Supplemental file 1

Clinicopathologic features and treatment outcome of 88 Asian patients with T-cell large granular lymphocyte leukemia identified from the literature

Case / gender / age / Hb / LGL / ANC / Plat / liver / spleen / PRCA / AID / infection / other disorders / TCR / steriod / cyclophosphamide / CsA / other Rx / outcome / References
1 / F / 60 / 4.7 / 5 / 0.6 / 200 / enlarged / normal / present / absent / absent / nil / Re / U / U / NA / NA / NR / Oshimi 1988
2 / F / 36 / 5.8 / 1.8 / 3.2 / 508 / normal / normal / present / absent / absent / renal allograft / Re / NA / R / NA / NA / CR / Masuda 1998
3 / M / 75 / 9.7 / 1.8 / 0.8 / 26 / normal / normal / absent / absent / present / nil / Re / NA / NA / NA / NA / dead / Akashi 1998
4 / M / 71 / 9.5 / 23 / 16 / 64 / normal / normal / absent / absent / present / nil / Re / NA / NA / NA / NA / spontaneous remission / Takeuchi 1999
5 / M / 48 / 5.7 / 5.3 / 1.2 / 619 / enlarged / normal / present / absent / absent / nil / Re / NA / NA / R / NA / CR / Saitoh 2000
6 / F / 33 / 7.6 / 0.36 / 1.64 / 192 / normal / normal / present / absent / absent / parvovirus B19 / Re / NA / NA / NA / NA / NR / Kondo 2001
7 / F / 63 / 11 / 31.6 / 5.2 / NA / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / chemotherapy / NR / Matsuo 2002
8 / M / 76 / 11.5 / 7.4 / 5.2 / 228 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Karasawa 2003
9 / F / 72 / 11.3 / 7.5 / 2.6 / 45 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Karasawa 2003
10 / F / 84 / 12.5 / 8.3 / 7.2 / 233 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Karasawa 2003
11 / M / 74 / 8.8 / 5.8 / 1.7 / 42 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Karasawa 2003
12 / M / 27 / 13.1 / 0.7 / 2.4 / 95 / normal / normal / absent / absent / absent / aplastic anemia / Re / NA / NA / NA / NA / NA / Karasawa 2003
13 / F / 66 / 10.8 / 1.6 / 2.9 / 26 / normal / normal / absent / absent / absent / ITP / Re / NA / NA / NA / NA / NA / Karasawa 2003
14 / F / 64 / 11.2 / 11.9 / 5.2 / 242 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Karasawa 2003
15 / M / 68 / 8.6 / 6.5 / 6.3 / 649 / normal / normal / present / absent / absent / nil / Re / NA / NA / NA / NA / NA / Karasawa 2003
16 / M / 56 / 9.6 / 2.1 / 2.3 / 257 / normal / normal / absent / absent / absent / Bechet / Re / NA / NA / NA / NA / NA / Karasawa 2003
17 / F / 68 / 7.3 / 2.4 / 2.5 / 467 / normal / normal / absent / absent / absent / AIHA / Re / NA / NA / NA / NA / NA / Karasawa 2003
18 / M / 23 / 13.8 / 3.2 / 6.7 / 213 / normal / enlarged / absent / absent / absent / nil / Re / NA / NA / NA / NA / NR / Wong 2003
19 / M / 77 / 10.9 / 0.9 / 1.7 / 184 / normal / normal / absent / absent / absent / AML / Re / NA / NA / NA / NA / NR / Kato 2004
20 / M / 51 / 6.6 / 1.6 / 3.4 / 254 / normal / normal / present / absent / absent / nil / Re / U / NA / NA / NA / dead / Tanaka 2006
21 / M / 61 / 10.3 / 13.1 / 4.2 / 106 / normal / normal / absent / absent / absent / autologous HSCT / Re / NA / NA / NA / NA / NR / Narumi 2004
22 / M / 46 / 9.5 / 3.0 / 1.0 / 402 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / spontaneous remission / Shichishima 2004
23 / M / 56 / 8.9 / 7.9 / 16.8 / 41 / normal / normal / absent / absent / absent / nil / NA / NA / NA / NA / chlorambucil / NA / Kwong 1995
24 / M / 49 / 8.8 / 11.1 / 8.1 / 183 / normal / normal / present / absent / absent / nil / NA / NA / NA / U / ATG / NR / Kwong 1995
25 / F / 57 / 6 / 10.8 / 7.2 / 85 / normal / normal / absent / absent / absent / nil / NA / NA / NA / NA / chlorambucil / NR / Kwong 1995
26 / F / 37 / 3.6 / 2.6 / 3.7 / NA / normal / normal / present / absent / absent / nil / Re / NA / R / NA / NA / CR / Yamada 1997
27 / M / 53 / 7.4 / 2.4 / 2.4 / NA / normal / normal / present / absent / absent / nil / Re / NA / R / NA / NA / CR / Yamada 1997
28 / F / 73 / 12.9 / 7.7 / 3.1 / 430 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NR / Oshimi 1993
