Supplementary Table 1: Differentially Expressed Genes In HNF-4loxP/loxP; Ins.Cre mice as determined by SAM analysis
Gene Symbol / Fold Change / Gene Description / Entrez GeneIDRnase4 / -3.17 / ribonuclease, RNase A family 4 / 58809
Sult1d1 / -3.00 / sulfotransferase family 1D, member 1 / 53315
Cpb2 / -2.77 / carboxypeptidase B2 (plasma) / 56373
Ugt2b34 / -2.75 / UDP glucuronosyltransferase 2 family, polypeptide B34 / 100727
Xlkd1 / -2.72 / extra cellular link domain-containing 1 / 114332
Adh1 / -2.72 / alcohol dehydrogenase 1 (class I) / 11522
Ddc / -2.41 / dopa decarboxylase / 13195
Tat / -2.26 / tyrosine aminotransferase / 234724
Igf1 / -2.22 / insulin-like growth factor 1 / 16000
Dbp / -2.16 / D site albumin promoter binding protein / 13170
Man1a / -2.16 / mannosidase 1, alpha / 17155
Dpp4 / -2.15 / dipeptidylpeptidase 4 / 13482
Fxyd6 / -2.05 / FXYD domain-containing ion transport regulator 6 / 59095
Dsp / -2.05 / desmoplakin / 109620
Uox / -2.05 / urate oxidase / 22262
Sez6l / -2.04 / seizure related 6 homolog (mouse)-like / 56747
G6pc / -2.00 / glucose-6-phosphatase, catalytic / 14377
WASHU=ie36d08 / -1.90 / WASHU clone: ie36d08
6330403K07Rik / -1.81 / RIKEN cDNA 6330403K07 gene / 103712
Tacc2 / -1.80 / transforming, acidic coiled-coil containing protein 2 / 57752
Insrr / -1.76 / insulin receptor-related receptor / 23920
Syne1 / -1.68 / synaptic nuclear envelope 1 / 64009
Mt2 / -1.68 / metallothionein 2 / 17750
Slc30a8 / -1.67 / solute carrier family 30 (zinc transporter), member 8 / 239436
Il1r1 / -1.64 / interleukin 1 receptor, type I / 16177
Sephs2 / -1.63 / selenophosphate synthetase 2 / 20768
Tmod2 / -1.62 / tropomodulin 2 / 50876
B230206F22Rik / -1.61 / RIKEN cDNA B230206F22 gene / 78878
Marcks / -1.51 / myristoylated alanine rich protein kinase C substrate / 17118
Comt / -1.50 / catechol-O-methyltransferase / 12846
Parva / -1.49 / parvin, alpha / 57342
Nkx2-2 / -1.48 / NK2 transcription factor related, locus 2 (Drosophila) / 18088
Scarf1 / -1.48 / scavenger receptor class F, member 1 / 380713
2210412D01Rik / -1.47 / RIKEN cDNA 2210412D01 gene / 70178
IMAGE=5665886 / -1.45 / IMAGE clone: 5665886
Tbl3 / -1.44 / transducin (beta)-like 3 / 213773
Hmgn3 / -1.44 / high mobility group nucleosomal binding domain 3 / 94353
Rod1 / -1.43 / ROD1 regulator of differentiation 1 (S. pombe) / 230257
Rnase1 / -1.41 / ribonuclease, RNase A family, 1 (pancreatic) / 19752
Cotl1 / -1.41 / coactosin-like 1 (Dictyostelium) / 72042
Fbxo21 / -1.40 / F-box only protein 21 / 231670
2510015F01Rik / -1.38 / RIKEN cDNA 2510015F01 gene / 70021
Pdk4 / -1.38 / pyruvate dehydrogenase kinase, isoenzyme 4 / 27273
2310056B04Rik / -1.38 / RIKEN cDNA 2310056B04 gene / 70402
Rab3b / -1.38 / RAB3B, member RAS oncogene family / 69908
Rab33a / -1.37 / RAB33A, member of RAS oncogene family / 19337
St5 / -1.36 / suppression of tumorigenicity 5 / 76954
6530411B15Rik / -1.35 / RIKEN cDNA 6530411B15 gene / 103743
Alcam / -1.35 / activated leukocyte cell adhesion molecule / 11658
Insm1 / -1.31 / insulinoma-associated 1 / 53626
Ccnd1 / -1.31 / cyclin D1 / 12443
Igsf4a / -1.29 / immunoglobulin superfamily, member 4A / 54725
Ier2 / -1.29 / immediate early response 2 / 15936
Psat1 / -1.28 / phosphoserine aminotransferase 1 / 107272
Stab1 / -1.26 / stabilin 1 / 192187
Clstn3 / -1.26 / calsyntenin 3 / 232370
Cebpz / -1.19 / CCAAT/enhancer binding protein zeta / 12607
IMAGE=2648398 / 9.20 / IMAGE clone: 2648398
Cish / 6.07 / cytokine inducible SH2-containing protein / 12700
Ngfr / 5.85 / nerve growth factor receptor (TNFR superfamily, member 16) / 18053
Igfbp5 / 5.76 / insulin-like growth factor binding protein 5 / 16011
