Steven Grinspoon, M.D.
Curriculum Vitae
Part I: General Information
Name: Steven K. Grinspoon
Office Address:Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital,
Boston, MA 02114, 617-726-3870
Fax:617-726-5072
Education:
1983 B.A.Cornell University
1988 M.D.University of Rochester School of Medicine and Dentistry
Post-doctoral Training:
Internships and Residencies:
1988-1991 Resident in Medicine, Columbia-Presbyterian Hospital, New York
1991-1992Chief Resident in Medicine, Columbia-Presbyterian Hospital, New York
Clinical and Research Fellowships:
1992-1993 Clinical Fellow, Endocrine Unit, Massachusetts General Hospital
1993-1995 Research Fellow, Neuroendocrine Unit, Massachusetts General Hospital
Licensure and Certification:
1991American Board of Internal Medicine Certificate
1992Massachusetts License Registration
1995Endocrinology and Metabolism
Academic Appointments:
1992-1995Postdoctoral Research Fellow in Medicine, Harvard Medical School
1995-1996Instructor in Medicine, Harvard Medical School
1997-Assistant Professor of Medicine, Harvard Medical School
Hospital and Affiliated Institution Appointments:
1992-1993Essential Clinical Fellow, Department of Medicine, Massachusetts General Hospital
1993-1995Research Fellow, Department of Medicine, Massachusetts General Hospital
1995-1996Clinical Assistant in Medicine, Massachusetts General Hospital
1996-1998Assistant in Medicine, Massachusetts General Hospital
1998-Assistant Physician, Massachusetts General Hospital
1998-Associate Physician to the Affiliate Staff, Brigham and Women’s Hospital
Other Professional Positions and Major Visiting Appointments:
1998-Visiting Scientist, Massachusetts Institute of Technology
Hospital and Service Responsibilities:
1995-Attending Physician, Neuroendocrine Unit, Massachusetts General Hospital
1995-Attending Physician, Baker Service, Massachusetts General Hospital
1996-Attending Physician, Endocrinology Consult Service, Massachusetts General Hospital
Major Administrative Responsibilities:
1999-Assistant Director, General Clinical Research Center, Massachusetts Institute of Technology
Major Committee Assignments:
Local/Regional
1995-1997Member, Executive Committee, Boston Obesity Nutrition Research Center
1997-Member, Scientific Advisory Committee, General Clinical Research Center, Massachusetts General Hospital
National
1997Member, American Association of Clinical Endocrinologists AMAP Accreditation Self Assessment Committee - Pituitary Section
1998-Member, AIDS Clinical Trials Group Metabolic Focus Section
1998-Vice Chairman, AIDS Clinical Trial Group Protocol 5005S, Glucose Metabolism, Lipid Disorders, and Body Composition Changes in Subjects Treated with Efavirenz or Nelfinivir
1999-Member, University of California, Universitywide AIDS Research Program,
Study Section: Clinical Studies: HIV/OI/Malignancies
1999-Member, National Institutes of Health - Review Committee Member, National Center for Research Resources
1999-Section Leader, Department of Health and Human Services - Expert Panel on National HIV/AIDS Nutrition Guidelines
Professional Societies:
1992-Member, American College of Physicians
1996-Member, Endocrine Society
1996-Member, American Society for Bone and Mineral Research
1998-Member, American Association of Clinical Endocrinologists
1998-Member, The Pituitary Society
Editorial Boards:
2000-2004Member, Editorial Board, Journal of Clinical Endocrinology and Metabolism
Awards and Honors:
1980College Scholar, Cornell University
1982Phi Beta Kappa
1983Magna Cum Laude
Report of Teaching
Continuing Medical Education Courses
1995-Endocrine Postgraduate Course, Harvard Medical School
Lecturer -"HIV and the Endocrine System: What We Need to Know"
Preceptor - Pituitary Problem Session
1996-AIDS Postgraduate Course, Harvard Medical School
