 4, subfamily F, polypeptide 8 / Electron transport (GO:0006118) / 33.19
1551 / Cytochrome P450, family 3, subfamily A, polypeptide 7 / Monooxygenase activity (GO:0004497) / 24.90
1592 / Cytochrome P450, family 26, subfamily A, polypeptide 1 / Oxygen binding (GO:0019825) / 2.25
763 / Carbonic anhydrase VA, mitochondrial / One-carbon compound metabolism (GO:0006730) / 6.26
55301 / Thioesterase domain containing 1 / Hydrolase activity, acting on ester bonds (GO:0016788) / 2.44
1373 / Carbamoyl-phosphate synthetase 1 / Pyrimidine base biosynthesis (GO:0019856) / 9.31
151531 / Uridine phosphorylase 2 / Nucleoside metabolism (GO:0009116); Reserve ATP production [EG]. / 389.58
51733 / Ureidopropionase, beta / Nitrogen metabolism (GO:0006807) / 4.45
7363 / UDP glycosyltransferase 2 family, polypeptide B4 / Xenobiotic metabolism (GO:0006805) / 7.43
11227 / UDP-N-acetyl-alpha-D-galactosamine / UDP-glycosyltransferase activity (GO:0008194) / 2.09
79799 /

UDP-glucosyltransferase

/ Transferring hexosyl groups (GO:0016758) / 57.14
1723 / Dihydroorotate dehydrogenase / Pyrimidine nucleotide biosynthesis (GO:0006221) / 0.24
1562 / Cytochrome P450, family 2 / Monooxygenase activity (GO:0004497);oxygen binding (GO:0019825) / 0.44
6718 / Aldo-keto reductase family 1 / Oxidoreductase activity (GO:0016491) / 0.42
1555 / Cytochrome P450, family 2, subfamily B, polypeptide 6 / Cytochrome P450 activity (GO:0015034);monooxygenase activity (GO:0004497) / 0.14
51117 / Coenzyme Q4 homolog (yeast) / Ubiquinone biosynthesis (GO:0006744) / 0.27
Lipid metabolism
2168 / Fatty acid binding protein 1, l / Fatty acid metabolism (GO:0006631) / 9.06
134526 / Cytosolic acetyl-CoA hydrolase / Fatty acid metabolism (GO:0006631) / 8.50
161247 / Similar to CG10671-like / Fatty acid metabolism (GO:0006631) / 5.34
51365 / Phospholipase A1 member A / Phospholipase A1 activity (GO:0008970) / 11.09
84647 / Phospholipase A2, group XIIB / Phospholipase A2 activity (GO:0004627) / 10.77
570 / Bile acid Coenzyme A : / Bile acid metabolism (GO:0008206) / 7.05
6017 / Retinaldehyde binding protein 1 vision / Vitamin A metabolism (GO:0006776) / 0.16
2166 / Fatty acid amide hydrolase / Hydrolase activity (GO:0016787) / 0.40
51179 / Hydroxyacid oxidase 2 (long chain) / Fatty acid alpha-oxidation (GO:0001561); / 0.21
345 / Apolipoprotein C-III (anti-3 glycerids) / Lipid catabolism (GO:0016042); lipid metabolism (GO:0006629) / 0.48
116519 / Apolipoprotein / Lipid binding (GO:0008289); lipid transport (GO:0006869) / 0.01
93100 / Similar to CG3714 gene product / 0.47
1807 / Dihydropyrimidinase / Nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0006139) / 0.01
93100 / Similar to CG3714 gene product / 0.47
2712 / Glycerol kinase 2 / Glycerol metabolism (GO:0006071); / 0.45
51205 / Lysophosphatidic acid phosphatase / Lipid metabolism (GO:0006629) / 0.39
26007 / DKFZP586B1621 protein / Glycerol metabolism (GO:0006071) / 0.21
1723 / Dihydroorotate dehydrogenase / Pyrimidine nucleotide biosynthesis (GO:0006221) / 0.24
mit 3158 / 3-hydroxy-3-methylglutaryl-coenzyme A synthase 2 (mitochondrial) / Acetyl-CoA metabolism (GO:0006084); / 0.23
8431 / Nuclear receptor subfamily 0, group B, member 2 / Cholesterol metabolism (GO:0008203); / 0.38
51129 / Angiopoietin-like 4 / Negative regulation of lipoprotein lipase activity (GO:0051005) / 0.12
54988 / Hypothetical protein FLJ20581 / catalytic activity (GO:0003824);metabolism (GO:0008152) / 0.25
81932 / Chromosome 9 open reading frame 158 / Metabolism (GO:0008152) / 0.29
8856 / Nuclear receptor subfamily 1, / Lipid metabolism (GO:0006805) / 0.37
Protein and amino acid metabolism
212 / Aminolevulinate, delta-, synthase 2 / 5-aminolevulinate synthase activity (GO:0003870) / 20.87
162417 / N-acetylglutamate synthase / Arginine biosynthesis (GO:0006526) (GO:0003991) / 18.72
115290 / F-box only protein 26 / Protein catabolism (GO:0030163) / 2.71
162540 / Intramembrane protease 5 / Proteolisis and peptidolysis (GO:0006508) / 2.76
8858 / Protein Z, vitamin K-dependent plasma glycoprotein / Proteolisis and peptidolysis (GO:0006508) / 48.22
6999 / Tryptophan 2,3-dioxygenase / Tryptophan metabolism (GO:0006568) / 42.59