Penk1 / 5.64 / preproenkephalin 1 / 18619
Psmc1 / 5.41 / protease (prosome, macropain) 26S subunit, ATPase 1 / 19179
Tnfrsf11b / 4.27 / tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) / 18383
Neb / 3.95 / nebulin / 17996
IMAGE=5669117 / 3.35 / IMAGE clone: 5669117
B3galt3 / 3.19 / UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3 / 26879
Hsbp1 / 3.10 / heat shock factor binding protein 1 / 68196
Rasgrp1 / 2.85 / RAS guanyl releasing protein 1 / 19419
4930485D02Rik / 2.78 / RIKEN cDNA 4930485D02 gene / 75812
Dapp1 / 2.71 / dual adaptor for phosphotyrosine and 3-phosphoinositides 1 / 26377
Lgmn / 2.62 / legumain / 19141
2410003B16Rik / 2.51 / RIKEN cDNA 2410003B16 gene / 72333
Rph3a / 2.40 / rabphilin 3A / 19894
Egf / 2.31 / epidermal growth factor / 13645
Rdh16 / 2.28 / retinol dehydrogenase 16 / 19683
Derl3 / 2.25 / Der1-like domain family, member 3 / 70377
Spp1 / 2.22 / secreted phosphoprotein 1 / 20750
Mgst1 / 2.02 / microsomal glutathione S-transferase 1 / 56615
IMAGE=5679779 / 1.99 / IMAGE clone: 5679779
Pycr1 / 1.98 / pyrroline-5-carboxylate reductase 1 / 209027
Sart3 / 1.96 / squamous cell carcinoma antigen recognized by T-cells 3 / 53890
Uhrf2 / 1.95 / ubiquitin-like, containing PHD and RING finger domains 2 / 109113
Chgb / 1.94 / chromogranin B / 12653
Oat / 1.94 / ornithine aminotransferase / 18242
Racgap1 / 1.85 / Rac GTPase-activating protein 1 / 26934
Tle4 / 1.84 / transducin-like enhancer of split 4, homolog of Drosophila E(spl) / 21888
Nef3 / 1.77 / neurofilament 3, medium / 18040
IMAGE=1482832 / 1.74 / IMAGE clone: 1482832
Tnfrsf1a / 1.74 / tumor necrosis factor receptor superfamily, member 1a / 21937
Cops6 / 1.74 / COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana) / 26893
Myh10 / 1.72 / myosin, heavy polypeptide 10, non-muscle / 77579
Scn2b / 1.71 / sodium channel, voltage-gated, type II, beta / 72821
Vil2 / 1.70 / villin 2 / 22350
Nucb2 / 1.70 / nucleobindin 2 / 53322
Slc23a2 / 1.69 / solute carrier family 23 (nucleobase transporters), member 2 / 54338
Prpf18 / 1.68 / PRP18 pre-mRNA processing factor 18 homolog (yeast) / 67229
AI987712 / 1.67 / expressed sequence AI987712 / 105935
Hdlbp / 1.67 / high density lipoprotein (HDL) binding protein / 110611
Srp14 / 1.67 / signal recognition particle 14 / 20813
Hrb2 / 1.65 / HIV-1 Rev binding protein 2 / 52705
Fkbp11 / 1.65 / FK506 binding protein 11 / 66120
Mbtd1 / 1.63 / mbt domain containing 1 / 103537
Mtac2d1 / 1.63 / membrane targeting (tandem) C2 domain containing 1 / 74413
2900073G15Rik / 1.63 / RIKEN cDNA 2900073G15 gene / 67268
Aldh9a1 / 1.62 / aldehyde dehydrogenase 9, subfamily A1 / 56752
1700019H03Rik / 1.62 / RIKEN cDNA 1700019H03 gene / 71857
Sparcl1 / 1.60 / SPARC-like 1 (mast9, hevin) / 13602
Gcsh / 1.59 / glycine cleavage system protein H (aminomethyl carrier) / 68133
Mrpl44 / 1.59 / mitochondrial ribosomal protein L44 / 69163
Sdcbp / 1.59 / syndecan binding protein / 53378
Gsta3 / 1.57 / glutathione S-transferase, alpha 3 / 14859
Prepl / 1.57 / prolyl endopeptidase-like / 213760
Rps6ka5 / 1.56 / ribosomal protein S6 kinase, polypeptide 5 / 73086
Fgl2 / 1.56 / fibrinogen-like protein 2 / 14190
1300018J18Rik / 1.53 / RIKEN cDNA 1300018J18 gene / 223776
E430025E21Rik / 1.53 / RIKEN cDNA E430025E21 gene / 223593
Laptm4b / 1.52 / lysosomal-associated protein transmembrane 4B / 114128
Lsm6 / 1.52 / LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) / 78651
A330097E02Rik / 1.50 / RIKEN cDNA A330097E02 gene / 320555
Mbc2 / 1.50 / membrane bound C2 domain containing protein / 23943
Lrrc8c / 1.50 / leucine rich repeat containing 8 family, member C / 100604
Cd24a / 1.50 / CD24a antigen / 12484
