SM Secondary Malignancy; CML Chronic Myeloid Leukaemia;

M- Male; F- Female; CP – Chronic phase, AP – Accelerated phase, CCyR – Complete cytogenetic remission, CHR – complete haematological remission, MMR – major molecular remission (molecular remission status defined based on ELN criteria), LFU – Lost to follow up, BC – blast crisis

SM – Secondary malignancy; CML – chronic myeloid leukaemia;

NA – Not available

• Decreasing NK cell activity following imatinib therapy making individuals prone to development of other malignancies (3).
• Concurrent exposure to tobacco and alcohol increases the likelihood of developing secondary head and neck malignancies (20).
• Acquiring additional cytogenetic abnormalities in patients on imatinib with CML in complete remission suggests role in carcinogenesis (26).
• Imatinib might inhibit other tyrosine kinases which are negative regulators of various cycle processes involved in stringent regulation of cell proliferation (27).
• Inhibitory impact of TKI (Imatinib) on dendritic cell and T cell stimulation (28, 29)
• Inhibition of C-ablkinases which have a role in potentiating apoptosis of DNA damaged cells (25).

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