58158 / Neurogenic differentiation 4 / Translation regulator activity (GO:0045182) / 2.45
3034 / Histidine ammonia-lyase / Ammonia ligase activity (GO:0016211) / 42.94
115290 / F-box only protein 26 / Arotein catabolism (GO:0030163) / 2.71
866 / Serine (or cysteine) proteinase inhibitor, / Serine-type endopeptidase inhibitor activity (GO:0004867) / 4.51
79660 / Protein phosphatase 1, regulatory / Putative phosphatase regulatory subunit (IPR005036) / 4.33
5009 / Ornithine carbamoyltransferase / Amino acid metabolism (GO:0006520) / 2.96
2153 / Coagulation factor V / Blood coagulation (GO:0007596) / 2.62
2158 / Coagulation factor IX / Blood coagulation (GO:0007596) / 3.30
2160 / Coagulation factor XI / Blood coagulation (GO:0007596) / 10.40
2165 / Coagulation factor XIII, B polypeptide / Blood coagulation (GO:0007596) / 175.83
1491 / Cystathionase / Amino acid metabolism (GO:0006520) / 6.97
5340 / Plasminogen / Trypsin activity (GO:0004295) / 3.53
56926 / Hypothetical protein from EUROIMAGE 2021883 / Peptidase activity (GO:0008233) / 2.45
58158 / Neurogenic differentiation 4 / Translation regulator activity (GO:0045182) / 0.32
54345 / SRY (sex determining region Y)-box 18 / translation regulator activity (GO:0045182) / 0.14
10661 / Kruppel-like factor 1 / Histogenesis and organogenesis (GO:0007397); translation regulator activity (GO:0045182) / 0.44
189 / Alanine-glyoxylate aminotransferase) / Transferase activity (GO:0016740) / 0.13
9027 / N-acetyltransferase 8 (camello like) / Transferase activity (GO:0016740) / 0.11
10799 / Ribonuclease P 40kDa subunit / Ribonuclease P activity (GO:0004526);tRNA processing (GO:0008033) / 0.19
6470 / Serine hydroxymethyltransferase 1 (soluble) / Glycine metabolism (GO:0006544); transferase activity (GO:0016740) / 0.09
113675 / Serine dehydratase-like / Amino acid metabolism (GO:0006520); lyase activity (GO:0016829) / 0.07
10248 / Processing of precursor 7, ribonuclease P subunit (S. cerevisiae) / tRNA processing (GO:0008033) / 0.27
7064 / Thimet oligopeptidase 1 / Proteolisis and peptidolysis (GO:0006508) / 0.18
10677 / Advillin / Methionyl-tRNA aminoacylation (GO:0006431) / 0.46
3026 / Hyaluronan binding protein 2 / Proteolisis and peptidolysis (GO:0006508);trypsin activity (GO:0004295) / 0.18
4324 / Matrix metalloproteinase 15 (membrane-inserted) / Proteolisis and peptidolysis (GO:0006508) / 0.25
Regulation of transcription
2494 / Nuclear receptor subfamily 5, / Transcription (GO:0006350) Tumor suppressor [EG] / 16.19
3170 / Forkhead box A2 / Transcription factor activity (GO:0003700) / 5.36
3175 / One cut domain, family member 1 HNF6; / Transcriptional activator activity (GO:0016563) / 4.38
51027 / CGI-143 protein TF, cell proliferation / Transcription regulator activity (GO:0030528) / 3.06
3169 / Forkhead box A1 / Transcription factor activity (GO:0003700) / 3.24
7554 / Zinc finger protein 8 (clone HF.18) / DNA binding (GO:0003677) / 2.66
57677 / FP14 zinc finger protein 14 homolog (mouse) / Transcription factor activity (GO:0003700) / 2.41
1369 / Carboxypeptidase N, polypeptide 1, 50kD / Zinc ion binding (GO:0008270) / 2.10
57677 / FP14 zinc finger protein 14 homolog (mouse) / Transcription factor activity (GO:0003700) / 2.987
1406 / Ranscription factor Photo_Rec. Circadian Clock / Visual perception (GO:0007601) / 2.951
4010 / LIM homeobox transcription factor 1, beta NSP-1 / Transcription factor activity (GO:0003700) / 2.95
3007 / Histone 1, H1d / Nucleosome assembly (GO:0006334) / 2.30
2968 / General transcription factor IIH, polypeptide 4, 52kDa / Transcription from Pol II promoter (GO:0006366) / 0.40

*Note common ploidy-associated traits in heart and liver indicative of increased specific activity like boosted specific functions (contraction in heat and immunity and metabolism in liver) and regulators of transcription, and changes indicative of energy economy switch from lipid to carbohydrate metabolism and triggering of NAD-metabolism, oxidation-reduction and reserve ATP producing pathways.

**Here and in the other tables: GO - Gene Ontology, EG - Entrez Gene (information from the Entrez Gene Summary field).