Gcdh / 1.49 / glutaryl-Coenzyme A dehydrogenase / 270076
Ocrl / 1.49 / oculocerebrorenal syndrome of Lowe / 320634
Gnai2 / 1.48 / guanine nucleotide binding protein, alpha inhibiting 2 / 14678
Pecr / 1.48 / peroxisomal trans-2-enoyl-CoA reductase / 111175
Cks1b / 1.47 / CDC28 protein kinase 1b / 54124
IMAGE=6436056 / 1.46 / IMAGE clone: 6436056
Emilin1 / 1.45 / elastin microfibril interfacer 1 / 100952
Mcfd2 / 1.44 / multiple coagulation factor deficiency 2 / 193813
Idh2 / 1.43 / isocitrate dehydrogenase 2 (NADP+), mitochondrial / 269951
Hba-a1 / 1.40 / hemoglobin alpha, adult chain 1 / 15122
Ndufb7 / 1.40 / NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7 / 66916
2810453I06Rik / 1.40 / RIKEN cDNA 2810453I06 gene / 67238
Csrp1 / 1.40 / cysteine and glycine-rich protein 1 / 13007
Eps15 / 1.39 / epidermal growth factor receptor pathway substrate 15 / 13858
Pls3 / 1.39 / plastin 3 (T-isoform) / 102866
Anxa6 / 1.39 / annexin A6 / 11749
AW550831 / 1.39 / expressed sequence AW550831 / 98715
Mal2 / 1.38 / mal, T-cell differentiation protein 2 / 105853
Kntc1 / 1.38 / kinetochore associated 1 / 208628
Hyal2 / 1.38 / hyaluronidase 2 / 15587
9530090G24Rik / 1.36 / RIKEN cDNA 9530090G24 gene / 108687
St3gal6 / 1.36 / ST3 beta-galactoside alpha-2,3-sialyltransferase 6 / 54613
Xpo6 / 1.35 / exportin 6 / 74204
Tacstd1 / 1.34 / tumor-associated calcium signal transducer 1 / 17075
Als2cr3 / 1.34 / amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 (human) / 70827
Prkar2b / 1.34 / protein kinase, cAMP dependent regulatory, type II beta / 19088
B4galt1 / 1.33 / UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 / 14595
Tax1bp1 / 1.33 / Tax1 (human T-cell leukemia virus type I) binding protein 1 / 52440
Sqstm1 / 1.32 / sequestosome 1 / 18412
Litaf / 1.32 / LPS-induced TN factor / 56722
Ubxd1 / 1.32 / UBX domain containing 1 / 66530
Dap / 1.32 / death-associated protein / 223453
Gm572 / 1.31 / gene model 572, (NCBI) / 230909
Tmem49 / 1.31 / transmembrane protein 49 / 75909
Ctrb1 / 1.31 / chymotrypsinogen B1 / 66473
Prss18 / 1.31 / protease, serine, 18 / 19144
Mpp1 / 1.30 / membrane protein, palmitoylated / 17524
3110002H16Rik / 1.30 / RIKEN cDNA 3110002H16 gene / 76482
Sat1 / 1.29 / spermidine/spermine N1-acetyl transferase 1 / 20229
Tbc1d4 / 1.29 / TBC1 domain family, member 4 / 210789
Smarcd1 / 1.28 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 / 83797
Slc31a1 / 1.28 / solute carrier family 31, member 1 / 20529
Serpinb6a / 1.28 / serine (or cysteine) proteinase inhibitor, clade B, member 6a / 20719
S100a11 / 1.27 / S100 calcium binding protein A11 (calizzarin) / 20195
Eno1 / 1.27 / enolase 1, alpha non-neuron / 13806
Hars / 1.27 / histidyl-tRNA synthetase / 15115
AA986860 / 1.25 / expressed sequence AA986860 / 212439
Pon2 / 1.25 / paraoxonase 2 / 330260
Sel1h / 1.24 / Sel1 (suppressor of lin-12) 1 homolog (C. elegans) / 20338
Tbc1d20 / 1.24 / TBC1 domain family, member 20 / 67231
C030002B11Rik / 1.24 / RIKEN cDNA C030002B11 gene / 78540
D5Ertd606e / 1.23 / DNA segment, Chr 5, ERATO Doi 606, expressed / 52398
Galnt7 / 1.23 / UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7 / 108150
Cugbp2 / 1.22 / CUG triplet repeat, RNA binding protein 2 / 14007
Pdia5 / 1.22 / protein disulfide isomerase associated 5 / 72599
1110020C13Rik / 1.21 / RIKEN cDNA 1110020C13 gene / 66151
Repin1 / 1.21 / replication initiator 1 / 58887
Nrxn3 / 1.21 / neurexin III / 18191
Tceb2 / 1.20 / transcription elongation factor B (SIII), polypeptide 2 / 67673
1810073N04Rik / 1.19 / RIKEN cDNA 1810073N04 gene / 72055
AU040320 / 1.19 / expressed sequence AU040320 / 100317
Sec61b / 1.18 / Sec61 beta subunit / 66212