Electronic supplementary material

APPENDIX

Study organization

Steering Committee (* Principal Investigator):

*T. Kadowaki(University of Tokyo), Y. Akanuma(The Institute for Adult Diseases, Asahi Life Foundation), C. Ito(Grand Tower Medical Court Life Care Clinic), Y. Iwamoto(Tokyo Women's Medical University School of Medicine), M. Noda(National Center for Global Health and Medicine), T. Yamazaki(University of Tokyo), T. Shiba(Toho University Ohashi Medical Center), M. Odawara(Tokyo Medical University), Y. Terauchi(Yokohama City University Graduate School of Medicine).

Endpoint Adjudication Committee:

K. Tobe(University of Toyama), K. Maemura(Nagasaki University).

Statistical Analysis Center:

J. Kishimoto(Kyushu University Hospital), T. Yamazaki(University of Tokyo).

Independent Data Monitoring Committee:

N. Yamada(University of Tsukuba), H. Orikasa(University of Toyama),

K. Yokote(Chiba University).

Clinical centers & Participating investigators:

Yatsushiro Social Insurance General Hospital: T. Sekigami, Yamaguchi Hospital: A. Yamauchi, Yotsuyasamoncho Clinic: S. Shimizu, Hanamaki General Hospital: K. Sato, Suzuki Clinic: K. Sasamoto, Biwako Ohashi Hospital: E. Ogura, Ebisu clinic: K. Nakajima, K. Suzuki, Grand Tower Medical Court: C. Ito, R. Fujikawa, Tokyo Eki Center-building clinic: A. Kiyosue, Y. Fukushima, Kamagaya General Hospital: Y. Shinoda, Diabetes And Lifestyle Center, Tomonaga Clinic: O. Tomonaga, Toho Hospital: M. Shitara, Koganeibashi Sakura Clinic: M. Sugimoto, Hotaruno Central Clinic: D. Uchida, Osaka Police Hospital: K. Kosugi, Nawa Clinic: C. Hirose, M. Hirose, Matsuura Clinic: Y. Matsuura, Shimonita Municipal Hospital: Y. Shoda, Kyousaikai Sakurai Hospital: M. Sakurai, Toranomon Hospital: S. Hara, M. Miyakawa, Y. Mori, NTT West Tokai Hospital: K. Tsukada, Ihara Clinic: C. Ihara, Suruga Clinic: A. Yamauchi, Seino Internal Medicine Clinic: H. Seino, Nakano Egota Hospital: N. Yamamichi, S. Tamura, Kitazimabasi Clinic: J. Ueda, Yokohama Minoru Clinic: H. Kim, N. Nakamichi, C. Nakamura, Imamura Clinic: K. Imamura, Yamauchi Clinic: T. Shigihara, Yoshimoto eye clinic: H. Yoshimoto, Nakano Sun Bright Clinic: Y. Kure, Y. Washizawa, Yamaguchi Clinic: T. Yamaguchi, Oriso Clinic: S. Oriso, Kouhoukai Takagi Hospital: Y. Ono, Shyunan City Shin-Nanyo Hospital: A. Matsutani, Y. Nakamori, Yamane Hospital: Y. Yamane, Baba Internal Medicine Clinic: Y. Baba, Nakazato Medical Clinic DM: M. Nakazato, Tennoz Clinic: H. Katoh, KENKOKAN SUZUKI CLINIC: K. Suzuki, Gunma Hospital for Allergic & Respiratory Diseases: H. Inamura, J. Morioka, Ashida-geka-hihuka clinic: K. Ashida, Kenseido Clinic: A. Okuno, Hiroshima General Hospital: K. Ishida, S. Hiraoka, K. Ohguro, R. Kishimoto, K. Jitsuiki, JOHNAN MEDICAL CLINIC: K. Suzuki, Aoki Clinic: N. Aoki, M. Aoki, NTT West Takamatsu Hospital: T. Fukui, Ube Industries Central Hospital: S. Imoto, S. Miyamoto, Sugano Internal Medicine Clinic: M. Sugano, T. Matsuno, Ashiho general clinic: M. Tanaka, Kogure Clinic: H. Kogure, Fujino Clinic: K. Fujno, Urasoe General Hospital Medical Examination Center: T. Hisada, Ninomiya clinic: K. Ninomiya, Fujiyamadai Clinic: N. Akiyama, Anan Kyoei Hospital: Y. Ohshima, H. Azuma, Tokushima Red Cross Hospital: Y. Tobetto, Y. Hiasa, Enomoto Internal Medicine Clinic: T. Enomoto, Toumei Atsugi Clinic: N. Nomura, Yoshida Hospital: M. Okada, Y. Iwashima, Kumagayageka Hospital: I. Inoue, Yamamoto clinic: H. Yamamoto, Hiroshima Red Cross Hospital & Atomic Bomb Survivors Hospital: F. Sawano, M. Shiwa, TAKAMURA CLINIC: I. Takamura, Jikei University School of Medicine: S. Katoh, K. Taki, N. Tajima, K. Utsunomiya, NTT East Corporation Sapporo Hospital: J. Takeuchi, Yamada Red Cross Hospital: K. Murata, R.Fujiwara, R.Sasaki, National Hospital Organization Kobe Medical Center: Y. Miwa, Akita Red Cross Hospital: T. Goto, Watanabe orthopedic and medical clinic: T. Ueno, Sakado Internal Medical Dispensary: T. Senda, KUSHIMA INTERNAL MEDICAL CLINIC: M. Kushima, Hosoya Clinic: T. Hosoya, Kuriyama Central Hospital: H. Moriyama, KKR SAPPORO medical