Supplemental Table 1: Multivariate Analyses of Transplant Outcomes (N=1250)
Supplemental Table 1: Multivariate analyses of transplant outcomes (n=1250)
Progression/relapse / Non-relapse mortality / LFS / OSHR1 (95% CI) / P1 / HR1 (95% CI) / P1 / HR1 (95% CI) / P1 / HR1 (95% CI) / P1
Use of ATG versus not / 1.1 (0.9-1.4) / 0.40 / 0.9 (0.6-1.3) / 0.60 / 1.0 (0.8-1.2) / 0.78 / 0.9 (0.8-1.2) / 0.60
Use of alemtuzumab vs. not / 1.0 (0.7-1.3) / 0.75 / 0.9 (0.6-1.3) / 0.57 / 0.9 (0.7-1.2) / 0.45 / 0.9 (0.7-1.1) / 0.31
Year of transplantation > median / 1.1 (0.9-1.4) / 0.52 / 1.1 (0.8-1.5) / 0.61 / 1.1 (0.9-1.3) / 0.42 / 1.1 (0.9-1.3) / 0.46
Patient age (/10 years) / 1.0 (0.9-1.1) / 0.96 / 1.3 (1.1-1.6) / 0.002 / 1.1 (1.0-1.2) / 0.09 / 1.1 (1.0-1.2) / 0.04
Diagnosis to allo-SCT > median / 0.9 (0.7-1.1) / 0.25 / 1.1 (0.8-1.5) / 0.63 / 0.9 (0.8-1.1) / 0.48 / 1.0 (0.8-1.1) / 0.59
Female donor to male recipient / 1.1 (0.9-1.4) / 0.41 / 1.5 (1.1-2.1) / 0.02 / 1.2 (1.0-1.5) / 0.04 / 1.3 (1.0-1.6) / 0.02
Patient CMV seropositivity / 0.9 (0.7-1.2) / 0.45 / 1.3 (0.9-1.9) / 0.15 / 1.0 (0.8-1.2) / 0.86 / 1.1 (0.9-1.3) / 0.51
Donor CMV seropositivity / 0.9 (0.7-1.2) / 0.61 / 1.5 (1.0-2.1) / 0.04 / 1.1 (0.9-1.3) / 0.44 / 1.1 (0.9-1.3) / 0.51
Poor cytogenetics or FLT3-ITD / 1.8 (1.4-2.3) / <0.0001 / 0.7 (0.5-1.2) / 0.18 / 1.4 (1.2-1.7) / 0.001 / 1.5 (1.2-1.9) / 0.0001
High activity centers2 / 0.8 (0.6-1.0) / 0.02 / 0.7 (0.5-1.0) / 0.05 / 0.8 (0.6-0.9) / 0.004 / 0.8 (0.6-0.9) / 0.006
1Statistically significant factors are in bold; 2arbitrarily defined as center that contributed for >10 patients in the current study.
LFS, leukemia-free survival; OS, overall survival; GVHD, graft-versus-host disease; ATG, anti-thymocyte globulin; CMV, cytomegalovirus.
List of institutions reporting data included in this study (Nº preceding name is the EBMT center identification code):
230 Marseille [Paoli Calmettes]727 Salamanca [H Clinico]
267 Pessac [H Haut-Leveque]
387 Birmingham [Queen Elizabeth]
624 Toulouse [H Purpan]
718 Pilsen [Charles Univ H]
168 Ankara [Hacettepe Univ]
207 Paris [St Louis]
253 Nantes [Hotel Dieu]
257 Dublin [St James]
740 Linköping [Univ H]
759 Barcelona [H Univ Bellvitge]
717 Nottingham [City H]
763 London [Kings College H]
255 Oxford [Radcliffe H]
276 Newcastle-Upon-Tyne [Royal Victoria]
672 Strasbourg [H Hautepierre]
807 Berlin [Charite Univ]
209 Leuven [Univ H]
270 Grenoble [H A Michallon]
754 Tel-Hashomer [Univ Adults]
768 London [S Bartholomew`s]
813 Milano [S Raffaele]
823 Plymouth [Derriford H]
289 Goeteborg [Sahlgrenska Univ H]
601 Manchester [Royal Infirmary]
713 Leicester [Royal Infirmary]
212 Stockholm [Univ H]
260 Barcelona [SCreu i S Pau]
613 Barcelona [H Trias i Pujol]
780 Manchester [Christie]
238 Córdoba [Reina Sofia]
386 Bristol [Royal H Sick Children]
766 Napoli [Federico II]
208 Zürich [208]
228 Edinburgh [Western General]
291 Porto [Inst Oncologia]
676 Vandoeuvre_Les_Nancy [H d`Enfants]
218 London [Royal Marsden]
224 London [UCL]
244 Glasgow [Royal Infirmary]
286 Pavia [S Matteo]
926 Montpellier [University]
235 Oslo [Rikshospitalet]
262 Paris [Pitie-Salpetrriere]
524 Heidelberg [Medizinishce Kl]
574 Olomouc [Univ H]
597 Brno [Univ H]
663 Valencia [H Univ La Fe]
810 Freiburg [University]
264 Poitiers [H La Miletrie]
304 Firenze [Careggi-Meyer]
561 Thessaloniki [G Papanicolaou G H]
566 Cambridge [Addenbrookes H]
659 Brest [H Agustin-Morvan]
666 Villejuif [Gustave Roussy]
671 Lyon [H E Herriot]
778 Sheffield [Royal Hallamshire]
170 Trabzon [Karadeniz Tech Univ]
216 London [Royal Free]
283 Lund [Univ H]
501 Liverpool [Royal Univ H]
589 Adana [Baskent Univ]
650 Angers [CHRU]
692 Palermo [La Maddalena]
704 Southampton [General H]