29 / M / 56 / 14.7 / 16.8 / 4.7 / 360 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NR / Oshimi 1993
30 / F / 60 / 10.3 / 13.1 / 1.9 / 290 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NR / Oshimi 1993
31 / M / 69 / 17.6 / 15.3 / 5.7 / 190 / normal / normal / absent / absent / absent / HT / Re / NA / NA / NA / NA / NR / Oshimi 1993
32 / F / 53 / 10 / 6.5 / 2 / 140 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NR / Oshimi 1993
33 / F / 67 / 11 / 10.9 / 4.2 / 160 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NR / Oshimi 1993
34 / F / 22 / 10 / 3.4 / 2.1 / 430 / normal / normal / present / absent / absent / nil / Re / NA / NA / NA / NA / NR / Oshimi 1993
35 / F / 53 / 11.4 / 8.5 / 3.8 / 290 / normal / normal / present / absent / absent / nil / G / NA / NA / NA / NA / NR / Oshimi 1993
36 / F / 62 / 5.8 / 5.1 / 2.1 / 310 / normal / normal / present / absent / absent / nil / Re / NA / NA / NA / NA / NR / Oshimi 1993
37 / F / 66 / 2.5 / 2.6 / 6.7 / 370 / normal / normal / present / absent / absent / nil / NA / NA / NA / NA / NA / NR / Oshimi 1993
38 / M / 71 / 6.8 / 6.2 / 4.1 / 330 / normal / normal / present / present / absent / nil / G / NA / NA / NA / NA / NR / Oshimi 1993
39 / M / 85 / 5.4 / 8.9 / 0.9 / 140 / normal / normal / present / absent / absent / nil / Re / NA / NA / NA / NA / NR / Oshimi 1993
40 / F / 58 / 7.5 / 4 / 8 / NA / normal / normal / present / absent / absent / nil / G / NA / NA / NA / NA / NR / Oshimi 1993
41 / F / 58 / 7 / 11.9 / 2.3 / 280 / normal / normal / present / present / absent / nil / Re / NA / NA / NA / NA / NR / Oshimi 1993
42 / M / 41 / 5.2 / 10 / 6.9 / 180 / normal / enlarged / present / absent / absent / nil / Re / NA / NA / NA / NA / NR / Oshimi 1993
43 / M / 42 / 4.3 / 14 / 6.9 / 270 / normal / normal / present / absent / absent / nil / Re / NA / NA / NA / NA / NR / Oshimi 1993
44 / M / 68 / 4.6 / 5 / 2.2 / 350 / enlarged / enlarged / present / absent / absent / nil / Re / NA / NA / NA / NA / spontaneous remission / Oshimi 1993
45 / F / 80 / 11.7 / 9.7 / 3.8 / 220 / normal / normal / absent / absent / absent / HT / Re / NA / NA / NA / NA / NR / Oshimi 1993
46 / M / 72 / 14.8 / 10.9 / 5.3 / 250 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NR / Oshimi 1993
47 / F / 30 / 10.5 / 42.7 / 5.3 / 340 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NR / Oshimi 1993
48 / F / 60 / 4.7 / 4.4 / 1.2 / 200 / normal / normal / present / absent / absent / nil / Re / NA / NA / NA / NA / NR / Oshimi 1993
49 / M / 84 / 10.2 / 3.6 / 6 / 220 / normal / normal / absent / absent / absent / nil / NA / NA / NA / NA / NA / NR / Oshimi 1993
50 / F / 24 / 12.2 / 4.9 / 3.5 / 180 / normal / normal / absent / absent / absent / nil / NA / NA / NA / NA / NA / NR / Oshimi 1993
51 / F / 70 / 13.3 / 10 / 3.6 / 273 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NR / Morikawa 1990
52 / M / 30 / 7.9 / 0.85 / 4.15 / 333 / enlarged / enlarged / absent / absent / absent / nil / NA / NA / NA / NA / NA / NR / Ohno 1989
53 / M / 41 / 5.8 / 3.6 / 1.6 / NA / normal / normal / present / absent / absent / nil / Re / NA / NA / NA / NA / NR / Lee 2002
54 / M / 69 / 17.6 / 15.3 / 4.8 / 190 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
55 / M / 56 / 14.7 / 16.8 / 3.7 / 360 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
56 / M / 80 / 14.6 / 7.4 / 3.8 / 181 / normal / normal / absent / absent / absent / nil / NA / NA / NA / NA / NA / NA / Kawahara 2009
57 / F / 73 / 12.9 / 7.7 / 0.2 / 130 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
58 / F / 53 / 11.4 / 8.5 / 1.1 / 290 / normal / normal / present / absent / absent / nil / G / NA / NA / R / NA / NA / Kawahara 2009
59 / F / 67 / 11.0 / 10.9 / 1.4 / 160 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
60 / F / 60 / 10.3 / 13.1 / 0.6 / 290 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
61 / F / 60 / 10.3 / 2.1` / 0.9 / 170 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
