SCHEME OF STUDIES
B.PHARM SEMESTER V
Session 2016-17, 2017-18 and 2018-19
PAPER NO TITLE OF PAPER HRS/WEEK
I THEORY
5001 / PHARMACEUTICS -V ( Biological Pharmacy) /3 hrs
5002 / PHARMACEUTICAL ANALYSIS II /3 hrs
5003 / PHARMACOGNOSY AND NATURAL PRODUCTS-III /3 hrs
5004 / INDUSTRIAL MANAGEMENT AND PHARMACEUTICAL MARKETING /3 hrs
II LABORATORY (PRACTICAL)
5021 / PHARMACEUTICS LABORATORY-V (Biological Pharmacy) /6hrs
5022 / PHARMACEUTICAL ANALYSIS II / 6hrs5023 / PHARMACOGNOSY AND NATURAL PRODUCTS LABORATORY / 6hrs
III PROBLEM BASED LEARNING WORKSHOP
S.No. /TITLE OF WORKSHOP
1. / PHARMACEUTICS -V (Biological Pharmacy) / 1 hr2. / PHARMACEUTICAL ANALYSIS II / 1 hr
3. / PHARMACOGNOSY AND NATURAL PRODUCTS-III / 1 hr
4. / INDUSTRIAL MANAGEMENT AND PHARMACEUTICAL MARKETING / 1 hr
5001 PHARMACEUTICS -V (Biological Pharmacy)
Max Marks: 70 Max Time 3hrs.
Internal Assessment: 30 Marks only 3 hrs/Week
Total Marks: 100
INSTRUCTIONS FOR THE PAPER SETTERS
The question paper will consist of three sections A, B and C. Each of sections A and B will have four questions from the respective sections of the syllabus. Each question shall carry 7 marks. Section C will consist of 14 short answer type of 2 marks each.
INSTRUCTIONS FOR THE CANDIDATES
Candidates are required to attempt any three questions from section A and any three questions from section B. Section C is compulsory.
Section- A
1. Disinfection: Factors influencing disinfection, dynamics of disinfection, disinfectants, antiseptics and their evaluation. (4 lectures)
2. Sterilization: Methods of sterilization i.e. physical, chemical , heat, radiation, gaseous and filtration methods, evaluation of efficiency of sterilization methods, equipments employed on large scale sterilization, examples of the materials sterilized by different methods, sterility indicators. (6 lectures)
3. Sterility Testing: Sterility testing of products according to I.P., B.P. and U.S.P. sterility testing of parenteral products (solid, liquids), ophthalmic and other sterile products according to I.P., B.P. and U.S.P., sterility testing of sterile surgical devices, dressings, implants, hemostats, surgical ligatures and sutures, pyrogen testing (Rabbit and LAL test). (8 lectures)
4. Aseptic Technique: Sources of contamination and methods of prevention, designing of aseptic area, laminar flow equipments, their service and maintenance (3 lectures)
5. Microbiological Standardization: Microbiological methods for standardization of antibiotics, vitamins and aminoacids (5 lectures)
Section- B
6. Microbial Spoilage and Preservation of Pharmaceutical Products: Types of spoilage, factors affecting the microbial spoilage of pharmaceutical products, sources and types of microbial contaminants, assessment of microbial contamination and spoilage, preservation of pharmaceutical products using antimicrobial agents, evaluation of microbial stability of formulation (5 lectures)
7. Control of Microbial Contamination during Manufacture: General aspect of environmental cleanliness and hygiene, quality of starting materials, process design, quality and documentation (3 lectures)
8. Immunological Preparations: General method of preparation of bacterial vaccines, viral vaccines, rickettsial vaccines, antitoxins, serum immune blood additives and interferon. Methods of preparation, standardization and storage of BCG vaccine, Diptheria toxoid, small pox vaccine, polio vaccine, tetanus antitoxin, vitamine B12 and diagnostic biologicals. (8 lectures)
9. Blood and Glandular Products : Preparation of extracts and isolation of pure substances for the preparation of dosage from pituitary, adrenal, thyroid, ovary, pancreas, stomach and liver, official blood products and plasma expanders (8 lectures)
BOOKS RECOMMENDED
1. W.B. Hugo and A.D. Russel, Pharmaceutical Microbiology, 5th edition, Blackwell Scientific Publications, Oxford U.K., 1977.