728 Madrid [Puerta de Hierro]
787 Regensburg [University]
145 Stuttgart [Robert Bosch Kh]
204 Ulm [Medizin Kl / Polikl]
215 Brussels [Jules Bordet]
250 Saint_Etienne [St Etienne]
251 Caen [Hopital, Hematol]
282 Valencia [H Clinico]
294 Milano [Osp Niguarda]
295 Hannover [Medical Univ]
303 Cardiff [Univ Wales]
584 Barcelona [V d`Hebron Adults]
627 Kayseri [Erciyes Univ]
769 Sevilla [Virgen del Rocio]
788 Ancona-Torrete [Umberto I]
919 Antalya [Medical Park H]
258 Jerusalem [Univ Hadassah]
344 Aberdeen [Royal Infirmary]
537 Las_Palmas_De_Gran_Canaria [H Dr. Negrin]
538 Wroclaw [Ctr Cell Transpl]
598 San_Sebastian [H Aranzazu]
614 Hamburg [Univ H]
644 Vilnius [Santariskiy Kl]
677 Katowice [Silesian Med Acad]
729 Hradec_Králové [Charles Univ H, Hematol]
730 Poznan [K Marcinkowski Univ]
731 Umeå [Univ H]
735 Murcia [H M Meseguer]
941 Rouen [Becquerel]
141 Brescia [Civili, Adulti]
160 Paris [H Necker]
169 Ankara [Gazi Univ]
214 Barcelona [H Clinic]
225 Turku [University]
233 Besancon [H Jean Minjoz]
240 Bologna [S Orsola-Malpighi]
256 Kiel [UKSH]
284 Birmingham [Heartlands H]
346 Sofia [Queen Johanna]
392 Palermo [Osp V Cervello]
523 Nice [H de l`ARCHET I]
656 Prague [Ist Hematology]
798 Christchurch [Canterbury Health]
153 Hamburg [AK St Georg]
205 London [Hammersmith]
231 Torino [S. Giovanni (CTO)]
266 Uppsala [Univ H]
268 Belfast [City H]
273 Clermont-Ferrand [Jean Perrin]
307 Rome [Univ S Cuore]
397 Riyadh [King Faisal]
506 Brugge [AZ Sint-Jan]
556 Budapest [National Med Ctr]
587 Reggio_Calabria [Centro Trapianti]
625 Nürnberg [Klinikum]
642 Oviedo [H Covadonga]
658 Bergamo [Ospedale, ematol]
661 Rennes [H Sud/Pontchaillou]
693 Warsaw [Inst Haematology]
705 Udine [Univ H]
721 London [Guy`s H]
786 Mainz [Johannes-Gutenberg]
825 Alessandria [SS Antonio e Biagio]
223 Tübingen [UnivTubingen]
234 Brussels [St. Luc]
254 Leeds [St James]
259 Essen [Univ H]
261 Geneva [261]
265 Milano [Osp Maggiore]
305 Torino [Regina Margherita]
321 Siena [Le Scotte]
345 Haifa [Rambam MCH]
369 Beirut [American Univ]
427 Bucharest [Fundeni Clin Inst]
534 Cologne [Univ, Medicine]
539 London [St George`s]
544 Monza [Osp S Gerardo]
559 Granada [Virgen de las Nieves]
577 Pamplona [H de Navarra]
588 Amsterdam [VU Univ Med Ctr]
610 Bratislava [Univ H]
616 Milano [INT]
623 Verona [Policlinico]
628 Izmir [Ege Univ Med Sch]
630 Brussels [Univ H]
649 Bari [Univ Studi]
784 Essen [Evangelisches Kh]
809 Erlangen [University]
977 Limoges [CHRU]
161 Tel_Aviv [Sourasky]
178 Targu-Mures [Sectia Clin]
203 Leiden [Univ H]
217 Genova [S Martino]
236 Madrid [Princesa]
246 Rotterdam [Erasmus ` den Hoed]
252 Creteil [H Mondor Hematol]
287 Rome [S Camillo - Forlanini]
290 Karlsruhe [Klinikum]
299 Bolzano [Osp S Maurizio]
302 Zagreb [Univ H Rebro]
308 Graz [Medical Univ]
311 Wiesbaden [Kl Diagnostik]
331 Milano [Ist Europeo Oncologia]
339 Antwerp [AZ Stuivenberg]
402 Gaziantep [Gaziantep U]
423 Ankara [Oncology R&E H]
513 Munich [Kl Grosshadern]
565 Maastricht [Univ H]
590 Berlin [Benjamin Franklin]
602 Bremen [Kl Bremen-Mitte]
606 Cuneo [S Croce e Carle]
607 Napoli [Osp Cardarelli]
609 Ampang [Hospital, BMT unit]
615 Madrid [H Ramón y Cajal]
617 Ankara [Ibni Sina H]
645 Marburg [Philipps Univ]
646 Roeselare [Heilig Hartziekenhuis]
665 Clamart [H Percy]
703 Alger [Pierre et Marie Curie]
722 Palma_De_Mallorca [Son Dureta]
725 St._Petersburg [Pavlov Med Univ]
751 Athens [St. Savas]
755 Petach-Tikva [Schneider Children]
756 Rome [Tor Vergata]
785 Homburg [Univ Saarland]
789 Avellino [S G Moscati]
797 Vicenza [Osp S Bartolo]
808 Dresden [Universitaets Kl]
816 Warsaw [Military Med Acad]
819 Madrid [H G Marañón]
954 Warsaw [Central]
987 Genova [S Martino, 1]
Baron et al., Page 1