Supplement 1: Serum inflammatory markers in CRMO and controls

CRMO vs. CD / Eotaxin / IL-12 / IL-1RA / sIL-2R / IL-6 / MCP-1 / MIG / MIP-1b / RANTES
p-value / <0.001 / <0.001 / <0.001 / <0.001 / <0.001 / <0.001 / <0.001 / <0.001 / 0.480
CRMO vs. JIA / Eotaxin / IL-12 / IL-1RA / sIL-2R / IL-6 / MCP-1 / MIG / MIP-1b / RANTES
p-value / (1.0) / (0.06) / (0.22) / (0.37) / (0.38) / (0.16) / (1.0) / (1.0) / (1.0)
CRMO vs. Con. / Eotaxin / IL-12 / IL-1RA / sIL-2R / IL-6 / MCP-1 / MIG / MIP-1b / RANTES
p-value / <0.001 / <0.001 / (0.684) / <0.001 / <0.001 / <0.001 / <0.001 / <0.001 / <0.001
CD vs. JIA / Eotaxin / IL-12 / IL-1RA / sIL-2R / IL-6 / MCP-1 / MIG / MIP-1b / RANTES
p-value / <0.001 / <0.001 / (1.0) / <0.001 / <0.001 / <0.001 / <0.001 / <0.001 / (1.0)
CD vs. Con. / Eotaxin / IL-12 / IL-1RA / sIL-2R / IL-6 / MCP-1 / MIG / MIP-1b / RANTES
p-value / <0.001 / <0.001 / (0.06) / 0.012 / <0.001 / <0.001 / 0.010 / (0.21) / <0.001
JIA vs. Con. / Eotaxin / IL-12 / IL-1RA / sIL-2R / IL-6 / MCP-1 / MIG / MIP-1b / RANTES
p-value / 0.006 / <0.001 / (1.0) / <0.001 / <0.001 / <0.001 / <0.001 / <0.001 / <0.001

For the comparison of serum inflammatory markers between patients with CRMO, JIA or Crohn’s disease at the time of diagnosis, and controls, data were analyzed using non-parametric Kruskal-Wallis tests (variance analysis) followed by Mann-Whitney U test and pairwise comparison. In the table, results from Mann-Whitney U test are displayed. For Bonferroni correction p values were multiplied with the number of comparisons (x6). P values <0.05 were considered statistically significant. P values that did not indicate statistical significance after Bonferoni correction are in parentheses.