Summary of cerebrospinal fluid routine parameters in neurodegenerative diseases

Sarah Jesse1, MD, Johannes Brettschneider1, MD, Sigurd D. Süssmuth1, MD, Bernhard G. Landwehrmeyer1, Prof. MD, Christine A.F. von Arnim1, Prof. MD, Albert C. Ludolph1, Prof. MD, Hayrettin Tumani1, Prof. MD, Markus Otto1, Prof. MD 1Department of Neurology, University of Ulm, Germany

Corresponding author:

Markus Otto, MD

Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075 Ulm, Germany

phone: -49-731-500 63010; fax: -49-731-500 63012

email:

Online Resource Table 1

Frequencies of intrathecal Ig-synthesis are illustrated for all groups investigated.

The evaluation refers to two different cut-off values: 3s-level: QIgX>Qlim (31) (Qmean+3s range) and 2s-level [(Qmean+(Qlim - Qmean) x 0,67]. Frequencies could be calculated as n/N x 100 in %.

PD / intrathecal synthesis
number / IgG / IgA / IgM
> 3s Level / n (3) / 0 / 0 / 0
> 2s Level / n (2) / 0 / 0 / 0
total number / N / 47 / 47 / 47
/ MD / intrathecal synthesis
number / IgG / IgA / IgM
> 3s Level / N (3) / 0 / 0 / 0
> 2s Level / N (2) / 0 / 0 / 0
total number / N / 20 / 20 / 19
PSP / intrathecal synthesis
number / IgG / IgA / IgM
> 3s Level / n (3) / 0 / 0 / 0
> 2s Level / n (2) / 0 / 0 / 0
total number / N / 16 / 16 / 16
/ AD / intrathecal synthesis
number / IgG / IgA / IgM
> 3s Level / N (3) / 0 / 2 / 3
> 2s Level / N (2) / 0 / 2 / 3
total number / N / 289 / 289 / 289
MSA-P / intrathecal synthesis
number / IgG / IgA / IgM
> 3s Level / n (3) / 0 / 0 / 0
> 2s Level / n (2) / 0 / 0 / 1
total number / N / 12 / 12 / 12
/ FTLD / intrathecal synthesis
number / IgG / IgA / IgM
> 3s Level / N (3) / 0 / 0 / 0
> 2s Level / N (2) / 0 / 0 / 0
total number / N / 28 / 28 / 27
MSA-C / intrathecal synthesis
number / IgG / IgA / IgM
> 3s Level / n (3) / 0 / 0 / 0
> 2s Level / n (2) / 0 / 0 / 0
total number / N / 13 / 13 / 13
/ VD / intrathecal synthesis
number / IgG / IgA / IgM
> 3s Level / N (3) / 0 / 0 / 0
> 2s Level / N (2) / 0 / 0 / 0
total number / N / 13 / 13 / 13
CBD / intrathecal synthesis
number / IgG / IgA / IgM
> 3s Level / n (3) / 0 / 0 / 0
> 2s Level / n (2) / 0 / 0 / 0
total number / N / 5 / 5 / 5
/ PDD / intrathecal synthesis
number / IgG / IgA / IgM
> 3s Level / N (3) / 0 / 0 / 2
> 2s Level / N (2) / 1 / 1 / 2
total number / N / 25 / 25 / 25
SCA / intrathecal synthesis
number / IgG / IgA / IgM
> 3s Level / N (3) / 0 / 0 / 0
> 2s Level / N (2) / 0 / 0 / 0
total number / N / 6 / 6 / 6
/ HD / intrathecal synthesis
number / IgG / IgA / IgM
> 3s Level / n (3) / 0 / 0 / 0
> 2s Level / n (2) / 0 / 0 / 0
total number / N / 31 / 31 / 31
MND / intrathecal synthesis
number / IgG / IgA / IgM
> 3s Level / n (3) / 1 / 1 / 1
> 2s Level / n (2) / 1 / 1 / 1
total number / N / 177 / 177 / 177
/ CON / intrathecal synthesis
number / IgG / IgA / IgM
> 3s Level / n (3) / 0 / 0 / 0
> 2s Level / n (2) / 0 / 0 / 0
total number / N / 83 / 83 / 83