Supplement 6. L and D-enantiomer reference values (N=451) in plasma and CSF before removal of outliers.
Cerebrospinal fluid (μmol/L)L-Alanine / D-Alanine / Glycine / L-Serine / D-Serine / L-Proline / D-Proline
Total (N=406) / 31.5 ± 7.69 / 0.17 ± 0.13 / 6.57 ± 2.91 / 23.9 ± 4.33 / 1.26 ± 0.23 / 0.78 ± 0.56 / 0.011 ± 0.011
Men (N=286)
18-30 yrs (N=90) / 29.1 ± 6.47 / 0.14 ± 0.08 / 5.94 ± 2.45 / 24.7 ± 3.53 / 1.31 ± 0.22 / 0.67 ± 0.33 / 0.008 ± 0.008
30-45 yrs (N=90) / 31.3 ± 7.56 / 0.20 ± 0.16 / 6.68 ± 2.57 / 23.2 ± 4.11 / 1.23 ± 0.24 / 0.80 ± 0.51 / 0.010 ± 0.008
45-60 yrs (N=106) / 35.4 ± 8.17 / 0.19 ± 0.131 / 6.62 ± 2.25 / 22.4 ± 3.68 / 1.20 ± 0.22 / 0.87 ± 0.53 / 0.015 ± 0.015
Women (N=120)
18-30 yrs (N=24) / 27.3 ± 6.52 / 0.20 ± 0.21 / 5.86 ± 2.98 / 24.5 ± 3.29 / 1.39 ± 0.22 / 0.59 ± 0.37 / 0.006 ± 0.005
30-45 yrs (N=43) / 29.0 ± 6.49 / 0.13 ± 0.053 / 7.23 ± 5.03 / 25.9 ± 7.00 / 1.29 ± 0.25 / 0.76 ± 0.72 / 0.007 ± 0.005
45-60 yrs (N=53) / 32.4 ± 7.31 / 0.17 ± 0.18 / 7.20 ± 3.11 / 25.1 ± 3.89 / 1.32 ± 0.23 / 0.85 ± 0.90 / 0.012 ± 0.013
Plasma (μmol/L)
L-Alanine / D-Alanine / Glycine / L-Serine / D-Serine / L-Proline / D-Proline
Total (N=389) / 335 ± 74.1 / 0.87 ± 0.52 / 169 ± 49.9 / 85.5 ± 19.1 / 1.10 ± 0.25 / 178 ± 48.4 / 0.34 ± 0.25
Men (N=278)
18-30 yrs (N=83) / 346 ± 76.6 / 0.88 ± 0.46 / 177 ± 48.4 / 92.7 ± 27.3 / 1.17 ± 0.27 / 202 ± 45.8 / 0.32 ± 0.20
30-45 yrs (N=91) / 340 ± 73.9 / 1.01 ± 0.65 / 164 ± 46.6 / 82.3 ± 14.9 / 1.12 ± 0.29 / 189 ± 53.2 / 0.38 ± 0.20
45-60 yrs (N=104) / 351 ± 70.9 / 0.88 ± 0.50 / 158 ± 35.9 / 80.8 ± 15.3 / 1.07 ± 0.22 / 178 ± 39.7 / 0.43 ± 0.32
Women (N=111)
18-30 yrs (N=21) / 289 ± 70.0 / 0.88 ± 0.60 / 133 ± 44.8 / 85.7 ± 16.4 / 1.00 ± 0.24 / 153 ± 62.9 / 0.26 ± 0.16
30-45 yrs (N=41) / 297 ± 73.9 / 0.66 ± 0.34 / 186 ± 54.9 / 89.7 ± 17.7 / 1.04 ± 0.25 / 150 ± 33.5 / 0.25 ± 0.14
45-60 yrs (N=49) / 321 ± 65.7 / 0.83 + 0.51 / 190 ± 64.8 / 86.9 ± 15.5 / 1.01 ± 0.31 / 151 ± 37.3 / 0.32 ± 0.21