Supplemental Table 1. Patient Clinic Characteristics and CD68+ TAMs Expression in all ENKTL Cases.
Case / Gender / Age (year) / Primary site / stage / Biopsy site / EBER / CD3 / TIA-1 / granzyme B / perforin / CD56 / Ki-67(%) / CD68+cells/ hpf / Treatment / Survival / Survival time(month)
1 / female / 51 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / + / 70+ / 60 / CT+RT / yes / 148
2 / female / 47 / extra-UENKTL / Ⅱ / vulva skin / + / + / + / + / + / + / 50+ / 32 / CT+RT / yes / 144
3 / female / 51 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / + / 30+ / 55 / CT+RT / yes / 113
4 / female / 28 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / ﹣ / 70+ / 70 / CT+RT / yes / 100
5 / male / 33 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 50+ / 32 / CT+RT / yes / 66
6 / male / 67 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / - / 80+ / 90 / CT / no / 7
7 / male / 39 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 90+ / 38 / CT+RT / yes / 81
8 / male / 38 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / + / 30+ / 19 / CT+RT / yes / 80
9 / male / 49 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 95+ / 98 / CT / no / 10
10 / female / 24 / UENKTL / Ⅳ / nasal cavity / + / + / + / + / + / + / 70+ / 101 / CT / no / 14
11 / male / 61 / extra-UENKTL / Ⅱ / stomach wall / + / + / + / + / + / - / 80+ / 89 / CT+RT / no / 31
12 / male / 25 / extra-UENKTL / Ⅰ / frontal lobe / + / + / + / + / + / + / 80+ / 99 / CT+RT / no / 19
13 / female / 40 / extra-UENKTL / Ⅳ / ileocecus / + / + / + / + / + / - / 80+ / 87 / CT / no / 22
14 / male / 42 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / + / 20+ / 52 / CT+RT / yes / 30
15 / male / 43 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / + / 60+ / 103 / CT+RT / no / 21
16 / female / 53 / UENKTL / Ⅳ / epiglottis / + / + / + / + / + / + / 90+ / 92 / CT / no / 4
17 / male / 38 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 20+ / 50 / CT+RT / yes / 75
18 / male / 48 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 70+ / 52 / CT+RT / yes / 77
19 / male / 26 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 80+ / 23 / CT+RT / yes / 58
20 / male / 35 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 60+ / 44 / CT+RT / yes / 53
21 / female / 70 / UENKTL / Ⅲ / nasal cavity / + / + / + / + / + / - / 70+ / 32 / CT / no / 6
22 / male / 34 / UENKTL / Ⅳ / nasal cavity / + / + / + / + / + / + / 50+ / 60 / CT / yes / 71
23 / male / 44 / extra-UENKTL / Ⅱ / left testis / + / + / + / + / + / + / 90+ / 62 / CT+RT / yes / 74
24 / female / 50 / UENKTL / Ⅳ / nasal cavity / + / + / + / + / + / + / 20+ / 39 / CT / yes / 79
25 / male / 36 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 40+ / 51 / CT+RT / yes / 61
26 / female / 52 / extra-UENKTL / Ⅳ / limbs skin / + / + / + / + / + / + / 50+ / 88 / CT / no / 12
27 / male / 61 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / + / 20+ / 61 / CT+RT / no / 21
28 / female / 32 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / - / 50+ / 22 / CT+RT / yes / 65
29 / male / 39 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 30+ / 44 / CT+RT / yes / 70
30 / male / 39 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 50+ / 16 / CT+RT / yes / 65
31 / female / 73 / extra-UENKTL / Ⅳ / spleen, bone marrow / + / + / + / + / + / + / 80+ / 63 / CT / no / 5
32 / male / 37 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 50+ / 29 / CT+RT / yes / 64
33 / female / 40 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 20+ / 21 / CT+RT / yes / 61
34 / male / 38 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / + / 60+ / 78 / CT+RT / yes / 58
35 / male / 43 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 50+ / 82 / CT / no / 27
36 / male / 49 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / + / 30+ / 29 / CT+RT / yes / 61
37 / male / 37 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 80+ / 71 / CT+RT / no / 7
38 / male / 65 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 90+ / 70 / CT+RT / yes / 41
39 / male / 32 / extra-UENKTL / Ⅳ / Ileum / + / + / + / + / + / + / 50+ / 41 / CT / no / 5
40 / male / 33 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / - / 90+ / 67 / CT+RT / yes / 54
41 / male / 55 / extra-UENKTL / Ⅱ / facial skin / + / + / + / + / + / + / 80+ / 63 / CT+RT / yes / 84
42 / male / 49 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 30+ / 72 / CT+RT / yes / 54
43 / male / 47 / UENKTL / Ⅳ / nasal cavity / + / + / + / + / + / + / 70+ / 67 / CT / no / 9
44 / female / 29 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 50+ / 55 / CT+RT / yes / 52
45 / male / 46 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / + / 90+ / 73 / CT / no / 10
46 / male / 59 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / - / 30+ / 31 / CT+RT / yes / 79
47 / female / 52 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 90+ / 43 / CT+RT / yes / 51
48 / female / 47 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / + / 40+ / 76 / CT+RT / yes / 57
49 / male / 34 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 40+ / 89 / CT+RT / yes / 46
50 / male / 47 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 30+ / 27 / CT+RT / yes / 47
51 / male / 62 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / + / 80+ / 34 / CT+RT / no / 15
52 / female / 38 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / + / 50+ / 99 / CT+RT / yes / 51
53 / female / 49 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / + / 60+ / 41 / CT+RT / no / 27
54 / male / 47 / extra-UENKTL / Ⅳ / thigh muscle / + / + / + / + / + / + / 70+ / 38 / CT / yes / 52
55 / male / 65 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / - / 30+ / 68 / CT+RT / yes / 52
56 / male / 52 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / + / 50+ / 36 / CT+RT / yes / 49
57 / male / 37 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / - / 50+ / 55 / CT+RT / yes / 49
58 / male / 47 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 40+ / 30 / CT+RT / yes / 47
59 / female / 24 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 30+ / 45 / CT+RT / yes / 45
60 / male / 42 / extra-UENKTL / Ⅳ / testis / + / + / + / + / + / + / 90+ / 52 / CT / yes / 34
61 / female / 51 / extra-UENKTL / Ⅳ / intestinal wall / + / + / + / + / + / + / 90+ / 106 / CT / no / 7
62 / male / 58 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 80+ / 46 / CT+RT / yes / 38
63 / male / 23 / UENKTL / Ⅳ / nasal cavity / + / + / + / + / + / + / 80+ / 45 / CT / yes / 4
64 / male / 50 / extra-UENKTL / Ⅲ / mandibular lymph nodes / + / + / + / + / + / - / 70+ / 79 / CT / no / 12
65 / female / 59 / extra-UENKTL / Ⅳ / cervical lymph nodes / + / + / + / + / + / + / 70+ / 32 / CT / no / 2
66 / female / 66 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 50+ / 36 / CT+RT / no / 15
67 / male / 21 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 20+ / 35 / CT+RT / yes / 44
68 / female / 42 / UENKTL / Ⅰ / nasal cavity / + / + / + / + / + / + / 60+ / 40 / CT+RT / yes / 43
69 / male / 27 / UENKTL / Ⅱ / nasal cavity / + / + / + / + / + / + / 60+ / 34 / CT+RT / no / 10
70 / female / 59 / extra-UENKTL / Ⅳ / limbs skin / + / + / + / + / + / + / 80+ / 27 / CT / no / 7