Lecturer - “Wasting and Endocrine Disorders”
Clinical Supervisory Responsibilities
1991-1992Attending physician, ward medical service, Columbia-Presbyterian Hospital
1995-Preceptor, Neuroendocrine Clinic, Massachusetts General Hospital
1995-Teaching attending, Baker Service, Massachusetts General Hospital
1996-Teaching attending, Endocrinology Consult Service, Massachusetts General Hospital
Teaching Leadership Roles
1995-1996 Endocrinology Lecture Series, Institute of Health Professions, Massachusetts General Hospital
1998Chairperson, “Massachusetts General Hospital Symposium on Medical and Bone Complications of Eating Disorders”
1998Chairperson, “Massachusetts General Hospital Symposium on Muscle Loss and Fat Redistribution in HIV Disease: An Endocrine Approach”
1998Emergency Lecture Series, Massachusetts General Hospital
1999Chairperson, “Massachusetts General Hospital Symposium on Novel Treatment Strategies for Anorexia Associated Bone Loss in the Year 2000”
National/International Contributions
Invited Presentations - Regional
1991-1992Speaker, (Bi-weekly presentations), Morbidity and Mortality Conference
Columbia-Presbyterian Hospital, NY, NY
1991-1992Speaker, Morning Report
Columbia-Presbyterian Hospital, NY, NY
Invited Presentations - Regional (Cont’d)
1992Speaker, Medical Grand Rounds
Columbia Presbyterian Hospital, NY, NY
"Salt-Sensitive Hypertension”
1992Speaker, Endocrine Grand Rounds
Columbia Presbyterian Hospital, NY, NY
"Endocrine Manifestations of HIV Disease"
1995Speaker, Research Update
Boston Researchers in Eating Disorders, Boston, MA
"Use of rhIGF-I to Stimulate Bone Formation in Anorexia Nervosa"
1996Speaker, Research Update
Fenway Community Health Center, Boston, MA
"The Role of Hormones and Metabolism in AIDS Wasting"
1996Speaker, Boston Nutrition Seminar Series
Massachusetts Institute of Technology, Boston, MA
“Effects of Acute and Chronic Undernutrition on Bone”
1996Speaker, Endocrine Grand Rounds
Boston University Medical Center, Boston, MA
“Anabolic Strategies in AIDS Wasting”
1996Speaker, Monthly HIV Update
Dimmock Community Health Center, Boston, MA
“Endocrine Manifestations of HIV Disease”
1997Speaker, Endocrine Grand Rounds
Columbia Presbyteriian Medical Center, New York, NY
“Anabolic Strategies in AIDS Wasting”
1997Speaker, Research Update,
Multicultural AIDS Coalition of Boston, MA
“Use of Testosterone in Men and Women with AIDS Wasting”
1997Speaker, Research Update, Anorexia Research Group
Westwood Lodge, Westwood, MA
“Update on Mechanisms and Therapeutic Strategies for Osteoporosis in Anorexia Nervosa”
1997Speaker, Research Update
Boston Researchers in Eating Disorders, Boston, MA
“ Effects of rhIGF-I on Bone in Anorexia Nervosa”
1997Speaker, Adolescent Medicine Series
University of Massachusetts Medical Center, Worcester, MA
“Mechanisms and Treatment Options for Bone Loss in Anorexia Nervosa”
1997Speaker, AIDS Conference
New England Medical Center, Boston, MA
“HIV-Related Endocrinopathies”
1998Speaker, Clinical Seminar Series
Boston Obesity Research Center, Boston, MA
“Practical Considerations in the Design and Implementation of a Clinical Research Study”
1998Speaker, Health Education Seminar Series
Wellesley College, Wellesley, MA
“Treatment Strategies for Osteoporosis in Anorexia Nervosa”
1999Speaker, Combined AIDS Seminar,
Lemuel Shattuck Hospital,Boston, MA
“Hypogonadism in the AIDS Wasting Syndrome”
Invited Presentations - Regional (Cont’d)
1999Speaker, Research Seminar Series
USDA Human Nutrition Research Center on Aging
Tufts University, Boston, MA
“Strategies to Build Lean Body Mass and Reduce Fat Mass in HIV-Infected Patients”
1999Speaker, New England AIDS Education and Training Seminar,
Dimmock Health Center, Boston, MA
“HIV/AIDS Update: A Program for Community Health Center Providers.”
