Supplementary Table 1 Characteristics of studies included in meta-analysis of the association between +915G/C polymorphism in the TGF-β1 gene and hypertension

Study / Region / Geographic location / Gender (M/F) / Age, mean±SD, year / Sample size / Genotype distribution
in cases/ controls / PHWE a / Definition
(SBP/DBP, mmHg)
Cases / Controls / Cases / Controls / Cases / Controls / GG / GC / CC / Hypertension / Control
Wei,2005 / Guangxi / South / 103/69 / 105/75 / 62.7±9.2 / 60.3±7.5 / 172 / 180 / 158/168 / 13/12 / 1/0 / 0.644 / ≥140/90 / <140/90
Tang,2006 / Hunan / South / 70/52 / 58/43 / 54.7±7.4 / 52.7±7.9 / 122 / 101 / 107/86 / 13/13 / 2/2 / 0.060 / ≥140/90 / <140/90
Zhang,2006 / Shandong / North / 54/41 / Matched / 71.5±10.1 / Matched / 95 / 105 / 90/99 / 4/5 / 1/1 / 0.007 / ≥140/90 / <140/90
Wang,2007 / Shandong / North / 147/139 / 111/102 / 57.7±11.6 / 56.3±9.2 / 286 / 213 / 257/195 / 17/13 / 12/5 / <0.001 / ≥140/90 / <140/90
Wei,2007 / Guangxi / South / 72/48 / 77/53 / 63.2±9.5 / 60.5±8.1 / 120 / 130 / 109/121 / 10/9 / 1/0 / 0.683 / ≥140/90 / <140/90
Zhao,2010 / Xinjiang / North / 171/194 / 192/243 / 48.5±9.4 / 46.9±10.3 / 365 / 435 / 354/426 / 11/9 / 0/0 / 0.827 / ≥140/90 / <140/90
He,2010 / Xinjiang / North / 179/208 / 188/225 / 49.3 / 48.9 / 387 / 413 / 383/412 / 4/1 / 0/0 / 0.980 / ≥140/90 / <140/90
SD, standard deviation; NA, not available
a P value for Hardy-Weinberg equilibrium in controls

Supplementary Table 2 Characteristics of studies included in meta-analysis of the association between +869T/C polymorphism in the TGF-β1 gene and hypertension

Study / Region / Geographic location / Gender (M/F) / Age, mean±SD, year / Sample size / Genotype distribution
in cases /controls / PHWE a / Definition
(SBP/DBP, mmHg)
Cases / Controls / Cases / Controls / Cases / Controls / TT / TC / CC / Hypertension / Control
Wei,2005 / Guangxi / South / 103/69 / 105/75 / 62.7±9.2 / 60.3±7.5 / 172 / 180 / 33/56 / 88/87 / 51/37 / 0.763 / ≥140/90 / <140/90
Hu,2006 / Shanghai / South / 275/121 / 146/68 / 56.6±11.5 / 56.2±6.5 / 396 / 214 / 122/64 / 157/89 / 117/61 / 0.014 / ≥140/90 / <140/90
Tang,2006 / Hunan / South / 70/52 / 58/43 / 54.7±7.4 / 52.7±7.9 / 122 / 101 / 39/39 / 49/56 / 34/6 / 0.015 / ≥140/90 / <140/90
Zhang,2006 / Shandong / North / 54/41 / Matched / 71.5±10.1 / Matched / 95 / 105 / 26/30 / 48/52 / 21/23 / 0.958 / ≥140/90 / <140/90
Wang,2007 / Shandong / North / 147/139 / 111/102 / 57.7±11.6 / 56.3±9.2 / 286 / 213 / 76/65 / 142/104 / 68/44 / 0.839 / ≥140/90 / <140/90
Wei,2007 / Guangxi / South / 72/48 / 77/53 / 63.2±9.5 / 60.5±8.1 / 120 / 130 / 22/40 / 58/62 / 40/28 / 0.665 / ≥140/90 / <140/90
Zhang,2009 / Guangdong / South / NA / NA / NA / NA / 52 / 49 / 15/17 / 27/23 / 10/9 / 0.834 / ≥140/90 / <140/90
Zhao,2010 / Xinjiang / North / 171/194 / 192/243 / 48.5±9.4 / 46.9±10.3 / 365 / 435 / 63/113 / 150/203 / 152/119 / 0.166 / ≥140/90 / <140/90
He,2010 / Xinjiang / North / 179/208 / 188/225 / 49.3 / 48.9 / 387 / 413 / 74/108 / 153/187 / 160/118 / 0.056 / ≥140/90 / <140/90
SD, standard deviation; NA, not available
a P value for Hardy-Weinberg equilibrium in controls

Supplementary Table 3 Pooled ORs and 95%CIs of the association between +869T/C polymorphism in the TGF-β1 gene and hypertension

Contrasts / No. of studies (cases/controls) / CC vs. TT / TC vs. TT / CC+TC vs. TT / CC vs.TC+TT / C vs. T
OR / 95% CI / PH / OR / 95% CI / PH / OR / 95% CI / PH / OR / 95% CI / PH / OR / 95% CI / PH
All / 9 (1995/1840) / 1.80 / 1.34-2.44 / 0.014 / 1.20 / 1.03-1.41 / 0.626 / 1.39 / 1.20-1.61 / 0.298 / 1.56 / 1.22-2.00 / 0.013 / 1.36 / 1.18-1.57 / 0.025
Region
North / 4 (1133/1166) / 1.82 / 1.45-2.28 / 0.179 / 1.21 / 0.98-1.50 / 0.939 / 1.43 / 1.18-1.73 / 0.478 / 1.62 / 1.35-1.94 / 0.159 / 1.35 / 1.12-1.63 / 0.078
South / 5 (862/674) / 2.04 / 1.12-3.72 / 0.007 / 1.19 / 0.93-1.51 / 0.218 / 1.34 / 1.07-1.68 / 0.142 / 1.71 / 1.04-2.82 / 0.008 / 1.38 / 1.08-1.77 / 0.034
Sample size in cases
<150 / 4 (389/385) / 2.10 / 1.02-4.34 / 0.045 / 1.18 / 0.84-1.64 / 0.484 / 1.41 / 1.03-1.92 / 0.547 / 1.82 / 0.88-3.76 / 0.012 / 1.40 / 1.06-1.84 / 0.152
≥150 / 5 (1606/1455) / 1.69 / 1.22-2.35 / 0.032 / 1.21 / 1.01-1.45 / 0.445 / 1.39 / 1.17-1.64 / 0.115 / 1.50 / 1.19-1.89 / 0.084 / 1.34 / 1.12-1.60 / 0.017
OR, odds ratio; CI, confidence interval; PH, P value based on Q test for between-study heterogeneity