2. Gilbert S. Banker and Christopher T. Rhodes, Modern Pharmaceutics, 2nd edition, Marcel Dekker Inc., New York, U.S.A., 1990.
3. Gennaro A. R.(ed), Remington’s Pharmaceutical Sciences, 18th edition, Mack Publishing Company, Pennsylvania, U.S.A., 1990.
4. G. Reed (ed), Prescott and Dunn’s Industrial Microbiology 4 th edition CBS Publishers and Distributors, Delhi, India, 1982.
5002 PHARMACEUTICAL ANALYSIS-II
Max Marks:70 Max Time 3hrs.
Internal Assessment: 30 Marks only 3 hrs/Week
Total Marks: 100
INSTRUCTIONS FOR THE PAPER SETTERS
The question paper will consist of three sections A, B and C. Each of sections A and B will have four questions from the respective sections of the syllabus. Each question shall carry 7 marks. Section C will consist of 14 short answer type of 2 marks each.
INSTRUCTIONS FOR THE CANDIDATES
Candidates are required to attempt any three questions from section A and any three questions from section B. Section C is compulsory.
Section -A
1. Non-Aqueous Titrations: Theoretical considerations, scope and limitations, acid base equilibria in non aqueous media, titration of weak bases, titration of weak acids. Indicators. Pharmaceutical products should be selected for illustration. e.g.ephedrine, phensuximide and ethsuximide. (4 lectures)
2. Complexometric Titrations: Concept of complexation and chelation, Werner’s coordination number and electronic structure of complex ions, stability constants, titration curves, masking and demasking agents. Types of complexometric titration, metal ion indicators, factors influencing the stability of complexes, applications e.g. calcium gluconate, bismuth carbonate and bismuth sub-nitrate. (4 lectures)
3. Aquametry: Brief account of aquametry. Physical methods for water determination,azeotropic distillation, refractive index, spectrophotometricmethod.Electrochemical methods, chemical methods for water determination, Karl Fischer’s method of moisture determination, other chemical methods involving use of organic and inorganic reagents. (3 lectures)
4. Phase Solubility Analysis: Theory, experimental procedure, applications in pharmaceutical analysis. (3 lectures)
5. Miscellaneous Methods of Analysis: Kjeldahl’s nitrogen determination. Determination of alcohol in liquid galenicals. Oxygen flask combustion, gasometry. (3 lectures)
6. Ion-Exchange and Molecular Sieve Processes: Theory of ion exchange, type of exchangers, ion exchange equilibrium, ion exchange capacity, ion exchange separation, applications in pharmaceutical analysis, molecular sieve separation and applications. (8 lectures)
Section- B
7. Chromatography: Introduction, classification and study of different chromatographic methods and its applications. Theory of chromatography, retention mechanisms, and band broadening. Preparative thin layer chromatography including centrifugally controlled circular TLC, quantitative TLC, Chromatoscanning, finger printing technique. Droplet counter current chromatography. GLC and HPLC, instrumentation with particular reference to its application in quantitative estimation of drugs. Size exclusion chromatography and its applications. (10 lectures)
8. Potentiometry: The electric cell, electrode potential,half cells, types of half cells, sign conventions, Nernst equation, salt bridge, activity series, standard potential, standard hydrogen electrode, measuring the relative voltage of half cells, calculations of standard potential, reference electrodes, indicator electrodes.Theoretical considerations of potentiometry, ion selective electrodes, measurement of potential, location of end point, equipment, potentiometric acid- base titrations, direct measurement of metal concentrations, determination of Ksp, pH measurement, oxidation reduction titrations, applications in pharmacy. (5 lectures)
9. Conductometric Analysis: Definitions of units in conductometric titrations, determination of water, analysis of salt solutions , measurement of conductance, high frequency (oscillometric) method, applications. (5 lectures)
10. Coulometric Titrations: Controlled potential and constant current coulometry, cell design, instrumentation, advantages and limitations, electrode selection and applications. (3 lectures)
11. Polarography: Theory, mass transport processes, current processes, current potential relationship,polarization, choice of electrodes, effect of oxygen, instrumentation, calculation of concentration, laboratory design and safety. (2 lectures)
12. Amperometric Titrations: Concepts and applications of amperometric titrations. (2 lectures)
BOOKS RECOMMENDED:
1. A.H.Beckett and J.B.Stenlake, Practical Pharmaceutical Chemistry, vol. I & II, The Athlone Press of The University of London, U.K., 1976.