center: Y. Fujiwara, T. Honda, Ajihara Clinic: T. Ajihara, Niigata City General Hospital: S. Soda, Shirouzu Clinic: K. Shirouzu,Tomishiro Central Hospital: M. Higa, T. Tohma, M. Takara, University of the Ryukyus: M. Shimabukuro, SAKURAI Clinic: J. Sakurai, Ohta Clinic: A. Ohta, Yabuki Clinic: T. Yabuki, Internal Medicine and Pediatrics Mukahira Clinic: K. Mukahira, K. Mukahira, Shitennoji hidein clinic: H. Sawaoka, K. Kamiya, Ojin Clinic: T. Hirai, Kaishunsou Hospital: T. Ando, Misakinaika Clinic: N. Kuribayashi, Kochi Memorial Hospital: N. Hisakawa, General Rehabilitation Center Midori Hospital: Y. Tanabe, Koga General Hospital: T. Kuribayashi, Kawauchi Clinic: A. Kawacuhi, Kamimura Clinic: N. Kamimura, Kansai Medical University: H. Otani, H. Park, Kagoshima Medical Center: N. Koriyama, Shirai Clinic: K. Shirai, Mitsui Memorial Hospital: M. Yamakado, Takatsuki general hospital: Y. Tominaga, The University of Tokushima Graduate School of Health Biosciences: S. Yagi, K. Aihara, M. Akaike, M. Sata, T. Matsumoto, Heiwadai Hospital: S. Nakamura, Akatsuka Clinic: H. Akatsuka, Yamaguchi Clinic: A. Yamauchi, Tomita clinic: T. Tomita, Kurosawa Clinic: T. Kurosawa, Saiseikai Nara Hospital: N. Hamazaki, A. Okuyama, T. Imai, Chugoku Rousai Hospital: A. Miyauchi, Japan Labour Health and Welfare Organization TOKYO ROSAI HOSPITAL: K. Kuwabara, Shindouhigashi Oota Naika: H. Oota, Komatsu medical clinic: K. Komatsu, Shizuoka City Shizuoka Hospital: M. Waki, Tenryo Hospital: E. Kuroda, Kaneko Internal Medicine & Gastrointestinal Clinic: H. Kaneko, Kawaragi Clinic: K. Matsubara, W. Sekino, Hidakami Central Clinic: I. Segawa, Kimura Iin: K. Kimura, Takaishi Fujii Hospital: M. Mune, Diabetes Center, Takamatsu Hospital: S. Murao, Kotani Diabetes Clinic: K. Kotani, Nakazono Clinic: M. Nakazono, Kuwamizu Hospital: F. Ohoishi, Tokyo Otsuka clinic, Tokyo Women’s Medical University: S. Otake, J. Wada, T. Nakagami, Akahane Clinic: I. Akahane, Nagahama City Hospital: M. Nishimura, TENO CLINIC: S. Teno, Ogiwara Clinic: S. Ishigouoka, Nozaki Clinic: M. Nozaki, Kyoto Renaiss Hospital: A. Nishiyama, Takenaka Clinic: K. Takenaka, Tokuyama Central Hospital: K. Hatao, Hamada Medical Center: K. Kawada, Murakami Clinic: M. Murakami, Anzai Clinic: J. Anzai, Institute of Geriatrics Tokyo Women's Medical University: N. Ujihara, Ishida Clinic: K. Ishida, The Fraternity Memorial Hospital: Y. Kushikata, Shizuoka General Hospital: T. Inoue, Takao Clinic: Y. Takao, Kyoto Second Red Cross Hospital: M. Deguchi, Kusatsu General Hospital: A. Wada, M. Ohnishi, T. Matsumoto, Suehiro Clinic: M. Suehiro, Kansai Rosai Hospital: S. Gorogawa, T. Ikeda, Takagi Naika Junkankinaika Clinic: S. Takagi, Tanaka iin: S. Tanaka, Hashimoto medical clinic: H. Hashimoto, Hiroshima University: K. Yamane, S. Nakanishi, T. Awaya, Ayame Medical Clinic: H. Ayame, Zentsuji National Hospital: K. Yoshida, Siminnomori hospital: Y. Miyazono, Tanaka Clinic: H. Tanaka, Matsuo Clinc: T. Matsuo, Izu Hospital NTT EC: T. Kurosawa, H. Hosokai, Kondou medical clinic: R. Kondou, Ebina Medical Support Center: H. Sugihara, Urban-heights clinic: M. Yaida, Kochi Medical School, Kochi University: M. Inoue, K. Arii, Y. Ikeda, T. Suehiro, Yamagata Clinic: F. Yamagata, Kato Internal Medicine Clinic: T. Kato, Kurabatyashi Clinic: M. Kurabayashi, Kawabata naika syoukakika clinic: H. Kawabata, Obayashi Clinic: K. Obayashi, Jissen Women's University: T. Matsushima, The Institute for Adult Diseases, Asahi Life Foundation: H. Kitazato, Kazama Clinic: H. Kazama, Yamanote Medical Clinic: Y. Hori, Ishitaniiin: K. Ishitani, Miyakonojo Medical Association Hospital: K. Nakatsuru, Ishiduka Internal Medicine & Gastrointestinal Clinic: D. Ishiduka, Saitama Medical Center, Saitama Medical University: Y. Imai, Inoue Internal Medicine Clinic: M. Inoue, SEIREI SAKURA Citizen Hospital: N. Sasaki, Motomura clinic: T. Motomura, Iryouhoujin Tamura iin: T. Nishi, TODA Internal medicine & Rehabilitation Clinic: M. Toda, Chugoku Rousai Hospital: A. Miyauchi, Geshi Hospital: M. Yamamoto, Yatsuda Community Hospital: K. Sonoda