SNP / H-W
p-value / MAF / Minor allele / H-W
p-value / MAF / Minor allele / H-W
p-value / MAF / Minor allele
rs10516800 / 0.83 / 0.278 / C / 0.15 / 0.278 / C / 1.00 / 0.241 / C
rs11730582 / 0.66 / 0.122 / C / 0.07 / 0.443 / T / 1.00 / 0.349 / C
rs28357094 / 0.14 / 0.078 / G / 0.02 / 0.215 / G / 1.00 / 0.161 / G
rs2853749 / 0.82 / 0.432 / T / 0.04 / 0.324 / T / 1.00 / 0.308 / T
rs11728697 / 1.00 / 0.211 / T / 0.10 / 0.396 / C / 0.81 / 0.402 / T
rs6532040 / 0.87 / 0.445 / G / 0.81 / 0.282 / G / 0.64 / 0.241 / G
rs1126772 / 0.41 / 0.054 / G / 0.97 / 0.291 / G / 0.83 / 0.161 / G
rs9138 / 0.52 / 0.151 / C / 0.90 / 0.335 / C / 0.81 / 0.287 / C
rs7655182 / 0.34 / 0.476 / G / 0.97 / 0.329 / A / 0.92 / 0.321 / A
Supplemental Table 1 Hardy-Weinberg p-values and minor allele frequencies in each ancestral background
H-W p-value = p-value for departure from expected Hardy-Weinberg proportions by Chi-square distribution, MAF = minor allele frequency
Supplemental Figure Legends
Supplemental Figure 1 Serum IFN-α activity in SLE patients stratified by age and OPN genotype in each ancestral background. A, B, and C show data from African-American, European-American, and Hispanic-American ancestries respectively. Similar non-significant trends are demonstrated in each ancestral background (all p-values >0.05), suggesting that the age-related genetic effect is similar across the various ancestral groups.
Supplemental Figure 2 Serum OPN levels in SLE patients stratified by age and OPN genotype in each ancestral background. A, B, and C show data from African-American, European-American, and Hispanic-American ancestries respectively. Similar non-significant trends are demonstrated in each ancestral background (all p-values >0.05), suggesting that the age-related genetic effect is similar across the various ancestral groups.
Supplemental Figure 1
Supplemental Figure 2