Supplemental Table 6. Opioid Use at Last Chemotherapy, After Last Chemotherapy and at Death

Supplemental Table 6. Opioid use at last chemotherapy, after last chemotherapy and at death

Regular use of opioids at last chemotherapy / Cumulative and mean daily opioid doses after last chemotherapy / Regular use of opioids at death
<60 mg/day / ≥60 mg/day / <60 mg/day / ≥60 mg/day / <60 mg/day / ≥60 mg/day
N / 62 / 32 / 151 / 72 / 101 / 124
Total opioid (mg/day)
Mean ± SD
Median
Range / 24.8 ± 10.4
22.5
7.5–50.0 / 123.1 ± 75.8
90.1
60.0–360.4 / 33.3 ± 13.7
30.0
5.2–57.6 / 357.1 ± 1408.8
120.0
60.0–15360.0
Cumulative opioid (mg)
Mean ± SD
Median
Range / 843.5 ± 1204.2
412.5
10.0–5763.8 / 8114.4 ± 16849.5
3292.6
80.0–127204.0
Mean opioid dose (mg/day)
Mean ± SD
Median
Range / 30.6 ± 13.8
29.5
3.7–56.7 / 154.5 ± 143.3
101.3
62.7–1078.1
Distribution (N)
30mg/day
≥30 to <60 mg/day
≥60 to <120mg/day
≥120 to <300mg/day
≥300mg/day / 34
28 / 18
12
2 / 77
74 / 42
25
5 / 39
62 / 58
46
20
Morphine
Oral
Extended
N
Mean ± SD (mg/day) / 6
25.0 ± 13.8 / None / 16
271.9 ± 205.7 / 2
1080.0 ± 810.0 / 2
30.0 ± 28.3 / None
Immediate
N
Mean ± SD (mg/day) / None / None / 17
142.6 ± 143.9 / 4
427.5 ± 299.6 / None / None
Suppository
N
Mean ± SD (mg/day) / None / None / 15
556.1 ± 856.9 / 17
674.1 ± 643.1 / None / None
Intravenous
N
Mean ± SD (mg/day) / None / None / 113
226.0 ± 239.4 / 60
3761.3 ± 15420.5 / 77
34.9 ± 13.7 / 97
189.9 ± 320.5
Oxycodone
Oral
Extended
N
Mean ± SD (mg/day) / 45
24.2 ± 11.1 / 10
96.8 ± 70.6 / 59
507.3 ± 810.2 / 39
3032.1 ± 4608.3 / 6
15.0 ± 0.0 b / 2
135.0 ± 63.6
Immediate
N
Mean ± SD (mg/day) / None / None / 58
256.7 ± 402.1 / 47
1592.7 ± 2555.7 / None / None
Intravenous
N
Mean ± SD (mg/day) / None / None / 2
240.0 ± 60.0 / 3
3673.3 ± 3930.1 / 2
48.0 ± 13.6 / 3
710.4 ± 1006.1
Fentanyl
Transdermal
N
Mean ± SD (mg/day) / 8
30.0 ± 0.0 a / 25
118.9 ± 81.1 / 55
653.1 ± 822.9 / 37
3058.0 ± 5398.2 / 13
30.0 ± 0.0 b / 30
130.1 ± 138.9
Intravenous
N
Mean ± SD (mg/day) / None / None / 5
572.0 ± 631.1 / 6
4235.0 ± 5722.6 / 2
19.2 ± 0.0 / 8
2444 ± 5261.0
Tramadol
Oral
N
Mean ± SD (mg/day) / 3
20.0 ± 0.0 a / None / 3
876.7 ± 419.7 / 2
270.0 ± 30.0 / None / None

Extended, extended-release; Immediate, immediate-release; SD, standard deviation

a all patients were treated using the same opioid dose from a fentanyl patch or tramadol at admission

b all patients used a same dose of oral oxycodone or transdermal patch at death

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