1999Speaker, Endocrine Grand Rounds
New England Medical Center, Boston, MA
“Endocrine Manifestations of HIV Disease”
1999Speaker, Advanced Clinical Seminar on HIV/AIDS
Dartmouth-Hitchcock Medical Center, Lebanon, NH
“Wasting, Lipodystrophy and Other Issues in HIV Care”
1999Speaker, McGill University AIDS Centre Rounds, Montreal, Canada
“ Endocrine Disorders in HIV Disease”
Invited Presentations - National
1997Panelist, NIH Conference on AIDS Wasting Syndrome, Bethesda, MD
“Endocrinology of AIDS, Growth Hormone and Testosterone”
1997Speaker, Annual Meeting, New England College Health Associations, Boston, MA
“Mechanisms and Therapeutic Options for the Treatment of Bone Loss in Anorexia Nervosa”
1997Speaker, Annual Meeting of the New England Consortium of Student Health Practitioners, Boston, MA
“Bone Loss in Anorexia Nervosa”
1998Speaker, Annual Meeting, Advances in Mineral Metabolism, Aspen, CO
“Effects of IGF-I on Bone”
1998Speaker, “Symposium on Clinical Care Issues for Women Living with HIV/AIDS in the United States, “ Harvard AIDS Institute, Boston, MA,
“Endocrine Disorders in HIV-Infected Women”
1998Speaker, “Current Challenges in HIV Disease, “ International AIDS Society-USA , New York, NY
“Metabolic and Hormonal Complications of Protease Inhibitor Use”
1998Speaker, Annual Meeting, National Primary Care Conference of Nurse Practitioners, Boston, MA
“Treatment Strategies for Bone Loss in Anorexia Nervosa”
1999Speaker, International AIDS Society USA, Improving the Management of HIV Disease: An Advanced Course in HIV Pathogenesis, Antiretrovirals and Other Selected Issues in HIV Disease, Cleveland, Ohio
“Long-Term Complications of Antiviral Therapy
1999Chair, Breakout Session, Glucose Metabolism, 1st International Workshop on Adverse Drug reactions and Lipodystrophy in HIV, San Diego, CA
1999Speaker, Twenty-Seventh AIDS Clinical Trials Group Meeting, Washington, D.C.
“Fasting Hyperinsulinemia and Regional Body Composition Changes in HIV- Infected Men and Women”
1999Speaker, 1999 National Conference on Women and HIV/AIDS
“Gender Specific Differences in Body Composition and Substrate Metabolism: the Role of Testosterone and Insulin in HIV-infected Women” in the the Symposium
“HIV, Nutrition and Metabolics”
Invited Presentations - International
1996Speaker, International Symposium on Insulin-Like Growth Factor -I, Institut Scientifique Roussel, Paris, France,
“Role of Growth Factors in Skeletal Tissue”
1998Speaker, Revolutionizing Women’s Healthcare: A Consensus Conference, Cancun, Mexico,
“Determinants of Bone Accretion in Anovulatory Women”
1998Speaker, Symposium on Wasting, Metabolism and Altered Body Shape,
12th World AIDS Conference, Geneva, Switzerland,
“Testosterone and Testosterone Analogues”
1999Speaker, University College Dublin, Medical Research Forum
Dublin, Ireland
“Endocrine Manifestations of HIV Disease: Old and New”
1999Speaker, 3rd International Conference on Nutrition and HIV Infection, Cannes, France
“Endocrine Disorders in HIV Disease - Relationship to the Wasting and Lipodystrophy Syndromes”
Professional and Educational Leadership Roles
1998Faculty, 1998 Endocrine Sociey Clinical Endocrinology Update, Boston, MA
1999American Association of Clinical Endocrinologists, Patient Assessment Guidelines, “Growth Hormone Deficiency and It’s Therapy in the Adult”
1999Chairperson, Diabetes and Lipid Metabolism, Oral Session, Annual Meeting of the Endocrine Society
Bibliography:
Original Articles
1.Grinspoon S, Bilezikian J. AIDS and the endocrine system. N Engl J Med. 1992; 327:1360-65.
2.Siegel L, Grinspoon S, Garvey G, Bilezikian J. Sepsis and adrenal function. Trends in Endocrinology and Metabolism. 1994; 5:324-28.
3.Grinspoon S, Clemmons D, Swearingen B, Klibanski A. Serum IGFBP-3 levels in the diagnosis of acromegaly. J Clin Endocrinol Metab. 1995; 80:927-32.
4. Grinspoon SK, Daniels GH. Increased levothyroxine requirement in a patient with cryptic celiac-sprue disease. Endocrine Practice. 1995;1:88-90.
5.Grinspoon SK, Baum HBA, Peterson S, Klibanski A. Effects of rhIGF-I administration on bone turnover during short-term fasting. J Clin Invest. 1995; 96: 900-6.
6.Grinspoon SK, Baum HBA, Kim V, Coggins C, Klibanski A. Decreased bone formation and increased mineral dissolution during acute fasting in young women. J Clin Endocrinol Metab. 1995; 80:3628-33.