2. J.Bassett, R.C.Denny, G.H. Jeffery and J. Medhan, Vogel’s Text Book of Quantitative Inorganic Analysis Including Elementary Instrumental Analysis, IVth edition, The ELBS and Longman,London, U.K., 1978.
3. H.H.Willard, L.L.Merriet and J.A. Dean, Instrumental Methods of Analysis, 5th edition,Van Nostrand Reinhold, New York , U.S.A., 1974.
4. L.G.Chatten, A Text Book of Pharmaceutical Chemistry vol. I & II, Marcel Dekker, New York, U.S.A., 1969.
5. K.A. Connors, A Text Book of Pharmaceutical Analysis, 3rd edition, Wiley-Inter-Science, New York, U.S.A., 1982.
6. A.M. Kinevol and F.B. Digangi. Jenkin’s Quantitative Pharmaceutical Chemistry Mc Graw Hill Book Co, New York, U.S.A., 1977.
7. R.E. Schirmer, Modern Methods of Pharmaceutical Analysis vol I,II, and III, CRC Press, Florida, U.S.A., 1982.
8. D.A. Skoog, Principles of Instrumental Analysis, 3rd edition, Holt Richard and Winston Inc., New York U.S.A., 1985.
5003 - PHARMACOGNOSY AND NATURAL PRODUCTS – III
Max Marks: 70 Time allowed: 3hrs.
Internal Assessment: 30 Marks only 3hrs/Week
Total Marks 100
INSTRUCTIONS FOR THE PAPER SETTERS
The question paper will consist of three sections A, B and C. Each of sections A and B will have four questions from the respective sections of the syllabus. Each question shall carry 7 marks. Section C will consist of 14 short answer type of 2 marks each.
INSTRUCTIONS FOR THE CANDIDATES
Candidates are required to attempt any three questions from section A and any three questions from section B. Section C is compulsory.
Section- A
1. Introduction to phenolic compounds: An overview of different phenolic compounds and their uses (3 lectures)
2. Flavonoids: Chemistry, classification and identification of flavonoids. Study of flavonoid containing plants (biological source, geographical sources, plant description, constituents, and uses): orange and Ruta graveolens. (5 lectures)
3. Coumarins: Chemistry, classification and identification of coumarins. Study of coumarins containing plants (biological source, geographical sources, plant description, constituents, and uses): Psoralea, Ammi majus, Ammi visnaga. (3 lectures)
4. Tannins: Study of tannins and tannin containing plants (biological source, geographical sources, plant description, constituents, tests for identification and uses): catechu (pale and black), tannic acid galls, harar and bahera. (4 lectures)
5. Lipids: Classification, chemistry and biogenesis of lipids. General method of extraction and purification of fixed oils. Study of lipid products (biological source, description, preparation, chemical constituents, tests for identity and uses): arachis oil, castor oil, sesame oil, cotton seed oil, chaulmoogra oil, olive oil, wool fat, codliver oil, shark liver oil, cocoa butter, bees wax. (6 lectures)
Section -B
6. Resin and Resin Combinations: Nature, occurance, chemistry, collection, preparation and uses of drugs containing balsams (tolu balsam, peru balsam, benzoin); resin acid (colophony), gum resin (myrrh, asafoetida) and resins (colocynth, ginger, turmeric, capsicum, cannabis,) glycoresins ( jalap, podophyllum). (5 lectures)
7. Plant Enzymes: Introduction, general methods of isolation, purification, and applications. Biological sources, methods of separation, chemical nature and uses of: Papain, Diastase, Pepsin, Bromelains, Ficin, Trypsin, Maltase, Pancreatin, Urokinase, Hyaluronidase, Asparaginase, Pectinase. (6 lectures)
8. Glycosides: Chemistry and biogenesis of glycosides. General methods of isolation and purification of glycosides. Study of drugs containing (biological source, description, chemical constituents, tests for identity and uses): anthraquinone glycosides (cascara, aloe, rhubarb, senna); cardiac glycosides (digitalis, strophanthus , squill, thevetia); bitter glycosides (quassia, gentian, chirata ); saponins (liquorice, dioscorea, quillaia, ginseng); flavonoid glycosides (rutin ) others (psoralea, Ammi majus). (7 lectures)
9. Vitamins: Introduction and general properties. Study of natural sources rich in vitamins: amla, lemon, carrot, cod liver oil and shark liver oil. (5 lectures)
10. Pharmaceutical aids: Study of natural products used as pharmaceutical aids: Talc, kaolin, bentonite, gelatin and natural colours. (6 lectures)
