Core Resources for TB Medical Consultants

You can access the Core TB Resources below by pressing CTRL+left click on the web links (Requires Internet connection)

National Guidelines

1) Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in Health-Care Settings,2005MMWR 2005; 54 (No. RR-17) 1-141.

a. Erata (September 25, 2006)

b. Risk Assessment Worksheet (September 27, 2006)

c. Additional FAQs (February 12, 2007)

2) Guidelines for the Investigation of Contacts of Persons with Infectious Tuberculosis: Recommendations from the National Tuberculosis Controllers Association and CDC.MMWR 2005; 54 (No. RR-15, 1-37)

3) Guidelines for Using the QuantiFERON®-TB Gold Test for Detecting Mycobacterium tuberculosis Infection, United States MMWR 2005; 54 (No. RR-15) 49-55

QuantiFERON®-TB GoldTesting Services: This list of institutions that have agreed to provide QFT testing services to outside physicians and laboratories can be accessed at

4) Controlling Tuberculosis in the United States:Recommendations from the American Thoracic Society, CDC, and the Infectious Diseases Society of America.

MMWR 2005; 54 (No. RR-12)

5) Tuberculosis Associated with Blocking Agents Against Tumor Necrosis Factor - Alpha- California, 2002–2003 - MMWR 2004; 53 (No. 30)

6) Treatment of Tuberculosis - MMWR 2003; 52 (No. RR-11)

a) Erata (January 7, 2005) – MMWR 2005;53 (No. 51-52): 1203

b)Hepatotoxicity of Antituberculosis Therapy: An Official ATS Statement – Am J Respir Crit Care Med; 2006;174:935-972

7) Targeted Tuberculin Testing and Treatment of Latent Tuberculosis Infection - MMWR 2000; 49 (No. RR-6)

a) Update: Adverse Event Data and Revised American Thoracic Society/CDC Recommendations Against the Use of Rifampin and Pyrazinamide for Treatment of Latent Tuberculosis Infection - MMWR 2003; 52 (No. 31)

8) HIV-Related TB Treatment

a) Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis – CDC. December 2007.

b)Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. (For TB/HIV co-infection treatment, see pages52-54 and related tables on pages 87-96).Panel on Antiretroviral Guidelines for Adult and Adolescents. U.S. Department of Healthand Human Services. January 29, 2008.

The U.S. Department of Health and Human Services (HHS)issues guidelines and documents for the medical management of HIV infection and issues surrounding HIV infection. The guidelines documents are periodically reviewed and updated by panels of HIV experts and can be accessed at

9) Diagnostic Standards/Classification of TB in Adults and Children. American Journal of Respiratory and Critical Care Medicine 2000; 161.

a) Updated Guidelines for the Use of Nucleic Acid Amplification Tests in the Diagnosis of Tuberculosis. MMWR 2009;58:7-10.

10) Pediatric Tuberculosis Collaborative Group.Targeted Tuberculin Skin Testing and Treatment of Latent Tuberculosis Infection in Children and Adolescents.Pediatrics 2004; 114: 1175-1201

11) An Official ATS/IDSA Statement:Diagnosis, Treatment, and Prevention of Nontuberculous Mycobacterial Diseases. American Journalof Respiratory and Critical Care Medicine2007; 175:367-416

12) Prevention and Control of Tuberculosis in Correctional and Detention Facilities: Recommendations from CDC. MMWR 2006;55(No. RR-9): 1-61.

13) Extensively Drug-Resistant Tuberculosis (XDR-TB)

  1. Emergence of Mycobacterium tuberculosis with Extensive Resistance to Second-Line Drugs - Worldwide, 2000-2004 - MMWR 2006;55:301-305
  1. Notice to Readers: Revised Definition of Extensively Drug-Resistant Tuberculosis - MMWR 2006;55:1176
  1. Extensively Drug Resistant Tuberculosis (XDR TB) - Update from CDC/DTBE10-20-06
  1. Report of the meeting of the WHO Global Task Force on XDR-TB, Geneva, Switzerland, October 9-10, 2006
  1. Extensively Drug-Resistant Tuberculosis – United States, 1993-2006 – MMWR 2007; 56:250-253 (No. 11)
  1. Interim Laboratory Biosafety Guidance for Extensively Drug-Resistant (XDR) Mycobacterium tuberculosis strains (March 26, 2007)
  1. Algorithms for the Management of Contacts Exposed to a Case of XDR TB CDC, Division of TB Elimination. Email correspondence June 2, 2007.

for Contacts to XDR TB.pdf

  1. XDR TB Contact Investigation Form CDC, Division of TB Elimination
  1. Plan to Combat XDR TB – MMWR 2009;58(No RR3):1-43

Other Resources

1) TreatmentPocketCardsNew JerseyMedicalSchool Global Tuberculosis Institute

a) Treatment of Tuberculosis: Standard Therapy for Active Disease in Adults and Adolescents(2007)

b) Treatment of Tuberculosis (TB) in Adult and Adolescent Patients Co-Infected with the Human Immunodeficiency Virus (HIV) (2007)

c) Treatment of Tuberculosis: Standard Therapy for Active Disease in Children (2007)

2) Francis J. Curry National Tuberculosis Center and California Department of Health Services, 2008:Drug-Resistant Tuberculosis: A Survival Guide for Clinicians, 2nd edition

3) Francis J. Curry National Tuberculosis Center:Radiographic Manifestations of Tuberculosis: A Primer for Clinicians, Second Edition

4) Treatment Guidelines from the Medical Letter: Drugs for Tuberculosis. 2007;5(55)15-22.

Treatment Guidelines - The Medical Letter 2007.pdf

5) Tuberculosis and Air Travel – Guidelines for Prevention and Control, Third Edition – World Health Organization (2008)

6) TB-Related News and Journal Items Weekly Update:Provided by the CDC as a public service, subscribers receive:

• A weekly update of TB-related news items

• Citations and abstracts to new scientific TB journal articles

• TB conference announcements

• TB job announcements

To subscribe to this service, visit:

7)TB Fact Sheets

Developed by CDC, these 2-page fact sheets provide health care providers with summary information and references related to current recommendations in the diagnosis, treatment, and management of TB. These can be accessed at

Listing of Core TB Resourceswith Outside Links02-20-09