Original Articles (Cont’d)
7.Grinspoon S, Gulick T, Askari H, Landt M, Lee K, Anderson E, Ma Z, Vignati L, Bowsher R, Herzog D, Klibanski A. Serum leptin levels in women with anorexia nervosa. J Clin Endocrinol Metab. 1996;81:3861-3.
8.Grinspoon S, Corcoran C, Lee K, Burrows B, Hubbard J, Katznelson L, Walsh M, Guccione A, Cannan J, Heller H, Basgoz N, Klibanski A. Loss of lean body and muscle mass correlates with androgen levels in hypogonadal men with AIDS wasting. J Clin Endocrinol Metab. 1996;81:4051-8.
9.Grinspoon S, Baum H, Lee K, Anderson E, Herzog D, Klibanski A. Effects of short-term rhIGF-I administration on bone turnover in osteopenic women with anorexia nervosa. J Clin Endocrinol Metab. 1996;81:3864-70.
10.Grinspoon S, Corcoran C, Miller K, Biller B, Askari H, Wang E, Hubbard J, Anderson E, Basgoz N, Heller H, Klibanski A. Body Composition and Endocrine Function in Women with AIDS Wasting. J Clin Endocrol Metab. 1997;82:1332-7.
11.Grinspoon S, Askari H, Landt ML, Nathan DM, Schoenfeld DA, Hayden DL, Laposata M, Hubbard J, Klibanski, A. Effects of Fasting and Glucose on Basal and Overnight Leptin Concentrations in Normal Weight Women. Am J Clin Nutr. 1997;66:1352-6.
12. Miller KK, Daly PA, Sentochnik D, Doweiko J, Samore M, Basgoz NO, Grinspoon SK. Pseudo-Cushing’s Syndrome in HIV-infected Patients. Clin Inf Dis. 1998;27:68-72.
13.Grinspoon S, Corcoran C, Askari H, Schoenfeld D, Wolf L, Burrows B, Walsh M, Hayden D, Parlman K, Anderson E, Basgoz N, Klibanski A, .Effects of Androgen Administration in Men with the AIDS Wasting Syndrome: A Randomized, Placebo- Controlled Trial. Ann Int Med. 1998;129:18-26.
14.Miller KK, Parulekar MS, Schoenfeld E, Anderson E, Hubbard J, Klibanski A, Grinspoon SK. Decreased Leptin Levels in Normal Weight Women with Hypothalamic Amenorrhea: The Effects of Body Composition and Nutritional Intake. J Clin Endocrinol Metab. 1998;83:2309-12.
15. Grinspoon S, Corcoran C, Miller K, Wang E, Hubbard J, Schoenfeld D, Anderson E, Basgoz N, Klibanski A. Determinants of Increased Energy Expenditure in HIV- Infected Women. Am J Clin Nutr. 1998;68:720-5.
16.Miller K, Corcoran C, Armstrong C, Caramelli K, Anderson A, Cotton D, Basgoz N, Hirschhorn L, Tuomala R, Schoenfeld D, Daugherty C, Mazer N, Grinspoon S. Transdermal Testosterone Administration in Women with AIDS Wasting: A Pilot Study. J Clin Endocrinol Metab. 1998;83:2717-25.
17.Swearingen B, Barker FG, Katznelson L, Biller BMK, Grinspoon S, Klibanski A,
Moayeri N, Black P, Zervas NT. Long-term Mortality After Transsphenoidal Surgery and Adjunctive Therapy for Acromegaly. J Clin Endocrinol Metab. 1998;83:3419-26.
18. Grinspoon S, Corcoran C, Stanley T, Katznelson L, Klibanski A. Effects of Androgen Administration on the GH-IGF-I Axis in Men with AIDS Wasting. J Clin Endocrinol Metab. 1998;83:4251-6.
Original Articles (Cont’d)
19. Grinspoon S, Corcoran C, Rosenthal D, Stanley T, Parlman K, Costello M, Treat M, Davis S, Burrows B, Basgoz N, Klibanski A. Quantitative Assessment of Cross Sectional Muscle Area, Functional Status and Muscle Strength in Men with
the AIDS Wasting Syndrome. J Clin Endocrinol Metab. 1999;84:201-6.
20. Grinspoon S, Corcoran C, Stanley T, Anderson E, Hubbard J, Basgoz N, Klibanski A. Sustained Anabolic Effects of Long-Term Androgen Administration in Men with AIDS Wasting. Clin Inf Dis. 1999;28:634-6.
