Supplementary: CO-INVESTIGATORS:

Orhan Aktas, MD (Universitat Dusseldorf, Germany,Co-Investigator); Metha Apiwattanakul, MD (Prasat Neurological Institute Bangkok, Thailand,Co-Investigator); BrendaBanwell, MD (The Children’s Hospital of Philadelphia, University of Pennsylvania, USA,Co-Investigator); Denis Bichuetti, MD, PhD (Universidade Federal de Sao Paulo, Sao Paulo, Brazil,Co-Investigator); SimonBroadley, BSc (Hons,Co-Investigator), MB, ChB, MRCP(UK,Co-Investigator),PhD, CCST(Neurology,Co-Investigator),FRACP (School of Medicine, Griffith University, Gold Coast Campus, QLD, Australia & Department of Neurology, Gold Coast University Hospital, Southport, QLD, Australia,Co-Investigator); PhilippeCabre, MD (CHRU Pierre Zobda-Quitman, Fort de France, Martinique, French West Indies,Co-Investigator); TanujaChitnis, MD (Brigham and Women’s Hospital and Massachusetts General Hospital, Boston, USA.,Co-Investigator); Jerome De Seze, MD, PhD (University Hospital of Strasbourg, Strasbourg, France,Co-Investigator); KazuoFujihara, MD (Tohoku University Graduate School of Medicine, Sendai, Japan,Co-Investigator); BenjaminGreenberg, MD (University of Texas Southwestern Medical Center at Dallas, Dallas, USA,Co-Investigator); KerstinHellwig. MD (St Josef Hospital Bochum, Bochum, Germany,Co-Investigator); RaffaeleIorio, MD (Institute of Neurology, Catholic University of Sacred Heart, Rome Italy,Co-Investigator); SvenJarius, MD (UniversitatKlinikum, Heidelberg, Germany,Co-Investigator); EricKlawiter, MD (Massachusetts General Hospital, Harvard Medical School, Boston, MA,Co-Investigator); IngoKleiter, MD (St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany,Co-Investigator); MarcoLana-Peixoto, MD, PhD (University of Minas Gerais Medical School, Belo Horizonte, Brazil,Co-Investigator); Nakashima, MD (Tohoku University, Sendai, Japan,Co-Investigator); KevinO'Connor, PhD (Yale University School of Medicine, New Haven, CT, USA,Co-Investigator); JacquelinePalace, DM, FRCP (Oxford University Hospitals Trust, Oxford,Co-Investigator); Friedman Paul, MD (Charité University Medicine Berlin, Berlin, Germany,Co-Investigator); NarapornPrayoonwiwat, MD (Siriraj Hospital, Mahidol University, Bangkok, Thailand,Co-Investigator); KlemensRuprecht, MD (Charité University Medicine Berlin, Berlin, Germany,Co-Investigator); OlafStuve, MD, PhD (University of Texas Southwestern Medical Center at Dallas, Dallas, USA,Co-Investigator); Thomas Tedder, PhD (Duke University Medical Center, Durham, NC,Co-Investigator); SilviaTenembaum, MD (National Pediatric Hospital Dr. Juan P. Garrahan, Buenos Aires, Argentina,Co-Investigator); Katja van Herle, MD (The Guthy Jackson Charitable Foundation, San Diego, CA, USA,Co-Investigator); Danielle van Pelt, MD (Department of Neurology, Erasmus MC, Rotterdam, The Netherlands,Co-Investigator); PabloVilloslada, MD (Hospital Clinic and Institute of Biomedical Research August Pi Sunyer (IDIBAPS,Co-Investigator), Barcelona, Spain,Co-Investigator); Emmanuelle Waubant, MD, PhD (University of Califronia San Francisco, USA,Co-Investigator); BrianWeinshenker, MD (Mayo Clinic, Rochester, MN, USA,Co-Investigator); DeanWingerchuk, MD (Mayo Clinic, Scottsdale, AZ, USA,Co-Investigator); JensWürfel, MD (Charité – Universitätsmedizin Berlin, Germany & University Medicine Göttingen, Germany,Co-Investigator); ScottZamvil, MD, PhD (University of California San Francisco, USA,Co-Investigator).