BOOKS RECOMMENDED
1 V.E. Tyler , L.R. Brady and J.E. Robbers, Pharmacognosy , 9th edition, Lea & Febiger, Philadelphia, U.S.A., 1988.
2 W.C. Evans, Trease and Evans' Pharmacognosy 16th edition, Bailliere Tindal, London, U.K, 2009.
3 T. Robinson, The organic constituents of higher plants, Burgess Publishing Co., Minneapolis, U.S.A., 1967.
4 B. P. Jackson and D.W. Snowdon, Powdered vegetable drugs, Stanley Thornes Ltd, London, U.K., 1974.
5 T. W. Wallis, Textbook of Pharmacogonsy, 5th edition, CBS, Delhi, India, 1985.
6. I.L.Finar,Organic Chemistry Vol. I and II, 6th edition, The English Language Book Society and Longman Group Limited,London, U.K.1995
5004- INDUSTRIAL MANAGEMENT AND PHARMACEUTICAL MARKETING
Max Marks: 70 Time allowed: 3hrs.
Internal Assessment: 30 Marks only 3hrs/Week
Total Marks 100
INSTRUCTIONS FOR THE PAPER SETTERS
The question paper will consist of three sections A, B and C. Each of sections A and B will have four questions from the respective sections of the syllabus. Each question shall carry 7 marks. Section C will consist of 14 short answer type of 2 marks each.
INSTRUCTIONS FOR THE CANDIDATES
Candidates are required to attempt any three questions from section A and any three questions from section B. Section C is compulsory.
Section- A
1. Basic Principle of Organization of Management: Evolution of management theory, system approach, organizational climate, globalization, quality management, decision making, rational mode of decision making and strategic planning. (8 lectures)
2. Human Resource Management: Organisational structure and its type, man power planning, recruitment and selection, performance appraisal, compensation, promotions, transfers, leadership, team work, authority delegation and job design. Motivation, its objectives, types and theories. Communication, its nature, importance and types. Barriers to communication, communication failure and modes of effective communication. Problem of labor management, industrial disputes and their remedies. Grievances and conflicts, their causes and handling procedures. (8 lectures)
3. Finance Management: Capital planning, types and uses of budget, preparation of budget, forecasting techniques, financial statements and financial analysis. (7 lectures)
Section -B
4. Material Management: Objective and organization of purchasing, methods of purchasing and vendor analysis. Materials handling, equipment, inventory control-objectives, inventory classification such as FIFO, ABC, FSN, and VED analysis. Value engineering, lead time, EOQ, inventory carrying costs and safety stock. (9 lectures)
5. Production Management: Facilities location and planning, various factors affecting choice of location. Plant lay out designs-tableting capsule, perenterals, ointments and stores. Process layout and product layout. Production planning and control-types of production, line of balancing, scheduling and control of production. Work study-need, methods, flow patterns and charts, motion and operation analysis. Time study-performance rating, developing standards. Waste management, operation research, management of information systems and technology management. (8 lectures)
6. Marketing Management: Goals, strategic planning and marketing environment. Analysis of market potential-market research, marketing organization and demand forecasting. Product management (designing products), pricing and promotion, sales and distribution, competitors analysis. (8 lectures)
BOOKS RECOMMENDED :
1. J.A.F. Stoner, R.E. Freeman and D.R. Gilbert, Management, 6th edition, Prentice Hall, Delhi, India, 1996.
2. P. Kotler, Marketing Management-Analysis, Planning, Implementation and Control 8th edition, Prentice Hall, Delhi, India, 1996.