21.Hadigan C, Miller K, Corcoran C, Anderson E, Basgoz N, Grinspoon S. Fasting Hyperinsulinemia and Changes in Regional Body Composition in HIV-Infected Women. J Clin Endocrinol Metab. 1999;84:1932-7.
22. Swearingen B, Biller BMK, Barker FG, Katznelson L, Grinspoon S, Klibanksi A, Zervas N. Long-Term Mortality after Transsphenoidal Surgery for Cushing Disease. Ann Int Med. 1999;130:821-4.
23. Grinspoon S, Miller K, Coyle C, Krempin J, Armstrong C, Pitts S, Herzog D, Klibanski A. Severity of Osteopenia in Estrogen Deficient Women with Anorexia Nervosa and Hypothalamic Amenorrhea. J Clin Endocrinol Metab. 1999;84:2049- 55.
24. Soyka L, Grinspoon S, Levitsky L, Herzog D, Klibanski A. The Effects of Anorexia Nervosa on Bone Metabolism in Female Adolescents. J Clin Endocrinol Metab 1999; 84: 4489-96.
25.Hadigan C, Corcoran C, Stanley T, Piecuch S, Klibanski A, Grinspoon S. Fasting Hyperinsulinemia in HIV-Infected Men: Relationship to Body Composition, Gonadal Function and Protease Inhibitor Use . J Clin Endocrinol Metab. 2000; 85: 35-41.
26.Hadigan CM, Anderson EJ, Miller KM, Hubbard JL, Herzog DB, Klibanski A, Grinspoon S. Assessment of Macronutrient and Micronutrient Intake in Women with Anorexia Nervosa. International Journal of Eating Disorders. 1999 (In Press).
27.Grinspoon S. Hypermetabolism and Progression of HIV-infection. Am J Clin Nutr. 1999;70:300 (letter).
28.Grinspoon S, Corcoran C, Stanley T, Baaj A, Basgoz N, Klibanski A. Effects of Hypogonadism and Testosterone Administration on Depression Indices in HIV-Infected Men. J Clin Endocrinol Metab. 2000; 85: 60-5.
Reviews
1.Grinspoon S, Bilezikian J. Endocrine manifestations of AIDS. Trends in Endocrinology and Metabolism 1993; 4:315-317.
2.Grinspoon S, Bilezikian J. Endocrine abnormalities in HIV infection. The AIDS Reader 1993; 3:191-198.
3.Grinspoon S, Bilezikian J. HIV infection and endocrine disease: Editorial review. Current Opinion in Endocrinology and Diabetes 1994; 1:3-6.
Reviews (Cont’d)
4.Grinspoon S, Bilezikian J. Clinical update: Metabolic and endocrinologic disturbances in HIV Infection. ENDOtrends 1994; 4:1-3.
5.Grinspoon S, Biller B. Laboratory assessment of adrenal insufficiency. J Clin Endocrinol Metab. 1994; 79:923-931.
6.Grinspoon S. AIDS: Endocrinologic and metabolic considerations. Ann Med. 1994; 26:321-323.
7.Grinspoon S, Herzog D, Klibanski A. Mechanisms and treatment options for bone loss in anorexia nervosa. Pharmacol Bul. 1997;3:399-404.
8.Grinspoon S. Neuroendocrine manifestations of AIDS. The Endocrinologist. 1997;7:32-38.
9.Corcoran C, Grinspoon S. Diagnosis and Treatment of Endocrine Disorders in the HIV-Infected Patient. Journal of the International Association of Physicians in AIDS Care. February 1998:10-14,34.
10.Grinspoon S. Effects of HIV infection on the hypothamic-pituitary-adrenal axis. The AIDS Reader (editorial). 1999 (In Press).
11. Corocoran C, Grinspoon S. The use of testosterone and testosterone analogues in the AIDS wasting syndrome The AIDS Reader. 1999 (In Press).
12.Becker A, Grinspoon S, Klibanski A. Herzog D. The Assessment and Management of Eating Disorders. N Engl J Med. 1999; 340:1092-1098.
13. Corocoran C, Grinspoon S. Treatments for wasting in patients with AIDS. N Engl J Med. 1999; 349:1740-50.
Chapters
1.Grinspoon S, Donovon D, Bilezikian J. Etiology and Pathogenesis of Hormonal and Metabolic Disorders in HIV Infection. In: Norbiato G, ed. Hormonal and Metabolic Disorders in Acquired Immunodeficiency Syndrome. London: Bailliere Tindal, 1994; 8:735-737.
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