62 / F / 65 / 10.1 / 4.9 / 0.5 / 165 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NR / NA / NA / Kawahara 2009
63 / F / 22 / 10.0 / 3.4 / 0.8 / 430 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
64 / F / 71 / 9.6 / 0.7 / 7.6 / 497 / normal / normal / present / PN / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
65 / M / 78 / 9.4 / 1.2 / 3.1 / 333 / normal / normal / present / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
66 / F / 48 / 9.1 / 12.2 / 1.2 / 401 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
67 / F / 34 / 8.0 / 2.7 / 2.7 / 445 / normal / enlarged / present / CD / present / nil / Re / NA / NA / R / NA / dead / Kawahara 2009
68 / F / 58 / 7.5 / 4.0 / 6.0 / NA / normal / normal / absent / RA / absent / nil / G / NA / NA / NA / NA / NA / Kawahara 2009
69 / M / 52 / 7.5 / 9.3 / 1.5 / NA / normal / normal / absent / AIHA / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
70 / F / 60 / 7.3 / 1.4 / 1.3 / 342 / normal / normal / present / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
71 / M / 58 / 7.2 / 3.1 / 1.0 / 276 / normal / enlarged / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
72 / F / 58 / 7.0 / 11.9 / 0.7 / 280 / normal / normal / present / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
73 / M / 71 / 6.8 / 6.2 / 3.3 / 330 / normal / normal / present / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
74 / F / 62 / 5.8 / 5.1 / 0.8 / 310 / normal / normal / present / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
75 / M / 69 / 5.5 / 4.2 / 0.8 / 324 / normal / normal / present / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
76 / M / 85 / 5.4 / 8.9 / 0.7 / 140 / normal / normal / absent / absent / absent / nil / NA / NA / NA / NA / NA / dead / Kawahara 2009
77 / F / 42 / 5.4 / 2.9 / 1.1 / 635 / normal / normal / present / absent / absent / nil / Re / NA / NA / NR / NA / NA / Kawahara 2009
78 / M / 41 / 5.2 / 10.0 / 1.5 / 180 / normal / enlarged / present / absent / absent / nil / G / NA / NA / NA / NA / NA / Kawahara 2009
79 / M / 68 / 4.6 / 5.0 / 0.4 / 350 / normal / enlarged / present / absent / absent / nil / Re / NA / NA / NA / NA / spontaneous remission / Kawahara 2009
80 / M / 81 / 4.5 / 2.2 / 2.6 / 291 / normal / normal / present / absent / absent / nil / Re / NA / NA / NR / NA / dead / Kawahara 2009
81 / M / 42 / 4.3 / 14.0 / 0.6 / 270 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
82 / F / 66 / 2.5 / 2.6 / 4.8 / 370 / normal / normal / present / RA / absent / nil / NA / NA / NA / NA / NA / NA / Kawahara 2009
83 / M / 72 / 14.8 / 10.9 / 3.1 / 250 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
84 / M / 40 / 13.5 / 8.5 / 1.5 / 198 / normal / normal / absent / absent / absent / nil / NA / NA / NA / NA / NA / NA / Kawahara 2009
85 / M / 51 / 12.1 / 3.6 / 3.2 / 232 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
86 / F / 80 / 11.7 / 9.7 / 1.5 / 220 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / dead / Kawahara 2009
87 / F / 30 / 10.5 / 42.7 / 1.4 / 340 / normal / normal / absent / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009
88 / F / 60 / 4.7 / 4.4 / 0.7 / 200 / normal / normal / present / absent / absent / nil / Re / NA / NA / NA / NA / NA / Kawahara 2009

M: male; F: female; age: age in years; Hb: hemoglobin (g/dL); LGL: large granular lymphocyte count (x 109/L); Plat: platelet count (x 109/L); liver: hepatomegaly; spleen: splenomegaly; PRCA: pure red cell aplasia; AID: autoimmune diseases

Infection: recurrent infections; TCR: T cell receptor gene rearrangement; steroid: response to corticosteroids; cyclophosphamide: response to cyclophosphamide; CsA: response to cyclosporine, Rx: therapy; ATG: anti-thymocyte globulin

AIHA: autoimmune hemolytic anemia; AML: acute myeloid leukemia; HSCT: hematopoietic stem cell transplantation; HT: hypertension; Re: rearranged; G: germline; NA: not available; R: response, U: un-responsive; NR: non-remission; CR: complete remission